Pheromone-dependent G1 cell cycle arrest requires Far1 phosphorylation, but may not involve inhibition of Cdc28-Cln2 kinase, in vivo

Molecular and Cellular Biology

Volumn 18, Issue 7, 1998, Pages 3681-3691

  Gartner, Anton ^a,c   Jovanović, Alexandra ^a   Jeoung, Doo Il ^b   Bourlat, Sarah ^a   Cross, Frederick R ^b   Ammerer, Gustav ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b ROCKEFELLER UNIVERSITY   (United States)

^c Simons Center for Quantitative Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHEROMONE; A MATING FACTOR; A-MATING FACTOR; CELL CYCLE PROTEIN; CLN2 PROTEIN, YEAST; CYCLIN DEPENDENT KINASE 1; CYCLINE; ENZYME INHIBITOR; FAR1 PROTEIN, S CEREVISIAE; FUNGAL PROTEIN; GROWTH INHIBITOR; HISTIDINE; LIPOPROTEIN; REPRESSOR PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SERINE; THREONINE;

ARTICLE; CATALYSIS; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GROWTH INHIBITION; IMMUNOPRECIPITATION; MATING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RECEPTOR UPREGULATION; YEAST; ANIMAL; BINDING SITE; CELL DIVISION; DRUG ANTAGONISM; GENETICS; METABOLISM; MOUSE; MUTAGENESIS; ONCOGENE MYC; PHOSPHORYLATION;

ANIMALS; BINDING SITES; CDC28 PROTEIN KINASE, S CEREVISIAE; CELL CYCLE PROTEINS; CELL DIVISION; CYCLINS; ENZYME INHIBITORS; FUNGAL PROTEINS; G1 PHASE; GENES, MYC; GROWTH INHIBITORS; HISTIDINE; LIPOPROTEINS; MICE; MUTAGENESIS; PHEROMONES; PHOSPHORYLATION; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SERINE; THREONINE;

EID: 0031595259     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.7.3681     Document Type: Article

References (56)

1. Barral, Y., S. Jentsch, and C. Mann. 1995. G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev. 9:399-409.
2. Blondel, M., and C. Mann. 1996. G2 cyclins are required for the degradation of G1 cyclins in yeast. Nature 384:279-281.
3. Chang, F., and I. Herskowitz. 1990. Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of G1 cyclin, CLN2. Cell 63:999-1011.
4. Chang, F., and I. Herskowitz. 1992. Phosphorylation of Far1 in response to α-factor: a possible requirement for cell cycle arrest. Mol. Biol. Cell 3:445-450
5. mpk, the meiosis activated myelin basic protein kinase. J. Biol. Chem. 266:15180-15184.
6. Cook, J. G., L. Bardwell, and J. Thorner. 1997. Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signaling pathway. Nature 390:85-88.
7. Cook, J. G., L. Bardwell, S. J. Kron, and J. Thorner. 1996. Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae. Genes Dev. 10:2831-2848.
8. Correa-Bordes, J., and P. Nurse. 1995. p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase. Cell 83:1001-1009.
9. Cross, F. 1990. Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START I arrest and is independent of the mating pheromone signal. Mol. Cell. Biol. 10:6482-6490.
10. 9a. Cross, F. Unpublished data.
11. 9b. Cross, F., and J. McKinney. Unpublished data.
12. Dirick, L., T. Böhm, and K. Nasmyth. 1995. Roles and regulation of the Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. EMBO J. 14:4803-4813.
13. Dorer, R., P. M. Pryciak, and L. H. Hartwell. 1996. Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients. J. Cell Biol. 131:845-861.
14. Elion, E. A., B. Satterberg, and J. R. Kranz. 1993. Fus3 phosphorylates multiple components of the mating signal transduction cascade: evidence for Ste12 and Far1. Mol. Biol. Cell 4:495-510.
15. Errede, B., A. Gartner, Z. Zhaoqing, K. Nasmyth, and G. Ammerer. 1993. A pheromone induced kinase cascade in S. cerevisiae: activation of the Fus3 kinase by the Ste7 kinase in vitro. Nature 362:261-264.
16. Evan, G. L., G. K. Lewis, G. Ramsay, and J. M. Bishop. 1985. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol. 5:3610-3616.
17. Feldman, R. M., C. C. Correll, K. B. Kaplan, and R. J. Deshais. 1997. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91:221-230.
18. Field, J., J. Nikawa, D. Broek, B. MacDonald, L. Rodgers, I. Wilson, I. Lerner, and M. Wigler. 1988. Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol. Cell. Biol. 8:2149-2165.
19. Futcher, B. A. 1991. Saccharomyces cerevisiae cell cycle: cdc28 and the G1 cyclins. Semin. Cell Biol. 2:205-212.
20. 17a. Gartner, A. Unpublished data.
21. 17b. Gartner, A., and G. Ammerer. Unpublished data.
22. Gartner, A., K. Nasmyth, and G. Ammerer. 1992. Signal transduction in S. cerevisiae requires threonine and tyrosine phosphorylation of Fus3 and Kss1. Genes Dev. 6:1305-1318.
23. Henchoz, S., Y. Chi, B. Catarin, I. Herskowitz, R. J. Deshaies, and M. Peter. 1997. Phosphorylation-and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. Genes Dev. 11:3046-3060.
24. Herskowitz, I. 1995. MAP kinase pathways in yeast: for mating and more. Cell 80:187-197.
25. Horecka, J., and G. F. Sprague, Jr. 1996. Identification and characterization of FAR3, a gene required for pheromone-mediated G1 arrest in Saccharomyces cerevisiae. Genetics 144:905-921.
26. Hui, Z., G. J. Hannon, and D. Beach. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8:1750-1758.
27. Inouye, C., N. Dhillon, and J. Thorner. 1997. Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling. Science 278: 103-106.
28. Jeoung, D.-I., L. J. W. M. Oehlen, and F. R. Cross. 1998. Cln3-associated kinase activity in Saccharomyces cerevisiae is regulated by the mating factor pathway. Mol. Cell. Biol. 18:433-441.
29. Lanker, S., M. H. Valdivieso, and C. Wittenberg. 1996. Rapid degradation of the G1 cyclin Cln2 induced by CDK dependent phosphorylation. Science 271:1597-1601.
30. Lew, D. J., and S. I. Reed. 1993. Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins. J. Cell Biol. 120:1305-1320.
31. Madhani, H. D., C. A. Styles, and G. R. Fink. 1997. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 91:673-684.
32. 1 phase specificity of cell cycle arrest by mating factor in Saccharomyces cerevisiae. Mol. Cell. Biol. 15:2509-2516.
33. McKinney, J. D., F. Chang, N. Heintz, and F. R. Cross. 1993. Negative regulation of FAR1 at the start of the yeast cell cycle. Genes Dev. 7:833-843.
34. Nasmyth, K. 1996. At the heart of the budding yeast cell cycle. Trends Genet. 12:405-412.
35. Neiman, A., and I. Herskowitz. 1994. Regulation of a yeast protein kinase cascade, in vitro: activation of the yeast MEK homologue Ste7 by Ste11. Proc. Natl. Acad. Sci. USA 91:3398-3402.
36. Oehlen, L. J., J. R. McKinney, and F. R. Cross. 1996. Ste12 and Mcm1 regulate cell cycle-dependent transcription of FAR1. Mol. Cell. Biol. 16: 2830-2837.
37. Oehlen, L. J., and F. R. Cross. 1994. G1 cyclins CLN1 and CLN2 repress the mating factor response pathway at START in the yeast cell cycle. Genes Dev. 8:1058-1070.
38. Peter, M., and I. Herskowitz. 1994. Direct inhibition of the yeast cyclin dependent kinase Cdc28-Cln by Far1. Science 265:1228-1231.
39. Peter, M., A. Gartner, J. Horecka, G. Ammerer, and I. Herskowitz. 1993. Far1 links the signal transduction pathway to the cell cycle machinery in yeast. Cell 73:747-760.
40. Reed, S. I. 1980. The selection of S. cerevisiae mutants defective in the START event of cell division. Genetics 95:561-567.
41. Reed, S. I. 1992. The role of p34 kinases in the G1 to S-phase transition. Annu. Rev. Cell Biol. 8:529-561.
42. Richardson, H. E., C. Wittenberg, F. Cross, and S. I. Reed. 1989. An essential G1 function for cyclin like proteins in yeast. Cell 59:1127-1133.
43. Schneider, B. L., Q. F. Yang, and A. B. Futcher. 1996. Linkage of replication to start by the Cdk inhibitor Sic1. Science 272:560-562.
44. sic1 controls the G1 to S transition in S. cerevisiae. Cell 79:233-244.
45. Sheaff, R. J., M. Groudine, M. Gordon, J. M. Roberts, and B. E. Clurman. 1997. Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev. 11:1464-1478.
46. Skowyra, D., K. I. Craig, M. Tyers, S. J. Elledge, and J. W. Harper. 1997. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91:209-219.
47. Song, O. K., J. W. Dolan, V. I. Yuan, and S. Fiels. 1991. Pheromone dependent phosphorylation of the yeast Ste12 protein correlates with transcriptional activation. Genes Dev. 5:741-750.
48. Sprague, G. F. 1991. Assay of yeast mating reaction. Methods Enzymol. 194:77-93.
49. Stuart, D., and C. Wittenberg. 1995. CLN3, not positive feedback determines the timing of CLN2 transcription in cycling cells. Genes Dev. 9:2780-2794.
50. Tedford, K., S. Kim, D. Sa, K. Stevens, and M. Tyers. 1997. Regulation of the mating pheromone and invasive growth responses in yeast by the two MAP kinase substrates Rst1 and Rst2. Curr. Biol. 7:22-238.
51. 1-phase Cdc28 kinase complexes. Mol. Cell. Biol. 13:5659-5669.
52. Tyers, M., G. Tokiwa, and B. Futcher. 1993. Comparison of the Saccharomyces G1 cyclins: Cln3 may be an upstream activator Cln1, Cln2 and other cyclins. EMBO J. 12:1955-1968.
53. Valtz, N., M. Peter, and I. Herskowitz. 1995. FAR1 is required for oriented polarization of yeast cells in response to mating pheromones. J. Cell Biol. 131:863-873.
54. Verma, R., R. S. Annan, M. J. Huddleston, S. A. Carr, G. Reynard, and R. J. Deshaies. 1997. Phosphorylation of sic1p by G1 cdk required for its degradation and entry into S phase. Science 278:455-460.
55. Willems, A. R., S. Lanker, E. E. Patton, K. L. Craig, T. F. Nason, N. Mathias, R. Kobayashi, C. Wittenberg, and M. Tyers. 1996. Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell 86:453-463.
56. cdc28 protein kinase. Cell 62:225-237.