Reconstructing voltage sensor-pore interaction from a fluorescence scan of a voltage-gated K+ channel

Neuron

Volumn 27, Issue 3, 2000, Pages 585-595

  Gandhi, Chris S ^a   Loots, Eli ^a   Isacoff, Ehud Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENT DYE; MEMBRANE PROTEIN; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CHANNEL GATING; DROSOPHILA; ELECTRIC POTENTIAL; FLUORESCENCE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SENSOR; X RAY CRYSTALLOGRAPHY; XENOPUS;

EID: 0033680734     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)00068-4     Document Type: Article

References (69)

1. Contribution of the S4 segment to gating charge in the Shaker K channel
2. + channel gating
3. Voltage-insensitive gating after charge neutralization mutations in the S4 segment segment of Shaker Channels
4. +]: A tale of two inactivation mechanisms
5. + channel
6. + channels: II The components of gating currents and a model of channel activation
7. + channel
8. Cysteines in the Shaker K channel are not essential for channel activity or zinc modulation
9. Structure and function of voltage-gated ion channels
10. Characterizing voltage-dependent conformational changes in the Shaker K channel with fluorescence
11. Structural implications of fluorescence quenching in the Shaker K channel
12. Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy
13. The selectivity filter of a potassium channel, murine Kir 2.1 investigated using scanning cysteine mutagenesis
14. The structure of the potassium channel: Molecular basis of K conduction and selectivity
15. + channels in open, closed, and inactivated conformations
16. Role of individual surface charges of voltage-gated K channels
17. Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel
18. Modulation of the Shaker K(+) channel gating kinetics by the S3-S4 linker
19. + channel
20. Mutations in the K channel signature sequence
21. The lipid-protein interface of a Shaker K channel
22. A new twist in the saga of charge movement in voltage-dependent ion channels
23. Molecular determinants of external barium block in shaker potassium channels
24. Potassium-dependent changes in the conformation of the Kv2.1 potassium channel pore
25. Substituted-cysteine accessibility method
26. Modulation of C-type inactivation by K at the potassium channel selectivity filter
27. Contribution of the selectivity filter to inactivation in potassium channels
28. Primary structure and functional expression of a mouse inward rectifier potassium channel
29. + channel S4
30. Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation
31. Images of purified Shaker potassium channels
32. α-helical structural elements within the voltage-sensing domains of a K channel
33. A localized interaction surface for voltage sensing domains on the pore domain of a K channel
34. Dynamic rearrangement of the outer mouth of a K channel during gating
35. Incremental reductions of positive charge within the S4 region of a voltage-gated K channel result in corresponding decrease in gating charge
36. Protein rearrangements underlying slow inactivation of the Shaker K channel
37. Effects of external cations and mutations in the pore region on c-type inactivation of shaker potassium channels
38. Structural conservation in prokaryotic and eukaryotic potassium channels
39. Independence and cooperativity in rearrangements of a potassium channel voltage sensor revealed by single subunit fluorescence
40. Direct physical measure of conformational rearrangement underlying potassium channel gating
41. Role of the S3-S4 linker in Shaker potassium channel activation
42. Molecular rearrangements in the ligand-binding domain of cyclic nucleotidegated channels
43. Transmembrane structure of an inwardly rectifying potassium channel
44. Helical structure and packing orientation of the S2 segment in the Shaker K channel
45. Cooperative subunit interactions in C-type inactivation of K channels
46. + channels
47. + channel occurs by a cooperative mechanism
48. Coassembly of synthetic segments of shaker K channel within phospholipid membranes
49. Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K channels
50. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels
51. Voltage sensing residues in the S2 and S4 segments of the Shaker K channel
52. The inward rectification mechanism of the HERG cardiac potassium channel
53. Role of the S4 in cooperativity of voltage-dependent potassium channel activation
54. Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation
55. + channel
56. Ion conduction through c-type inactivated shaker channels
57. Macroscopic Na currents in the nonconducting Shaker potassium channel mutant W434F
58. + channel through multiple binding sites
59. + channels
60. + channel subunits
61. Voltage-dependent structural interactions in the shaker K(+) channel
62. Projection structure of the nicotinic acetylcholine receptor: Distinct conformations of the alpha subunits
63. Effect of cysteine substitutions on the topology of the S4 segment of the Shaker potassium channel: Implications for molecular models of gating
64. Evidence for voltage-dependent S4 movement in sodium channels
65. Molecular basis of charge movement in voltage-gated sodium channels
66. Probing the outer vestibule of a sodium channel voltage sensor
67. Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel
68. The moving parts of voltage-gated ion channels
69. Shaker potassium channel gating. III: Evaluation of kinetic models for activation