Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels

Journal of General Physiology

Volumn 113, Issue 1, 1999, Pages 139-151

  Bao, Hongxia ^a   Hakeem, Atiya ^a   Henteleff, Mark ^a   Starkus, John G ^a   Rayner, Martin D ^a,b  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF HAWAII   (United States)

Author keywords

Charge neutralizations; Ion channel gating; S4 mutations; Voltage sensitivity

Indexed keywords

4 AMINOPYRIDINE; CALCIUM ION; POTASSIUM CHANNEL; POTASSIUM ION; RUBIDIUM;

ANIMAL CELL; ARTICLE; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CONTROLLED STUDY; GENE MUTATION; NONHUMAN; OOCYTE; POTASSIUM CURRENT; PROTEIN DOMAIN; SURFACE CHARGE; VOLTAGE CLAMP; XENOPUS LAEVIS;

ALGORITHMS; ANIMALS; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; ION CHANNEL GATING; MEMBRANE POTENTIALS; MICE; MODELS, BIOLOGICAL; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; XENOPUS LAEVIS;

EID: 0032920625     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.113.1.139     Document Type: Article

References (55)

1. + channel. Neuron. 16: 1169-1177.
2. Armstrong, C.M. 1981. Sodium channels and gating currents. Physiol. Rev. 61:644-683.
3. Bao, H., A. Hakeem, K. McCormack, M. Rayner, and J. Starkus. 1996. Voltage-insensitive gating in Shaker B S4 mutants. Biophys. J. 70:A189.
4. Bezanilla, F., and E. Stefani. 1994. Voltage-dependent gating of ionic channels. Annu. Rev. Biophys. Biomol. Struct. 23:819-846.
5. Catterall, W.A. 1986. Molecular properties of voltage-sensitive sodium channel. Annu. Rev. Biochem. 55:953-985.
6. Colquhoun, D., and F.J. Sigworth. 1983. Fitting and statistical analysis of single-channel records. In Single Channel Recording. B. Sakmann and E. Neher, editors. Plenum Publishing Corp., New York. 505 pp.
7. + conduction and selectivity. Science. 280:69-77.
8. Greenblatt, R.E., Y. Blatt, and M. Montai. 1985. The structure of the voltage-sensitive sodium channel. Inferences derived from computer-aided analysis of the Electrophorus electricus channel primary structure. FEBS Lett. 193:125-134.
9. Guy, H.R., and P. Seetharamulu. 1986. Molecular model of the action potential sodium channel. Prof. Natl. Acad. Sci USA. 83:508-512.
10. + channel signature sequence. Biophys. J. 66: 1061-1067.
11. Hille, B. 1992. Ionic Channels of Excitable Membranes. 2nd ed. Sinauer Associates, Inc., Sunderland, MA. 59-82.
12. Hodgkin, A.L., and A.F. Huxley. 1952. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond.). 117:500-544.
13. Hoshi, T., W.N. Zagotta, and R.W. Aldrich. 1994. Shaker potassium channel gating I: transitions near the open state. J. Gen. Physiol. 103:249-278.
14. Hurst, R.S., M.P. Kavanaugh, J. Yakel, J.P. Adelman, and R.A. North. 1992. Cooperative interactions among subunits of a voltage-dependent potassium channel. J Biol. Chem. 267:23742-23745.
15. Iverson, L.E., and B. Rudy. 1990. The role of divergent amino and carboxyl domains on the inactivation properties of potassium channels derived from the Shaker gene of Drosophila, J. Neurosci. 10:2903-2916.
16. + channel S4. Neuron. 16:387-397.
17. Levy, D. L., and C. Deutsch. 1996. Recovery from C-type inactivation is modulated by extracellular potassium. Biophys. J. 70:798-805.
18. + channel. Nature. 353:752-756.
19. + channel. Neuron. 19: 175-184.
20. Llano, I., C.K. Webb, and F. Bezanilla. 1988. Potassium conductance of the squid giant axon. J. Gen. Physiol. 92:179-196.
21. + channels are due to the specific charge content of their respective S4 regions. Neuron. 10:1121-1129.
22. + channel result in corresponding decreases in gating charge. Neuron. 8:531-540.
23. + channel. J. Gen. Physiol. 112: 377-389.
24. + channel. Neuron. 2:327-336.
25. López-Barneo, J., T. Hoshi, S.H. Heinemann, and R.W. Aldrich. 1993. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels. 1:61-71.
26. Mannuzzu, L.M., M.M. Moronne, and E.Y. Isacoff. 1996. Direct physical measure of conformational rearrangement underlying potassium channel gating. Science. 271:213-216.
27. + channels. J. Gen. Physiol. 87: 795-816.
28. + channel by three amino acid substitutions. Neuron. 16:853-858.
29. + channels. Neuron. 12:301-315.
30. Noda, M., T. Ikeda, T. Kayano, H. Suzuki, H. Takeshima, M. Kurasaaki, H. Takahashi, and S. Numa. 1986. Existence of distinct sodium channel messenger RNAs in rat brain. Nature. 320: 188-192.
31. Noda M., T. Tanabe, T. Takai, T. Kayano, and T. Ikeda. 1984. Primary structure of the Electrophorus electricus sodium channel deduced from cDNA sequence. Nature. 312:121-127.
32. + channel. Neuron. 14:1293-1301.
33. Papazian, D.M., L.C. Timpe, Y.N. Jan, and L.Y. Jan. 1991. Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature. 349:305-310.
34. Perozo, E., L. Santacruz-Toloza, E. Stefani, E. Bezanilla, and D.M. Papazian. 1994. S4 mutations alter gating currents of Shaker K channels. Biophys. J. 66:345-354.
35. + channels in the squid giant axon. J. Gen. Physiol. 98:1-34.
36. Schoppa, N.E., and F.J. Sigworth. 1998a. Activation of Shaker potassium channels I. Characterization of voltage-dependent transitions. J. Gen. Physiol 111:271-294.
37. Schoppa, N.E., and F.J. Sigworth. 1998b. Activation of Shaker potassium channels II. Kinetics of the V2 mutant channel. J. Gen. Physiol. 111:295-311.
38. Schoppa, N.E., and F.J. Sigworth. 1998c. Activation of Shaker potassium channels III. An activation gating model for wild-type and V2 mutant channels. J. Gen. Physiol 111:313-342.
39. + channel. Neuron. 16:1159-1167.
40. Sigworth, F.J. 1994. Voltage gating of ion channels. Q. Rev. Biophys. 27:1-40.
41. Smith-Maxwell, C.J., J.L. Ledwell, and R.W. Aldrich. 1998a. Role of the S4 in cooperativity of voltage-dependent potassium channel activation. J. Gen. Physiol, 111:399-420.
42. Smith-Maxwell, C.J., J.L. Ledwell, and R.W. Aldrich. 1998b. Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation. J. Gen. Physiol 111:421-439.
43. Starkus, J.G., L. Kuschel, M.D. Rayner, and S.H. Heinemann. 1997. Ion conduction through C-type inactivated Shaker channels. J. Gen. Physiol. 110:539-550.
44. +. Nature. 291: 427-429.
45. Tanabe, T., H. Takeshima, A. Mikami, V. Flovkerzi, Takahashi, K. Kangawa, M. Kojima, T. Hirose, and S. Numa. 1987. Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature. 328:313-318.
46. Tempel, B.L., D.M. Papazian, T.L. Schwarz, Y.N. Jan, and L.Y. Jan. 1987. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. Science. 237:770-775.
47. Tytgat, J., and P. Hess. 1992. Evidence for cooperative interaction in potassium channel gating. Nature. 359:420-423.
48. Woodhull, A.M. 1973. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61:687-708.
49. Yang, N., A.L. George, and R. Horn. 1996. Molecular basis of charge movement in voltage-gated sodium channels. Neuron. 16:113-122.
50. Yang, N., and R. Horn. 1995. Evidence for voltage-dependent S4 movement in sodium channels. Neuron. 15:213-218.
51. Yusaf, S.P., D. Wray, and A. Sivaprasadarao. 1996. Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel. Pflügers, Arch. 433:91-97.
52. Zagotta, W.N., T. Hoshi, J. Dittman, and R.W. Aldrich, 1994a. Shaker potassium channel gating II: transitions in the activation pathway. J. Gen. Physiol. 103:279-319.
53. Zagotta, W.N., T. Hoshi, J. Dittman, and R.W. Aldrich. 1994b. Shaker potassium channel gating III: evaluation of kinetic models for activation. J. Gen. Physiol. 103:321-362.
54. Zagotta, W.N., T. Hoshi, and R.W. Aldrich. 1989. Gating of single Shaker potassium channels in Drosophila muscle and in Xenopus oocytes injected with Shaker mRNA. Proc. Natl. Acad. Sci. USA. 86: 7243-7247.
55. Zheng, J., and F.J. Sigworth. 1998. Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels. J. Gen. Physiol. 112:457-474.