Selection of a human anti-progesterone antibody fragment from a transgenic mouse library by ARM ribosome display

Journal of Immunological Methods

Volumn 231, Issue 1-2, 1999, Pages 105-117

  He, Mingyue ^a   Menges, Margit ^a,b   Groves, Maria A T ^a   Corps, Elaine ^a   Liu, Hong ^a   Brüggemann, Marianne ^a   Taussig, Michael J ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Progesterone; Ribosome display; Single chain antibody; Transgenic mouse

Indexed keywords

ANTIBODY; ANTIGESTAGEN; IMMUNOGLOBULIN LIGHT CHAIN; MESSENGER RNA; PROGESTERONE;

ANTIBODY PRODUCTION; ARTICLE; GENE LIBRARY; GENE SEQUENCE; HORMONE BINDING; HUMAN; HYBRIDOMA; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOME; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; CLONING, MOLECULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HUMANS; HYBRIDOMAS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PROGESTERONE; RIBOSOMES; SERUM ALBUMIN, BOVINE;

ANIMALIA; BOVINAE; ESCHERICHIA COLI; EUKARYOTA; MURINAE; MUS MUSCULUS;

EID: 0033505816     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(99)00144-1     Document Type: Article

References (27)

1. Arevalo, J., Stura, E.A., Taussig, M.J., Wilson, I.A., 1993. Three-dimensional structure of an anti-steroid Fab' and progesterone-Fab' complex. J. Mol. Biol. 231, 103-118.
2. Brüggemann, M., Neuberger, M.S., 1996. Strategies for expressing human antibody repertoires in transgenic mice. Immunol. Today 17, 391.
3. Brüggemann, M., Taussig, M.J., 1997. Production of human antibody repertoires in transgenic mice. Curr. Opin. Biotechnol. 8, 455.
4. Fishwild, D.M., O'Donnell, S.L., Bengoechea, T., Hudson, D.V., Harding, F., Bernhard, S.L., Jones, D., Kay, R.M., Higgins, K.M., Schramm, S.R., Lonberg, N., 1996. High avidity human Igk monoclonal antibodies from a novel strain of minilocus transgenic mice. Nat. Biotechnol. 14, 845.
5. Georgiou, G., Poetschke, H.L., Stathopoulos, C., Francisco, J.A., 1993. Practical applications of engineering gram-negative bacterial cell surfaces. Trends Biotechnol. 11, 6.
6. Griffiths, A.D., Malmqvist, M., Marks, J.D., Bye, J.M., Embleton, M.J., McCafferty, J., Baier, M., Holliger, K.P., Gorick, B.D., Hughs-Jone, N.C., Hoogenboom, H.R., Winter, G., 1993. Human anti-self antibodies with high specificity from phage display libraries. EMBO J. 12, 725.
7. Griffiths, A.D., Williams, S.C., Hartley, O., Tomlinson, I.M., Waterhouse, P., Crosby, W.L., Kontermann, R.E., Jones, P.T., Low, N.M., Allison, T.J., Prospero, T.D., Hoogenboom, H.R., Nissin, A., Cox, J.P.L., Harrison, J.L., Zaccolo, M., Gherardi, E., Winter, G., 1994. Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 13, 3245.
8. Hanes, J., Plückthun, A., 1997. In vitro selection and evolution of functional proteins by using ribosome display. Proc. Natl. Acad. Sci. U.S.A. 94, 4937.
9. Hanes, J., Jermutus, L., Weber-Bornhauser, Bosshard, H.R., Plückthun, A., 1998. Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries. Proc. Natl. Acad. Sci. U.S.A. 95, 14130.
10. He, M., Taussig, M.J., 1997. Antibody-ribosome-mRNA (ARM) complexes as efficient selection particles for in vitro display and evolution of antibody combining sites. Nucleic Acids Res. 25, 5132.
11. H/K) expressed in E. coli. Immunology 84, 662.
12. Kasahara, N., Dozy, A.M., Kan, Y.W., 1994. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. Science 266, 1373.
13. Kieke, M.C., Cho, B.K., Boder, E.T., Kranz, D.M., Wittrup, K.D., 1997. Isolation of anti-T cell receptor scFv mutants by yeast surface display. Protein Eng. 10, 1303.
14. Kitamura, D., Roes, J., Kühn, R., Rajewsky, K., 1991. A B cell deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350, 423.
15. Makeyev, E.V., Kolb, V.A., Spirin, A.S., 1999. Cell-free immunology: construction and in vitro expression of a PCR-based library encoding a single-chain antibody repertoire. FEBS Lett. 444, 177.
16. Marks, J.D., Hoogenboom, H.R., Bonnert, T.P., McCafferty, J., Griffiths, A.D., Winter, G., 1991. By-passing immunisation. Human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 222, 581.
17. Mattheakis, L.C., Bhatt, R.R., Dower, W.J., 1994. An in vitro polysome display system for identifying ligands from very large peptide libraries. Proc. Natl. Acad. Sci. U.S.A. 91, 9022.
18. McCafferty, J., Hoogenboom, H.R., Chiswell, D.J. (Eds.), 1996. Antibody Engineering: A Practical Approach. IRL Press, Oxford Univ. Press, Oxford.
19. Mendez, M.J., Green, L.L., Corvalan, J.R.F. et al., 1997. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nat. Genet. 15, 146.
20. Nicholson, I.C., Zou, X., Popov, A.V., Neuberger, M.S., Corps, E.M., Humphreys, A.S., Taussig, M.J., Ayling, C., Xian, J., Brüggemann, M., 1999. Antibody repertoire of four and five feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain YACs.
21. Popov, A.V., Zou, X., Xian, J., Nicholson, I.C., Brüggemann, M., 1999. A human immunoglobulin lambda locus is similarly well expressed in mice and humans. J. Exp. Med. 189, 1611.
22. Sims, M.J., Krawinkel, U., Taussig, M.J., 1992. Characterisation of germline genes of the VGAM3.8 gene family from BALB/c mice. J. Immunol. 149, 1642-1648.
23. Stansfield, I., Jones, K.M., Tuite, M.F., 1995. The end in sight: terminating translation in eukaryotes. Trends Biochem. Sci. 20, 489.
24. Taussig, M.J., Groves, M.T.A., Menges, M., Liu, H., He, M., 1999. ARM complexes for in vitro display and evolution of antibody combining sites. In: Shepherd, P., Dean, C. (Eds.), Monoclonal Antibodies: A Practical Approach. Oxford Univ. Press, in press.
25. Winter, G., Griffiths, A.D., Hawkins, R.E., Hoogenboom, H.R., 1994. Making antibodies by phage display technology. Annu. Rev. Immunol. 12, 433.
26. Zou, X., Xian, J., Popov, A.V., Rosewell, I.R., Müller, M., Brüggemann, M., 1995. Subtle differences in antibody responses and hypermutation of λ light chains in mice with a disrupted κ constant region. Eur. J. Immunol. 25, 2154.
27. Zou, X., Xian, J., Davies, N.P., Popov, A.V., Brüggemann, M., 1996. Dominant expression of a 1.3 Mb human Igκ locus replacing mouse light chain production. FASEB J. 10, 1227.