Milk fat conjugated linoleic acid (CLA) inhibits growth of human mammary MCF-7 cancer cells

Anticancer Research

Volumn 20, Issue 5 B, 2000, Pages 3591-3601

  O'Shea, M ^a   Devery, R ^a   Lawless, F ^a   Murphy, J ^a   Stanton, C ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

Conjugated linoleic acid; Linoleic acid; MCF 7 cells; Milk fat

Indexed keywords

CATALASE; GLUTATHIONE PEROXIDASE; LINOLEIC ACID; MILK FAT; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL;

ANTIOXIDANT ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL COUNT; CELL MEMBRANE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIPID COMPOSITION; LIPID PEROXIDATION; PEROXIDATION; PRIORITY JOURNAL; SOYBEAN;

ANIMALS; BREAST NEOPLASMS; CARBON RADIOISOTOPES; CATALASE; CATTLE; CELL DIVISION; CELL SURVIVAL; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; FEMALE; GLUTATHIONE PEROXIDASE; GROWTH INHIBITORS; HUMANS; LINOLEIC ACIDS; LIPID PEROXIDATION; MILK; SOYBEANS; SUPEROXIDE DISMUTASE; TUMOR CELLS, CULTURED;

EID: 0033637794     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Elevation of conjugated cis-9, trans-11-octadecadienoic acid in bovine milk because of dietary supplementation
2. Cows' milkfat components as potential anticarcinogenic agents
3. Biohydrogenation of unsaturated fatty acids
4. Biosynthesis of conjugated linoleic acid and its incorporation into meat and milk in ruminants
5. Conjugated linoleic acid. A powerful anticarcinogen from animal fat sources
6. Dietary Conjugated linoleic acid modulation of phorbol ester skin tumour promotion
7. The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet
8. Protection of conjugated linoleic acids against 2-amino-3-methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: A study of inhibitory mechanisms
9. Intake of dairy products and the risk of breast cancer
10. Conjugated linoleic acid and the risk of breast cancer
11. Conjugated linoleic acid-enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats
12. Inhibition of Benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid
13. Mammary cancer prevention by conjugated dienoic derivative of linoleic acid
14. DNA adducts of heterocyclic amines: Formation, removal and inhibition by dietary component
15. A beef derived mutagenesis modulator inhibits initiation of mouse epidermal tumours by 7,12-dimethylbenz[a]anthracene
16. Mammary cancer prevention by conjugated dienoic derivative of linoleic acid
17. Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells in primary culture
18. Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid
19. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens
20. The nature of diene conjugation in human serum, bile and duodenal juice
21. Identification of a diene Conjugated component of human lipid as octadeca - 9,11 dienoic acid
22. Effect of Cheddar cheese consumption on plasma conjugated linoleic acid concentrations in men
23. Diet as a source of phospholipid esterified 9,11-octadecadienoic acid in humans
24. Dietary trans fatty acids increase conjugated linoleic acid levels in human serum
25. Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue
26. High-fat dairy product consumption increases D9c, 11t-18:2 (rumenic acid) and total lipid concentrations of human milk
27. Antioxidant enzyme defence responces of human MCF-7 and SW480 cancer cells to conjugated linoleic acid
28. Differential Stimulatory and inhibitory responses of human MCF- 7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture
29. Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture
30. The growth inhibitory effect of conjugated linoleic acid on MCF- 7 cells is related to estrogen response system
31. A method for the measurement of linoleic acid, 18:2 (9,11), in serum phospholipid, and possible origins
32. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans
33. Conjugated linoleic acid content of milk and cheese from cows fed extruded oilseeds
34. Dietary fatty acid sources affect comjugated linoleic acid concentrations in milk from lactating dairy cows
35. The enrichment of bovine milkfat with conjugated linoleic acid by dry fractionation technology
36. Effect on cow performance and milk fat composition of including full fat soyabean and rapeseed in the concentrate mixture for lactating dairy cows
37. Silver-ion high performance liquid chromatographic separation and identification of conjugated linoleic acid isomers
38. Rapid separation of neutral lipids, free fatty acids and polar lipids using pre-packed silica Sep-Pak columns
39. A simple method for the isolation and purification of total lipid from animal tissues
40. Dietary influences on bovine milk cis-9, trans- 11conjugated linoleic acid content
41. Comparison of methylation methods for the quantitation of conjugated linoleic acid isomers
42. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and bcarotene on the in vitro growth of human cancer cells
43. The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumour cell lines is in part due to increased lipid peroxidation
44. Glutathione-reductase in himan and murine lungtumors-high-levels of messanger-RNA and enzymatic-activity
45. Inhibitors of ras farnesylation revert the increased resistance oxidative stress in K-ras transformed NIH 3t3 cells
46. Changes in glutathione redox cycling and oxidative stress response in the malignant progression of Nb 2 lymphoma cells