Effect of lonidamine on the mitochondrial potential in situ in ehrlich ascites tumor cells

Anticancer Research

Volumn 16, Issue 1, 1996, Pages 419-424

  Pulselli, Rossana ^a   Amadio, Lorena ^a   Fanciulli, Maurizio ^a   Floridi, Aristide ^a,b  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Ehrlish ascites tumor cells; Glycolysis; Lonidamine; Mitochondrial membrane

Indexed keywords

GLUCOSE; LONIDAMINE; ROTENONE;

ARTICLE; CELL METABOLISM; CONTROLLED STUDY; EHRLICH ASCITES TUMOR CELL; GLYCOLYSIS; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, EHRLICH TUMOR; ELECTRON TRANSPORT; GLUCOSE; GLYCOLYSIS; INDAZOLES; INTRACELLULAR MEMBRANES; MALE; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; OXYGEN CONSUMPTION; PHENAZINES; ROTENONE; SPECTROPHOTOMETRY;

EID: 0029968371     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Floridi A, Paggi MG, Marcante ML, Silvestrini B, Caputo and De Martino C: Lonidamine, a selective inhibitor of aerobic murine tumour cells. J Ntl Cancer Inst 66: 497-99, 1981.
2. Floridi A, Paggi MG, D'Atri S, De Martino C, Marcante ML, Silvestrini B and Caputo A: Effect of Ionidamine on the energy metabolism of Ehrlich ascites tumour cells. Cancer Res 1: 4661-66, 1981.
3. 14C-labeled glucose by human astrocytoma cells. Exp Mol Pathol 47: 154-165, 1987.
4. Floridi A and Lenhinger AL: Action of the antitumor and antispermatogenic agent Ionidamine on electron transport in Ehrlich ascites tumour mitochondria. Arch Biochem Biophys 226: 73-83, 1983.
5. Pedersen PL: Tumor mitochondria and bioenergetics of cancer cell. Prog Exp Tumour Res 22: 190-274, 1978.
6. Floridi A, Delpino A, Nista A, Feriozzi R, Marcante ML, Silvestrini B and Caputo A: Effect of Ionidamine on protein synthesis in neoplastic cells. Exp Mol Pathol 42: 293-305, 1985.
7. Delpino A, Nista A, Marcante ML, Ferrini U, Silvestrini B, Caputo A and Floridi A: Induction of stress proteins by Ionidamine in human and murine melanoma cells. Exp Mol Pathol 44: 197-206, 1986.
8. Floridi A, Gentile FP, Bruno T, Castiglione S, Zeuli M and Benassi M: Growth inhibition by rhein and Ionidamine of human glioma cells in vitro. Anticancer Res 10: 1633-36, 1990.
9. Floridi A, Gentile FP, Bruno T, Delpino A, Iacobini C, Paggi MG, Castiglione S and Benassi M: Thermal behaviour of a human glioma cell line and its response to combinations of hyperthermia and Ionidamine. Oncology Res 5: 1-10, 1993.
10. Cividalli A, Gentile FP, Alonzi A, Benassi M, Mauro F and Floridi A: In vivo control of tumour growth by Ionidamine and radiations influence of the timing and sequence of drug administration and irradiation treatment Int J Oncol 1: 561-65, 1992.
11. Cividalli A, Gentile FP, Begnozzi L, Chiatti L, Benassi M and Floridi A: In vivo control of tumour growth with the association of Ionidamine with radiation and/or hyperthermia. Int J Oncol 2: 791-95, 1993.
12. Åkerman KEO: Qualitative measurements of the mitochondrial membrane potential in situ in Ehrlich ascites tumour cells using the safranine method. Biochem Biophys Acta 546: 341-47, 1979.
13. Bogucka K, Wroniszewska A, Bednarek M, Duszynski J and Wojtczak: Energetics of Ehrlich ascites mitochondria: membrane potential of isolated mitochondria and mitochondria within digitonin-permeabilized cells. Biochem Biophys Acta 1015: 503-509, 1990.
14. Olavarria JS, Galindo C, Montero M, Baquero Y, Vitorica J and Satrustegui J: Measurements of in situ mitochondrial membrane potential in Ehrlich ascites tumour cells during aerobic glycolysis Biochem Biophys Acta 935: 322-332, 1988.
15. Hohorst HJ: Determination with lactic dehydrogenase and DPN. In: Methods of Enzymatic Analysis (Bergmayer Hu ed) New York, Academic press 1965: pp 226-270.
16. Colonna R, Massari S, and Azzone GF: The problem of cation-binding sites in the energized membrane of intact mitochondria. Eur J Biochem 34: 577-585, 1973.
17. Demetrakopulos GE, Linn B and Amos H: Rapid loss of ATP by tumour cells deprived of glucose: contrast to normal cells. Biochem Biophys Res Commun 82: 787-794, 1978.
18. Hess B and Chance B: Metabolic control mechanism. VI Chemical events after addition of glucose to ascites tumor cells. J Biol Chem 236: 239-246, 1961.