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Volumn 42, Issue 3-4, 1997, Pages 150-156

Aliphatic propargylamines: New antiapoptotic drugs

Author keywords

Aliphatic propargylamines; Apoptosis; Monoamine oxidase B inhibitors; Neural rescue

Indexed keywords

MONOAMINE OXIDASE B INHIBITOR; NEUROPROTECTIVE AGENT; PROPARGYLAMINE DERIVATIVE; SELEGILINE; UNCLASSIFIED DRUG;

EID: 0031393126     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199711/12)42:3/4<150::AID-DDR6>3.0.CO;2-P     Document Type: Review
Times cited : (95)

References (88)
  • 1
    • 0026308236 scopus 로고
    • Selegiline in de novo Parkinsonian patients: The French selegiline multicenter trial (FSMT)
    • Allain H, Cougnand J, Neukinch HC (1991): Selegiline in de novo Parkinsonian patients: The French selegiline multicenter trial (FSMT). Acta Neurol Scand 84(Suppl 136):73-78.
    • (1991) Acta Neurol Scand , vol.84 , Issue.136 SUPPL. , pp. 73-78
    • Allain, H.1    Cougnand, J.2    Neukinch, H.C.3
  • 2
    • 0027200694 scopus 로고
    • Death of axotomised immature rat facial motor neurones: Stereospecific rescue by R(-)deprenyl independently of MAO inhibition
    • Ansari KS, Yu PH, Kruck TX, Tatton WG (1993): Death of axotomised immature rat facial motor neurones: Stereospecific rescue by R(-)deprenyl independently of MAO inhibition. J Neurosci 13:4042-4053.
    • (1993) J Neurosci , vol.13 , pp. 4042-4053
    • Ansari, K.S.1    Yu, P.H.2    Kruck, T.X.3    Tatton, W.G.4
  • 3
    • 0028278638 scopus 로고
    • The functional role of monoamine oxidase A and B in the mammalian central nervous system
    • Berry MD, Juorio AV, Paterson IA (1994a): The functional role of monoamine oxidase A and B in the mammalian central nervous system. Prog Neurobiol 42:375-391.
    • (1994) Prog Neurobiol , vol.42 , pp. 375-391
    • Berry, M.D.1    Juorio, A.V.2    Paterson, I.A.3
  • 4
    • 0028030607 scopus 로고
    • Possible mechanisms of action of (-) deprenyl and other MAO-B inhibitors in some neurological and psychiatric disorders
    • Berry MD, Juorio AV, Paterson IA (1994b): Possible mechanisms of action of (-) deprenyl and other MAO-B inhibitors in some neurological and psychiatric disorders. Prog Neurobiol 44:141-161.
    • (1994) Prog Neurobiol , vol.44 , pp. 141-161
    • Berry, M.D.1    Juorio, A.V.2    Paterson, I.A.3
  • 5
    • 0024207347 scopus 로고
    • Prevention of the DSP-4-induced noradrenergic neurotoxicity by irreversible, not by reversible, MAO-B inhibitors
    • Bertocci B, Gill G, DaPrada M (1988): Prevention of the DSP-4-induced noradrenergic neurotoxicity by irreversible, not by reversible, MAO-B inhibitors. Pharmacol Res Commun 20:131-132.
    • (1988) Pharmacol Res Commun , vol.20 , pp. 131-132
    • Bertocci, B.1    Gill, G.2    DaPrada, M.3
  • 6
    • 0027289608 scopus 로고
    • L-Deprenyl increases GFAP immunoreactivity selectively in activated astrocytes in rat brain
    • Biagini G, Zoli M, Fuxe K, Agnati LF (1993): L-Deprenyl increases GFAP immunoreactivity selectively in activated astrocytes in rat brain. NeuroReport 4:955-958.
    • (1993) NeuroReport , vol.4 , pp. 955-958
    • Biagini, G.1    Zoli, M.2    Fuxe, K.3    Agnati, L.F.4
  • 7
    • 0031961731 scopus 로고    scopus 로고
    • Catecholamine metabolism: From molecular understanding to clinical diagnosis and treatment
    • Boulton AA, Eisenhofer G (1998): Catecholamine metabolism: From molecular understanding to clinical diagnosis and treatment. Adv Pharmacol 42:273-292.
    • (1998) Adv Pharmacol , vol.42 , pp. 273-292
    • Boulton, A.A.1    Eisenhofer, G.2
  • 9
    • 0029624322 scopus 로고
    • Canine pituitary-dependent hyperadrenocorticism: A spontaneous animal model for neurodegenerative disorders and their treatment with L-deprenyl
    • Bruyette DS, Ruehl WW, Smidberg TL (1995): Canine pituitary-dependent hyperadrenocorticism: A spontaneous animal model for neurodegenerative disorders and their treatment with L-deprenyl. Prog Brain Res 106:207-215.
    • (1995) Prog Brain Res , vol.106 , pp. 207-215
    • Bruyette, D.S.1    Ruehl, W.W.2    Smidberg, T.L.3
  • 10
    • 0028943869 scopus 로고
    • (-)Deprenyl increases the survival of rat retinal ganglion cells after optic nerve crush
    • Buys YM, Trope GM, Tatton WG (1995): (-)Deprenyl increases the survival of rat retinal ganglion cells after optic nerve crush. Curr Eye Res 14:119-126.
    • (1995) Curr Eye Res , vol.14 , pp. 119-126
    • Buys, Y.M.1    Trope, G.M.2    Tatton, W.G.3
  • 13
    • 0028176919 scopus 로고
    • Effects of L-deprenyl, its structural analogues and some MAO inhibitors on dopamine uptake
    • Fang J, Yu PH (1994): Effects of L-deprenyl, its structural analogues and some MAO inhibitors on dopamine uptake. Neuropharmacology 33:763-768.
    • (1994) Neuropharmacology , vol.33 , pp. 763-768
    • Fang, J.1    Yu, P.H.2
  • 14
    • 0029017401 scopus 로고
    • Lack of protective effect of R(-)deprenyl on programmed cell death of mouse thymocytes induced by dexamethasone
    • Fang J, Zuo DM, Yu PH (1995): Lack of protective effect of R(-)deprenyl on programmed cell death of mouse thymocytes induced by dexamethasone. Life Sci 57:15-22.
    • (1995) Life Sci , vol.57 , pp. 15-22
    • Fang, J.1    Zuo, D.M.2    Yu, P.H.3
  • 15
    • 2642644524 scopus 로고    scopus 로고
    • Selegiline slows down the decline of cognitive and electrophysiological functions in Alzheimer's disease
    • Judd LL, Saleta B, Filip V (eds): Basel: Karger
    • Filip V, Davis I, Klaschka J, Kolibas E (1997): Selegiline slows down the decline of cognitive and electrophysiological functions in Alzheimer's disease. In Judd LL, Saleta B, Filip V (eds): Basic and Clinical Science of Mental and Addictive Disorders. Basel: Karger, pp 238-240.
    • (1997) Basic and Clinical Science of Mental and Addictive Disorders , pp. 238-240
    • Filip, V.1    Davis, I.2    Klaschka, J.3    Kolibas, E.4
  • 16
    • 0025171524 scopus 로고
    • Protection against DSP-4-induced neurotoxicity by deprenyl is not related to its inhibition of MAO-B
    • Finnegan KT, Skratt JS, Irwin I, Delanney LE, Langston J-W (1990): Protection against DSP-4-induced neurotoxicity by deprenyl is not related to its inhibition of MAO-B. Eur J Pharmacol 184:119-126.
    • (1990) Eur J Pharmacol , vol.184 , pp. 119-126
    • Finnegan, K.T.1    Skratt, J.S.2    Irwin, I.3    Delanney, L.E.4    Langston, J.-W.5
  • 17
    • 0028182783 scopus 로고
    • Lifespan of immunosuppressed NMRI-mice is increased by deprenyl
    • Freisleben HJ, Lehr F, Fuchs J (1994): Lifespan of immunosuppressed NMRI-mice is increased by deprenyl. J Neural Transm (Suppl): 41:231-236.
    • (1994) J Neural Transm (Suppl) , vol.41 , pp. 231-236
    • Freisleben, H.J.1    Lehr, F.2    Fuchs, J.3
  • 18
    • 0030798026 scopus 로고    scopus 로고
    • Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice
    • Freisleben HJ, Neeb A, Lehr F, Ackerman H (1997): Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice. Arz Forsh/Drug Res 47:776-780.
    • (1997) Arz Forsh/Drug Res , vol.47 , pp. 776-780
    • Freisleben, H.J.1    Neeb, A.2    Lehr, F.3    Ackerman, H.4
  • 20
    • 0028316987 scopus 로고
    • Atypical metabolism of deprenyl and its enantiomer, (s)-(+)-N,α-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6
    • Grace JM, Kinter MT, Macdonald TL (1994): Atypical metabolism of deprenyl and its enantiomer, (s)-(+)-N,α-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6. Chem Res Toxicol 7:286-290.
    • (1994) Chem Res Toxicol , vol.7 , pp. 286-290
    • Grace, J.M.1    Kinter, M.T.2    Macdonald, T.L.3
  • 22
    • 0012162453 scopus 로고
    • Effects of MAO-B inhibitors on dopaminergic function: Role of 2-phenylethylamine and aromatic L-amino acid decarboxylase
    • Lieberman et al. (eds): New York: Marcel Dekker
    • Juorio AV, Li X-M, Paterson IA, Boulton AA (1994): Effects of MAO-B inhibitors on dopaminergic function: Role of 2-phenylethylamine and aromatic L-amino acid decarboxylase. In Lieberman et al. (eds): MAO Inhibition in Neurological Diseases. New York: Marcel Dekker, pp 181-200.
    • (1994) MAO Inhibition in Neurological Diseases , pp. 181-200
    • Juorio, A.V.1    Li, X.-M.2    Paterson, I.A.3    Boulton, A.A.4
  • 23
    • 0025057155 scopus 로고
    • Chromatographic studies on the binding, action and metabolism of (-)-deprenyl
    • Kalász H, Kerecsen L, Knoll J, Pucsok J (1990): Chromatographic studies on the binding, action and metabolism of (-)-deprenyl. J Chromatog 499:589-599.
    • (1990) J Chromatog , vol.499 , pp. 589-599
    • Kalász, H.1    Kerecsen, L.2    Knoll, J.3    Pucsok, J.4
  • 24
    • 0020085133 scopus 로고
    • Metabolism of (-)deprenyl to amphetamine and methamphetamine may be responsible for deprenyl's therapeutic benefit: A biochemical assessment
    • Karoum F, Chuang L-W, Eisler T, Calne DB, Liebowitz MR, Quitkin FM, Klein DF, Wyatt RJ (1982): Metabolism of (-)deprenyl to amphetamine and methamphetamine may be responsible for deprenyl's therapeutic benefit: A biochemical assessment. Neurology 32:503-509.
    • (1982) Neurology , vol.32 , pp. 503-509
    • Karoum, F.1    Chuang, L.-W.2    Eisler, T.3    Calne, D.B.4    Liebowitz, M.R.5    Quitkin, F.M.6    Klein, D.F.7    Wyatt, R.J.8
  • 25
    • 0027455791 scopus 로고
    • Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats - Further evidence
    • Kitani K, Kanai S, Sato Y, Ohta M, Ivo GO, Canillo M-C (1993): Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats - further evidence. Life Sci 52:281-288.
    • (1993) Life Sci , vol.52 , pp. 281-288
    • Kitani, K.1    Kanai, S.2    Sato, Y.3    Ohta, M.4    Ivo, G.O.5    Canillo, M.-C.6
  • 26
    • 0024375994 scopus 로고
    • Striatal dopamine, sexual activity and lifespan. Longevity of rats treated with (-)deprenyl
    • Knoll J, Dallo J, Yen TT (1990): Striatal dopamine, sexual activity and lifespan. Longevity of rats treated with (-)deprenyl. Life Sci 45:525-531.
    • (1990) Life Sci , vol.45 , pp. 525-531
    • Knoll, J.1    Dallo, J.2    Yen, T.T.3
  • 27
    • 0028197308 scopus 로고
    • Sexually low performing male rats die earlier than their high performing peers and (-)deprenyl treatment eliminates this difference
    • Knoll J, Yen TT, Mikla I (1994): Sexually low performing male rats die earlier than their high performing peers and (-)deprenyl treatment eliminates this difference. Life Sci 15:1047-1057.
    • (1994) Life Sci , vol.15 , pp. 1047-1057
    • Knoll, J.1    Yen, T.T.2    Mikla, I.3
  • 28
    • 0028982658 scopus 로고
    • L-Deprenyl reduces brain damage in rats exposed to transient hypoxia-ischaemia
    • Knollema S, Aukema W, Hom H, Korf J, Ter-Horst GJ (1995): L-Deprenyl reduces brain damage in rats exposed to transient hypoxia-ischaemia. Stroke 26:1883-1887.
    • (1995) Stroke , vol.26 , pp. 1883-1887
    • Knollema, S.1    Aukema, W.2    Hom, H.3    Korf, J.4    Ter-Horst, G.J.5
  • 30
    • 0026564087 scopus 로고
    • Specific irreversible MAO-B inhibitors stimulate gene expression of aromatic l-amino acid decarboxylase in PC12 cells
    • Li X-M, Juorio AV, Paterson IA, Zhu MY, Boulton AA (1992): Specific irreversible MAO-B inhibitors stimulate gene expression of aromatic l-amino acid decarboxylase in PC12 cells. J Neurochem 59:2324-2327.
    • (1992) J Neurochem , vol.59 , pp. 2324-2327
    • Li, X.-M.1    Juorio, A.V.2    Paterson, I.A.3    Zhu, M.Y.4    Boulton, A.A.5
  • 31
    • 0027358777 scopus 로고
    • Reduction in GFAP mRNA abundance induced by (-)deprenyl and other MAO-B inhibitors in C6 glioma cells
    • Li X-M, Qi J, Juorio AV, Boulton AA (1993): Reduction in GFAP mRNA abundance induced by (-)deprenyl and other MAO-B inhibitors in C6 glioma cells. J Neurochem 61:1573-1576.
    • (1993) J Neurochem , vol.61 , pp. 1573-1576
    • Li, X.-M.1    Qi, J.2    Juorio, A.V.3    Boulton, A.A.4
  • 32
    • 0029619614 scopus 로고
    • Some new mechanisms underlying the actions of (-)deprenyl: Possible relevance to neurodegeneration
    • Li X-M, Juorio AV, Boulton AA (1995a): Some new mechanisms underlying the actions of (-)deprenyl: Possible relevance to neurodegeneration. Prog Brain Res 106:99-112.
    • (1995) Prog Brain Res , vol.106 , pp. 99-112
    • Li, X.-M.1    Juorio, A.V.2    Boulton, A.A.3
  • 33
    • 25344460023 scopus 로고
    • Deprenyl enhances NGF-induced increase in superoxide dismutase mRNA in PC12 cells
    • Li X-M, Qi J, Juorio AV, Boulton AA (1995b): (-)Deprenyl enhances NGF-induced increase in superoxide dismutase mRNA in PC12 cells. J. Neurochem. 65(Suppl):S103D.
    • (1995) J. Neurochem. , vol.65 , Issue.SUPPL.
    • Li, X.-M.1    Qi, J.2    Juorio, A.V.3    Boulton, A.A.4
  • 34
    • 0344952759 scopus 로고    scopus 로고
    • (-)Deprenyl down-regulates the low affinity NGF receptor (LNGFR, p75) in PC 12 cells
    • Li X-M, Konradi C, Qi J, Juorio AV, Boulton AA (1996): (-)Deprenyl down-regulates the low affinity NGF receptor (LNGFR, p75) in PC 12 cells. J Neurochem 66(Suppl):S11A.
    • (1996) J Neurochem , vol.66 , Issue.SUPPL.
    • Li, X.-M.1    Konradi, C.2    Qi, J.3    Juorio, A.V.4    Boulton, A.A.5
  • 37
    • 0031037391 scopus 로고    scopus 로고
    • Pharmacokinetcs and bioequivalence of the main metabolites of selegiline: Desmethylselegiline, methamphetamine and amphetamine after oral administration of selegiline
    • Mascher HJ, Kikuta C, Millendorfer A, Schiel H, Ludwig G (1997): Pharmacokinetcs and bioequivalence of the main metabolites of selegiline: Desmethylselegiline, methamphetamine and amphetamine after oral administration of selegiline. Int J Clin Pharmacol Ther 35:9-13.
    • (1997) Int J Clin Pharmacol Ther , vol.35 , pp. 9-13
    • Mascher, H.J.1    Kikuta, C.2    Millendorfer, A.3    Schiel, H.4    Ludwig, G.5
  • 39
    • 0031020650 scopus 로고    scopus 로고
    • L-deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro
    • Mytilineou C, Radcliffe PM, Leonardi EK, Werner P, Olanow WC (1997a): L-deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro. J Neurochem 68:33-39.
    • (1997) J Neurochem , vol.68 , pp. 33-39
    • Mytilineou, C.1    Radcliffe, P.M.2    Leonardi, E.K.3    Werner, P.4    Olanow, W.C.5
  • 40
    • 0031037786 scopus 로고    scopus 로고
    • L-(-)-Desmethylselegiline, a metabolite of selegiline(L-(-)-deprenyl) protects mesencephalic dopamine neurons from excitotoxicity in vitro
    • Mytilineou C, Radcliffe PM, Olanow WC (1997b): L-(-)-Desmethylselegiline, a metabolite of selegiline(L-(-)-deprenyl) protects mesencephalic dopamine neurons from excitotoxicity in vitro. J Neurochem 68:434-136.
    • (1997) J Neurochem , vol.68 , pp. 434-1136
    • Mytilineou, C.1    Radcliffe, P.M.2    Olanow, W.C.3
  • 41
    • 0024456653 scopus 로고
    • Effect of deprenyl on the progression of disability in early Parkinson's disease
    • Parkinson Study Group (1989): Effect of deprenyl on the progression of disability in early Parkinson's disease. N Eng J Med 321:1364-1371.
    • (1989) N Eng J Med , vol.321 , pp. 1364-1371
  • 42
    • 0027530638 scopus 로고
    • Effect of tocopherol and deprenyl on the progression of disability in early Parkinsons disease
    • Parkinson Study Group (1993): Effect of tocopherol and deprenyl on the progression of disability in early Parkinsons disease. N Eng J Med 328:176-183.
    • (1993) N Eng J Med , vol.328 , pp. 176-183
  • 44
    • 77956767839 scopus 로고    scopus 로고
    • Antiapoptotic actions of monoamine oxidase B inhibitors
    • Paterson IA, Tatton WG (1998): Antiapoptotic actions of monoamine oxidase B inhibitors. Adv Pharmacol 42:312-315.
    • (1998) Adv Pharmacol , vol.42 , pp. 312-315
    • Paterson, I.A.1    Tatton, W.G.2
  • 45
    • 0025647353 scopus 로고
    • 2-Phenylethylamine: A modulator of catecholamine transmission in the mammalian central nervous system?
    • Paterson IA, Juorio AV, Boulton AA (1990): 2-Phenylethylamine: A modulator of catecholamine transmission in the mammalian central nervous system? J Neurochem 55:1827-1837.
    • (1990) J Neurochem , vol.55 , pp. 1827-1837
    • Paterson, I.A.1    Juorio, A.V.2    Boulton, A.A.3
  • 47
  • 48
    • 0344662841 scopus 로고    scopus 로고
    • Aliphatic propargylamines prevent hippocampal neuronal death induced by hypoxia-ischaemia
    • Paterson IA, Davis BA, Durden DA, Boulton AA (1997b): Aliphatic propargylamines prevent hippocampal neuronal death induced by hypoxia-ischaemia. J Neurochem 69(Suppl):S137A.
    • (1997) J Neurochem , vol.69 , Issue.SUPPL.
    • Paterson, I.A.1    Davis, B.A.2    Durden, D.A.3    Boulton, A.A.4
  • 49
    • 0343961618 scopus 로고    scopus 로고
    • The anti-apoptotic effects of 2HMP is due to a desmethyl metabolite
    • abstract 880.6
    • Paterson, IA, Dyck LE, Durden DA, Davis BA, Lui Y, Boulton AA (1997c): The anti-apoptotic effects of 2HMP is due to a desmethyl metabolite. J Neurosci 23(Suppl 2):2254(abstract 880.6).
    • (1997) J Neurosci , vol.23 , Issue.2 SUPPL. , pp. 2254
    • Paterson, I.A.1    Dyck, L.E.2    Durden, D.A.3    Davis, B.A.4    Lui, Y.5    Boulton, A.A.6
  • 50
    • 0031914155 scopus 로고    scopus 로고
    • R-deprenyl and R-2-heptyl-n-methylproparglyamine prevent apoptosis in cerebellar granule neurons induced by cytosine arabinoside but not low extracellular potassium
    • Paterson IA, Zhang D, Warrington RC, Boulton AA (1998): R-deprenyl and R-2-heptyl-n-methylproparglyamine prevent apoptosis in cerebellar granule neurons induced by cytosine arabinoside but not low extracellular potassium. J Neurochem 70:515-523.
    • (1998) J Neurochem , vol.70 , pp. 515-523
    • Paterson, I.A.1    Zhang, D.2    Warrington, R.C.3    Boulton, A.A.4
  • 51
    • 0019824482 scopus 로고
    • Amphetamine, p-hydroxyamphetamine, and b-phenylethylamine in mouse brain and urine after (-)- and (+)-deprenyl administration
    • Philips SR (1981): Amphetamine, p-hydroxyamphetamine, and b-phenylethylamine in mouse brain and urine after (-)-and (+)-deprenyl administration. J Pharm Pharmacol 33:739-741.
    • (1981) J Pharm Pharmacol , vol.33 , pp. 739-741
    • Philips, S.R.1
  • 52
    • 0018068203 scopus 로고
    • Amphetamine and 2-phenylethylamine in post-mortem Parkinson brain after (-)deprenyl administration
    • Reynolds GR, Riederer P, Sandler M, Jellinger K, Seemann D (1978): Amphetamine and 2-phenylethylamine in post-mortem Parkinson brain after (-)deprenyl administration. J Neural Trans 43:271-277.
    • (1978) J Neural Trans , vol.43 , pp. 271-277
    • Reynolds, G.R.1    Riederer, P.2    Sandler, M.3    Jellinger, K.4    Seemann, D.5
  • 53
    • 0026492963 scopus 로고
    • Deficits in cholinergic neurotransmission markers induced by ethylcholine mustard aziridinium (AF64A) in the rat hippocampus: Sensitivity to treatment with the MAO-B inhibitor L-deprenyl
    • Ricci A, Mancini M, Strocchi P, Bongrani S, Bronzetti E (1992): Deficits in cholinergic neurotransmission markers induced by ethylcholine mustard aziridinium (AF64A) in the rat hippocampus: Sensitivity to treatment with the MAO-B inhibitor L-deprenyl. Drugs Exp Clin Res 18:163-171.
    • (1992) Drugs Exp Clin Res , vol.18 , pp. 163-171
    • Ricci, A.1    Mancini, M.2    Strocchi, P.3    Bongrani, S.4    Bronzetti, E.5
  • 54
    • 0027292598 scopus 로고
    • Deprenyl increases survial of rat foetal nigral neurones in culture
    • Roy E, Bedard PJ (1993): Deprenyl increases survial of rat foetal nigral neurones in culture. NeuroReport 4:1183-1186.
    • (1993) NeuroReport , vol.4 , pp. 1183-1186
    • Roy, E.1    Bedard, P.J.2
  • 55
    • 0029564645 scopus 로고
    • Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease - Clinical presentation, cognitive testing, pathology and response to L-deprenyl therapy
    • Ruehl WW, Bruyette DS, DePaoli A, Cotman CW, Head E, Milgram NW, Cummings BJ (1995): Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease - clinical presentation, cognitive testing, pathology and response to L-deprenyl therapy. Prog Brain Res 106:217-225.
    • (1995) Prog Brain Res , vol.106 , pp. 217-225
    • Ruehl, W.W.1    Bruyette, D.S.2    DePaoli, A.3    Cotman, C.W.4    Head, E.5    Milgram, N.W.6    Cummings, B.J.7
  • 58
    • 0026514670 scopus 로고
    • Deprenyl reduces the death of motoneurones caused by axotomy
    • Salo PT, Tatton WG (1992): Deprenyl reduces the death of motoneurones caused by axotomy. J Neurosci Res 31:394-400.
    • (1992) J Neurosci Res , vol.31 , pp. 394-400
    • Salo, P.T.1    Tatton, W.G.2
  • 60
    • 2642640392 scopus 로고    scopus 로고
    • Possible benefits of a combination of selegiline and cholinesterase inhibitors
    • Judd LL, Saleta B, Filip V (eds): Basel: Karger
    • Schneider LS, Olin JT, Pawluczyk S (1997): Possible benefits of a combination of selegiline and cholinesterase inhibitors. In Judd LL, Saleta B, Filip V (eds): Basic and Clinical Science of Mental and Addictive Disorders. Basel: Karger, pp 235-237.
    • (1997) Basic and Clinical Science of Mental and Addictive Disorders , pp. 235-237
    • Schneider, L.S.1    Olin, J.T.2    Pawluczyk, S.3
  • 61
    • 0028121120 scopus 로고
    • Increased CNTF gene expression in process-bearing astrocytes following injury is augmented by L(-)deprenyl
    • Seniuk NA, Henderson JT, Tatton WG, Roder JC (1994): Increased CNTF gene expression in process-bearing astrocytes following injury is augmented by L(-)deprenyl. J Neurosci Res 37:278-286.
    • (1994) J Neurosci Res , vol.37 , pp. 278-286
    • Seniuk, N.A.1    Henderson, J.T.2    Tatton, W.G.3    Roder, J.C.4
  • 65
    • 0029731378 scopus 로고    scopus 로고
    • Modulation of gene expression rather than monoamine oxidase inhibition: (-)-Deprenyl-related compounds in controlling neurodegeneration
    • Tatton W, Chalmers-Redman RME (1996): Modulation of gene expression rather than monoamine oxidase inhibition: (-)-Deprenyl-related compounds in controlling neurodegeneration. Neurology 47(suppl 3):S171-S183.
    • (1996) Neurology , vol.47 , Issue.3 SUPPL.
    • Tatton, W.1    Chalmers-Redman, R.M.E.2
  • 66
    • 0026353406 scopus 로고
    • Rescue of dying neurons: A new action for deprenyl in MPTP Parkinsonism
    • Tatton WG, Greenwood CE (1991): Rescue of dying neurons: A new action for deprenyl in MPTP Parkinsonism. J Neurosci Res 30:666-672.
    • (1991) J Neurosci Res , vol.30 , pp. 666-672
    • Tatton, W.G.1    Greenwood, C.E.2
  • 67
    • 0027941312 scopus 로고
    • (-)Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis
    • Tatton WG, Ju WYL, Holland DP, Tai C, Kwan M (1994): (-)Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. J Neurochem 63:1572-1575.
    • (1994) J Neurochem , vol.63 , pp. 1572-1575
    • Tatton, W.G.1    Ju, W.Y.L.2    Holland, D.P.3    Tai, C.4    Kwan, M.5
  • 68
    • 0030612215 scopus 로고    scopus 로고
    • Aopotosis in neurodegenerative disorders: Potential for therapy by modifying gene transcription
    • Tatton WG, Chalmers-Redman RME, Ju WYH, Wadia J, Tatton NA (1997): Aopotosis in neurodegenerative disorders: Potential for therapy by modifying gene transcription. J Neural Trans 49:245-268.
    • (1997) J Neural Trans , vol.49 , pp. 245-268
    • Tatton, W.G.1    Chalmers-Redman, R.M.E.2    Ju, W.Y.H.3    Wadia, J.4    Tatton, N.A.5
  • 69
    • 0024343466 scopus 로고
    • The effect of deprenyl (selegiline) on the natural history of Parkinson's disease
    • Tetrud JW, Langston JW (1989): The effect of deprenyl (selegiline) on the natural history of Parkinson's disease. Science 245:519-522.
    • (1989) Science , vol.245 , pp. 519-522
    • Tetrud, J.W.1    Langston, J.W.2
  • 70
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thomson CB (1995): Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thomson, C.B.1
  • 71
    • 0022638352 scopus 로고
    • Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: Relationship of metabolism to MAO-B inhibitory potency
    • Yoshida T, Yamada Y, Yamamoto T, Kuroiwa Y (1986): Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: Relationship of metabolism to MAO-B inhibitory potency. Xenobiotica 16:129-136.
    • (1986) Xenobiotica , vol.16 , pp. 129-136
    • Yoshida, T.1    Yamada, Y.2    Yamamoto, T.3    Kuroiwa, Y.4
  • 72
    • 0030641754 scopus 로고    scopus 로고
    • Understanding Parkinson's disease
    • Youdim MBH, Riederer P (1997): Understanding Parkinson's disease. Sci Am 276:52-59.
    • (1997) Sci Am , vol.276 , pp. 52-59
    • Youdim, M.B.H.1    Riederer, P.2
  • 73
    • 0024623978 scopus 로고
    • Deamination of aliphatic amines of different chain lengths by rat liver MAO-A & B
    • Yu PH (1989): Deamination of aliphatic amines of different chain lengths by rat liver MAO-A & B. J Pharm Pharmacol 41:205-208.
    • (1989) J Pharm Pharmacol , vol.41 , pp. 205-208
    • Yu, P.H.1
  • 74
    • 0026655680 scopus 로고
    • Aliphatic propargylamines: Potent, selective, irreversible MAO-B inhibitors
    • Yu PH, Davis BA, Boulton AA (1992a): Aliphatic propargylamines: potent, selective, irreversible MAO-B inhibitors. J Med Chem 35:3705-3713.
    • (1992) J Med Chem , vol.35 , pp. 3705-3713
    • Yu, P.H.1    Davis, B.A.2    Boulton, A.A.3
  • 77
    • 0027242401 scopus 로고
    • Effect of structural modification of alkyl N-propargylamines on the selective inhibition of MAO-B activity
    • Yu PH, Davis BA, Boulton AA (1993b): Effect of structural modification of alkyl N-propargylamines on the selective inhibition of MAO-B activity. Biochem Pharmacol 46:753-757.
    • (1993) Biochem Pharmacol , vol.46 , pp. 753-757
    • Yu, P.H.1    Davis, B.A.2    Boulton, A.A.3
  • 78
    • 0028057394 scopus 로고
    • Neurochemical and neuroprotective effects of some aliphatic propargylamines: New selective nonamphetamine-like MAO-B inhibitors
    • Yu PH, Davis BA, Durden DA, Barber A, Terleckyj I, Nicklas WG, Boulton AA (1994a): Neurochemical and neuroprotective effects of some aliphatic propargylamines: New selective nonamphetamine-like MAO-B inhibitors. J Neurochem 62:697-704.
    • (1994) J Neurochem , vol.62 , pp. 697-704
    • Yu, P.H.1    Davis, B.A.2    Durden, D.A.3    Barber, A.4    Terleckyj, I.5    Nicklas, W.G.6    Boulton, A.A.7
  • 79
    • 0028020079 scopus 로고
    • Neuroprotective effect of some monoamine oxidase-B inhibitors against DSP-4 induced noradrenaline depletion in the mouse hippocampus
    • Yu PH, Davis BA, Fang J, Boulton AA (1994b): Neuroprotective effect of some monoamine oxidase-B inhibitors against DSP-4 induced noradrenaline depletion in the mouse hippocampus. J Neurochem 63:1820-1828.
    • (1994) J Neurochem , vol.63 , pp. 1820-1828
    • Yu, P.H.1    Davis, B.A.2    Fang, J.3    Boulton, A.A.4
  • 80
    • 0029559253 scopus 로고
    • Neurochemical, neuroprotective and neurorescue effects of aliphatic N-methylpropargylamines: New MAO-B inhibitors without amphetamine-like properties
    • Yu PH, Davis BA, Zhang X, Zuo D-M, Fang J, Lai C-T, Li X-M, Paterson IA, Boulton AA (1995): Neurochemical, neuroprotective and neurorescue effects of aliphatic N-methylpropargylamines: New MAO-B inhibitors without amphetamine-like properties. Prog Brain Res 106:113-121.
    • (1995) Prog Brain Res , vol.106 , pp. 113-121
    • Yu, P.H.1    Davis, B.A.2    Zhang, X.3    Zuo, D.-M.4    Fang, J.5    Lai, C.-T.6    Li, X.-M.7    Paterson, I.A.8    Boulton, A.A.9
  • 82
    • 0028981070 scopus 로고
    • Neuroprotection of R(-)-deprenyl and N-2-hexyl-N-methylpropargylamine on DSP-4 induced degeneration of noradrenergic neurons in the rat locus coeruleus
    • Zhang X, Zuo D-M, Yu PH (1995a): Neuroprotection of R(-)-deprenyl and N-2-hexyl-N-methylpropargylamine on DSP-4 induced degeneration of noradrenergic neurons in the rat locus coeruleus. Neuroscience 186:45-48.
    • (1995) Neuroscience , vol.186 , pp. 45-48
    • Zhang, X.1    Zuo, D.-M.2    Yu, P.H.3
  • 83
    • 0029066255 scopus 로고
    • Depletion of NOS activity in the rat dentate gyrus neurons by DSP-4 and protection by deprenyl
    • Zhang X, Yu PH (1995b): Depletion of NOS activity in the rat dentate gyrus neurons by DSP-4 and protection by deprenyl. Brain Res Bull 38:307-311
    • (1995) Brain Res Bull , vol.38 , pp. 307-311
    • Zhang, X.1    Yu, P.H.2
  • 84
    • 0029973665 scopus 로고    scopus 로고
    • Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain
    • Zhang X, Boulton AA, Yu PH (1996a): Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain. Eur J Neurosci 8:1432-1440.
    • (1996) Eur J Neurosci , vol.8 , pp. 1432-1440
    • Zhang, X.1    Boulton, A.A.2    Yu, P.H.3
  • 85
    • 0029740221 scopus 로고    scopus 로고
    • MK-801 induces apoptotic neuronal death in the rat retrosplenial cortex; Prevention by cycloheximide and R(-)-2-hexyl-N-methylpropargylaminc
    • Zhang X, Boulton AA, Zuo DM, Yu PH (1996b): MK-801 induces apoptotic neuronal death in the rat retrosplenial cortex; Prevention by cycloheximide and R(-)-2-hexyl-N-methylpropargylaminc. J Neurosci Res 46:82-89.
    • (1996) J Neurosci Res , vol.46 , pp. 82-89
    • Zhang, X.1    Boulton, A.A.2    Zuo, D.M.3    Yu, P.H.4
  • 86
    • 0029938017 scopus 로고    scopus 로고
    • Immunohistochemical evidence of neuroprotection by R(-)-deprenyl and N-(2-hexyl)-N-methylpropargylamine on DSP-4-induced degeneration of rat brain noradrenergic axons and terminals
    • Zhang X, Zuo DM, Davis BA, Boulton AA, Yu PH (1996c): Immunohistochemical evidence of neuroprotection by R(-)-deprenyl and N-(2-hexyl)-N-methylpropargylamine on DSP-4-induced degeneration of rat brain noradrenergic axons and terminals. J Neurosci Res 43:482-489.
    • (1996) J Neurosci Res , vol.43 , pp. 482-489
    • Zhang, X.1    Zuo, D.M.2    Davis, B.A.3    Boulton, A.A.4    Yu, P.H.5
  • 87
    • 0030976602 scopus 로고    scopus 로고
    • Gradation of kainic acid-elicited rat limbic seizures and expression of hippocampal heat shock protein-70
    • Zhang X, Gelowitz DL, Lai CT, Boulton AA, Yu PH (1997): Gradation of kainic acid-elicited rat limbic seizures and expression of hippocampal heat shock protein-70. Eur J Neurosci 9:760-769.
    • (1997) Eur J Neurosci , vol.9 , pp. 760-769
    • Zhang, X.1    Gelowitz, D.L.2    Lai, C.T.3    Boulton, A.A.4    Yu, P.H.5
  • 88
    • 0029619445 scopus 로고
    • Increased survival of dopaminergic neuroblastoma in co-cultures with C6 glioma by R(-)deprenyl
    • Zuo DM, Yu PH (1995): Increased survival of dopaminergic neuroblastoma in co-cultures with C6 glioma by R(-)deprenyl. Prog Brain Res 106:199-205.
    • (1995) Prog Brain Res , vol.106 , pp. 199-205
    • Zuo, D.M.1    Yu, P.H.2


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