-
1
-
-
0026308236
-
Selegiline in de novo Parkinsonian patients: The French selegiline multicenter trial (FSMT)
-
Allain H, Cougnand J, Neukinch HC (1991): Selegiline in de novo Parkinsonian patients: The French selegiline multicenter trial (FSMT). Acta Neurol Scand 84(Suppl 136):73-78.
-
(1991)
Acta Neurol Scand
, vol.84
, Issue.136 SUPPL.
, pp. 73-78
-
-
Allain, H.1
Cougnand, J.2
Neukinch, H.C.3
-
2
-
-
0027200694
-
Death of axotomised immature rat facial motor neurones: Stereospecific rescue by R(-)deprenyl independently of MAO inhibition
-
Ansari KS, Yu PH, Kruck TX, Tatton WG (1993): Death of axotomised immature rat facial motor neurones: Stereospecific rescue by R(-)deprenyl independently of MAO inhibition. J Neurosci 13:4042-4053.
-
(1993)
J Neurosci
, vol.13
, pp. 4042-4053
-
-
Ansari, K.S.1
Yu, P.H.2
Kruck, T.X.3
Tatton, W.G.4
-
3
-
-
0028278638
-
The functional role of monoamine oxidase A and B in the mammalian central nervous system
-
Berry MD, Juorio AV, Paterson IA (1994a): The functional role of monoamine oxidase A and B in the mammalian central nervous system. Prog Neurobiol 42:375-391.
-
(1994)
Prog Neurobiol
, vol.42
, pp. 375-391
-
-
Berry, M.D.1
Juorio, A.V.2
Paterson, I.A.3
-
4
-
-
0028030607
-
Possible mechanisms of action of (-) deprenyl and other MAO-B inhibitors in some neurological and psychiatric disorders
-
Berry MD, Juorio AV, Paterson IA (1994b): Possible mechanisms of action of (-) deprenyl and other MAO-B inhibitors in some neurological and psychiatric disorders. Prog Neurobiol 44:141-161.
-
(1994)
Prog Neurobiol
, vol.44
, pp. 141-161
-
-
Berry, M.D.1
Juorio, A.V.2
Paterson, I.A.3
-
5
-
-
0024207347
-
Prevention of the DSP-4-induced noradrenergic neurotoxicity by irreversible, not by reversible, MAO-B inhibitors
-
Bertocci B, Gill G, DaPrada M (1988): Prevention of the DSP-4-induced noradrenergic neurotoxicity by irreversible, not by reversible, MAO-B inhibitors. Pharmacol Res Commun 20:131-132.
-
(1988)
Pharmacol Res Commun
, vol.20
, pp. 131-132
-
-
Bertocci, B.1
Gill, G.2
DaPrada, M.3
-
6
-
-
0027289608
-
L-Deprenyl increases GFAP immunoreactivity selectively in activated astrocytes in rat brain
-
Biagini G, Zoli M, Fuxe K, Agnati LF (1993): L-Deprenyl increases GFAP immunoreactivity selectively in activated astrocytes in rat brain. NeuroReport 4:955-958.
-
(1993)
NeuroReport
, vol.4
, pp. 955-958
-
-
Biagini, G.1
Zoli, M.2
Fuxe, K.3
Agnati, L.F.4
-
7
-
-
0031961731
-
Catecholamine metabolism: From molecular understanding to clinical diagnosis and treatment
-
Boulton AA, Eisenhofer G (1998): Catecholamine metabolism: From molecular understanding to clinical diagnosis and treatment. Adv Pharmacol 42:273-292.
-
(1998)
Adv Pharmacol
, vol.42
, pp. 273-292
-
-
Boulton, A.A.1
Eisenhofer, G.2
-
8
-
-
0004479609
-
Aliphatic N-methylpropargylamines: Monoamine oxidase B inhibitors and antiapoptotic drugs
-
Boulton AA, Yu PH, Davis BA, Paterson IA, Li X-M, Juorio AV, Durden DA, Dyck LE (1998): Aliphatic N-methylpropargylamines: Monoamine oxidase B inhibitors and antiapoptotic drugs. Adv Pharmacol 42:308-311.
-
(1998)
Adv Pharmacol
, vol.42
, pp. 308-311
-
-
Boulton, A.A.1
Yu, P.H.2
Davis, B.A.3
Paterson, I.A.4
Li, X.-M.5
Juorio, A.V.6
Durden, D.A.7
Dyck, L.E.8
-
9
-
-
0029624322
-
Canine pituitary-dependent hyperadrenocorticism: A spontaneous animal model for neurodegenerative disorders and their treatment with L-deprenyl
-
Bruyette DS, Ruehl WW, Smidberg TL (1995): Canine pituitary-dependent hyperadrenocorticism: A spontaneous animal model for neurodegenerative disorders and their treatment with L-deprenyl. Prog Brain Res 106:207-215.
-
(1995)
Prog Brain Res
, vol.106
, pp. 207-215
-
-
Bruyette, D.S.1
Ruehl, W.W.2
Smidberg, T.L.3
-
10
-
-
0028943869
-
(-)Deprenyl increases the survival of rat retinal ganglion cells after optic nerve crush
-
Buys YM, Trope GM, Tatton WG (1995): (-)Deprenyl increases the survival of rat retinal ganglion cells after optic nerve crush. Curr Eye Res 14:119-126.
-
(1995)
Curr Eye Res
, vol.14
, pp. 119-126
-
-
Buys, Y.M.1
Trope, G.M.2
Tatton, W.G.3
-
11
-
-
0343089901
-
-
Patent filed USA, July 14, 1997
-
Durden DD, Paterson IA, Davis BA, Yu PH, Li X-M, Boulton AA (1997): Aliphatic propargylamines as cellular rescue agents. Patent filed USA, July 14, 1997.
-
(1997)
Aliphatic Propargylamines As Cellular Rescue Agents
-
-
Durden, D.D.1
Paterson, I.A.2
Davis, B.A.3
Yu, P.H.4
Li, X.-M.5
Boulton, A.A.6
-
13
-
-
0028176919
-
Effects of L-deprenyl, its structural analogues and some MAO inhibitors on dopamine uptake
-
Fang J, Yu PH (1994): Effects of L-deprenyl, its structural analogues and some MAO inhibitors on dopamine uptake. Neuropharmacology 33:763-768.
-
(1994)
Neuropharmacology
, vol.33
, pp. 763-768
-
-
Fang, J.1
Yu, P.H.2
-
14
-
-
0029017401
-
Lack of protective effect of R(-)deprenyl on programmed cell death of mouse thymocytes induced by dexamethasone
-
Fang J, Zuo DM, Yu PH (1995): Lack of protective effect of R(-)deprenyl on programmed cell death of mouse thymocytes induced by dexamethasone. Life Sci 57:15-22.
-
(1995)
Life Sci
, vol.57
, pp. 15-22
-
-
Fang, J.1
Zuo, D.M.2
Yu, P.H.3
-
15
-
-
2642644524
-
Selegiline slows down the decline of cognitive and electrophysiological functions in Alzheimer's disease
-
Judd LL, Saleta B, Filip V (eds): Basel: Karger
-
Filip V, Davis I, Klaschka J, Kolibas E (1997): Selegiline slows down the decline of cognitive and electrophysiological functions in Alzheimer's disease. In Judd LL, Saleta B, Filip V (eds): Basic and Clinical Science of Mental and Addictive Disorders. Basel: Karger, pp 238-240.
-
(1997)
Basic and Clinical Science of Mental and Addictive Disorders
, pp. 238-240
-
-
Filip, V.1
Davis, I.2
Klaschka, J.3
Kolibas, E.4
-
16
-
-
0025171524
-
Protection against DSP-4-induced neurotoxicity by deprenyl is not related to its inhibition of MAO-B
-
Finnegan KT, Skratt JS, Irwin I, Delanney LE, Langston J-W (1990): Protection against DSP-4-induced neurotoxicity by deprenyl is not related to its inhibition of MAO-B. Eur J Pharmacol 184:119-126.
-
(1990)
Eur J Pharmacol
, vol.184
, pp. 119-126
-
-
Finnegan, K.T.1
Skratt, J.S.2
Irwin, I.3
Delanney, L.E.4
Langston, J.-W.5
-
17
-
-
0028182783
-
Lifespan of immunosuppressed NMRI-mice is increased by deprenyl
-
Freisleben HJ, Lehr F, Fuchs J (1994): Lifespan of immunosuppressed NMRI-mice is increased by deprenyl. J Neural Transm (Suppl): 41:231-236.
-
(1994)
J Neural Transm (Suppl)
, vol.41
, pp. 231-236
-
-
Freisleben, H.J.1
Lehr, F.2
Fuchs, J.3
-
18
-
-
0030798026
-
Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice
-
Freisleben HJ, Neeb A, Lehr F, Ackerman H (1997): Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice. Arz Forsh/Drug Res 47:776-780.
-
(1997)
Arz Forsh/Drug Res
, vol.47
, pp. 776-780
-
-
Freisleben, H.J.1
Neeb, A.2
Lehr, F.3
Ackerman, H.4
-
20
-
-
0028316987
-
Atypical metabolism of deprenyl and its enantiomer, (s)-(+)-N,α-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6
-
Grace JM, Kinter MT, Macdonald TL (1994): Atypical metabolism of deprenyl and its enantiomer, (s)-(+)-N,α-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6. Chem Res Toxicol 7:286-290.
-
(1994)
Chem Res Toxicol
, vol.7
, pp. 286-290
-
-
Grace, J.M.1
Kinter, M.T.2
Macdonald, T.L.3
-
21
-
-
84996113615
-
Pharmacokinetics and metabolism of selegiline
-
Heinonen EH, Myllyla V, Sotaniemi K, Lammintausta R, Salonen JS, Anttila M, Savljarvim, Kotila M, Rinne UK (1989): Pharmacokinetics and metabolism of selegiline. Acta Neurol Scand 126:93-99.
-
(1989)
Acta Neurol Scand
, vol.126
, pp. 93-99
-
-
Heinonen, E.H.1
Myllyla, V.2
Sotaniemi, K.3
Lammintausta, R.4
Salonen, J.S.5
Anttila, M.6
Savljarvim7
Kotila, M.8
Rinne, U.K.9
-
22
-
-
0012162453
-
Effects of MAO-B inhibitors on dopaminergic function: Role of 2-phenylethylamine and aromatic L-amino acid decarboxylase
-
Lieberman et al. (eds): New York: Marcel Dekker
-
Juorio AV, Li X-M, Paterson IA, Boulton AA (1994): Effects of MAO-B inhibitors on dopaminergic function: Role of 2-phenylethylamine and aromatic L-amino acid decarboxylase. In Lieberman et al. (eds): MAO Inhibition in Neurological Diseases. New York: Marcel Dekker, pp 181-200.
-
(1994)
MAO Inhibition in Neurological Diseases
, pp. 181-200
-
-
Juorio, A.V.1
Li, X.-M.2
Paterson, I.A.3
Boulton, A.A.4
-
23
-
-
0025057155
-
Chromatographic studies on the binding, action and metabolism of (-)-deprenyl
-
Kalász H, Kerecsen L, Knoll J, Pucsok J (1990): Chromatographic studies on the binding, action and metabolism of (-)-deprenyl. J Chromatog 499:589-599.
-
(1990)
J Chromatog
, vol.499
, pp. 589-599
-
-
Kalász, H.1
Kerecsen, L.2
Knoll, J.3
Pucsok, J.4
-
24
-
-
0020085133
-
Metabolism of (-)deprenyl to amphetamine and methamphetamine may be responsible for deprenyl's therapeutic benefit: A biochemical assessment
-
Karoum F, Chuang L-W, Eisler T, Calne DB, Liebowitz MR, Quitkin FM, Klein DF, Wyatt RJ (1982): Metabolism of (-)deprenyl to amphetamine and methamphetamine may be responsible for deprenyl's therapeutic benefit: A biochemical assessment. Neurology 32:503-509.
-
(1982)
Neurology
, vol.32
, pp. 503-509
-
-
Karoum, F.1
Chuang, L.-W.2
Eisler, T.3
Calne, D.B.4
Liebowitz, M.R.5
Quitkin, F.M.6
Klein, D.F.7
Wyatt, R.J.8
-
25
-
-
0027455791
-
Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats - Further evidence
-
Kitani K, Kanai S, Sato Y, Ohta M, Ivo GO, Canillo M-C (1993): Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats - further evidence. Life Sci 52:281-288.
-
(1993)
Life Sci
, vol.52
, pp. 281-288
-
-
Kitani, K.1
Kanai, S.2
Sato, Y.3
Ohta, M.4
Ivo, G.O.5
Canillo, M.-C.6
-
26
-
-
0024375994
-
Striatal dopamine, sexual activity and lifespan. Longevity of rats treated with (-)deprenyl
-
Knoll J, Dallo J, Yen TT (1990): Striatal dopamine, sexual activity and lifespan. Longevity of rats treated with (-)deprenyl. Life Sci 45:525-531.
-
(1990)
Life Sci
, vol.45
, pp. 525-531
-
-
Knoll, J.1
Dallo, J.2
Yen, T.T.3
-
27
-
-
0028197308
-
Sexually low performing male rats die earlier than their high performing peers and (-)deprenyl treatment eliminates this difference
-
Knoll J, Yen TT, Mikla I (1994): Sexually low performing male rats die earlier than their high performing peers and (-)deprenyl treatment eliminates this difference. Life Sci 15:1047-1057.
-
(1994)
Life Sci
, vol.15
, pp. 1047-1057
-
-
Knoll, J.1
Yen, T.T.2
Mikla, I.3
-
28
-
-
0028982658
-
L-Deprenyl reduces brain damage in rats exposed to transient hypoxia-ischaemia
-
Knollema S, Aukema W, Hom H, Korf J, Ter-Horst GJ (1995): L-Deprenyl reduces brain damage in rats exposed to transient hypoxia-ischaemia. Stroke 26:1883-1887.
-
(1995)
Stroke
, vol.26
, pp. 1883-1887
-
-
Knollema, S.1
Aukema, W.2
Hom, H.3
Korf, J.4
Ter-Horst, G.J.5
-
30
-
-
0026564087
-
Specific irreversible MAO-B inhibitors stimulate gene expression of aromatic l-amino acid decarboxylase in PC12 cells
-
Li X-M, Juorio AV, Paterson IA, Zhu MY, Boulton AA (1992): Specific irreversible MAO-B inhibitors stimulate gene expression of aromatic l-amino acid decarboxylase in PC12 cells. J Neurochem 59:2324-2327.
-
(1992)
J Neurochem
, vol.59
, pp. 2324-2327
-
-
Li, X.-M.1
Juorio, A.V.2
Paterson, I.A.3
Zhu, M.Y.4
Boulton, A.A.5
-
31
-
-
0027358777
-
Reduction in GFAP mRNA abundance induced by (-)deprenyl and other MAO-B inhibitors in C6 glioma cells
-
Li X-M, Qi J, Juorio AV, Boulton AA (1993): Reduction in GFAP mRNA abundance induced by (-)deprenyl and other MAO-B inhibitors in C6 glioma cells. J Neurochem 61:1573-1576.
-
(1993)
J Neurochem
, vol.61
, pp. 1573-1576
-
-
Li, X.-M.1
Qi, J.2
Juorio, A.V.3
Boulton, A.A.4
-
32
-
-
0029619614
-
Some new mechanisms underlying the actions of (-)deprenyl: Possible relevance to neurodegeneration
-
Li X-M, Juorio AV, Boulton AA (1995a): Some new mechanisms underlying the actions of (-)deprenyl: Possible relevance to neurodegeneration. Prog Brain Res 106:99-112.
-
(1995)
Prog Brain Res
, vol.106
, pp. 99-112
-
-
Li, X.-M.1
Juorio, A.V.2
Boulton, A.A.3
-
33
-
-
25344460023
-
Deprenyl enhances NGF-induced increase in superoxide dismutase mRNA in PC12 cells
-
Li X-M, Qi J, Juorio AV, Boulton AA (1995b): (-)Deprenyl enhances NGF-induced increase in superoxide dismutase mRNA in PC12 cells. J. Neurochem. 65(Suppl):S103D.
-
(1995)
J. Neurochem.
, vol.65
, Issue.SUPPL.
-
-
Li, X.-M.1
Qi, J.2
Juorio, A.V.3
Boulton, A.A.4
-
34
-
-
0344952759
-
(-)Deprenyl down-regulates the low affinity NGF receptor (LNGFR, p75) in PC 12 cells
-
Li X-M, Konradi C, Qi J, Juorio AV, Boulton AA (1996): (-)Deprenyl down-regulates the low affinity NGF receptor (LNGFR, p75) in PC 12 cells. J Neurochem 66(Suppl):S11A.
-
(1996)
J Neurochem
, vol.66
, Issue.SUPPL.
-
-
Li, X.-M.1
Konradi, C.2
Qi, J.3
Juorio, A.V.4
Boulton, A.A.5
-
36
-
-
0025972929
-
Effects of a MAO-B inhibitor in the treatment of Alzheimer's disease
-
Mangoni A, Grassi MP, Frattola L, Piolti R, Bani S, Mota A, Marconi A, Smirne S (1991): Effects of a MAO-B inhibitor in the treatment of Alzheimer's disease. Eur J 31:100-107.
-
(1991)
Eur J
, vol.31
, pp. 100-107
-
-
Mangoni, A.1
Grassi, M.P.2
Frattola, L.3
Piolti, R.4
Bani, S.5
Mota, A.6
Marconi, A.7
Smirne, S.8
-
37
-
-
0031037391
-
Pharmacokinetcs and bioequivalence of the main metabolites of selegiline: Desmethylselegiline, methamphetamine and amphetamine after oral administration of selegiline
-
Mascher HJ, Kikuta C, Millendorfer A, Schiel H, Ludwig G (1997): Pharmacokinetcs and bioequivalence of the main metabolites of selegiline: Desmethylselegiline, methamphetamine and amphetamine after oral administration of selegiline. Int J Clin Pharmacol Ther 35:9-13.
-
(1997)
Int J Clin Pharmacol Ther
, vol.35
, pp. 9-13
-
-
Mascher, H.J.1
Kikuta, C.2
Millendorfer, A.3
Schiel, H.4
Ludwig, G.5
-
38
-
-
0025050782
-
Maintenance on L-deprenyl prolongs life in aged male rats
-
Milgram NW, Racine RJ, Nellis P, Mendonca A, Ivy GO (1990): Maintenance on L-deprenyl prolongs life in aged male rats. Life Sci 47:415-420.
-
(1990)
Life Sci
, vol.47
, pp. 415-420
-
-
Milgram, N.W.1
Racine, R.J.2
Nellis, P.3
Mendonca, A.4
Ivy, G.O.5
-
39
-
-
0031020650
-
L-deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro
-
Mytilineou C, Radcliffe PM, Leonardi EK, Werner P, Olanow WC (1997a): L-deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro. J Neurochem 68:33-39.
-
(1997)
J Neurochem
, vol.68
, pp. 33-39
-
-
Mytilineou, C.1
Radcliffe, P.M.2
Leonardi, E.K.3
Werner, P.4
Olanow, W.C.5
-
40
-
-
0031037786
-
L-(-)-Desmethylselegiline, a metabolite of selegiline(L-(-)-deprenyl) protects mesencephalic dopamine neurons from excitotoxicity in vitro
-
Mytilineou C, Radcliffe PM, Olanow WC (1997b): L-(-)-Desmethylselegiline, a metabolite of selegiline(L-(-)-deprenyl) protects mesencephalic dopamine neurons from excitotoxicity in vitro. J Neurochem 68:434-136.
-
(1997)
J Neurochem
, vol.68
, pp. 434-1136
-
-
Mytilineou, C.1
Radcliffe, P.M.2
Olanow, W.C.3
-
41
-
-
0024456653
-
Effect of deprenyl on the progression of disability in early Parkinson's disease
-
Parkinson Study Group (1989): Effect of deprenyl on the progression of disability in early Parkinson's disease. N Eng J Med 321:1364-1371.
-
(1989)
N Eng J Med
, vol.321
, pp. 1364-1371
-
-
-
42
-
-
0027530638
-
Effect of tocopherol and deprenyl on the progression of disability in early Parkinsons disease
-
Parkinson Study Group (1993): Effect of tocopherol and deprenyl on the progression of disability in early Parkinsons disease. N Eng J Med 328:176-183.
-
(1993)
N Eng J Med
, vol.328
, pp. 176-183
-
-
-
44
-
-
77956767839
-
Antiapoptotic actions of monoamine oxidase B inhibitors
-
Paterson IA, Tatton WG (1998): Antiapoptotic actions of monoamine oxidase B inhibitors. Adv Pharmacol 42:312-315.
-
(1998)
Adv Pharmacol
, vol.42
, pp. 312-315
-
-
Paterson, I.A.1
Tatton, W.G.2
-
45
-
-
0025647353
-
2-Phenylethylamine: A modulator of catecholamine transmission in the mammalian central nervous system?
-
Paterson IA, Juorio AV, Boulton AA (1990): 2-Phenylethylamine: A modulator of catecholamine transmission in the mammalian central nervous system? J Neurochem 55:1827-1837.
-
(1990)
J Neurochem
, vol.55
, pp. 1827-1837
-
-
Paterson, I.A.1
Juorio, A.V.2
Boulton, A.A.3
-
46
-
-
0029416898
-
Inhibition of MAO-B by (-)-deprenyl alters dopamine metabolism in the macaque (Macaca fascicularis) brain
-
Paterson IA, Davis BA, Durden DA, Juorio AV, Yu PH, Ivy G, Milgram W, Mendonca A, Wu P, Boulton AA (1995): Inhibition of MAO-B by (-)-deprenyl alters dopamine metabolism in the macaque (Macaca fascicularis) brain. Neurochem Res 20:1503-1510.
-
(1995)
Neurochem Res
, vol.20
, pp. 1503-1510
-
-
Paterson, I.A.1
Davis, B.A.2
Durden, D.A.3
Juorio, A.V.4
Yu, P.H.5
Ivy, G.6
Milgram, W.7
Mendonca, A.8
Wu, P.9
Boulton, A.A.10
-
48
-
-
0344662841
-
Aliphatic propargylamines prevent hippocampal neuronal death induced by hypoxia-ischaemia
-
Paterson IA, Davis BA, Durden DA, Boulton AA (1997b): Aliphatic propargylamines prevent hippocampal neuronal death induced by hypoxia-ischaemia. J Neurochem 69(Suppl):S137A.
-
(1997)
J Neurochem
, vol.69
, Issue.SUPPL.
-
-
Paterson, I.A.1
Davis, B.A.2
Durden, D.A.3
Boulton, A.A.4
-
49
-
-
0343961618
-
The anti-apoptotic effects of 2HMP is due to a desmethyl metabolite
-
abstract 880.6
-
Paterson, IA, Dyck LE, Durden DA, Davis BA, Lui Y, Boulton AA (1997c): The anti-apoptotic effects of 2HMP is due to a desmethyl metabolite. J Neurosci 23(Suppl 2):2254(abstract 880.6).
-
(1997)
J Neurosci
, vol.23
, Issue.2 SUPPL.
, pp. 2254
-
-
Paterson, I.A.1
Dyck, L.E.2
Durden, D.A.3
Davis, B.A.4
Lui, Y.5
Boulton, A.A.6
-
50
-
-
0031914155
-
R-deprenyl and R-2-heptyl-n-methylproparglyamine prevent apoptosis in cerebellar granule neurons induced by cytosine arabinoside but not low extracellular potassium
-
Paterson IA, Zhang D, Warrington RC, Boulton AA (1998): R-deprenyl and R-2-heptyl-n-methylproparglyamine prevent apoptosis in cerebellar granule neurons induced by cytosine arabinoside but not low extracellular potassium. J Neurochem 70:515-523.
-
(1998)
J Neurochem
, vol.70
, pp. 515-523
-
-
Paterson, I.A.1
Zhang, D.2
Warrington, R.C.3
Boulton, A.A.4
-
51
-
-
0019824482
-
Amphetamine, p-hydroxyamphetamine, and b-phenylethylamine in mouse brain and urine after (-)- and (+)-deprenyl administration
-
Philips SR (1981): Amphetamine, p-hydroxyamphetamine, and b-phenylethylamine in mouse brain and urine after (-)-and (+)-deprenyl administration. J Pharm Pharmacol 33:739-741.
-
(1981)
J Pharm Pharmacol
, vol.33
, pp. 739-741
-
-
Philips, S.R.1
-
52
-
-
0018068203
-
Amphetamine and 2-phenylethylamine in post-mortem Parkinson brain after (-)deprenyl administration
-
Reynolds GR, Riederer P, Sandler M, Jellinger K, Seemann D (1978): Amphetamine and 2-phenylethylamine in post-mortem Parkinson brain after (-)deprenyl administration. J Neural Trans 43:271-277.
-
(1978)
J Neural Trans
, vol.43
, pp. 271-277
-
-
Reynolds, G.R.1
Riederer, P.2
Sandler, M.3
Jellinger, K.4
Seemann, D.5
-
53
-
-
0026492963
-
Deficits in cholinergic neurotransmission markers induced by ethylcholine mustard aziridinium (AF64A) in the rat hippocampus: Sensitivity to treatment with the MAO-B inhibitor L-deprenyl
-
Ricci A, Mancini M, Strocchi P, Bongrani S, Bronzetti E (1992): Deficits in cholinergic neurotransmission markers induced by ethylcholine mustard aziridinium (AF64A) in the rat hippocampus: Sensitivity to treatment with the MAO-B inhibitor L-deprenyl. Drugs Exp Clin Res 18:163-171.
-
(1992)
Drugs Exp Clin Res
, vol.18
, pp. 163-171
-
-
Ricci, A.1
Mancini, M.2
Strocchi, P.3
Bongrani, S.4
Bronzetti, E.5
-
54
-
-
0027292598
-
Deprenyl increases survial of rat foetal nigral neurones in culture
-
Roy E, Bedard PJ (1993): Deprenyl increases survial of rat foetal nigral neurones in culture. NeuroReport 4:1183-1186.
-
(1993)
NeuroReport
, vol.4
, pp. 1183-1186
-
-
Roy, E.1
Bedard, P.J.2
-
55
-
-
0029564645
-
Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease - Clinical presentation, cognitive testing, pathology and response to L-deprenyl therapy
-
Ruehl WW, Bruyette DS, DePaoli A, Cotman CW, Head E, Milgram NW, Cummings BJ (1995): Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease - clinical presentation, cognitive testing, pathology and response to L-deprenyl therapy. Prog Brain Res 106:217-225.
-
(1995)
Prog Brain Res
, vol.106
, pp. 217-225
-
-
Ruehl, W.W.1
Bruyette, D.S.2
DePaoli, A.3
Cotman, C.W.4
Head, E.5
Milgram, N.W.6
Cummings, B.J.7
-
56
-
-
0030755327
-
Treatment with L-deprenyl prolongs life in elderly dogs
-
Ruehl WW, Entriken TL, Muggenburg BA, Bruyette DS, Griffith WG, Hahn FF (1997): Treatment with L-deprenyl prolongs life in elderly dogs. Life Sci 61:1037-1044.
-
(1997)
Life Sci
, vol.61
, pp. 1037-1044
-
-
Ruehl, W.W.1
Entriken, T.L.2
Muggenburg, B.A.3
Bruyette, D.S.4
Griffith, W.G.5
Hahn, F.F.6
-
57
-
-
77956779134
-
Therapeutic actions of L-deprenyl in dogs: A model of human brain aging
-
Ruehl WW, Neilson J, Hart B, Head E, Bruyette DS, Cummings BJ (1998): Therapeutic actions of L-deprenyl in dogs: A model of human brain aging. Adv Pharmacol 42:316-319.
-
(1998)
Adv Pharmacol
, vol.42
, pp. 316-319
-
-
Ruehl, W.W.1
Neilson, J.2
Hart, B.3
Head, E.4
Bruyette, D.S.5
Cummings, B.J.6
-
58
-
-
0026514670
-
Deprenyl reduces the death of motoneurones caused by axotomy
-
Salo PT, Tatton WG (1992): Deprenyl reduces the death of motoneurones caused by axotomy. J Neurosci Res 31:394-400.
-
(1992)
J Neurosci Res
, vol.31
, pp. 394-400
-
-
Salo, P.T.1
Tatton, W.G.2
-
59
-
-
0030967165
-
A controlled trial of selegiline, alpha-tocopheral or both, as a treatment for Alzheimer's
-
Sano M, Ernesto C, Thomas RG, Kauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS, Thal LF (1997): A controlled trial of selegiline, alpha-tocopheral or both, as a treatment for Alzheimer's. N Engl J Med 336:1216-1222.
-
(1997)
N Engl J Med
, vol.336
, pp. 1216-1222
-
-
Sano, M.1
Ernesto, C.2
Thomas, R.G.3
Kauber, M.R.4
Schafer, K.5
Grundman, M.6
Woodbury, P.7
Growdon, J.8
Cotman, C.W.9
Pfeiffer, E.10
Schneider, L.S.11
Thal, L.F.12
-
60
-
-
2642640392
-
Possible benefits of a combination of selegiline and cholinesterase inhibitors
-
Judd LL, Saleta B, Filip V (eds): Basel: Karger
-
Schneider LS, Olin JT, Pawluczyk S (1997): Possible benefits of a combination of selegiline and cholinesterase inhibitors. In Judd LL, Saleta B, Filip V (eds): Basic and Clinical Science of Mental and Addictive Disorders. Basel: Karger, pp 235-237.
-
(1997)
Basic and Clinical Science of Mental and Addictive Disorders
, pp. 235-237
-
-
Schneider, L.S.1
Olin, J.T.2
Pawluczyk, S.3
-
61
-
-
0028121120
-
Increased CNTF gene expression in process-bearing astrocytes following injury is augmented by L(-)deprenyl
-
Seniuk NA, Henderson JT, Tatton WG, Roder JC (1994): Increased CNTF gene expression in process-bearing astrocytes following injury is augmented by L(-)deprenyl. J Neurosci Res 37:278-286.
-
(1994)
J Neurosci Res
, vol.37
, pp. 278-286
-
-
Seniuk, N.A.1
Henderson, J.T.2
Tatton, W.G.3
Roder, J.C.4
-
64
-
-
0023184673
-
L-deprenyl in Alzheimer's disease: Preliminary evidence for behavioural change with MAO-B inhibitors
-
Tariot PN, Cohen PM, Sunderland T, Newhouse PA, Yount D, Mellow AM, Weingartner H, Mueller EA, Murphy DL (1987): L-deprenyl in Alzheimer's disease: Preliminary evidence for behavioural change with MAO-B inhibitors. Arch Gen Psychiatry 44:427-433.
-
(1987)
Arch Gen Psychiatry
, vol.44
, pp. 427-433
-
-
Tariot, P.N.1
Cohen, P.M.2
Sunderland, T.3
Newhouse, P.A.4
Yount, D.5
Mellow, A.M.6
Weingartner, H.7
Mueller, E.A.8
Murphy, D.L.9
-
65
-
-
0029731378
-
Modulation of gene expression rather than monoamine oxidase inhibition: (-)-Deprenyl-related compounds in controlling neurodegeneration
-
Tatton W, Chalmers-Redman RME (1996): Modulation of gene expression rather than monoamine oxidase inhibition: (-)-Deprenyl-related compounds in controlling neurodegeneration. Neurology 47(suppl 3):S171-S183.
-
(1996)
Neurology
, vol.47
, Issue.3 SUPPL.
-
-
Tatton, W.1
Chalmers-Redman, R.M.E.2
-
66
-
-
0026353406
-
Rescue of dying neurons: A new action for deprenyl in MPTP Parkinsonism
-
Tatton WG, Greenwood CE (1991): Rescue of dying neurons: A new action for deprenyl in MPTP Parkinsonism. J Neurosci Res 30:666-672.
-
(1991)
J Neurosci Res
, vol.30
, pp. 666-672
-
-
Tatton, W.G.1
Greenwood, C.E.2
-
67
-
-
0027941312
-
(-)Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis
-
Tatton WG, Ju WYL, Holland DP, Tai C, Kwan M (1994): (-)Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. J Neurochem 63:1572-1575.
-
(1994)
J Neurochem
, vol.63
, pp. 1572-1575
-
-
Tatton, W.G.1
Ju, W.Y.L.2
Holland, D.P.3
Tai, C.4
Kwan, M.5
-
68
-
-
0030612215
-
Aopotosis in neurodegenerative disorders: Potential for therapy by modifying gene transcription
-
Tatton WG, Chalmers-Redman RME, Ju WYH, Wadia J, Tatton NA (1997): Aopotosis in neurodegenerative disorders: Potential for therapy by modifying gene transcription. J Neural Trans 49:245-268.
-
(1997)
J Neural Trans
, vol.49
, pp. 245-268
-
-
Tatton, W.G.1
Chalmers-Redman, R.M.E.2
Ju, W.Y.H.3
Wadia, J.4
Tatton, N.A.5
-
69
-
-
0024343466
-
The effect of deprenyl (selegiline) on the natural history of Parkinson's disease
-
Tetrud JW, Langston JW (1989): The effect of deprenyl (selegiline) on the natural history of Parkinson's disease. Science 245:519-522.
-
(1989)
Science
, vol.245
, pp. 519-522
-
-
Tetrud, J.W.1
Langston, J.W.2
-
70
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Thomson CB (1995): Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462.
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thomson, C.B.1
-
71
-
-
0022638352
-
Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: Relationship of metabolism to MAO-B inhibitory potency
-
Yoshida T, Yamada Y, Yamamoto T, Kuroiwa Y (1986): Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: Relationship of metabolism to MAO-B inhibitory potency. Xenobiotica 16:129-136.
-
(1986)
Xenobiotica
, vol.16
, pp. 129-136
-
-
Yoshida, T.1
Yamada, Y.2
Yamamoto, T.3
Kuroiwa, Y.4
-
72
-
-
0030641754
-
Understanding Parkinson's disease
-
Youdim MBH, Riederer P (1997): Understanding Parkinson's disease. Sci Am 276:52-59.
-
(1997)
Sci Am
, vol.276
, pp. 52-59
-
-
Youdim, M.B.H.1
Riederer, P.2
-
73
-
-
0024623978
-
Deamination of aliphatic amines of different chain lengths by rat liver MAO-A & B
-
Yu PH (1989): Deamination of aliphatic amines of different chain lengths by rat liver MAO-A & B. J Pharm Pharmacol 41:205-208.
-
(1989)
J Pharm Pharmacol
, vol.41
, pp. 205-208
-
-
Yu, P.H.1
-
74
-
-
0026655680
-
Aliphatic propargylamines: Potent, selective, irreversible MAO-B inhibitors
-
Yu PH, Davis BA, Boulton AA (1992a): Aliphatic propargylamines: potent, selective, irreversible MAO-B inhibitors. J Med Chem 35:3705-3713.
-
(1992)
J Med Chem
, vol.35
, pp. 3705-3713
-
-
Yu, P.H.1
Davis, B.A.2
Boulton, A.A.3
-
76
-
-
2642671082
-
-
PCT #92/00090 Europe, USA, Canada, Japan, Australia, and several other countries
-
Yu PH, Davis BA, Boulton AA (1993a): Aliphatic Propargylamines as MAO-B Inhibitors and Neuroprotective agents. PCT #92/00090 Europe, USA, Canada, Japan, Australia, and several other countries.
-
(1993)
Aliphatic Propargylamines As MAO-B Inhibitors and Neuroprotective Agents
-
-
Yu, P.H.1
Davis, B.A.2
Boulton, A.A.3
-
77
-
-
0027242401
-
Effect of structural modification of alkyl N-propargylamines on the selective inhibition of MAO-B activity
-
Yu PH, Davis BA, Boulton AA (1993b): Effect of structural modification of alkyl N-propargylamines on the selective inhibition of MAO-B activity. Biochem Pharmacol 46:753-757.
-
(1993)
Biochem Pharmacol
, vol.46
, pp. 753-757
-
-
Yu, P.H.1
Davis, B.A.2
Boulton, A.A.3
-
78
-
-
0028057394
-
Neurochemical and neuroprotective effects of some aliphatic propargylamines: New selective nonamphetamine-like MAO-B inhibitors
-
Yu PH, Davis BA, Durden DA, Barber A, Terleckyj I, Nicklas WG, Boulton AA (1994a): Neurochemical and neuroprotective effects of some aliphatic propargylamines: New selective nonamphetamine-like MAO-B inhibitors. J Neurochem 62:697-704.
-
(1994)
J Neurochem
, vol.62
, pp. 697-704
-
-
Yu, P.H.1
Davis, B.A.2
Durden, D.A.3
Barber, A.4
Terleckyj, I.5
Nicklas, W.G.6
Boulton, A.A.7
-
79
-
-
0028020079
-
Neuroprotective effect of some monoamine oxidase-B inhibitors against DSP-4 induced noradrenaline depletion in the mouse hippocampus
-
Yu PH, Davis BA, Fang J, Boulton AA (1994b): Neuroprotective effect of some monoamine oxidase-B inhibitors against DSP-4 induced noradrenaline depletion in the mouse hippocampus. J Neurochem 63:1820-1828.
-
(1994)
J Neurochem
, vol.63
, pp. 1820-1828
-
-
Yu, P.H.1
Davis, B.A.2
Fang, J.3
Boulton, A.A.4
-
80
-
-
0029559253
-
Neurochemical, neuroprotective and neurorescue effects of aliphatic N-methylpropargylamines: New MAO-B inhibitors without amphetamine-like properties
-
Yu PH, Davis BA, Zhang X, Zuo D-M, Fang J, Lai C-T, Li X-M, Paterson IA, Boulton AA (1995): Neurochemical, neuroprotective and neurorescue effects of aliphatic N-methylpropargylamines: New MAO-B inhibitors without amphetamine-like properties. Prog Brain Res 106:113-121.
-
(1995)
Prog Brain Res
, vol.106
, pp. 113-121
-
-
Yu, P.H.1
Davis, B.A.2
Zhang, X.3
Zuo, D.-M.4
Fang, J.5
Lai, C.-T.6
Li, X.-M.7
Paterson, I.A.8
Boulton, A.A.9
-
81
-
-
0031847250
-
Aliphatic N-methylpropargylamines as potential neurorescue agents
-
in press
-
Yu PH, Zhang X, Zuo DM, Lai CT, Tieu BA, Davis BA, Boulton AA (1998): Aliphatic N-methylpropargylamines as potential neurorescue agents. Restorative Neurol Neurosci (in press).
-
(1998)
Restorative Neurol Neurosci
-
-
Yu, P.H.1
Zhang, X.2
Zuo, D.M.3
Lai, C.T.4
Tieu, B.A.5
Davis, B.A.6
Boulton, A.A.7
-
82
-
-
0028981070
-
Neuroprotection of R(-)-deprenyl and N-2-hexyl-N-methylpropargylamine on DSP-4 induced degeneration of noradrenergic neurons in the rat locus coeruleus
-
Zhang X, Zuo D-M, Yu PH (1995a): Neuroprotection of R(-)-deprenyl and N-2-hexyl-N-methylpropargylamine on DSP-4 induced degeneration of noradrenergic neurons in the rat locus coeruleus. Neuroscience 186:45-48.
-
(1995)
Neuroscience
, vol.186
, pp. 45-48
-
-
Zhang, X.1
Zuo, D.-M.2
Yu, P.H.3
-
83
-
-
0029066255
-
Depletion of NOS activity in the rat dentate gyrus neurons by DSP-4 and protection by deprenyl
-
Zhang X, Yu PH (1995b): Depletion of NOS activity in the rat dentate gyrus neurons by DSP-4 and protection by deprenyl. Brain Res Bull 38:307-311
-
(1995)
Brain Res Bull
, vol.38
, pp. 307-311
-
-
Zhang, X.1
Yu, P.H.2
-
84
-
-
0029973665
-
Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain
-
Zhang X, Boulton AA, Yu PH (1996a): Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain. Eur J Neurosci 8:1432-1440.
-
(1996)
Eur J Neurosci
, vol.8
, pp. 1432-1440
-
-
Zhang, X.1
Boulton, A.A.2
Yu, P.H.3
-
85
-
-
0029740221
-
MK-801 induces apoptotic neuronal death in the rat retrosplenial cortex; Prevention by cycloheximide and R(-)-2-hexyl-N-methylpropargylaminc
-
Zhang X, Boulton AA, Zuo DM, Yu PH (1996b): MK-801 induces apoptotic neuronal death in the rat retrosplenial cortex; Prevention by cycloheximide and R(-)-2-hexyl-N-methylpropargylaminc. J Neurosci Res 46:82-89.
-
(1996)
J Neurosci Res
, vol.46
, pp. 82-89
-
-
Zhang, X.1
Boulton, A.A.2
Zuo, D.M.3
Yu, P.H.4
-
86
-
-
0029938017
-
Immunohistochemical evidence of neuroprotection by R(-)-deprenyl and N-(2-hexyl)-N-methylpropargylamine on DSP-4-induced degeneration of rat brain noradrenergic axons and terminals
-
Zhang X, Zuo DM, Davis BA, Boulton AA, Yu PH (1996c): Immunohistochemical evidence of neuroprotection by R(-)-deprenyl and N-(2-hexyl)-N-methylpropargylamine on DSP-4-induced degeneration of rat brain noradrenergic axons and terminals. J Neurosci Res 43:482-489.
-
(1996)
J Neurosci Res
, vol.43
, pp. 482-489
-
-
Zhang, X.1
Zuo, D.M.2
Davis, B.A.3
Boulton, A.A.4
Yu, P.H.5
-
87
-
-
0030976602
-
Gradation of kainic acid-elicited rat limbic seizures and expression of hippocampal heat shock protein-70
-
Zhang X, Gelowitz DL, Lai CT, Boulton AA, Yu PH (1997): Gradation of kainic acid-elicited rat limbic seizures and expression of hippocampal heat shock protein-70. Eur J Neurosci 9:760-769.
-
(1997)
Eur J Neurosci
, vol.9
, pp. 760-769
-
-
Zhang, X.1
Gelowitz, D.L.2
Lai, C.T.3
Boulton, A.A.4
Yu, P.H.5
-
88
-
-
0029619445
-
Increased survival of dopaminergic neuroblastoma in co-cultures with C6 glioma by R(-)deprenyl
-
Zuo DM, Yu PH (1995): Increased survival of dopaminergic neuroblastoma in co-cultures with C6 glioma by R(-)deprenyl. Prog Brain Res 106:199-205.
-
(1995)
Prog Brain Res
, vol.106
, pp. 199-205
-
-
Zuo, D.M.1
Yu, P.H.2
|