Apoptosis in cerebellar granule neurones: Involvement of interleukin- 1β converting enzyme-like proteases

Journal of Neurochemistry

Volumn 68, Issue 4, 1997, Pages 1598-1605

  Taylor, Joanne ^a   Gatchalian, Christine L ^a   Keen, Gregory ^a   Rubin, Lee L ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; Cerebellar granule neurone; Interleukin 1 converting enzyme; Poly(ADP ribose) polymerase; Staurosporine

Indexed keywords

INTERLEUKIN 1BETA CONVERTING ENZYME; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEINASE; STAUROSPORINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CEREBELLUM; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; GRANULE CELL; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SEQUENCE HOMOLOGY; SPINAL GANGLION;

ANIMALIA;

EID: 0030939043     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68041598.x     Document Type: Article

References (43)

1. Bertrand R., Solary E., O'Connor P., Kohn K. W., and Pommier Y. (1994) Induction of a common pathway of apoptosis by staurosporine. Exp. Cell Res. 211, 314-321.
2. Cain K., Inayat-Hussain S. H., Couet C., and Cohen G. M. (1996) A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes. Biochem. J. 314, 27-32.
3. Charriaut-Marlangue C., Aggoun-Zouaoui D., Represa A., and Ben-Ari Y. (1996) Apoptotic features of selective neuronal death in ischemia, epilepsy and gp 120 toxicity. Trends Neurosci. 19, 109-114.
4. D'Mello S. R., Galli C., Ciotti T., and Calissano P. (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. USA 90, 10989-10993.
5. Enari M., Talanian R. V., Wong W. W., and Nagata S. (1996) Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380, 723-726.
6. Fraser A. and Evan G. (1996) A licence to kill. Cell 85, 781-784.
7. Gagliardini V., Fernandez P.-A., Lee R. K. K., Drexler H. C. A., Rotello R. J., Fishman M. C., and Yuan J. (1994) Prevention of vertebrate neuronal death by the crmA gene. Science 263, 826-828.
8. Galli C., Meucci O., Scorziello A., Werge T. M., Calissano P., and Schettini G. (1995) Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. J. Neurosci. 15, 1172-1179.
9. Gavrieli Y., Sherman Y., and Ben-Sasson S. A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
10. Ghosh A., Carnahan J., and Greenberg M. E. (1994) Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263, 1618-1623.
11. Ishizaki Y., Cheng L., Mudge A. W., and Raff M. C. (1995) Programmed cell death by default in embryonic cells, fibroblasts and cancer cells. Mol. Biol. Cell 6, 1443-1458.
12. Jacobson M. D., Burne J. F., King M. P., Miyashita T., Reed J. C., and Raff M. C. (1993) Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 361, 365-369.
13. Jacobson M. D., Burne J. F., and Raff M. C. (1994) Programmed cell death and Bcl-2 protection in the absence of a nucleus. EMBO J. 13, 1899-1910.
14. Jacobson M. D., Weil M., and Raff M. C. (1996) Role of Ced-3/ICE-family proteases in staurosprorine-induced programmed cell death. J. Cell Biol. 133, 1041-1051.
15. Kaufman S. H., Desnoyers S., Ottaviano Y., Davidson N. E., and Poirier G. G. (1993) Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 53, 3976-3985.
16. Keilhauer G., Faissner A., and Schachner M. (1985) Differential inhibition of neurone-neurone, neurone-astrocyte and astrocyte-astrocyte adhesion by L1, L2 and N-CAM antibodies. Nature 316, 728-730.
17. Kubo T., Nonomura T., Enokido Y., and Hatanaka H. (1995) Brain-derived neurotrophic factor (BDNF) can prevent apoptosis of rat cerebellar granule neurons in culture. Dev. Brain Res. 85, 249-258.
18. Kuida K., Lippke J. A., Ku G., Harding M. W., Livingston D. J., Su M. S.-S., and Flavell R. A. (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267, 2000-2003.
19. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
20. Lamarre D., Talbot B., de Murcia G., Laplante C., Leduc Y., Mazen A., and Poirier G. G. (1988) Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study. Biochim. Biophys. Acta 950, 147-160.
21. Lazebnik Y. A., Kaufmann S. H., Desnoyers S., Poirier G. G., and Earnshaw W. C. (1994) Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347.
22. Levick V., Coffey H., and D'Mello S. R. (1995) Opposing effects of thapsigargin on the survival of developing cerebellar granule neurons in culture. Brain Res. 676, 325-335.
23. Li P., Allen H., Banerjee S., Franklin S., Herzog L., Johnston C., McDowell J., Paskind M., Rodman L., Salfeld J., Towne E., Tracy D., Wardwell L., Wei F.-Y., Wong W., Kamen R., and Seshadri T. (1995) Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell 80, 401-411.
24. Liu X., Kim C. N., Pohl J., and Wang X. (1996) Purification and characterisation of an interleukin-1β-converting enzyme family protease that activates cysteine protease P32 (CPP32). J. Biol. Chem. 271, 13371-13376.
25. Martinou I., Fernandez P.-A., Missotten M., White E., Allet B., Sadoul R., and Martinou J.-C. (1995) Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation. J. Cell Biol. 128, 201-208.
26. Milligan C. E., Prevette D., Yaginuma H., Homma S., Cardwell C., Fritz L. C., Tomaselli K. J., Oppenheim R. W., and Schwartz L. M. (1995) Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro. Neuron 15, 385-393.
27. Miura M., Zhu H., Rotello R., Hartwieg E. A., and Yuan J. (1993) Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75, 653-660.
28. Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
29. Nicholson D. W. (1996) ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis. Nature Biotech. 14, 297-300.
30. Nicholson D. W., Ali A., Thornberry N. A., Vaillancourt J. P., Ding C. K., Gallant M., Gareau Y., Griffin P. R., Labelle M., Lazebnik Y. A., Munday N. A., Raju S. M., Smulson M. E., Yamin T.-T., Yu V. L., and Miller D. K. (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37-43.
31. Oberhammer F. A., Pavelka M., Sharma S., Tiefenbacher R., Purchio A. F., Bursch W., and Schulte-Hermann R. (1992) Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1. Proc. Natl. Acad. Sci. USA 89, 5408-5412.
32. Oppenheim R. W. (1991) Cell death during development of the nervous system. Annu. Rev. Neurosci. 14, 453-501.
33. Philpott K. L., McCarthy M. J., Becker D., Gatchalian C., and Rubin L. L. (1996) Morphological and biochemical changes in neurons: apoptosis versus mitosis. Eur. J. Neurosci. 8, 1906-1915.
34. Raff M. C., Barres B. A., Burne J. F., Coles H. S., Ishizak, Y., and Jacobson M. D. (1993) Programmed cell death and the control of cell survival: lessons from the nervous system. Science 262, 695-700.
35. Taylor J., Gatchalian C. L., Neame S. J., Desmond H. P., and Rubin L. L. (1995) Role of ICE-like proteases in neuronal apoptosis. Soc. Neurosci. Abstr. 21, 301.
36. Tewari M., Quan L. T., O'Rourke K., Desnoyers S., Zeng Z., Beidler D. R., Poirier G. G., Salveson G. S., and Dixit V. M. (1995) Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 81, 801-809.
37. Thompson C. B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462.
38. Thornberry N. A. and Molineaux S. M. (1995) Interleukin 1β converting enzyme: a novel cysteine protease required for IL-1β production 'and implicated in programmed cell death. Protein Sci. 4, 3-12.
39. Thornberry N. A., Bull H. G., Calaycay J. R., Chapman K. T., Howard A. D., Kostura M. J., Miller D. K., Molineaux S. M., Weidner J. R., Aunins J., Elliston K. O., Ayala J. M., Casano F. J., Chin J., Ding J. G.-F., Egger L. A., Gaffney E. P., Limjuco G., Palyha O. C., Raju S. M., Rolando A. M., Salley J. P., Yamin T.-T., Lee T. D., Shively J. E., MacCross M., Mumford R. A., Schmidt J. A., and Tocci M. J. (1992) A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 356, 768-774.
40. Troy C. M., Stefanis L., Prochiantz A., Greene L. A., and Shelanski M. L. (1996) The contrasting roles of ICE family proteases and interleukin-1β in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation. Proc. Natl. Acad. Sci. USA 93, 5635-5640.
41. Weil M., Jacobson M. D., Coles H. S., Davies T. J., Gardner R. L., Raff K. D., and Raff M. C. (1996) Constitutive expression of the machinery for programmed cell death. J. Cell Biol. 133, 1053-1059.
42. Yan G.-M., Ni B., Weller M., Wood K. A., and Paul S. M. (1994) Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons. Brain Res. 656, 43-51.
43. Yuan J., Shaham S., Ledoux S., Ellis J. M., and Horvitz J. R. (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin 1β converting enzyme. Cell 75, 641-652.