Reaction of O6-benzylguanine-resistant mutants of human O6- alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides

Journal of Biological Chemistry

Volumn 273, Issue 18, 1998, Pages 10863-10867

  Pegg, Anthony E ^a   Kanugula, Sreenivas ^a   Edara, Suvarchala ^a   Pauly, Gary T ^b   Moschel, Robert C ^b   Goodtzova, Karina ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE INHIBITOR; 6 O BENZYLGUANINE; 6 O METHYLGUANINE; ALANINE; ALKYLATING AGENT; MUTANT PROTEIN; OLIGODEOXYRIBONUCLEOTIDE; PROLINE; DRUG DERIVATIVE; GUANINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; O(6) BENZYLGUANINE; O(6)-BENZYLGUANINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DNA REPAIR; DRUG DESIGN; DRUG SENSITIVITY; ENZYME INACTIVATION; PRIORITY JOURNAL; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMISTRY; GENETICS; HUMAN; MOLECULAR GENETICS; POINT MUTATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; GUANINE; HUMANS; MOLECULAR SEQUENCE DATA; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OLIGODEOXYRIBONUCLEOTIDES; POINT MUTATION;

EID: 0032056364     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.18.10863     Document Type: Article

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