The potential role of glycine-160 of human O6-alkylguanine-DNA alkyltransferase in reaction with O6-benzylguanine as determined by site-directed mutagenesis and molecular modelling comparisons

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1342, Issue 1, 1997, Pages 90-102

  Rafferty, Joseph A ^a   Wibley, Jane E A ^b   Speers, Peter ^b   Hickson, Ian ^a   Margison, Geoffrey P ^a   Moody, Peter C E ^c   Douglas, Kenneth T ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

ATase; DNA receptor; O6 Alkylguanine; O6 Benzylguanine; O6 Methylguanine

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; DNA BINDING; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE EXPRESSION; MOLECULAR MODEL; MUTAGENESIS; MUTATION; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BINDING SITES; CALORIMETRY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLYCINE; GUANINE; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; THERMODYNAMICS; TRANSCRIPTION FACTORS;

ADA; BACILLUS SUBTILIS; ESCHERICHIA COLI; MAMMALIA; SACCHAROMYCES; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0030708542     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(97)00095-2     Document Type: Article

References (51)

1. Hall J., Montesano R. Mutat. Res. 233:1990;247-252.
2. Pegg A.E. Cancer Res. 50:1990;6119-6129.
3. G.P. Margison, P.J. O'Connor, Handbook of Experimental Pharmacology, Springer, Heidelberg, 1990.
4. Saffhill R., Margison G.P., O'Connor P.J. Biochim. Biophys. Acta. 823:1985;111-145.
5. Hayakawa H., Koike G., Sekiguchi M. J. Mol. Biol. 213:1990;739-747.
6. Rydberg B., Spurr N., Karran P. J. Biol. Chem. 265:1990;9563-9569.
7. Santibanez-Koref M., Elder R.H., Fan C., Cawkwell L., McKie J., Douglas K.T., Margison G.P., Rafferty J.A. Mol. Carcinog. 5:1992;161-169.
8. Shiota S., von Wronski M.A., Bigner D.D., Brent T.P., Mitra S. Biochemistry. 31:1992;1897-1903.
9. Sakumi K., Shiraishi A., Hayakawa H., Sekiguchi M. Nucleic Acids Res. 19:1991;5597-5601.
10. Potter P.M., Rafferty J.A., Cawkwell L., Wilkinson M.C., Cooper D.P., O'Connor P.J., Margison G.P. Carcinogenesis. 12:1989;727-733.
11. Rafferty J.A., Elder R.H., Watson A.J., Cawkwell L., Potter P.M., Margison G.P. Nucleic Acids Res. 20:1992;1891-1895.
12. Potter P.M., Wilkinson M.C., Fitton J., Carr F.J., Brennand J., Cooper D.P., Margison G.P. Nucleic Acids Res. 15:1987;9177-9193.
13. Morohoshi F., Hayashi K., Munakata N. Nucleic Acids Res. 17:1989;6531-6543.
14. McCarthy V.T., Lindahl T. Nucleic Acids Res. 13:1985;2683-2698.
15. Morohoshi F., Hayashi K., Munakata N. Nucleic Acids Res. 18:1990;5473-5480.
16. Hakura A., Morimoto K., Sofuni T., Nohmi T. J. Bacteriol. 173:1991;3663-3672.
17. Xiao W., Derfler B., Chen J., Samson L. EMBO J. 10:1991;2179-2186.
18. Ludlum D.B. Mutat. Res. 233:1990;117-126.
19. Sekiguchi M., Nakabeppu Y. Trends Genet. 3:1987;51-54.
20. Dumenco L.L., Allay N., Norton K., Gerson S.L. Science. 259:1993;219-222.
21. Nakatsuru Y., Matsukuma S., Nemoto N., Sugano H., Sekiguchi M., Ishikawa T. Proc. Natl. Acad. Sci. USA. 90:1993;6468-6472.
22. D'Incalci M., Citti L., Taverna P., Catapano C.V. Cancer Treat. Rev. 15:1988;279-292.
23. Redmond M.S., Joncourt F., Buser K., Ziemiecki A., Altermatt H.J., Fey M., Cerny T., Margison G.P. Cancer Res. 51:1991;4131-4134.
24. Lee S.M., Rafferty J.A., Elder R.H., Fan C., Bromley M., Harris M., Thatcher N., Potter P.M., Altermatt H.J., Perinat-Frey T., Cerny T., O'Connor P.J., Margison G.P. Br. J. Cancer. 66:1992;355-360.
25. Brent T.P., von Wronski M.A., Mathew A., Edwards C., Bromley M., Margison G.P., Rafferty J.A., Pegram C.N., Bigner D.D. Oncol. Res. 5:1993;83-86.
26. Wibley J.E.A., McKie J.H., Embrey K., Marks D.S., Douglas K.T., Moore M.H., Moody P.C.E. Anti-Cancer Drug Des. 10:1995;75-95.
27. Moore M.H., Gulbis J.M., Dodson E.J., Demple B., Moody P.C.E. EMBO J. 13:1994;1495-1501.
28. Fairbairn L.J., Watson A.J., Rafferty J.A., Elder R.H., Margison G.P. Exp. Hematol. 23:1995;112-116.
29. Moschel R.C., McDougall M.G., Dolan M.E., Stine L., Pegg A.E. J. Med. Chem. 35:1992;4486-4491.
30. Elder R.H., Margison P., Rafferty J.A. Biochem. J. 298:1994;231-235.
31. Crone T.M., Kanugula S., Pegg A.E. Carcinogenesis. 16:1995;1687-1692.
32. Imai Y., Oda H., Nakatsuru Y., Ishikawa T. Carcinogenesis. 16:1995;2441-2445.
33. Edara S., Kanugula S., Goodtzova K., Pegg A.E. Cancer Res. 56:1996;5571-5575.
34. Spratt T.E., de los Santos H. Biochemistry. 31:1992;3688-3694.
35. Pegg A.E., Boosalis M., Samson L., Moschel R.C., Byers T.L., Swenn K., Dolan M.E. Biochemistry. 32:1993;11998-12006.
36. Chae M., Swenn K., Sreenivas K., Dolan M.E., Pegg A.E., Moschel R.C. J. Med. Chem. 38:1995;359-365.
37. Chae M., McDougall M.G., Dolan M.E., Swenn K., Pegg A.E., Moschel R.C. J. Med. Chem. 37:1994;342-347.
38. Arris C.E., Bleasdale C., Calvert A.H., Curtin N.J., Dalby C., Golding B.T., Griffin R.J., Lunn J.M., Major G.N., Newell D.R. Anti-Cancer Drug Des. 9:1994;401-408.
39. J. Hine, Physical Organic Chemistry, McGraw-Hill, New York, 1962.
40. Rafferty J.A., Tumelty J., Skorvaga M., Elder R.H., Margison G.P., Douglas K.T. Biochem. Biophys. Res. Commun. 199:1994;285-291.
41. Roldan-Arjona T., Luque-Romero F.L., Ariza R.R., Jurado J.J., Pueyo C. Mol. Carcinog. 9:1994;200-209.
42. Sanger F., Nicklen S., Coulson A.R. Proc. Natl. Acad. Sci. USA. 74:1977;5463-5467.
43. M.O. Dayhoff, R.M. Schwatz, B.C. Drutt, Atlas of Protein Sequence and Structure 5, Suppl. 3, 1978, pp. 345-352.
44. Burley S.K., Petsko G.A. Science. 229:1985;23-29.
45. Lindsay D.S., Rippey N.S., Blagburn B.L. J. Parasitol. 81:1995;315-318.
46. Flocco M.M., Mowbray S.L. J. Mol. Biol. 235:1994;709-717.
47. Lim A., Li B.F.L. EMBO J. 15:1996;4050-4060.
48. Bender K., Federwisch M., Loggen U., Nehls P., Rajewsky M.F. Nucleic Acids Res. 24:1996;2087-2094.
49. T.H. Lowry, K.S. Richardson, Mechanism and Theory in Organic Chemistry, Harper and Row, New York, 1981.
50. Lindahl T., Sedgwick B. Ann. Rev. Biochem. 57:1988;133-157.
51. Bishop R.E., Moschel R.C. Chem. Res. Toxicol. 4:1991;647-654.