3-(1-Piperazinyl)-4,5-dihydro-1H-benzo[g]indazoles: High affinity ligands for the human dopamine D4 receptor with improved selectivity over ion channels

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 6, 1998, Pages 743-753

  Collins, Ian ^a   Rowley, Michael ^a   Davey, William B ^a   Emms, Frances ^a   Marwood, Rosemarie ^a   Patel, Shil ^a   Patel, Smita ^a   Fletcher, Alan ^a   Ragan, Ian C ^a   Leeson, Paul D ^a   Scott, Ann L ^b   Broten, Theodore ^b  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

4,5 1H Benzo g indazoles; Selective dopamine receptor ligands

Indexed keywords

CALCIUM CHANNEL; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; INDAZOLE DERIVATIVE; ION CHANNEL; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL; SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; DRUG BINDING; DRUG SELECTIVITY; HUMAN; LIGAND BINDING; NONHUMAN;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALCIUM CHANNELS; CELL LINE; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; HUMANS; INDAZOLES; ION CHANNEL GATING; ION CHANNELS; LIGANDS; MUSCLE, SKELETAL; POTASSIUM CHANNELS; RABBITS; RATS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; RECOMBINANT PROTEINS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031861192     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00028-5     Document Type: Article

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