No difference in the expression of the D4 gene in post-mortem frontal cortex from controls and schizophrenics

Neuroscience Letters

Volumn 219, Issue 3, 1996, Pages 163-166

  Mulcrone, J ^a   Kerwin, R W ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

D4; Dopamine; Frontal cortex; mRNA; Reverse transcription polymerase chain reaction; Schizophrenia

Indexed keywords

DOPAMINE 4 RECEPTOR; MESSENGER RNA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; AGED; CADAVER; FRONTAL LOBE; GENE EXPRESSION; HUMANS; POLYMERASE CHAIN REACTION; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; REFERENCE VALUES; RNA, MESSENGER; SCHIZOPHRENIA; TRANSCRIPTION, GENETIC;

EID: 0030606252     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13191-8     Document Type: Article

References (19)

1. [1] Carlsson, I.A., The current status of the dopamine hypothesis of schizophrenia, Neuropsychopharmacology, 1 (1988) 179-186.
2. [2] Clow, A., Theodoru, A., Jenner, P. and Marsden, C.D., Changes in rat striatal dopamine turnover and receptor activity during one years neuroleptic administration, Eur. J. Pharmacol., 63 (1980) 135-144.
3. [3] Creese, I., Burt, D.R. and Snyder, S.H., Dopamine receptor binding predicts clinical and pharmacological potencies of antipsychotic drugs, Science, 192 (1976) 481-483.
4. [4] Matsumoto, M., Hidaka, K., Tada, S., Tasaki, Y. and Yamaguchi, T., Full length cDNA cloning and distribution of human dopamine D4 receptor, Mol. Brain Res., 29 (1995) 157-162.
5. [5] Matsumoto, M., Hidaka, K., Tada, S., Tasaki, Y. and Yamaguchi, T., Low levels of mRNA for dopamine D4 receptor in human cerebral cortex and striatum, J. Neurochem., 66 (1996) 915-919.
6. [6] Meador-Woodruff, J.H., Neuroanatomy of dopamine receptor gene expression: potential substrates for neuropsychiatric illness, Clin. Neuropharmacol., 18 (1995) s14-s24.
7. [7] Murray, M.A., Hyde, T.M., Knable, M.B., Herman, M.M., Bigelow, L.B., Carter, J.M., Weinberger, D.R. and Kleinman, J.E., Distribution of putative D4 dopamine receptors in postmortem striatum from patients with schizophrenia, J. Neurosci., 15 (1995) 2186-2191.
8. [8] Mrzljak, L., Bergson, C., Pappy, M., Huff, R., Levenson, R. and Goldman-Rakic, P.S., Localisation of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature, 381 (1996) 245-248.
9. [9] Pilowsky, L.S., Costa, D.C. and Ell, P.J. et al., Clozapine, single photon emmision tomography and the D2 dopamine receptor blockade hypothesis of schizophrenia, Lancet, 340 (1992) 199-202.
10. [10] Pilowsky, L.S., Costa, D.C., Ell, P.J., Murray, R.M., Verhoeff, N.P.L.G. and Kerwin, R.W., Antipsychotic medication, D2 dopamine receptor blockade and clinical response - a 123I IBZM SPET (single photon emission tomography) study, Psychol. Med., 23 (1993) 791-799.
11. [11] Reynolds, G.P. and Mason, S.L., Are striatal dopamine D4 receptors increased in schizophrenia?, J. Neurochem,, 63 (1995) 1576-1577.
12. [12] Reynolds, G.P. and Mason, S.L., Absence of detectable striatal dopamine D4 receptors in drug treated schizophrenia, Eur. J. Pharmacol., 281 (1995) R5-R6.
13. [13] Schools, O., Seaman, P., Guan, H.C., Paterson, A.D. and Van Tol, H.M., Long term haloperidol elevates dopamine D4 receptors by two fold in rats, Eur. J. Pharmacol., 289 (1995) 67-.
14. [14] Seeman, P., Guan, H. and Van Tol, H.H.M., Dopamine D4 receptors elevated in schizophrenia, Nature, 365 (1993) 441-445.
15. [15] Seeman, P. and Van Tol, H.H.M., Dopamine D4 like receptor elevation in schizophrenia: cloned D2 and D4 receptors cannot be discriminated by raclopride competition against [3H] nemonapride, J. Neurochem., 64 (1995) 1413-1415.
16. 125I]epidepride, Eur. J. Pharmacol., 286 (1995) R3-R5.
17. [17] Shaikh, S., Owen, M., Asherson, P., McGuffin, P., Nanko, S., Murray, R.M. and Collier, D., Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia, Am. J. Med. Genet., 54 (1994) 8-11.
18. 3H]raclopride binding in postmortem caudate nucleus of subjects with schizophrenia or major depression, Brain Res., 681 (1995) 109-116.
19. [19] Van Tol, H.H.M., Bunzow, J.R., Guan, H., Sunahara, R.K., Seeman, P., Niznik, H.B. and Civelli, O., Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine, Nature, 350 (1991) 610-614.