Dopamine D4 receptors: A new opportunity for research on schizophrenia

Current Medicinal Chemistry

Volumn 5, Issue 2, 1998, Pages 77-100

  Liégeois, Jean François ^a   Eyrolles, Laurence ^a   Bruhwyler, Jacques ^b   Delarge, Jacques ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b Therabel Pharma Belgium   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; 4 (2 PYRIDINYL)PIPERAZINE; 4 CHLOROPHENYLPIPERAZINE METHYLAZAINDOL; CLOZAPINE; DIMETHOXYISOCHROMAN; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR AFFECTING AGENT; EMONAPRIDE; HALOPERIDOL; N (1 BENZYL 3 PYRROLIDINYL) 5 CHLORO 4 CYCLOPROPYLCARBOXAMIDO 2 METHOXYBENZAMIDE; U 54537; UNCLASSIFIED DRUG; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DRD3 PROTEIN, HUMAN; DRD4 PROTEIN, HUMAN; NEUROLEPTIC AGENT;

ARTICLE; DOPAMINE METABOLISM; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; RECEPTOR AFFINITY; SCHIZOPHRENIA; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; HUMAN; METABOLISM; REVIEW;

ANTIPSYCHOTIC AGENTS; CLOZAPINE; DOPAMINE ANTAGONISTS; DRUG DESIGN; HUMANS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RECEPTORS, DOPAMINE D4; SCHIZOPHRENIA;

EID: 0031594771     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (71)

1. Brunello, N.; Masotto, C.; Steardo, L.; Markstein, R.; Racagni, G. Neuropsychopharmacol., 1995, 13, 177.
2. Kinon, B.J.; Lieberman, J.A. Psychopharmacol. 1996, 124, 2.
3. Carlsson, A.; Lindqvist, M. Acta Pharmacol. Toxicol., 1963, 20, 140.
4. Kane, J.; Honigfeld, G.; Singer, J.; Meltzer, H.Y. Arch. Gen. Psychiatry, 1988, 45, 789.
5. Bruhwyler, J.; Chleide, E.; Mercier, M. Neurosci. Biobehav. Rev., 1990, 14, 357.
6. Van Tol, H.H.M.; Bunzow, J.R.; Guan, H.-C.; Sunahara, R.K.; Seeman, P.; Niznik, H. B.; Civelli, O. Nature, 1991, 350, 610.
7. Seeman, P. Neuropsychopharmacol., 1992, 7, 261.
8. Deutch, A.Y.; Lee, M.C.; Iadarola, M.J. Mol. Cell. Neurosci., 1992, 3, 332.
9. Seeman, P.; Van Tol, H.H.M. TiPS,1994, 15, 264.
10. Reynolds, G. P. Drugs, 1996, 51, 7.
11. Petronis, A.; Macciardi, F.; Athanassiades, A.; Paterson, A.D.; Verga, M.; Meltzer, H.Y.; Cols, P.; Buchanan, J.A.; Van Tol, H.H.M.; Kennedy, J.L. Am. J. Med. Gen., 1995, 60, 452.
12. Nanko, S.; Hattori, M.; Ikeda, K.; Sasaki, T.; Kazamatsuri, H.; Kuwata, S. Lancet 1993, 341, 689.
13. Rao, P.A.; Pickar, D.; Gejman, P.V.; Ram, A.; Gershon, E.S.; Gelernter, J. Arch. Gen. Psychiatry, 1994, 51, 912.
14. McHale, M.; Coldwell, M C.; Herrity, N.; Boyfield, I.; Winn, F.M.; Ball, S.; Cook, T.; Robinson, J.H.; Gloger, I.S. FEBS Letters, 1994, 345, 147.
15. McAllister, G.; Knowles, M.R.; Ward-Booth, S.M.; Sinclair, H.A.; Patel, S.; Marwood, R.; Emms, F.; Patel, S.; Smith, A.; Seabrook, G.R.; Freedman, S.B. J. Receptor Signal Transduction Res., 1995, 15, 267.
16. Bouvier, C.; Bunzow, J.R.; Guan, H.-C.; Unteutsch, A.; Civelli, O.; Grandy, D.K.; Van Tol, H.H.M. Eur. J. Pharmacol., 1995, 290, 11.
17. O'Hara, C. ; Tang, L.; Taussig, R.; Todd, R.D.; O'Malley, K. J. Pharmacol. Exp. Ther., 1996, 278, 354.
18. O'Hara, C.; Uhland-Smith, A.; O'Malley, K.; Todd, R.D. J. Pharmacol. Exp. Ther., 1996, 277, 186.
19. Seeman, P.; Guan, H.-C.; Van Tol, H.H.M. Nature, 1993, 365, 441.
20. Reynolds, G.P.; Mason, S.L. Eur. J. Pharmacol., 1995, 281, R5.
21. Seeman, P.; Guan, H.-C.; Van Tol, H.H.M. Eur. J. Pharmacol., 1995, 286, R3.
22. Sumiyoshi, T.; Stockmeier, C.A.; Overholser, J.C.; Thompson, P.A.; Meltzer, H.Y. Brain Research, 1995, 681, 109.
23. Nair, V.D.; Mishra, R.K. Developmental Brain Research, 1995, 90, 180.
24. Todd, R.D. Biol. Psychiatry, 1992, 31, 794.
25. Benes, F.M.; Davidson, J.; Bird, E.D. Arch. Gen Psychiatry, 1986, 43, 31.
26. Pfefferbaum, A.; Zipursky, R.B.; Lim, K.O.; Zatz, L.M.; Stahl, S.M.; Jernigan, T.L. Arch. Gen. Psychiatry, 1988, 45, 633.
27. Glase, S.A.; Akunne, H. C.; Georgic, L.M.; Heffner, T.G.; MacKenzie, R.G.; Manley, P.J.; Pugsley, T.A.; Wise, L.D. J. Med. Chem., 1997, 40, 1771.
28. Ohmori, J.; Maeno, K.; Hidaka, K.; Nakato, K.; Matsumoto, M.; Tada, S.; Hattori, H.; Sakamoto, S.; Tsukamoto, S.-I.; Usuda, S.; Mase, T. J. Med. Chem., 1996, 39, 2764.
29. Hidaka, K.; Tada, S.; Matsumoto, M.; Ohmori, J.; Tasaki, Y.; Nomura, T.; Usuda, S.; Yamaguchi, T. Br. J. Pharmacol., 1996, 117, 1625.
30. Boyfield, I.; Brown, T.H.; Coldwell, M.C.; Cooper, D.G.; Hadley, M.S.; Hagan, J.J.; Healy, M.A.; Johns, A.; King, R.J.; Middlemiss, D.N.; Nash, D.J.; Riley, G.J.; Scott, E.E.; Smith, S.A.; Stemp, G. J. Med. Chem., 1996, 39, 1946.
31. Boyfield, I.; Coldwell, M.C.; Hadley, M.S.; Healy, M.A.; Johns, A.; Nash, D.J.; Riley, G.J.; Scott, E.E.; Smith, S.A.; Stemp, G.; Wilson, K. Bioorg. Med. Chem. Letters, 1996, 6, 1227.
32. Perrone, R.; Berardi, F.; Colabufo, N.A.; Leopoldo, M.; Tortorella, V. Bioorg. Med. Chem. Lett., 1997, 7, 1327.
33. Thurkauf, A.; Yuan, J.; Chen, X.; Wasley, J.W.F.; Meade, R.; Woodruff, K. H.; Huston, K.; Ross, P.C. J. Med. Chem., 1995, 38, 4950.
34. Thurkauf, A.; Yuan, J.; Chen, X.; Wasley, J.W.F.; Paneitz, G.; Meade, R.; Woodruff, K. H.; Huston, K.; Ross, P.C. Med. Chem. Res., 1996, 6, 69.
35. Thurkauf, A.; Yuan, J.; Chen, X.; Shu He, X.; Wasley, J.W.F.; Hutchison, A.; Woodruff, K. H.; Meade, R.; Hoffman, D.C.; Donovan, H.; Jones- Hertzog, D. K. J. Med. Chem., 1997, 40, 1.
36. Kulagowski, J.J.;. Broughton, H.B; Curtis, N.R.; Mawer, I.M.; Ridgill, M.P.; Baker, R.; Emms, F.; Freedman, S.B.; Marwood, R.; Patel, S.; Patel, S.; Ragan, C.I.; Leeson, P.D. J. Med. Chem., 1996, 39, 1941.
37. Patel, S. IBC Conference Proceedings, London, March 1996.
38. Bristow, L.J.; Kramer, M.S.; Kulagowski, J.; Patel, S.; Ragan, C.I.; Seabrook, G.R. TiPS, 1997, 18, 186.
39. TenBrink, R.E.; Bergh, C.L.; Duncan, J. N.; Harris, D.W.; Huff, R.M.; Lahti, R.A.; Lawson, C.F.; Lutzke, B.S.; Martin, I.J.;. Rees, S.A; Schlachter, S.K.; Sih, J.C.; Smith, M.W. J. Med. Chem., 1996, 39, 2435.
40. Merchant, K.M.; Gill, G.S.; Harris, D.W.; Huff, R.M.; Eaton, M.J.; Lookingland, K.; Lutzke, B.S.; MacCall, R.B.; Piercey, M.F.; Schreur, P.J.; Sethy, V.H.; Smith, M.W.; Svensson, K.A.; Tang, A.H.; Vonvoigtlander, P.F.; TenBrink, R.E. J. Pharmacol. Exp. Ther., 1996, 279, 1392.
41. Rowley, M.; Broughton, H.B.; Collins, I.; Baker, R.; Emms, F.; Marwood, R.; Patel, S.; Ragan, C.I.; Freedman, S.B.; Leeson, P.D. J. Med. Chem., 1996, 39, 1943.
42. Rowley, M.; Collins, I.; Broughton, H.B.; Davey, W.B.; Baker, R.; Emms, F.; Marwood, R.; Patel, S.; Patel, S.; Ian Ragan, C.; Freedman, S.B.; Ball, R.; Leeson, P.D. J. Med. Chem., 1997, 40, 2374.
43. Abstract book of the 213th American Chemical Society National Meeting, San Francisco (April 1997)
44. Liégeois, J.-F.; Bruhwyler, J.; Damas, J.; Nguyen, T.P.; Chleide, E.; Mercier, M.; Rogister, F.; Delarge, J. J. Med. Chem., 1993, 36, 2107.
45. Liégeois, J.-F.; Rogister, F.; Bruhwyler, J.; Damas, J.; Nguyen, T.P.; Inarejos, M.I.; Chleide, E.; Mercier, M.; Delarge, J. J. Med. Chem., 1994, 37, 519.
46. Liégeois. J.-F.; Delarge, J. U.S. Pat. 5.393.752 1995 and Eur. Pat. 0.607.129.B1 1995.
47. Bruhwyler, J.; Liégeois, J.-F.; Chleide, E.; Rogister, F.; Damas, J.; Delarge, J.; Mercier, M. Behav. Pharmacol., M. 1992, 3, 567.
48. Meitzer, H.Y.; Matsubara, S.; Lee, J.C. J. Pharm. Exp. Ther., 1989, 251, 238.
49. Darmani, N.A.; Martin, B.R.; Glennon, R.A. J. Pharmacol. Exp. Ther. 1992, 262, 692.
50. Darmani, N.A.; Mock, O.B.; Towns, L.C.; Gerdes, C.F. Pharmacol. Biochem. Behav. 1994, 48, 383.
51. De Vry, J.; Benz, U.; Schreiber, R.; Traber, J. Eur. J. Pharmacol. 1993, 249, 331.
52. Wiley, J.L.; Compton, A.D.; Porter, J.H. Pharmacol. Biochem. Behav. 1993, 45, 263.
53. Moore, N.A.; Rees, G.; Sanger, G.; Tye, N.C. Behav. Pharmacol. 1994, 5, 196
54. Meert, T.F. Drug Dev. Res. 1986, 8, 197.
55. Awouters, F.; Niemegeers, C.J.E.; Megens, A.A.H.P.; Meert, T.F.; Janssen P.A.J. Drug Dev. Res. 1988, 15, 61.
56. Stutzmann, J.M.; Eon, B.; Darche, F.; Lucas, M.; Rataud, J.; Piot, O.; Blanchard, J.C.; Laduron, P.M. Neurosci. Lett. 1991, 128, 4.
57. Bruhwyler, J.; Chleide, E. Biological psychiatry 1990, 27, 1264.
58. Bruhwyler, J.; Chleide, E.; Houbeau, G.; Waegeneer, N.; Mercier, M. Pharmacol. Biochem. Behav. 1993, 44, 181.
59. Bruhwyler, J.; Chleide, E.; Liégeois, J.-F.; Delarge, J.; Mercier, M. Pharmacol. Biochem. Behav. 1990, 36, 57.
60. Bruhwyler, J.; Liégeois, J.-F.; Lejeune, C.; Register, F.; Delarge, J.; Géczy, J. Behav. Pharmacol. 1995, 6, 830.
61. Bruhwyler, J.; Liégeois, J.-F.; Bergman, J.; Goudie, A.; Taylor, A.; Meltzer, H.Y.; Delarge, J.; Géczy, J. Pharmacol. Res. in press.
62. Carey, G.J.; Bergman, J. Psychopharmacology 1997, 132, 261.
63. Taylor, A.; Goudie, A.; Smith, J.A. Abstract presented at the British Pharmacology Society, Brighton, december 1996.
64. Fischer, V.; Haar, J.A.; Greiner, L.; Lloyd, R.V.; Mason, R.P. Mol Pharmacol. 1991, 40, 846.
65. Liégeois, J.-F.; Register, F.; Delarge, J.; Pincemail, J. Arch. der Pharm. 1995, 328, 109.
66. Liégeois, J.-F.; Mouithys-Mickalad, A.; Bruhwyler, J.; Delarge, J.; Petit, C.; Kauffmann, J.-M.; Lamy, M. Biochem. Biophys. Res. Com. 1997, 238, 252-255
67. Liégeois, J.-F.; Bruhwyler, J.; Damas, J.; Rogister, F.; Masereel, B.; Geczy, J.; Delarge, J. Eur. J. Pharmacol. 1995, 273, R1.
68. Nakazato, A.; Kumagai, T.; Nagamine, M.; Gotoh, M.; Chaki, S.; Yoshikawa, R.; Okuyama, S.; Yoshida, M.; Tomisawa, K. Abstracts book P-6.31. XIV International Symposium Med. Chem. Maastricht (NL) September 1996.
69. Doble, A.; Girdlestone, D.; Piot, O.; Allam, D.; Betschart, J.; Boireau, A.; Dupuy, A.; Guérémy, C.; Ménager, J.; Zundel, J.L.; Blanchard, J.-C. Br. J. Pharmacol. 1992, 105, 27.
70. Heuillet, E.; Petitet, F.; Mignani, S.; Malleron, J.-L.; Lavayre, J.; Néliat, G.; Doble, A.; Blanchard, J.-C. Eur. J. Pharmacol. 1996, 314, 229.
71. Seeman, P.; Corbett, R.; Van Tol, H.H.M. Neuropsychopharmacol. 1997, 16, 93.