Chromeno[3,4-c]pyridin-5-ones: Selective human dopamine D4 receptor antagonists as potential antipsychotic agents

Journal of Medicinal Chemistry

Volumn 40, Issue 17, 1997, Pages 2688-2693

  Unangst, Paul C ^a   Capiris, Thomas ^a   Connor, David T ^a   Heffner, Thomas G ^a   MacKenzie, Robert G ^a   Miller, Steven R ^a   Pugsley, Thomas A ^a   Wise, Lawrence D ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 BENZYL 8 METHYL 1,2,3,4 TETRAHYDROCHROMENO[3,4 C]PYRIDIN 5 ONE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; NEUROLEPTIC AGENT; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CORPUS STRIATUM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIPPOCAMPUS; HUMAN; NONHUMAN; PSYCHOSIS; RECEPTOR AFFINITY; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; HUMANS; KINETICS; LEVODOPA; MODELS, CHEMICAL; PIPERAZINES; PYRIDINES; PYRIDONES; PYRROLES; RATS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0030859157     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970170v     Document Type: Article

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