Genomic structure of the human pre-T cell receptor α chain and expression of two mRNA isoforms

European Journal of Immunology

Volumn 28, Issue 11, 1998, Pages 3824-3831

  Saint Ruf, Claude ^a   Lechner, Oskar ^a   Feinberg, Jacqueline ^a   Von Boehmer, Harald ^a  

^a INSERM   (France)

Author keywords

Gene expression; Genomic structure; mRNA isoform; pT ; T cell development

Indexed keywords

CYSTEINE; HLA ANTIGEN; MEMBRANE PROTEIN; MESSENGER RNA; T LYMPHOCYTE RECEPTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; CHROMOSOME 6P; CONTROLLED STUDY; CYTOPLASM; DIMERIZATION; EXON; GENE EXPRESSION; GENE LOCATION; GENE SEQUENCE; GENE STRUCTURE; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYMOCYTE;

HUMANS; PRECIPITIN TESTS; PROTEIN PRECURSORS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RNA SPLICING; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0031739791     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199811)28:11<3824::AID-IMMU3824>3.0.CO;2-9     Document Type: Article

References (25)

1. Groettrup, M., Ungewiss, K., Azogui, O., Palacios, R., Owen, M. J., Hayday, A. C. and von Boehmer, H., A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein. Cell 1993. 75: 283-294.
2. von Boehmer, H. and Fehling, H. J., Structure and function of the pre-T cell receptor. Annu. Rev. Immunol. 1997. 15: 433-452.
3. Aifantis, I., Buer, J., von Boehmer, H. and Azogui, O., Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus. Immunity 1997. 7: 601-607.
4. Saint-Ruf, C., Ungewiss, K., Groettrup, M., Bruno, L., Fehling, H. J. and von Boehmer, H., Analysis and expression of a cloned pre-T-cell receptor gene. Science 1994. 266: 1208-1212.
5. Del Porto, P., Bruno, L., Mattei, M. G., von Boehmer, H. and Saint-Ruf, C., Cloning and comparative analysis of the human pre-T-cell receptor alpha chain gene. Proc. Natl. Acad. Sci. USA 1995. 19: 121058-12109.
6. Fehling, H. J., Laplace, C., Mattei, M. G., Saint-Ruf, C. and von Boehmer, H., Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene, Immunogenetics 1995. 42: 275-281.
7. Nizetic, D., Monard, S., Young, B., Cotter, F., Zehetner, G. and Lehrach, H., Construction of cosmid libraries from flow-sorted human chromosomes 1, 6, 7, 11, 13, and 18 for reference library resources. Mamm. Genome 1994. 5: 801-802.
8. Shortle, V. P., Malaspina, P., Fox, M., Dooley, J. S., Volz, A., Ziegler, A., Trowsdale, J., Morrison, K. M. and Edwards, Y. H., A cosmid library specific for human chromosome regions 6p21.3 and 6q27. Mamm. Genome 1993. 4: 493-498.
9. Cosson, P., Lankford, S. P., Bonifacino, J. S. and Klausner, R. D., Membrane protein association by potential intramembrane charge pairs. Nature 1991. 351: 414-416.
10. Leiden, J. M. and Thompson, C. B., Transcriptional regulation of T-cell genes during T-cell development. Curr. Opin. Immunol. 1994. 6: 231-237.
11. Peterson, C. L. and Calame, K., Proteins binding to site C2 (muE3) in the immunoglobulin heavy-chain enhancer exist in multiple oligomeric forms. Mol. Cell Biol. 1989. 9: 776-786.
12. McDougall, S., Peterson, C. L. and Calame, K., A transcriptional enhancer 3′ of C beta 2 in the T cell receptor beta locus. Science 1988. 24: 205-208.
13. Georgiev, G. P., Mobile genetic elements in animal cells and their biological significance. Eur J. Biochem. 1984. 145: 203-220.
14. Berger, M. A., Dave, V., Rhodes, M. R., Bosma, G. C., Bosma, M. J., Kappes, D. J. and Wiest, D. L., Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3δ is physically associated but not functionally required. J. Exp. Med. 1997. 186: 1461-1467.
15. Hounsell, E. F., Davies, M. J. and Renouf, D. V., O-linked glycosylation structure and function. Glycoconj. J. 1996. 13: 19-26.
16. Bruno, L., Rocha, B., Rolink, A., von Boehmer, H. and Rodewald, H. R., Intra- and extrathymic expression of pre-T cell receptor a gene. Eur. J. Immunol. 1995. 25: 1877-1882.
17. Barber, D. F., Passoni, L., Wen, L., Geng, L. and Hayday, A. C., Cutting edge: The expression in vivo of a second isoform of pTα: implications for the mechanism of pTα action. J. Immunol. 1998. 161: 11-16.
18. Groettrup, M., Baron, A., Griffiths, G., Palacios, R. and von Boehmer, H., T cell receptor (TCR) βchain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines. EMBO J. 1992. 11: 2735-2746.
19. Irving, B. A., Alt, R W. and Killeen, N., Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science 1998. 280: 905-908.
20. Minowada, J., Ohnuma, T. and Moore, G. E., Rosetteforming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes. J. Natl. Cancer Inst. 1972. 49: 891-895.
21. Fitzgerald, T. J., Neale, G. A., Raimondi, S. C. and Goohra, R. M., Rhom-2 expression not always correlates with abnormalities on chromosome 11 at band p13 in T cell acute lymphoblastic leukemia. Blood 1992. 80: 3189-3197.
22. Sambrook, J., Fritsch, E. F. and Maniatis, T. (Eds.), Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor 1989.
23. Birnboim, H. C. and Doly, J., A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res. 1979. 7: 1513-1523.
24. Groettrup, M. and von Boehmer, H., A role for a pre-T-cell receptor in T-cell development, Immunol. Today 1993. 14: 610-614.
25. Ungewiss, K., Cloning and expression of a pre-T cell receptor gene. PhD thesis, Univ. Basel, Switzerland 1996.