Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes

Immunity

Volumn 7, Issue 5, 1997, Pages 591-599

  O'Shea, Clodagh C ^a   Thornell, Anders P ^a   Rosewell, Ian R ^a   Hayes, Brian ^b   Owen, Michael J ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GLYCOPROTEIN; T LYMPHOCYTE RECEPTOR;

ALLELE; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0031433457     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80380-5     Document Type: Article

References (55)

1. Alarcon, B., Berkhout, B., Breitmeyer, J., and Terhorst, C. (1988). Assembly of the human T cell receptor-CD3 complex takes place in the endoplasmic reticulum and involves intermediary complexes between the CD3-gamma.delta.epsilon core and single T cell receptor alpha or beta chains. J. Biol. Chem. 263, 2953-2961.
2. Bejcek, B.E., Li, D.Y., and Deuel, T.F. (1989). Transformation by V-sis occurs by an internal autoactivation mechanism. Science 245, 1496-1499.
3. Boismenu, R., Rhein, M., Fischer, W.H., and Havran, W.L. (1996). A role for CD81 in early T cell development. Science 271, 198-200.
4. Borst, J., Jacobs, H., and Brouns, G. (1996). Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes. Curr. Opin. Immunol. 8, 181-190.
5. Brouns, G.S., de Vries, E., Neefjes, J.J., and Borst, J. (1996). Assembled pre-B cell receptor complexes are retained in the endoplasmic reticulum by a mechanism that is not selective for the pseudo-light chain. J. Biol. Chem. 271, 19272-19278.
6. Chaffin, K.E., Beals, C.R., Wilkie, T.M., Forbush, K.A., Simon, M.I., and Perlmutter, R.M. (1990). Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. EMBO J. 9, 3821-3829.
7. Dudley, E.C., Petrie, H.T., Shah, L.M., Owen, M.J., and Hayday, A.C. (1994). T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1, 83-93.
8. Fehling, H-J., Krotkova, A., Saint-Ruf, C., and von Boehmer, H. (1995). Crucial role of the pre-T-cell receptor a gene in development of αβ but not γδ T cells. Nature 375, 795-798.
9. - thymocyte differentiation. J. Immunol. 152, 4783-4792.
10. Groettrup, M., Ungewiss, K., Azogui, O., Palacios, R., Owen, M.J., Hayday, A.C., and von Boehmer, H. (1993). A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kDa glycoprotein. Cell 75, 283-294.
11. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
12. Hagman, J., Lo, D., Doglio, L.T., Hackett, J., Jr., Rudin, C.M., Haasch, D., Brinster, R., and Storb, U. (1989). Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene. J. Exp. Med. 169, 1911-1929.
13. Hall, C., Berkhout, B., Alarcon, B., Sancho, J., Wileman, T., and Terhorst, C. (1991). Requirements for cell surface expression of the human TCR/CD3 complex in non-T cells. Int. Immunol. 3, 359-368.
14. Huang, S.S., and Huang, J.S. (1988). Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by Suramin. J. Biol. Chem. 263, 12608-12618.
15. Jacobs, H., Vandeputte, D., Tolkamp, L., de Vries, E., Borst, J., and Berns, A. (1994). CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Eur. J. Immunol. 24, 934-939.
16. Jacobs, H., Iacomini, J., van de Ven, M., Tonegawa, S., and Berns, A. (1996). Domains of the TCRβ-chain required for early thymocyte development. J. Exp. Med. 184, 1833-1843.
17. Kearse, K.P., Roberts, J.L., Munitz, T.I., Wiest, D.L., Nakayama, T. and Singer, A. (1994). Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells. EMBO J. 13, 4504-4514.
18. Kisielow, P., and von Boehmer, H. (1995). Development and selection of T cells: facts and puzzles. Adv. Immunol. 58, 87-209.
19. Kitamura, D., Kudo, A., Schaal, S., Muller, W., Melchers, F., and Rajewsky, K. (1992). A critical role of λ5 protein in B cell development. Cell 69, 823-831.
20. Krimpenfort, P., Ossendorp, F., Borst, J., Melief, C., and Berns, A. (1989). T cell depletion in transgenic mice carrying a mutant gene for TCR-beta. Nature 341, 742-746.
21. Lassoued, K., Nuñez, C.A., Billips, L., Kubagawa, H., Monteiro, R.C., LeBien, T.W., and Cooper, M.D. (1993). Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation. Cell 73, 73-86.
22. Lee, B.A., and Donoghue, D.J. (1992). Regular retention of membrane-anchored v-sis abrogates autocrine signal transduction. J. Cell Biol. 118, 1057-1070.
23. Letourneur, F., Gaynor, E.C., Hennecke, S., Demolliere, C., Duden, R., Emr, S.D., Riezman, H., and Cosson, P. (1994). Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell 79, 1199-1207.
24. Levelt, C.N., Mombaerts, P., Iglesias, A., Tonegawa, S., and Eichmann, K. (1993). Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon. Proc. Natl. Acad. Sci. USA 90, 11401-11405.
25. Liu, C.P., Ueda, R., She, J., Sancho, J., Wang, B., Weddell, G., Loring, J., Kurahara, C., Dudley, E.C., Hayday, A., et al. (1993). Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine. EMBO J. 12, 4863-4875.
26. Love, P.E., Shores, E.W., Johnson, M.D., Tremblay, M.L., Lee, E.J., Grinberg, A., Huang, S.P., Singer, A., and Westphal, H. (1993). T cell development in mice that lack the zeta chain of the T cell antigen receptor complex. Science 261, 918-921.
27. Maguire, J.E., McCarthy, S.A., Singer, A., and Singer, D.S. (1990). Inverse correlation between steady-state RNA and cell surface T cell receptor levels. FASEB J. 4, 3131-3134.
28. Malissen, M.J., Trucy, E., Jourvin-Marche, P.A., Cazenave, R., Sollay, B., and Malissen, B. (1992). Regulation of TCR alpha and beta gene allelic exclusion during T-cell development. Immunol. Today 13, 315-322.
29. Malissen, M., Gillet, A., Rocha, B., Trucy, J., Vivier, E., Boyer, C., Kontgen, F., Brun, N., Mazza, G., Spanopoulou, E., et al. (1993). T cell development in mice lacking the CD3-zeta/eta gene. EMBO J. 12, 4347-4355.
30. Malissen, M., Gillet, A., Ardouin, L., Bouvier, G., Trucy, J., Ferrier, P., Vivier, E., and Malissen, B. (1995). Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene. EMBO J. 14, 4641-4653.
31. Mallick, C.A., Dudley, E.C., Viney, J.L., Owen, M.J., and Hayday, A.C. (1993). Rearrangement and diversity of T cell receptor β chain genes in thymocytes: a critical role for the β chain in development. Cell 73, 513-519.
32. Manolios, N., Letourneur, F., Bonifacino, J.S., and Klausner, R.D. (1991). Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor. EMBO J. 10, 1643-1651.
33. Mason, W.T., Hoyland, J., Davison, I., Carew, M.A., Somasundaram, B., Tregear, R., Zorec, R., Lledo, P.M., Shankar, G., and Horton, M. (1993). Quantitative real-time imaging of optical probes in living cells. In Fluorescent and Luminescent Probes for Biological Activity, W.T. Mason, ed. (London: Academic Press), pp. 161-195.
34. Molina, T.J., Kishihara, K., Siderovski, D.P., van Ewijk, W., Narendran, A., Timms, E., Wakeham, A., Paige, C.J., Hartmann, K.U., Veillette, A., et al. (1992). Profound block in thymocyte development in mice lacking p56lck. Nature 357, 161-164.
35. Mombaerts, P., Clarke, A.R., Rudnicki, M.A., Iacomini, J., Itohara, S., Lafaille, J.J., Wang, L., Ichikawa, Y., Jaenisch, R., Hooper, M.L., et al. (1992a). Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature 360, 225-231. (Erratum, 360, 491).
36. Mombaerts, P., Iacomini, J., Johnson, R.S., Herrup, K., Tonegawa, S., and Papaioannou, V.E. (1992b). RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877.
37. Nilsson, T., Jackson, M., and Peterson, P.A. (1989). Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum. Cell 58, 707-718.
38. Ohno, H., Aoe, T., Taki, S., Kitamura, D., Ishida, Y., Rajewsky, K., and Saito, T. (1993). Developmental and functional impairment of T cells in mice lacking CD3 zeta chains. EMBO J. 12, 4357-4366.
39. Pääbo, S., Weber, F., Nilsson, T., Schaffner, W., and Peterson, P.A. (1986). Structural and functional dissection of an MHC class I antigen-binding adenovirus glycoprotein. EMBO J. 5, 1921-1927.
40. Pearse, M., Wu, L., Egerton, M., Wilson, A., Shortman, K., and Scollay, R. (1989). A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor. Proc. Natl. Acad. Sci. USA 86, 1614-1618.
41. Robey, E., and Fowlkes, B.J. (1994). Selective events in T cell development. Annu. Rev. Immunol. 12, 675-705.
42. Rutledge, T., Cosson, P., Manolios, N., Bonifacino, J.S., and Klausner, R.D. (1992). Transmembrane helical interactions: zeta chain dimerization and functional association with the T cell antigen receptor. EMBO J. 11, 3245-3254.
43. Saint-Ruf, C., Ungewiss, K., Groettrup, M., Bruno, L., Fehling, H.J. and von Boehmer, H. (1994). Analysis and expression of a cloned pre-T cell receptor gene. Science 266, 1208-1212.
44. Shinkai, Y., Rathbun, G., Lam, K.P., Oltz, E.M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A.M., et al. (1992). RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855-867.
45. Sparkowski, J., Anders, J., and Schlegel, R. (1995). E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cells. EMBO J. 14, 3055-3063.
46. Terhorst, C., Simpson, S., Wang, B., She, J., Hall, C., Huang, M., Wileman, T., Eichmann, K., Holländer, G., Lavalt, C., et al. (1995). Plasticity of the TCR-CD3 complex. In T Cell Receptors, J.I. Bell, M.J. Owen, and E. Simpson, eds. (London: Oxford University Press), pp. 369-402.
47. Viney, J.L., Prosser, H.M., Hewitt, C.R., Lamb, J.R., and Owen, M.J. (1992). Generation of monoclonal antibodies against a human T cell receptor beta chain expressed in transgenic mice. Hybridoma 11, 701-713.
48. Viney, J.L., Prosser, H.M., Palmer, D.B., Lipoldova, M., Lamb, J.R. and Owen, M.J. (1993). Analysis of T cell repertoire and function in mice transgenic for the human V beta 3 TCR. Int. Immunol. 5, 1541-1549.
49. von Boehmer, H. (1995). Control of T-cell development by the pre-T and alpha beta T-cell receptor. Ann. N.Y. Acad. Sci. 766, 52-61.
50. Wallace, V.A., Kawai, K., Levelt, C.N., Kishihara, K., Molina, T., Timms, E., Pircher, H., Penninger, J., Ohashi, P.S., Eichmann, K. and Mak, T.W. (1995). T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes. Eur. J. Immunol. 25, 1312-1318.
51. Weiss, A., and Littman, D.R. (1994). Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274.
52. Wiest, D.L., Kearse, K.P., Shores, E.W., and Singer, A. (1994). Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes. J. Exp. Med. 180, 1375-1382.
53. Wilson, A., and MacDonald, H.R. (1995). Expression of genes encoding the pre-TCR and CD3 complex during thymus development. Int. Immunol. 7, 1659-1664.
54. Winkler, T.H., Rolink, A., Melchers, F., and Karasuyama, H. (1995). Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface. Eur. J. Immunol. 25, 446-450.
55. Xu, Y., Davidson, L., Alt., F.W., and Baltimore, D. (1996). Function of the pre-T-cell receptor a chain in T-cell development and allelic exclusion at the T-cell receptor β locus. Proc. Natl. Acad. Sci. USA, 93, 2169-2173.