Current perspectives on synovitis

Arthritis Research

Volumn 1, Issue 1, 1999, Pages 11-16

  Tak, Paul P ^a   Breedveld, Ferdinand C ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD68 ANTIGEN; CELL ADHESION MOLECULE; CYTOKINE; DECAY ACCELERATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ARTHROSCOPY; CELL AGGREGATION; CELL INFILTRATION; COMPUTER ANALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; HISTOPATHOLOGY; HUMAN; IMAGE ANALYSIS; INFLAMMATION; INFLAMMATORY CELL; INTERMETHOD COMPARISON; JOINT DESTRUCTION; LYMPHOCYTE; MACROPHAGE; METHODOLOGY; NEEDLE BIOPSY; NOTE; PATHOGENESIS; RHEUMATOID ARTHRITIS; SAMPLING; SYNOVITIS;

ARTHRITIS, RHEUMATOID; HUMANS; SYNOVIAL MEMBRANE; SYNOVITIS;

EID: 0033281719     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar4     Document Type: Note

References (104)

1. Examination of the synovium and synovial fluid
2. The role of synovial biopsy
3. Needle arthroscopy
4. Quantitative microscopic analysis of inflammation in rheumatoid arthritis synovial membrane samples selected at arthroscopy compared with samples obtained blindly by needle biopsy
5. Discovery and analysis of inflammatory disease-related genes using cDNA microarrays
6. Intraarticular variation in synovitis. Local macroscopic and microscopic signs of inflammatory activity are significantly correlated
7. Diagnostic arthroscopy
8. Analysis of the histologic variation of synovitis in rheumatoid arthritis
9. Microscopic measurement of synovial membrane inflammation in rheumatoid arthritis: Proposals for the evaluation of tissue samples by quantitative analysis
10. Distribution of T cells and signs of T-cell activation in the rheumatoid joint: Implications for semiquantitative comparative histology
11. Microscopic measurement of cellular infiltration in the rheumatoid arthritis synovial membrane: A comparison of semiquantitative and quantitative analysis
12. Variability in cytokine and cell adhesion molecule staining in arthroscopic synovial biopsies: Quantification using color video image analysis
13. Digital image analysis for the quantification of the cell infiltrate in synovial tissue
14. Analysis of the synovial cellular infiltrate in early rheumatoid synovial tissue in relation to local disease activity
15. Asymptomatic synovitis precedes clinically manifest arthritis
16. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis
17. Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis
18. Synovitis of recent onset. A clinicopathologic study during the first month of disease
19. Cellular immunohistopathology of acute, subacute, and chronic synovitis in rheumatoid arthritis
20. Early synovitis-synoviocytes and mononuclear cells
21. Expression of adhesion molecules in early rheumatoid synovial tissue
22. Poor expression of T cell-derived cytokines and activation and proliferation markers in early rheumatoid synovial tissue
23. Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and reactive arthritis
24. Synovial cytokine and growth factor regulation of MMPs/TIMPs: Implications for erosions and angiogenesis in early rheumatoid and psoriatic arthritis patients
25. Joint erosions and patients with early rheumatoid arthritis
26. Immunohistologic analysis of synovial tissue for differential diagnosis in early arthritis
27. Analysis of serial synovial biopsies as a screening method for predicting the effects of therapeutic interventions
28. Analysis of cell populations in rheumatoid arthritis synovial tissues
29. Human synovial mast cells. 1. Ultrastructural in situ and in vitro immunologic characterization
30. Granzyme positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue
31. Heterogeneity of rheumatoid arthritis: From phenotypes to genotypes
32. Pannocytes: Distinctive cells found in rheumatoid arthritis articular cartilage erosions
33. Characterisation of fibroblast-like cells in pannus lesions of patients with rheumatoid arthritis sharing properties of fibroblasts and chondrocytes
34. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis
35. The importance of the T cell in initiating and mainaining the chronic synovitis of rheumatoid arthritis
36. The role of T cells in the immunopathogenesis of rheumatoid arthritis. New perspectives
37. How important are T cells in chronic rheumatoid synovitis
38. Immunohistochemical analysis of synovial membranes from inflammatory and non-inflammatory arthritides: Scarcity of CD5 positive B cells and IL2 receptor bearing T cells
39. Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in synovitis
40. Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis
41. Decreased expression of signal-transducing CD3 zeta chains in T cells from the joints and peripheral blood of rheumatoid arthritis patients
42. An immunohistological analysis of lymphocyte subpopulations and their microenvironment in the synovial membranes of patients with rheumatoid arthritis using monoclonal antibodies
43. Rheumatoid arthritis: A disease of T-lymphocyte/macrophage immunoregulation
44. Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis
45. Immunohistochemical analysis of proliferating and antigen-presenting cells in rheumatoid synovial tissue
46. Differential expression of the costimulatory molecules B7.1 (CD80) and B7.2 (CD86) in rheumatoid synovial tissue
47. Functional differentiation of dendritic cells in rheumatoid arthritis: Role of CD86 in the synovium
48. Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis?
49. Presentation of self peptides by dendritic cells: Possible implications for the pathogenesis of rheumatoid arthritis
50. Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis
51. The presence of bacterial DNA and bacterial peptidoglycans in the joints of patients with rheumatoid arthritis and other arthritides
52. Direct evidence for the expression of multiple endogenous retroviruses in the synovial compartment in rheumatoid arthritis
53. Detection of bacterial DNA in joint samples from patients with undifferentiated arthritis and reactive arthritis, using polymerase chain reaction with universal 16S ribosomal RNA primers
54. The detection of DNA from a range of bacterial species in the joints of patients with a variety of arthritides using a nested, broad-range polymerase chain reaction
55. Fibroblast-like synoviocytes from rheumatoid arthritis patients have intrinsic properties of follicular dendritic cells
56. The identification of germinal centres and follicular dendritic cell networks in rheumatoid synovial tissue
57. Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis?
58. Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed agressors?
59. Role of endothelium in chronic inflammation
60. Rheumatoid arthritis: The multiple pathways to chronic synovitis
61. Proteinases in rheumatoid arthritis
62. Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis
63. Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids
64. Proliferative activity of cells in the synovium as demonstrated by a monoclonal antibody, Ki67
65. Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia: Results of proliferation cell nuclear antigen/cyclin, C-myc, and nucleolar organizer region staining
66. Apoptosis in rheumatoid arthritis
67. Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes
68. Ultrastructural demonstration of apoptosis, Fas and Bcl-2 expression of rheumatoid synovial fibroblasts
69. Apoptosis in rheumatoid arthritis synovium
70. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium
71. Mutations of the p53 tumour suppressor gene in erosive rheumatoid synovial tissue
72. Rheumatoid arthritis and p53: How oxidative stress might alter the course of inflammatory diseases
73. Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis
74. Invasive synovial fibroblasts express the novel anti-apoptotic molecule sentrin in the SCID mouse model of rheumatoid arthritis
75. NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint
76. Nuclear factor-kappa B in rheumatoid synovium: Localization of p50 and p65
77. Activation of the transcription factor nuclear factor-kappa B in human inflamed synovial tissue
78. Demonstration of granzyme A and perforin messenger RNA in the synovium of patients with rheumatoid arthritis
79. The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)
80. The prevalence and distribution of macrophages bearing Fc gamma R I, Fc gamma R II, and Fc gamma R-III in synovium
81. Synovial lining cell hyperplasia in rheumatoid arthritis: Dogma and fact
82. Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue
83. Distribution of macrophages in rheumatoid synovial membrane and its association with basic activity
84. Increased expression of p150,95 and CR3 leukocyte adhesion molecules by mononuclear phagocytes in rheumatoid synovial membranes. Comparison with osteoarthritic and normal synovial membranes
85. Expression of ICAM-R (ICAM-3), a novel counter-receptor for LFA-1, in rheumatoid and nonrheumatoid synovium: Comparison with other adhesion molecules
86. An immunohistochemical and immunoelectron microscopic study of adhesion molecules in synovial pannus formation in rheumatoid arthritis
87. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis
88. Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: Implications for the role of cytokines in cartilage destruction and repair
89. Macrophage inflammatory protein-1 alpha: A novel chemotactic cytokine for macrophages in rheumatoid arthritis
90. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis
91. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
92. Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha treatment in patients with rheumatoid arthritis
93. Treatment of rheumatoid arthritis with IL-1 inhibitors
94. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
95. Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody
96. Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor alpha, but not interleukin-10: Possible relevance to pathophysiology of rheumatoid arthritis
97. Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis
98. Interleukin-12 is expressed by infiltrating macrophages and synovial lining cells in rheumatoid arthritis and osteoarthritis
99. IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family
100. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
101. Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared to patients with Yersinia-induced arthritis and osteoarthritis
102. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor alpha production in rheumatoid arthritis
103. Direct contact with stimulated T cells induces the expression of IL-1 beta and IL-1 receptor antagonist in human monocytes. Involvement of serine/threonine phosphatases in differential regulation
104. Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes: Involvement of membrane-associated cytokines