Distribution of T cells and signs of T-cell activation in the rheumatoid joint: Implications for semiquantitative comparative histology

British Journal of Rheumatology

Volumn 37, Issue 3, 1998, Pages 324-330

  Dolhain, R J E M ^a   Ter Haar, N T ^a   De Kuiper, R ^a   Nieuwenhuis, I G ^a   Zwinderman, A H ^a   Breedveld, F C ^a   Miltenburg, A M M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Analysis of variance; Immunohistochemistry; Rheumatoid arthritis; T cells

Indexed keywords

CD3 ANTIGEN; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR; KI 67 ANTIGEN;

ARTICLE; CASE REPORT; CELLULAR DISTRIBUTION; HISTOLOGY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0031875864     PISSN: 02637103     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/37.3.324     Document Type: Article

References (24)

1. FitzGerald O, Bresnihan B. Synovial membrane cellularity and vascularity. Ann Rheum Dis 1995;54:511-5.
2. Panayi GS, Lanchbury JS, Kingsley GH. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum 1992;35:729-35.
3. El-Gabalawy HS, Keillor J. Immunohistologic study of T-cell receptor δ-chain expression in rheumatoid synovial membranes. Semin Arthritis Rheum 1992;21:239-45.
4. Lalor PA, Mapp PI, Hall PA, Revell PA. Proliferative activity of cells in the synovium as demonstrated by a monoclonal antibody, Ki67. Rheumatol Int 1987;7: 183-6.
5. Itoh J, Kinjoh K, Ohyama A, Nose M, Kyogoku M. Application of two-color immunofluorescence staining to demonstration of T-cells and HLA-DR-bearing cells in rheumatoid synovitis. J Histochem Cytochem 1992;40:1675-83.
6. Smith DM, O'Donnell J, Palmer DG, Rozenbilds M, Roberts-Thomson PJ. Immunohistochemical analysis of synovial membranes from inflammatory and non-inflammatory arthritides: scarcity of CD5 positive B cells and IL-2 receptor bearing T cells. Pathology 1992;24: 19-26.
7. Kobayashi I, Ziff M. Electron microscopic studies of lymphoid cells in the rheumatoid synovial membrane. Arthritis Rheum 1973;16:471-86.
8. 3H-thymidine incorporating cells in rheumatoid arthritis synovial membrane. Rheumatol Int 1986;6:269-71.
9. Husby G, Williams RC. Immunohistochemical studies of interleukin-2 and gamma-interferon in rheumatoid arthritis. Arthritis Rheum 1985;28:174-81.
10. Warren CJ, Howell WM, Bhambhani M, Cawley MID, Smith JL. An investigation of T-cell subset phenotype and function in the rheumatoid synovium using in situ hybridization for IL-2 mRNA. Immunology 1991; 72:250-5.
11. Yanni G, Whelan A, Feighery C et al. Contrasting levels of in vitro cytokine production by rheumatoid synovial tissues demonstrating different patterns of mononuclear cell infiltration. Clin Exp Immunol 1993;93:387-95.
12. Dolhain RJEM, Ter Haar NT, Hoefakker S et al. Increased expression of Interferon (IFN)-gamma together with IFN-gamma receptor in the rheumatoid synovial membrane compared with synovium of patients with osteoarthritis. Br J Rheumatol 1996;35:24-32.
13. Hoefakker S, Boersma WJA, Claassen E. Detection of human cytokines in situ using antibody and probe based methods. J Immunol Methods 1995;185:149-75.
14. k cross-reacting with human DR molecule. I. Cross-inhibition studies of mAb cell surface fixation and differential binding of mAb to detergent-solubilized HLA molecules immobilized to a solid phase by a first mAb. Eur J Immunol 1983;13:106-11.
15. Tak PP, Kummer JA, Hack CE et al. Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue. Arthritis Rheum 1994;37:1735-43.
16. Tak PP, Lindblad S, Klareskog L, Breedveld FC. Synovial biopsies for analysis of the synovial membrane: new perspectives. Newsl Eur Rheumatol Res 1994:27-9.
17. Tak PP, van der Lubbe PA, Cauli A et al. Reduction of synovial inflammation after anti-CD4 monoclonal antibody treatment in early rheumatoid arthritis. Arthritis Rheum 1995;38:1457-65.
18. Balsa A, Gamallo C, Martin-Mola E, Gijon-Banos J. Histologic changes in rheumatoid synovitis induced by naproxen and methotrexate. J Rheumatol 1993; 20:1472-7.
19. Ruderman EM, Weinblatt ME, Thurmond LM, Pinkus GS, Gravallese EM. Synovial tissue response to treatment with Campath-1H. Arthritis Rheum 1995;38:254-8.
20. Lindblad S, Hedfors E. Intraarticular variation in synovitis. Local macroscopic and microscopic signs of inflammatory activity are significantly correlated. Arthritis Rheum 1985;28:977-86.
21. Rooney M, Condell D, Quinlan W et al. Analysis of the histologic variation of synovitis in rheumatoid arthritis. Arthritis Rheum 1988;31:956-63.
22. Cruickshank B. Interpretation of multiple biopsies of synovial tissue in rheumatic diseases. Ann Rheum Dis 1952;11:137-45.
23. Hutton CW, Hinton C, Dieppe PA. Intra-articular variation of synovial changes in knee arthritis: biopsy study comparing changes in patellofemoral synovium and the medial tibiofemoral synovium. Br J Rheumatol 1987; 26:5-8.
24. Kennedy TD, Plater-Zyberk C, Partridge TA, Woodrow DF, Maini RN. Representative sample of rheumatoid synovium: a morphometric study. J Clin Pathol 1988; 41:841-6.