Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases

Cancer Surveys

Volumn 27, Issue , 1996, Pages 311-322

  Hotchin, Neil A ^a,b   Hall, Alan ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GUANOSINE TRIPHOSPHATASE; INTEGRIN;

CARCINOGENESIS; CELL ADHESION; CELL GROWTH; CYTOSKELETON; GROWTH REGULATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; CELL ADHESION; CELL DIVISION; CYTOSKELETON; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HUMANS; INTEGRINS; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 0029855239     PISSN: 02612429     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (73)

1. Adams AEM, Johnson DI, Longnecker RM, Sloat BF and Pringle JR (1990) CDC42 and CDC43, two additional genes involved in budding and establishment of cell polarity in the yeast Saccharomyces cerevisiae. Journal of Cell Biology 111 131-142
2. Adams JC and Watt FM (1993) Regulation of development and differentiation by the extracellular matrix. Development 117 1183-1198
3. Avraham H and Weinberg RA (1989) Characterization and expression of the human rhoH12 gene product. Molecular and Cell Biology 9 2058-2066
4. Bokoch GM, Bohl BP and Chuang TH (1994) Cuanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins. Journal of Biological Chemistry 269 31674-31679
5. Burridge K, Fath K, Kellt T, Nuckolls G and Turner C (1988) Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annual Review of Cell Biology 4 487-523
6. Chant J and Stowers L (1995) GTPase cascades choreographing cellular behaviour: movement, morphogenesis and more. Cell 81 1-4
7. Chen QM, Kinch MS, Lin TH, Burridge K and Juliano RL (1994) Integrin-mediated cell adhesion activates mitogen-activated protein kinases. Journal of Biological Chemistry 269 26602-26605
8. Chong LD, Traynor-Kaplan A, Bokoch GM and Schwartz MA (1994) The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 79 507-513
9. Clark EA and Brugge JS (1995) Integrins and signal transduction pathways: the road taken. Science 268 233-239
10. Coso OA, Chiarello M, Yu Y-C et al (1995) The small GTP-binding proteins Racl and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81 1137-1146
11. Diekmann D, Abo A, Johnston C, Segal AW and Hall A (1994) Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity. Science 265 531-533
12. Eaton S, Auvinen P, Luo L, Jan YN and Simons K (1995) CDC42 and Racl control different actin-dependent processes in the Drosophila wing disc epithelium. Journal of Cell Biology 131 151-164
13. Eva A and Aaronson SA (1985) Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature 316 273-275
14. Feig LA (1994) Guanine-nucleotide exchange factors - a family of positive regulators of ras and related GTPases. Current Opinion in Cell Biology 79 1157-1164
15. Folkman J and Moscona A (1978) Role of cell shape in growth control. Nature 273 345-349
16. Fukami K, Furuhashi K, Inagaki M, Endo T, Hatano S and Takenawa T (1992) Requirement of phosphatidyl 4,5 bisphosphate for α-actinin function. Nature 359 150-152
17. Guadagno TM and Assoian RK (1991) G1/S control of anchorage-independent growth in the fibroblast cell cycle. Journal of Cell Biology 115 1419-1425
18. Guadagno TM, Ohtsubo M, Roberts JM and Assoian RK (1993) A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262 1572-1575
19. Guan J-L, Trevithick JE and Hynes RO (1991) Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120kDa protein. Cell Regulation 2 951-964
20. Habets GG, Scholtes EH, Zuydgeest D et al (1994) Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell 77 537-549
21. Hall A (1994) Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annual Review of Cell Biology 10 31-54
22. Hansen LK, Mooney DJ, Vacanti JP and Ingber DE (1994) Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth. Molecular Biology of the Cell 5 967-975
23. Harden N, Loh HY, Chia W and Lim L (1995) A dominant inhibitory version of the small GTP-binding protein rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila. Development 121 903-914
24. Hart MJ, Eva A, Zangrilla D et al (1994) Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. Journal of Biological Chemistry 269 62-65
25. Hartwig JH, Bokoch GM, Carpenter CL et al (1995) Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilised human platelets. Cell 82 643-653
26. Hill CS, Wynne J and Treisman R (1995) The rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81 1159-1170
27. Hotchin NA and Hall A (1995) The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular Rho/Rac GTPases. Journal of Cell Biology 131 1857-1865
28. Hynes RO (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69 11-25
29. Jalink K, Vancorven EJ, Hengeveld T, Morii N, Narumiya S and Moolenaar WH (1994) Inhibition of lysophosphatidate- and thrombin-induced neunte retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. Journal of Cell Biology 126 801-810
30. Khosravi-Far R, Chrzanowska-Wodnicka M, Solski PA, Eva A, Burridge K and Der CJ (1994) Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras. Molecular and Cell Biology 14 6848-6857
31. Kornberg LJ, Earp HS, Turner CE, Prockop C and Juliano RL (1991) Signal transduction by integrins: increased protein tyrosine phosphorylation caused by integrin clustering. Proceedings of the National Academy of Sciences of the USA 88 8392-8396
32. Kozma R, Ahmed S, Best A and Lim L (1995) The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Molecular and Cell Biology 15 1942-1952
33. Lamarche N and Hall A (1994) GAPs for rho-related GTPases. Trends in Genetics 10 436-440
34. Lang P, Guizani L, Vitte-Mony I et al (1992) ADP ribosylation of the ras-related GTP-binding protein RhoA inhibits lymphocyte mediated cytotoxicity. Journal of Biological Chemistry 267 11677-11680
35. Li R, Zheng Y and Drubin DG (1995) Regulation of cortical actin cytoskelton assembly during polarized cell growth in budding yeast. Journal of Cell Biology 128 599-615
36. Luo L, Liao YJ, Lan LY and Jan YN (1994) Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes and Development 8 1787-1802
37. Machesky LM and Pollard TD (1993) Profilin as a potential mediator of membrane-cytoskeleton communication. Trends in Cell Biology 3 381-385
38. Mackay DJG, Nobes CD and Hall A (1995) The rho's progress: a potential role during neuritogenesis for the rho family of GTPases. Trends in Neurological Sciences 18 496-501
39. McNamee HP, Ingber DE and Schwartz MA (1993) Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. Journal of Cell Biology 121 673-678
40. Michiels F, Habets GG, Stam JC, van der Kammen RA and Collard JG (1995) A role for Rac in Tiam-1-induced membrane ruffling and invasion. Nature 375 338-340
41. Miki T, Smith CL, Long JE, Eva A and Fleming TP (1993) Oncogene ect2 is related to regulators of small GTP-binding proteins. Nature 362 462-465
42. Minden A, Lin A, Claret F-X, Abo A and Karin M (1995) Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81 1147-1157
43. ERK-2. Journal of Biological Chemistry 270 269-273
44. Moscow JA, He R, Gnarra JR et al (1994) Examination of human tumors for rhoA mutations. Oncogene 9 189-194
45. Nishiki T, Narumiya S, Morii N et al (1990) ADP-ribosylation of the rho/rac proteins induces growth inhibition, neunte outgrowth and acetylcholine esterase in cultured PC12 cells. Biochemical and Biophysical Research Communications 167 265-273
46. Nishiyama T, Sasaki T, Takaishi K et al (1994) Rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor and 12-O-tetradecanoylphorbol-13-acetate (TPA) induced membrane ruffling in KB cells. Molecular and Cell Biology 14 2447-2456
47. Nobes CD and Hall A (1995) Rho, rac and cdc42 regulate the assembly of multi-molecular focal complexes associated with actin stress fibres, lamellipodia and filopodia. Cell 81 53-62
48. Nobes CD, Hawkins P, Stephens L and Hall A (1995) Activation of the small GTP-binding proteins rho and rac by growth factor receptors. Journal of Cell Sciences 108 225-233
49. Olson MJ, Ashworth A and Hall A (1995) An essential role for rho, rac, and cdc42 GTPases in cell cycle progression through G1. Science 269 1270-1272
50. O'Neill C, Jordan P and Ireland G (1986) Evidence for two distinct mechanisms of anchorage stimulation in freshly explanted and 3T3 mouse fibroblasts. Cell 44 489-496
51. Perona R, Esteve P, Jimenez B, Ballestero RP, Ramon S and Lacal JC (1993) Tumorigenic activity of rho genes from Aplysia californica. Oncogene 8 1285-1292
52. Plopper GE, McNamee HP, Dike LE, Bojanowski K and Ingber DE (1995) Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Molecular Biology of the Cell 6 1349-1365
53. Qiu RG, Chen J, Kirn D, McCormick F and Symons M (1995) An essential role for rac in ras transformation. Nature 374 457-459
54. Ridley AJ and Hall A (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70 389-399
55. Ridley AJ and Hall A (1994) Signal transduction pathways regulating rho-mediated stress fibre formation: requirement for a tyrosine kinase. EMBO Journal 13 2600-2610
56. Ridley AJ, Paterson HF, Johnston C, Diekmann D and Hall A (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70 401-410
57. Ridley AJ, Comoglio PM and Hall A (1994) Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac and Rho in MDCK cells. Molecular and Cell Biology 15 1110-1122
58. Ron D, Zannini M, Lewis M et al (1991) A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human break-point cluster gene, bcr. New Biology 3 372-379
59. Schlaepfer DD, Hanks SK, Hunter T and Vandergeer P (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372 786-791
60. Schwartz MA, Lechene C and Ingber DE (1991) Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integral α5β1, independent of cell shape. Proceedings of the National Academy of Sciences of the USA 88 7849-7853
61. Self AJ, Paterson HF and Hall A (1993) Different structural organization of Ras and Rho effector domains. Oncogene 8 655-661
62. Small JV (1989) Microfilament-based motility in non-muscle cells. Current Opinion in Cell Biology 1 75-79
63. Stasia MJ, Jovan A, Bourmeyster N, Boquet P and Vignais PV (1991) ADP-ribosylation of a small GTP-binding protein in bovine neutrophils by the C3 oxoenzyme of Clostridium botulinum and effect on cell motility. Biochemical and Biophysical Research Communications 180 615-622
64. Stossel T (1993) On the crawling of animal cells. Science 260 1086-1094
65. Toksoz D and Williams DA (1994) Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. Oncogene 9 621-628
66. Tominaga T, Sugie K, Hirata M et al (1993) Inhibition of PMA-induced LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP-binding protein, rho. Journal of Cell Biology 120 1529-1537
67. Turner CE and Burridge K (1991) Transmembrane molecular assemblies in cell-extracellular matrix interactions. Current Opinion in Cell Biology 3 849-853
68. Vojtek AB and Cooper JA (1995) Rho family members: activators of MAP kinase cascades. Cell 82 527-529
69. Yamada KM and Miyamoto S (1995) Integrin transmembrane signaling and cytoskeletal control. Current Opinion in Cell Biology 7 681-689
70. Yamamoto M, Marui N, Sakai T et al (1993) ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle. Oncogene 8 1449-1455
71. Zangrilla D and Eva A (1995). Cell transformation by dbl oncogene. Methods in Enzymology 256 347-358
72. Zheng Y, Olson MF, Hall A, Cerione RA and Toksoz D (1995) Direct involvement of the small GTP-binding protein Rho in lbc oncogene function. Journal of Biological Chemistry 270 9031-9034
73. Zhu X and Assoian RK (1995) Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Molecular Biology of the Cell 6 273-282