Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb(III)

Science

Volumn 279, Issue 5347, 1998, Pages 81-84

  Feig, Andrew L ^a   Scott, William G ^b   Uhlenbeck, Olke C ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOZYME; RNA;

ARTICLE; BINDING SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RNA STRUCTURE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BINDING, COMPETITIVE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; MAGNESIUM; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC; TERBIUM;

EID: 0032472205     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.279.5347.81     Document Type: Article

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45. Supported by NSF (CHE-9504698 to A.L.F.) and NIH (GM-36944 to O.C.U.). We thank L. Behlen and J. Murray for preparing several of the synthetic oligonucleotides; E. Jabri, S. Cohen, and A. Klug for discussions; S. Price for help with data collection at Daresbury Laboratory; and W. Pieken for the 2′-amino cytosine phosphoramidite. Coordinates from the Tb(III) cocrystallization experiment have been deposited in the Nucleic Acids Database (NDB ID URX067).