Presenilin overexpression arrests cells in the G1 phase of the cell cycle: Arrest potentiated by the Alzheimer's disease PS2(N141I) mutant

American Journal of Pathology

Volumn 155, Issue 1, 1999, Pages 135-144

  Janicki, Susan M ^a   Monteiro, Mervyn J ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b Medical Biotechnology Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN; PRESENILIN 1; PRESENILIN 2; PROTEIN P21; PROTEIN P27; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; FEMALE; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MISSENSE MUTATION; MITOSIS INHIBITION; PRIORITY JOURNAL; STAINING; STEADY STATE;

EID: 0032984214     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65108-5     Document Type: Article

References (43)

1. Hardy J: Amyloid, the presenilins, and Alzheimer's disease. Trends Neurosci 1997, 4:154-159
2. Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S: Skeletal and CNS defects in presenilin-1-deficient mice. Cell 1997, 89:629-639
3. Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJ, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LH, Sisodia SS: Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature 1997, 387:288-292
4. Davis JA, Naruse S, Chen H, Eckman C, Younkin S, Price DL. Borchelt DR, Sisodia SS, Wong PC: An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron 1998, 20:603-609
5. Qian S, Jiang P, Guan XM, Singh G, Trumbauer ME, Yu H, Chen HY, Van de Ploeg LH, Zheng H: Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression Neuron. 1998, 20:611-617
6. Levitan D, Greenwald I: Facilitation of lin-12-mediated signalling by sel-12, a Caenortiabditis elegans S182 Alzheimer's disease gene. Nature 1995, 377:351-354
7. Levitan D, Doyle TG, Brousseau D, Lee MK, Thinakaran G, Slunt HH, Sisodia SS, Greenwald I: Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc Natl Acad Sci USA 1996, 93:14940-14944
8. Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grunberg J, Haass C: Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing. Genes Funct 1997, 2:149-159
9. Vito P, Lacana E, D'Adamio L: Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3 Science 1996, 271:521-525
10. Vito P, Wolozin B, Ganjei JK, Iwasaki K, Lacana E, D'Adamio L: Requirement of the familial Alzheimer's disease gene PS2 for apoptosis: opposing effect of ALG-3. J Biol Chem 1996, 271:31025-31028
11. Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacana E, Sunderland T, Zhao B, Kusiak JW, Wasco W, D'Adamio L: Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 1996, 274:1710-1713
12. Deng G, Pike CJ, Cotman CW: Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett 1996, 397:50-54
13. Guo Q, Furukawa K, Sopher BL, Pham DG, Xie J, Robinson N, Martin GM, Mattson MP: Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC 12 cells to death induced by amyloid β-peptide. Neuroreport 1996, 8:379-383
14. Janicki S, Monteiro MJ: Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I). J Cell Biol 1997, 139:485-495
15. Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, Mattson MP: Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: involvement of calcium and oxyradicals. J Neurosci 1997, 11:4212-4222
16. Wolozin B, Alexander P, Palacino J: Regulation of apoptosis by presenilin 1. Neurobiol Aging 1998, 19:S23-S27
17. Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C. Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA: Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 1998, 395:698-702
18. Meikrantz W, Schlegel R: Apoptosis and the cell cycle. J Cell Biochem 1995, 58:160-174
19. Lee MK, Xu Z, Wong PC, Cleveland DW: Neurofilaments are obligate heteropolymers in vivo. J Cell Biol 1993, 122:1337-1350
20. Monteiro MJ, Mical TI: Resolution of kinase activities during the HeLa cell cycle: identification of kinases with cyclic activities. Exp Cell Res 1996, 223:443-451
21. Monteiro MJ, Cleveland DW: Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits. J Cell Biol 1989, 108:579-593
22. Elledge SJ: Cell cycle checkpoints: preventing an identity crisis. Science 1996, 274:1664-1672
23. Paulovich AG, Toczyski DP, Hartwell LH: When checkpoints fail. Cell 1997, 88:315-321
24. Kastan MB, Zhan Q, el-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJJ: A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxiatelangiectasia. Cell 1992, 71:587-597
25. Levine AJ: p53, the cellular gatekeeper for growth and division. Cell 1997, 88:323-331
26. Sherr CJ: Cancer cell cycles. Science 1996, 274:1672-1677
27. Evan G, Littlewood T: A matter of life and cell death. Science 1998, 281:1317-1322
28. Ray WJ, Yao M, Nowotny P, Mumm J, Zhang W, Wu JY, Kopan R, Goate AM: Evidence for a physical interaction between presenilin and Notch. Proc Natl Acad Sci USA 1999, 96:3263-3268
29. Roperch JP, Alvaro V, Prieur S, Tuynder M, Nemani M, Lethrosne F, Piouffre L, Gendron MC, Israeli D, Dausset J, Oren M, Amson R, Telerman A: Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression. Nature Med 1998, 7:835-838
30. Murayama M, Tanaka S, Palacino J, Murayama O, Honda T, Sun X, Yasutake K, Nihonmatsu N, Wolozin B, Takashima A: Direct association of presenilin-1 with β-catenin. FEBS Lett 1998, 433:73-77
31. Zhou J, Liyanage U, Medina M, Ho C, Simmons AD, Lovett M, Kosik KS: Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport 1997, 8:1489-1494
32. Takashima A, Murayama M, Murayama O, Kohno T, Honda T, Yasutake K, Nihonmatsu N, Mercken M, Yamaguchi H, Sugihara S, Wolozin B: Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau. Proc Natl Acad Sci USA 1998, 95:9637-9641
33. Johnston LA, Edgar BA: Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Nature 1998, 394:82-84
34. Masliah E, Mallory M, Alford M, Hansen LA, Saitoh T: Immunoreactivity of the nuclear antigen p105 is associated with plaques and tangles in Alzheimer's disease. Lab Invest 1993, 69:562-569
35. Smith TW, Lippa CF: Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders. J Neuropathol Exp Neurol 1995, 54:297-303
36. Vincent I, Rosado M, Davies P: Mitotic mechanisms in Alzheimer's disease? J Cell Biol 1996, 132:413-425
37. McShea A, Harris PL, Webster KR, Wahl AF, Smith MA: Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am J Pathol 1997, 150:1933-1939
38. Nagy Z, Esiri MM, Cato AM, Smith AD: Cell cycle markers in the hippocampus in Alzheimer's disease. Acta Neuropathol 1997, 94: 6-15
39. Vincent I, Jicha G, Rosado M, Dickson DW: Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J Neurosci 1997, 17:3588-3598
40. Busser J, Geldmacher DS, Herrup K: Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci 1998, 18:2801-2807
41. Arendt T, Holzer M, Gartner U: Neuronal expression of cyclin dependent kinase inhibitors of the INK4 family in Alzheimer's disease. J Neural Transm 1998, 105:949-960
42. Raina AK, Monteiro MJ, McShea A, Smith MA: The role of cell cycle-mediated events in Alzheimer's Disease. Int J Exp Pathol 1999, 80:71-76
43. Park DS, Morris EJ, Padmanabhan J, Shelanski ML, Geller HM, Greene LA: Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents. J Cell Biol 1998, 143:457-467