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Volumn 6, Issue 2, 1999, Pages 163-169

Pleiotropic cellular effects of leptin

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; LEPTIN;

EID: 0032966955     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-199904000-00013     Document Type: Article
Times cited : (29)

References (85)
  • 1
    • 0031840497 scopus 로고    scopus 로고
    • From physiology to neuroendocrinology: A reappraisal of risk factors of body weight gain in humans
    • 1 Tataranni PA: From physiology to neuroendocrinology: a reappraisal of risk factors of body weight gain in humans. Diabetes Metab 1998, 24:108-115.
    • (1998) Diabetes Metab , vol.24 , pp. 108-115
    • Tataranni, P.A.1
  • 2
    • 0031978142 scopus 로고    scopus 로고
    • Leptin, leptin receptors, and the control of body weight
    • 2 Friedman JM: Leptin, leptin receptors, and the control of body weight. Nutr Rev 1998, 56:38-46.
    • (1998) Nutr Rev , vol.56 , pp. 38-46
    • Friedman, J.M.1
  • 3
  • 4
    • 0031435811 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight
    • 4 Considine RV, Caro JF: Leptin and the regulation of body weight. Int J Biochem Cell Biol 1997, 29:1255-1272.
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 1255-1272
    • Considine, R.V.1    Caro, J.F.2
  • 5
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • 5 Tartaglia LA: The leptin receptor. J Biol Chem 1997, 272:6093-6096.
    • (1997) J Biol Chem , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 7
    • 0032577350 scopus 로고    scopus 로고
    • Strategies and potential molecular targets for obesity treatment
    • 7 Campfield LA, Smith FJ, Burn P: Strategies and potential molecular targets for obesity treatment. Science 1998, 280:1383-1387.
    • (1998) Science , vol.280 , pp. 1383-1387
    • Campfield, L.A.1    Smith, F.J.2    Burn, P.3
  • 8
    • 0032065645 scopus 로고    scopus 로고
    • Clinical Review 94. What's in a name? In search of leptin's physiologic role
    • 8 Flier JS: Clinical Review 94. What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab 1998, 83:1407-1413. The hypothesis that leptin is actually better suited to signal energy deprivation than energy excess is put forth.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1407-1413
    • Flier, J.S.1
  • 10
    • 0029964871 scopus 로고    scopus 로고
    • Responses of leptin to short-term fasting and refeeding in humans: A link with ketogenesis but not ketones themselves
    • 10 Kolaczynski JW, Considine RV, Ohannesian J, Marco C, Opentanova I, Nyce MR, et al.: Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves. Diabetes 1996, 45:1511-1515.
    • (1996) Diabetes , vol.45 , pp. 1511-1515
    • Kolaczynski, J.W.1    Considine, R.V.2    Ohannesian, J.3    Marco, C.4    Opentanova, I.5    Nyce, M.R.6
  • 12
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • 12 Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998, 394:897-901. The ability of leptin to prevent a fasting-induced decrease in immune function is demonstrated as well as a direct effect of leptin to simulate proliferation of T cells.
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3    Baker, R.J.4    Bloom, S.R.5    Lechler, R.I.6
  • 13
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • 13 Chehab FF, Lim ME, Lu R: Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 1996, 12:318-320.
    • (1996) Nature Genetics , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 17
    • 0030980198 scopus 로고    scopus 로고
    • A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty
    • 17 Mantzoros CS, Flier JS, Rogol AD: A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab 1997, 82:1066-1070. Longitudinal study demonstrating a significant rise in serum leptin preceding the onset of puberty in boys as determined by the initial detection and subsequent rise in serum testosterone.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1066-1070
    • Mantzoros, C.S.1    Flier, J.S.2    Rogol, A.D.3
  • 18
    • 0030964490 scopus 로고    scopus 로고
    • Serum leptin levels in normal children: Relationship to age, gender, body mass index, pituitary-gonadal hormones and pubertal stage
    • 18 Garcia-Mayor RV, Andrade MA, Rios M, Lage M, Dieguez C, Casanueva FF: Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones and pubertal stage. J Clin Endocrinol Metab 1997, 82:2849-2855.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2849-2855
    • Garcia-Mayor, R.V.1    Andrade, M.A.2    Rios, M.3    Lage, M.4    Dieguez, C.5    Casanueva, F.F.6
  • 19
    • 9844227914 scopus 로고    scopus 로고
    • Plasma leptin levels in healthy children and adolescents: Dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone
    • 19 Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Muller J, et al.: Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab 1997, 82:2904-2910.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2904-2910
    • Blum, W.F.1    Englaro, P.2    Hanitsch, S.3    Juul, A.4    Hertel, N.T.5    Muller, J.6
  • 20
    • 0031444646 scopus 로고    scopus 로고
    • Leptin plasma levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosa
    • 20. Argente J, Barrios V, Chowen JA, Sinha MK, Considine RV: Leptin plasma levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosa. J Pediatr 1997, 131:833-838.
    • (1997) J Pediatr , vol.131 , pp. 833-838
    • Argente, J.1    Barrios, V.2    Chowen, J.A.3    Sinha, M.K.4    Considine, R.V.5
  • 22
    • 0030930441 scopus 로고    scopus 로고
    • Circulating leptin does not appear to provide a signal for triggering the initiation of puberty in the male rhesus monkey (Macaca Mulatta)
    • 22 Plant RM, Durrant AR: Circulating leptin does not appear to provide a signal for triggering the initiation of puberty in the male rhesus monkey (Macaca Mulatta). Endocrinology 1997, 138:4505-4508.
    • (1997) Endocrinology , vol.138 , pp. 4505-4508
    • Plant, R.M.1    Durrant, A.R.2
  • 23
    • 0030728771 scopus 로고    scopus 로고
    • Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor
    • 23 Gavrilova O, Barr V, Marcus-Samuels B, Reitman M: Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. J Biol Chem 1997, 272:30546-30551. Unique finding that the rodent placenta produces the soluble form of the leptin receptor as a binding protein during pregnancy.
    • (1997) J Biol Chem , vol.272 , pp. 30546-30551
    • Gavrilova, O.1    Barr, V.2    Marcus-Samuels, B.3    Reitman, M.4
  • 24
    • 0031031623 scopus 로고    scopus 로고
    • Leptin in human reproduction: Serum leptin levels in pregnant and lactating women
    • 24 Butte NF, Hopkinson JM, Nicolsol MA: Leptin in human reproduction: serum leptin levels in pregnant and lactating women. J Clin Endocrinol Metab 1997, 82:585-589.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 585-589
    • Butte, N.F.1    Hopkinson, J.M.2    Nicolsol, M.A.3
  • 25
    • 0030739466 scopus 로고    scopus 로고
    • Circulating leptin in women: A longitudinal study in the menstrual cycle and during pregnancy
    • 25 Hardie L, Trayhurn P, Abramovich D, Fowler P: Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol 1997, 47:101-106.
    • (1997) Clin Endocrinol , vol.47 , pp. 101-106
    • Hardie, L.1    Trayhurn, P.2    Abramovich, D.3    Fowler, P.4
  • 26
    • 0031834764 scopus 로고    scopus 로고
    • Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy
    • 26 Highman TJ, Friedman JE, Huston LP, Wong WW, Catalano PM: Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy. Am J Obstet Gynecol 1998, 178:1010-1015. Demonstration that the increase in leptin during pregnancy in humans is not entirely due to the increased accumulation of adipose tissue.
    • (1998) Am J Obstet Gynecol , vol.178 , pp. 1010-1015
    • Highman, T.J.1    Friedman, J.E.2    Huston, L.P.3    Wong, W.W.4    Catalano, P.M.5
  • 27
    • 0030866843 scopus 로고    scopus 로고
    • Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
    • 27 Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, et al.: Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nature Med 1997, 3:1029-1033.
    • (1997) Nature Med , vol.3 , pp. 1029-1033
    • Masuzaki, H.1    Ogawa, Y.2    Sagawa, N.3    Hosoda, K.4    Matsumoto, T.5    Mise, H.6
  • 30
    • 0030813619 scopus 로고    scopus 로고
    • Identification of a placental enhancer for the human leptin gene
    • 30 Bi S, Gavrilova O, Gong D-W, Mason MM, Reitman M: Identification of a placental enhancer for the human leptin gene. J Biol Chem 1997, 272:30583-30588. Finding of unique placental specific enhancer sequence and transcription factors that regulate the production of leptin by human placenta.
    • (1997) J Biol Chem , vol.272 , pp. 30583-30588
    • Bi, S.1    Gavrilova, O.2    Gong, D.-W.3    Mason, M.M.4    Reitman, M.5
  • 31
    • 0031558761 scopus 로고    scopus 로고
    • Increase in mouse leptin production by adipose tissue after midpregnancy: Gestational profile of serum leptin concentration
    • 31 Tomimatsu T, Yamaguchi M, Murakami T, Ogura K, Sakata M, Mitsuda N, et al.: Increase in mouse leptin production by adipose tissue after midpregnancy: gestational profile of serum leptin concentration. Biochem Biophys Res Commun 1997, 240:213-215.
    • (1997) Biochem Biophys Res Commun , vol.240 , pp. 213-215
    • Tomimatsu, T.1    Yamaguchi, M.2    Murakami, T.3    Ogura, K.4    Sakata, M.5    Mitsuda, N.6
  • 32
    • 0001643697 scopus 로고    scopus 로고
    • The placenta is not the main source of leptin production in the pregnant rat: Gestational profile of leptin in plasma and adipose tissues
    • 32 Kawai M, Yamaguchi M, Murakami T, Shima K, Murata Y, Kishi K: The placenta is not the main source of leptin production in the pregnant rat: gestational profile of leptin in plasma and adipose tissues. Biochem Biophys Res Commun 1997, 240:798-802.
    • (1997) Biochem Biophys Res Commun , vol.240 , pp. 798-802
    • Kawai, M.1    Yamaguchi, M.2    Murakami, T.3    Shima, K.4    Murata, Y.5    Kishi, K.6
  • 36
    • 0030777965 scopus 로고    scopus 로고
    • Presence of leptin in colostrum and/or breast milk from lactating mothers: A potential role in the regulation of neonatal food intake
    • 36 Casabiell X, Pineiro V, Tome MA, Peino R, Dieguez C, Casanueva FF: Presence of leptin in colostrum and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake. J Clin Endocrinol Metab 1997, 82:4270-4273. Observations that suggest that maternal leptin survives in the stomach and reaches the neonatal circulation.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 4270-4273
    • Casabiell, X.1    Pineiro, V.2    Tome, M.A.3    Peino, R.4    Dieguez, C.5    Casanueva, F.F.6
  • 40
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • 40 Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995, 269:546-549
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 41
    • 0030948734 scopus 로고    scopus 로고
    • Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells
    • 41 Kieffer TJ, Heller RS, Leech CA, Holz GG, Habener JF: Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes 1997, 46:1087-1093. Mechanism of leptin-inhibited insulin release is activation of ATP-sensitive potassium channels and hyperpolarization of the cell.
    • (1997) Diabetes , vol.46 , pp. 1087-1093
    • Kieffer, T.J.1    Heller, R.S.2    Leech, C.A.3    Holz, G.G.4    Habener, J.F.5
  • 42
    • 0030965884 scopus 로고    scopus 로고
    • Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
    • 42 Emilsson V, Liu YL, Cawthorne MA, Morton NM, Davenport M: Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 1997, 46:313-316.
    • (1997) Diabetes , vol.46 , pp. 313-316
    • Emilsson, V.1    Liu, Y.L.2    Cawthorne, M.A.3    Morton, N.M.4    Davenport, M.5
  • 43
    • 0031559857 scopus 로고    scopus 로고
    • Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets
    • 43 Pallett AL, Morton NM, Cawthorne MA, Emilsson V: Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets. Biochem Biophys Res Commun 1997, 238:267-270.
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 267-270
    • Pallett, A.L.1    Morton, N.M.2    Cawthorne, M.A.3    Emilsson, V.4
  • 44
    • 0030955188 scopus 로고    scopus 로고
    • Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice
    • 44 Chen NG, Swick AG, Romsos DR: Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice. J Clin Invest 1997, 100:1174-1179.
    • (1997) J Clin Invest , vol.100 , pp. 1174-1179
    • Chen, N.G.1    Swick, A.G.2    Romsos, D.R.3
  • 46
    • 0031590317 scopus 로고    scopus 로고
    • Inhibition of glucose-induced insulin secretion by long-term preexposure of pancreatic islets to leptin
    • 46 Roduit R, Thorens B: Inhibition of glucose-induced insulin secretion by long-term preexposure of pancreatic islets to leptin. FEBS Lett 1997, 415:179-182.
    • (1997) Febs Lett , vol.415 , pp. 179-182
    • Roduit, R.1    Thorens, B.2
  • 48
    • 2642653233 scopus 로고    scopus 로고
    • Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice
    • 48 Kulkarni RH, Wang Z-L, Wang R-M, Hurley JD, Smith DM, Ghatei MA, et al.: Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest 1997, 100:2729-2736. Systematic examination of leptin effects on insulin release from islets and following intraperitoneal administration. Observations suggest that leptin can inhibit insulin release acutely in vivo but effect may be dependent on route of administration.
    • (1997) J Clin Invest , vol.100 , pp. 2729-2736
    • Kulkarni, R.H.1    Wang, Z.-L.2    Wang, R.-M.3    Hurley, J.D.4    Smith, D.M.5    Ghatei, M.A.6
  • 49
    • 0031793899 scopus 로고    scopus 로고
    • Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans
    • 49 Poitout V, Rouault C, Guerre-Millo M, Briaud I, Reach G: Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans. Endocrinology 1998, 139:822-826.
    • (1998) Endocrinology , vol.139 , pp. 822-826
    • Poitout, V.1    Rouault, C.2    Guerre-Millo, M.3    Briaud, I.4    Reach, G.5
  • 50
    • 0031915043 scopus 로고    scopus 로고
    • Effects of leptin on insulin secretion from isolated rat pancreatic islets
    • 50 Ookuma M, Ookuma K, York DA: Effects of leptin on insulin secretion from isolated rat pancreatic islets. Diabetes 1998, 47:219-223.
    • (1998) Diabetes , vol.47 , pp. 219-223
    • Ookuma, M.1    Ookuma, K.2    York, D.A.3
  • 51
    • 0032169556 scopus 로고    scopus 로고
    • Leptin inhibits insulin secretion by activation of phosphodiesterase 3B
    • 51 Zhao AZ, Bronfeldt KE, Beavo JA: Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest 1998, 102:869-873. Examination of the intracellular signal cascade initiated by leptin to inhibit insulin release. Observations suggest that PDE3B may be mediator of leptin action in other cell types.
    • (1998) J Clin Invest , vol.102 , pp. 869-873
    • Zhao, A.Z.1    Bronfeldt, K.E.2    Beavo, J.A.3
  • 52
    • 0031470121 scopus 로고    scopus 로고
    • Leptin stimulates insulin secretion and synthesis in HIT-T 15 cells
    • 52 Shimizu H, Ohtani K, Tsuchiya T, Takahashi H, Uehara Y, Sato N, et al.: Leptin stimulates insulin secretion and synthesis in HIT-T 15 cells. Peptides 1997, 18:1263-1266.
    • (1997) Peptides , vol.18 , pp. 1263-1266
    • Shimizu, H.1    Ohtani, K.2    Tsuchiya, T.3    Takahashi, H.4    Uehara, Y.5    Sato, N.6
  • 53
    • 0030886339 scopus 로고    scopus 로고
    • Direct stimulation of basal insulin secretion by physiological concentrations of leptin in pancreatic beta cells
    • 53 Tanizawa Y, Okuya S, Ishihara H, Asano T, Yada T, Oka Y: Direct stimulation of basal insulin secretion by physiological concentrations of leptin in pancreatic beta cells. Endocrinology 1997, 138:4513-4516.
    • (1997) Endocrinology , vol.138 , pp. 4513-4516
    • Tanizawa, Y.1    Okuya, S.2    Ishihara, H.3    Asano, T.4    Yada, T.5    Oka, Y.6
  • 55
    • 0030965794 scopus 로고    scopus 로고
    • Failure of leptin to counteract the effects of glucose on insulin and glucagon release by the perfused rat pancreas
    • 55 Leclercq-Meyer V, Mailaisse WJ: Failure of leptin to counteract the effects of glucose on insulin and glucagon release by the perfused rat pancreas. Med Sci Res 1997, 25:257-259.
    • (1997) Med Sci Res , vol.25 , pp. 257-259
    • Leclercq-Meyer, V.1    Mailaisse, W.J.2
  • 56
    • 0032566008 scopus 로고    scopus 로고
    • Failure of human and mouse leptin to affect insulin, glucagon and somatostatin secretion by the perfused rat pancreas at physiological glucose concentration
    • 56 Leclercq-Meyer V, Mailaisse WJ: Failure of human and mouse leptin to affect insulin, glucagon and somatostatin secretion by the perfused rat pancreas at physiological glucose concentration. Mol Cell Endocrinol 1998, 141:111-118. No effect of leptin on insulin release from perfused pancreas after three different studies. Observations suggest that leptin effects on isolated β-cells and islets may not be representative of actual effect of leptin in vivo.
    • (1998) Mol Cell Endocrinol , vol.141 , pp. 111-118
    • Leclercq-Meyer, V.1    Mailaisse, W.J.2
  • 57
    • 0031730278 scopus 로고    scopus 로고
    • Leptin affects pancreatic endocrine functions through the sympathetic nervous system
    • 57 Mizuno A, Murakami T, Otani S, Kuwajima M, Shima K: Leptin affects pancreatic endocrine functions through the sympathetic nervous system. Endocrinology 1998, 139:3863-3870. Demonstration that leptin can reduce insulin secretion from the pancreas in animals that have been vagotomized. Observations suggest that leptin may regulate insulin release in vivo through central nervous system mechanisms.
    • (1998) Endocrinology , vol.139 , pp. 3863-3870
    • Mizuno, A.1    Murakami, T.2    Otani, S.3    Kuwajima, M.4    Shima, K.5
  • 58
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • 58 Cohen B, Novick D, Rubinstein M: Modulation of insulin activities by leptin. Science 1996, 274:1185-1188.
    • (1996) Science , vol.274 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubinstein, M.3
  • 59
    • 0040381066 scopus 로고    scopus 로고
    • Leptin impairs metabolic actions of insulin in isolated rat adipocytes
    • 59 Muller G, Ertl J, Gerl M, Preibisch G: Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 1997, 272:10585-10593.
    • (1997) J Biol Chem , vol.272 , pp. 10585-10593
    • Muller, G.1    Ertl, J.2    Gerl, M.3    Preibisch, G.4
  • 60
    • 0031975899 scopus 로고    scopus 로고
    • Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes
    • 60 Zierath JR, Frevert EU, Ryder JW, Berggren P, Kahn BB: Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes. Diabetes 1998, 47:1-4.
    • (1998) Diabetes , vol.47 , pp. 1-4
    • Zierath, J.R.1    Frevert, E.U.2    Ryder, J.W.3    Berggren, P.4    Kahn, B.B.5
  • 61
    • 0031967643 scopus 로고    scopus 로고
    • Failure of leptin to affect basal and insulin-stimulated glucose metabolism of rat skeletal muscle in vitro
    • 61 Furnsinn C, Brunmair B, Furtmuller R, Roden M, Englisch R, Waldhausl W: Failure of leptin to affect basal and insulin-stimulated glucose metabolism of rat skeletal muscle in vitro. Diabetologia 1998, 41:524-529.
    • (1998) Diabetologia , vol.41 , pp. 524-529
    • Furnsinn, C.1    Brunmair, B.2    Furtmuller, R.3    Roden, M.4    Englisch, R.5    Waldhausl, W.6
  • 62
    • 0031764763 scopus 로고    scopus 로고
    • Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells
    • 62 Ranganathan S, Ciaraldi TP, Henry RR, Mudaliar S, Kern PA: Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells. Endocrinology 1998, 139:2509-2513.
    • (1998) Endocrinology , vol.139 , pp. 2509-2513
    • Ranganathan, S.1    Ciaraldi, T.P.2    Henry, R.R.3    Mudaliar, S.4    Kern, P.A.5
  • 63
    • 0030895726 scopus 로고    scopus 로고
    • Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a P13-kinase mediated effect
    • 63 Berti L, Kellerer M, Capp E, Haring HU: Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effect. Diabetologia 1997, 40:606-609.
    • (1997) Diabetologia , vol.40 , pp. 606-609
    • Berti, L.1    Kellerer, M.2    Capp, E.3    Haring, H.U.4
  • 64
    • 0001951380 scopus 로고    scopus 로고
    • Leptin increases basal and insulin-stimulated glucose uptake into human subcutaneous adipocytes
    • 64 Williams LB, Ohannesian DW, Kogon BE, Jones RM, Inman M, Huse J, et al.: Leptin increases basal and insulin-stimulated glucose uptake into human subcutaneous adipocytes. Diabetes 1998, 47(suppl 1):A73.
    • (1998) Diabetes , vol.47 , Issue.SUPPL. 1
    • Williams, L.B.1    Ohannesian, D.W.2    Kogon, B.E.3    Jones, R.M.4    Inman, M.5    Huse, J.6
  • 65
    • 0030737573 scopus 로고    scopus 로고
    • Effects of leptin on insulin sensitivity in normal rats
    • 65 Sivitz WI, Walsh SA, Morgan DA, Thomas MJ, Haynes WG: Effects of leptin on insulin sensitivity in normal rats. Endocrinology 1997, 138:3395-3401. Demonstration of improved glucose utilization during infusion of supraphysiologic concentrations of leptin. Concentrations used may suggest that effect was mediated through the central nervous system.
    • (1997) Endocrinology , vol.138 , pp. 3395-3401
    • Sivitz, W.I.1    Walsh, S.A.2    Morgan, D.A.3    Thomas, M.J.4    Haynes, W.G.5
  • 66
    • 0030847432 scopus 로고    scopus 로고
    • Acute stimulation of glucose metabolism in mice by leptin treatment
    • 66 Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ: Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 1997, 389:374-377. Demonstration that leptin improves glucose homeostasis through central nervous system mechanisms.
    • (1997) Nature , vol.389 , pp. 374-377
    • Kamohara, S.1    Burcelin, R.2    Halaas, J.L.3    Friedman, J.M.4    Charron, M.J.5
  • 67
    • 0029961204 scopus 로고    scopus 로고
    • The function of adipocytes in the bone marrow stroma: An update
    • 67 Gimble JM, Robinson CE, Wu X, Kelly KA: The function of adipocytes in the bone marrow stroma: an update. Bone 1996, 19:421-428.
    • (1996) Bone , vol.19 , pp. 421-428
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3    Kelly, K.A.4
  • 68
    • 17344372906 scopus 로고    scopus 로고
    • High expression of leptin by human bone marrow adipocytes in primary culture
    • 68 Laharrague P, Larrouy D, Fontanilles A-M, Truel N, Campfield A, Tenenbaum R, et a.: High expression of leptin by human bone marrow adipocytes in primary culture. FASEB J 1998, 12:747-752. Novel site of leptin production. Evidence suggests a paracrine mechanism for leptin in hematopoiesis.
    • (1998) Faseb J , vol.12 , pp. 747-752
    • Laharrague, P.1    Larrouy, D.2    Fontanilles, A.-M.3    Truel, N.4    Campfield, A.5    Tenenbaum, R.6
  • 69
    • 0030007116 scopus 로고    scopus 로고
    • Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction
    • 69 Cioffi JA, Shafer AW, Zupancic TJ, Smith-Gbur J, Mikhail A, Platika D, et al.: Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nature Med 1996, 2:585-589.
    • (1996) Nature Med , vol.2 , pp. 585-589
    • Cioffi, J.A.1    Shafer, A.W.2    Zupancic, T.J.3    Smith-Gbur, J.4    Mikhail, A.5    Platika, D.6
  • 71
    • 0029952911 scopus 로고    scopus 로고
    • Leptin can induce proliferation, differentiation, and functional activation of hematopoietic cells
    • 71 Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, Ng A, et al.: Leptin can induce proliferation, differentiation, and functional activation of hematopoietic cells. Proc Natl Acad Sci USA 1996, 93:14564-14568.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14564-14568
    • Gainsford, T.1    Willson, T.A.2    Metcalf, D.3    Handman, E.4    McFarlane, C.5    Ng, A.6
  • 73
    • 0030956390 scopus 로고    scopus 로고
    • The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
    • 73 Ghilardi N, Skoda RC: The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol 1997, 11:393-399.
    • (1997) Mol Endocrinol , vol.11 , pp. 393-399
    • Ghilardi, N.1    Skoda, R.C.2
  • 74
    • 0030736770 scopus 로고    scopus 로고
    • Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic cells
    • 74 Umemoto Y, Tsuji K, Yang F-C, Ebihara Y, Kaneko A, Furukawa S, et al.: Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic cells. Blood 1997, 90:3438-3443.
    • (1997) Blood , vol.90 , pp. 3438-3443
    • Umemoto, Y.1    Tsuji, K.2    Yang, F.-C.3    Ebihara, Y.4    Kaneko, A.5    Furukawa, S.6
  • 75
    • 0030955949 scopus 로고    scopus 로고
    • Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1/2 cells
    • 75 Takahashi Y, Okimura Y, Mizuno I, Iida K, Takahashi T, Kaji H, et al.: Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1/2 cells. J Biol Chem 1997, 272:12897-12900.
    • (1997) J Biol Chem , vol.272 , pp. 12897-12900
    • Takahashi, Y.1    Okimura, Y.2    Mizuno, I.3    Iida, K.4    Takahashi, T.5    Kaji, H.6
  • 76
    • 0031590853 scopus 로고    scopus 로고
    • Leptin induces proliferation of pancreatic β cell line MIN6 through activation of mitogen-activated protein kinase
    • 76 Tanabe K, Okuya S, Tanizawa Y, Matsutani A, Oka Y: Leptin induces proliferation of pancreatic β cell line MIN6 through activation of mitogen-activated protein kinase. Biochem Biophys Res Commun 1997, 241:765-768.
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 765-768
    • Tanabe, K.1    Okuya, S.2    Tanizawa, Y.3    Matsutani, A.4    Oka, Y.5
  • 78
    • 0032552112 scopus 로고    scopus 로고
    • The stomach is a source of leptin
    • 78 Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau J-P, Bortoluzzi M-N, et al.: The stomach is a source of leptin. Nature 1998, 394:790-793. Novel site of leptin production. Observations suggest that leptin may act as a meal ending satiety hormone by acting locally in the GI tract or through vagal afferents to the central nervous system.
    • (1998) Nature , vol.394 , pp. 790-793
    • Bado, A.1    Levasseur, S.2    Attoub, S.3    Kermorgant, S.4    Laigneau, J.-P.5    Bortoluzzi, M.-N.6
  • 79
    • 0030824058 scopus 로고    scopus 로고
    • Two types of leptin responsive gastric vagal afferent terminals: An in vitro single unit study in rats
    • 79 Wang YH, Tache Y, Sheibel AB, Go VLW, Wei JY: Two types of leptin responsive gastric vagal afferent terminals: an in vitro single unit study in rats. Am J Physiol 1997, 272:R833-R837.
    • (1997) Am J Physiol , vol.272
    • Wang, Y.H.1    Tache, Y.2    Sheibel, A.B.3    Go, V.L.W.4    Wei, J.Y.5
  • 82
    • 0030830662 scopus 로고    scopus 로고
    • Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats
    • 82 Dunbar JC, Hu Y, Lu H: Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 1997, 46:2040-2043.
    • (1997) Diabetes , vol.46 , pp. 2040-2043
    • Dunbar, J.C.1    Hu, Y.2    Lu, H.3
  • 83
    • 0032554469 scopus 로고    scopus 로고
    • Leptin in human plasma is derived in part from the brain, and cleared by the kidneys
    • 83 Esler M, Vaz M, Collier G, Nestel P, Jennings G, Kaye D, et al.: Leptin in human plasma is derived in part from the brain, and cleared by the kidneys. Lancet 1998, 351:879.
    • (1998) Lancet , vol.351 , pp. 879
    • Esler, M.1    Vaz, M.2    Collier, G.3    Nestel, P.4    Jennings, G.5    Kaye, D.6
  • 84
    • 0032543680 scopus 로고    scopus 로고
    • A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
    • 84 Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L: A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 1998, 393:684-688. Hypothesis put forth that leptin production may be regulated by hexosamine biosynthesis. The hexosamine pathway has been characterized as a cellular nutrient sensing mechanism that can contribute to glucose-induced insulin resistance.
    • (1998) Nature , vol.393 , pp. 684-688
    • Wang, J.1    Liu, R.2    Hawkins, M.3    Barzilai, N.4    Rossetti, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.