Leptin in human plasma is derived in part from the brain, and cleared by the kidneys

Lancet

Volumn 351, Issue 9106, 1998, Pages 879-

  Esler, Murray ^a   Vaz, Mario ^a   Collier, Greg ^a   Nestel, Paul ^a   Jennings, Garry ^a   Kaye, David ^a   Seals, Douglas ^a   Lambert, Gavin ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ADULT; AGED; ARTERIAL BLOOD; BLOOD LEVEL; BLOOD SAMPLING; BRACHIAL ARTERY; BRAIN; CLINICAL ARTICLE; CONTROLLED STUDY; FOREARM; HEART; HUMAN; INTERNAL JUGULAR VEIN; INTESTINE; KIDNEY; KIDNEY CLEARANCE; LIVER; MALE; OBESITY; PRIORITY JOURNAL; PROTEIN SECRETION; RADIAL ARTERY; SHORT SURVEY; VENOUS BLOOD;

EID: 0032554469     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)70289-0     Document Type: Article

References (5)

1. 1 Lindpainter K. Finding an obesity gene - a tale of mice and men. N Engl J Med 1995; 332: 679-80.
2. 2 Caro JF, Kolaczynski JW, Nyce MR, et al. Decreased cerebrospinal fluid/serum leptin ratio in obesity. Lancet 1996; 348: 159-61.
3. 3 Esler M, Jennings G, Lambert G, et al. Overflow of catecholamine neurotransmitters to the circulation: source, fate and functions. Physiol Rev 1990; 70: 963-85.
4. 4 Sinha MK, Opentanova I, Ohannesian JP, et al. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. J Clin Invest 1996; 98: 1277-82.
5. 5 Mazuzaki H, Ogawa Y, Sagawa N, et al. Non-adipose tissue production of leptin: leptin as a novel placental derived hormone in humans. Nat Med 1997; 3: 1029-33.