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Volumn 2, Issue C, 1997, Pages 243-278

Chapter 9 Changes in Neurotransmitter Signal Transduction Pathways in the Aging Brain

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EID: 0345590985     PISSN: 15663124     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1566-3124(08)60059-0     Document Type: Article
Times cited : (9)

References (145)
  • 2
    • 0027370167 scopus 로고
    • Cholinergic neurotransmission in the hippocampus of aged rats: influence of L-alpha-glycerylphophorylcholine treatment
    • Amenta F., Franch F., Ricci A., and Vega J.A. Cholinergic neurotransmission in the hippocampus of aged rats: influence of L-alpha-glycerylphophorylcholine treatment. Ann. N. Y. Acad. Sci. 695 (1993) 311-313
    • (1993) Ann. N. Y. Acad. Sci. , vol.695 , pp. 311-313
    • Amenta, F.1    Franch, F.2    Ricci, A.3    Vega, J.A.4
  • 3
    • 0026317276 scopus 로고
    • Neurotransmitters, neuroreceptors and aging
    • Amenta F., Zaccheo D., and Collier W.L. Neurotransmitters, neuroreceptors and aging. Mech. Aging Dev. 61 (1991) 249-273
    • (1991) Mech. Aging Dev. , vol.61 , pp. 249-273
    • Amenta, F.1    Zaccheo, D.2    Collier, W.L.3
  • 5
    • 0027051958 scopus 로고
    • The effect of aging on muscarinic receptor/G-protein coupling in the rat hippocampus and striatum
    • Anson R.M., Cutler R., Joseph J.A., Yamagami K., and Roth G.S. The effect of aging on muscarinic receptor/G-protein coupling in the rat hippocampus and striatum. Brain Res. 598 (1992) 302-306
    • (1992) Brain Res. , vol.598 , pp. 302-306
    • Anson, R.M.1    Cutler, R.2    Joseph, J.A.3    Yamagami, K.4    Roth, G.S.5
  • 7
    • 0028172230 scopus 로고
    • Dopamine Dl receptor mechanisms in the cognitive performance of young and aged monkeys
    • Arnsten A.F.T., Cai J.X., Murphy B.L., and Goldman-Rakic P.S. Dopamine Dl receptor mechanisms in the cognitive performance of young and aged monkeys. Psychopharmacol. 116 (1994) 143-151
    • (1994) Psychopharmacol. , vol.116 , pp. 143-151
    • Arnsten, A.F.T.1    Cai, J.X.2    Murphy, B.L.3    Goldman-Rakic, P.S.4
  • 8
    • 0029014326 scopus 로고
    • Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: The effects of quinpirole on memory and motor performance in monkeys.
    • Arnsten A.F.T., Cai J.X., Steere J.C., and Goldman-Rakic P.S. Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: The effects of quinpirole on memory and motor performance in monkeys. J. Neurosci. 15 (1995) 3429-3439
    • (1995) J. Neurosci. , vol.15 , pp. 3429-3439
    • Arnsten, A.F.T.1    Cai, J.X.2    Steere, J.C.3    Goldman-Rakic, P.S.4
  • 9
    • 0027301788 scopus 로고
    • Effect of aging in human cortical pre- and postsynaptic serotonin binding sites
    • Arranz B., Eriksson A., Mellerup E., Plenge P., and Marcusson J. Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. Brain Res. 620 (1993) 163-166
    • (1993) Brain Res. , vol.620 , pp. 163-166
    • Arranz, B.1    Eriksson, A.2    Mellerup, E.3    Plenge, P.4    Marcusson, J.5
  • 10
    • 0026746182 scopus 로고
    • Mouse telencephalon exhibits an age-related decrease in glutamate (AMPA) receptors but no change in nerve terminal markers
    • Bahr B.A., Godshall A.C., Hall R.A., and Lynch G. Mouse telencephalon exhibits an age-related decrease in glutamate (AMPA) receptors but no change in nerve terminal markers. Brain Res. 589 (1992) 320-326
    • (1992) Brain Res. , vol.589 , pp. 320-326
    • Bahr, B.A.1    Godshall, A.C.2    Hall, R.A.3    Lynch, G.4
  • 11
    • 0026683492 scopus 로고
    • Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age
    • Bannon M.J., Poosch M.S., Xia Y., Goebel D., Cassin B., and Kapatos G. Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age. Proc. Nat. Acad. Sci. USA 89 (1992) 7095-7099
    • (1992) Proc. Nat. Acad. Sci. USA , vol.89 , pp. 7095-7099
    • Bannon, M.J.1    Poosch, M.S.2    Xia, Y.3    Goebel, D.4    Cassin, B.5    Kapatos, G.6
  • 13
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus R.T., Dean R.L., Beer B., and Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 214 (1982) 408-417
    • (1982) Science , vol.214 , pp. 408-417
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 14
    • 0023743325 scopus 로고
    • Aging and brain choliergic muscarinic receptors: an autoradiographic study in the rat
    • Biegon A., Duvdevani R., Greenberger V., and Segal M. Aging and brain choliergic muscarinic receptors: an autoradiographic study in the rat. J. Neurochem. 51 (1988) 1381-1385
    • (1988) J. Neurochem. , vol.51 , pp. 1381-1385
    • Biegon, A.1    Duvdevani, R.2    Greenberger, V.3    Segal, M.4
  • 15
    • 0025909626 scopus 로고
    • Muscarinic acetylcholine receptor subtype mRNA expression ligand binding inn the aged rat forebrain., Neurobiol
    • Blake M.J., Appel N.M., Joseph J.A., Stagg C.A., Anson M., De Souza E.B., and Roth G.S. Muscarinic acetylcholine receptor subtype mRNA expression ligand binding inn the aged rat forebrain., Neurobiol. Aging 12 (1991) 193-199
    • (1991) Aging , vol.12 , pp. 193-199
    • Blake, M.J.1    Appel, N.M.2    Joseph, J.A.3    Stagg, C.A.4    Anson, M.5    De Souza, E.B.6    Roth, G.S.7
  • 16
    • 0026776218 scopus 로고
    • Delta-6 desaturation of alpha-linolenic acid in brain and liver during development and aging in the mouse
    • Bourre J.M., and Piciotti M. Delta-6 desaturation of alpha-linolenic acid in brain and liver during development and aging in the mouse. Neurosci. Lett. 141 (1995) 65-68
    • (1995) Neurosci. Lett. , vol.141 , pp. 65-68
    • Bourre, J.M.1    Piciotti, M.2
  • 18
    • 0023204923 scopus 로고
    • Aging of the nigrostriatal pathway in humans
    • Calne D.B., and Peppard R.F. Aging of the nigrostriatal pathway in humans. Can. J. Neurol. Sci. 14 (1987) 424-427
    • (1987) Can. J. Neurol. Sci. , vol.14 , pp. 424-427
    • Calne, D.B.1    Peppard, R.F.2
  • 19
    • 0028902823 scopus 로고
    • Lipid peroxidation contributes to age-related membrane rigidity
    • Choe M., Jackson C., and Yu B.P. Lipid peroxidation contributes to age-related membrane rigidity. Free Rad. Biol. Med. 18 (1995) 977-984
    • (1995) Free Rad. Biol. Med. , vol.18 , pp. 977-984
    • Choe, M.1    Jackson, C.2    Yu, B.P.3
  • 20
    • 0028893636 scopus 로고
    • Brain synaptosomal aging: free radicals and membrane fluidity
    • Choi J.H., and Yu B.P. Brain synaptosomal aging: free radicals and membrane fluidity. Free Rad. Biol. Med. 18 (1995) 133-139
    • (1995) Free Rad. Biol. Med. , vol.18 , pp. 133-139
    • Choi, J.H.1    Yu, B.P.2
  • 21
    • 0028031450 scopus 로고
    • Age-dependent decline of nigrostriatal dopaminergic function: a positron emission tomographic study of grandparents and their grandchildren
    • Cordes M., Snow B.J., Cooper S., Schulzer M., Pate B.D., Ruth T.J., and Calne D.B. Age-dependent decline of nigrostriatal dopaminergic function: a positron emission tomographic study of grandparents and their grandchildren. Arch. Neurol. 36 (1994) 667-670
    • (1994) Arch. Neurol. , vol.36 , pp. 667-670
    • Cordes, M.1    Snow, B.J.2    Cooper, S.3    Schulzer, M.4    Pate, B.D.5    Ruth, T.J.6    Calne, D.B.7
  • 22
    • 0031053533 scopus 로고    scopus 로고
    • Dopaminergic function in the neostriatum and nucleus accumbens of young and aged Fischer 344 rats
    • Crawford C.A., and Levine M.S. Dopaminergic function in the neostriatum and nucleus accumbens of young and aged Fischer 344 rats. Neurobiol. Aging 18 (1997) 57-66
    • (1997) Neurobiol. Aging , vol.18 , pp. 57-66
    • Crawford, C.A.1    Levine, M.S.2
  • 23
    • 0028027552 scopus 로고
    • Cholinergic and serotonergic stimulation of phosphoinositide hydroysis is decreased in Alzheimer's disease
    • Crews F.T., Kurian P., and Freund G. Cholinergic and serotonergic stimulation of phosphoinositide hydroysis is decreased in Alzheimer's disease. Life Sci. 55 (1994) 1993-2002
    • (1994) Life Sci. , vol.55 , pp. 1993-2002
    • Crews, F.T.1    Kurian, P.2    Freund, G.3
  • 24
    • 0028151332 scopus 로고
    • Area specific alterations in muscarinic stimulated low Km GTPase activity in aging and Alzheimer's disease: implications for altered signal transduction
    • Cutler R., Joseph J.A., Yamagami K., Villalobos-Molina R., and Roth G.S. Area specific alterations in muscarinic stimulated low Km GTPase activity in aging and Alzheimer's disease: implications for altered signal transduction. Brain Res. 664 (1994) 54-56
    • (1994) Brain Res. , vol.664 , pp. 54-56
    • Cutler, R.1    Joseph, J.A.2    Yamagami, K.3    Villalobos-Molina, R.4    Roth, G.S.5
  • 25
  • 26
    • 0025924457 scopus 로고
    • Dl and D2 dopamine receptors in human substantia nigra: localization and the effect of aging
    • De Keyser J., De Backer J., Vauquelin G., and Ebinger G. Dl and D2 dopamine receptors in human substantia nigra: localization and the effect of aging. J. Neurochem. 56 (1991) 1130-1133
    • (1991) J. Neurochem. , vol.56 , pp. 1130-1133
    • De Keyser, J.1    De Backer, J.2    Vauquelin, G.3    Ebinger, G.4
  • 27
    • 0029670369 scopus 로고    scopus 로고
    • Alpha-linolenic acid dietary deficiency alters age-related changes in dopaminergic and serotoninergic neurotransmission in the rat frontal cortex.
    • Delion S., Chalon S., Guilloteau D., Besnard J.C., and Durand G. Alpha-linolenic acid dietary deficiency alters age-related changes in dopaminergic and serotoninergic neurotransmission in the rat frontal cortex. J. Neurochem. 66 (1996) 1582-1591
    • (1996) J. Neurochem. , vol.66 , pp. 1582-1591
    • Delion, S.1    Chalon, S.2    Guilloteau, D.3    Besnard, J.C.4    Durand, G.5
  • 28
    • 0026527616 scopus 로고
    • Age-related variations in relative abundance fo alternative spliced D2 receptor mRNAs in brain areas of two rat strains
    • Della Vedova F., Fumagalli F., Sacchetti G., Racagni G., and Brunello N. Age-related variations in relative abundance fo alternative spliced D2 receptor mRNAs in brain areas of two rat strains. Mol. Brain Res. 12 (1992) 357-359
    • (1992) Mol. Brain Res. , vol.12 , pp. 357-359
    • Della Vedova, F.1    Fumagalli, F.2    Sacchetti, G.3    Racagni, G.4    Brunello, N.5
  • 29
    • 0025690113 scopus 로고
    • Age-related decrease in muscarinic cholinergic receptor binding in the human brain measured with positron emission tomography (PET)
    • Dewey S.L., Vilkow N.D., Logan J., McGregor R.R., Fowler J.S., Schyler D.J., and Bendriem B. Age-related decrease in muscarinic cholinergic receptor binding in the human brain measured with positron emission tomography (PET). J. Neurosci. Res. 27 (1990) 569-575
    • (1990) J. Neurosci. Res. , vol.27 , pp. 569-575
    • Dewey, S.L.1    Vilkow, N.D.2    Logan, J.3    McGregor, R.R.4    Fowler, J.S.5    Schyler, D.J.6    Bendriem, B.7
  • 30
    • 0030568969 scopus 로고    scopus 로고
    • Age-related changes in monoamines within the olfactory bulbs of the Fischer 344 male rat
    • Dluzen D.E. Age-related changes in monoamines within the olfactory bulbs of the Fischer 344 male rat. Mech. Aging Dev. 91 (1996) 37-45
    • (1996) Mech. Aging Dev. , vol.91 , pp. 37-45
    • Dluzen, D.E.1
  • 31
    • 0031031026 scopus 로고    scopus 로고
    • Serotonergic function of aging hippocampal CA3 phyramidal neurons: Electrophysiological assessment following adminsitration of 5,7-dihydroxytryptamine in the fimbria-fornix and cingulum bundle
    • Dugar A., and Lakoski J.M. Serotonergic function of aging hippocampal CA3 phyramidal neurons: Electrophysiological assessment following adminsitration of 5,7-dihydroxytryptamine in the fimbria-fornix and cingulum bundle. J. Neurosci. Res. 47 (1997) 58-67
    • (1997) J. Neurosci. Res. , vol.47 , pp. 58-67
    • Dugar, A.1    Lakoski, J.M.2
  • 33
    • 0029937457 scopus 로고    scopus 로고
    • The advantage of using positron emission tomography in drug research
    • Farde L. The advantage of using positron emission tomography in drug research. TINS 19 (1996) 211-214
    • (1996) TINS , vol.19 , pp. 211-214
    • Farde, L.1
  • 35
    • 0026587129 scopus 로고
    • Hypersensitivity to scopalamine in the elderly
    • Flicker C., Ferris S.H., and Serby M. Hypersensitivity to scopalamine in the elderly. Psychopharmacol. 107 (1992) 437-441
    • (1992) Psychopharmacol. , vol.107 , pp. 437-441
    • Flicker, C.1    Ferris, S.H.2    Serby, M.3
  • 37
    • 0029978498 scopus 로고    scopus 로고
    • Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in brain
    • Forster M.J., Dubey A., Dawson K., Stutts W.A., Lai H., and Sohal R.S. Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in brain. Proc. Natl. Acad. Sci. USA 93 (1996) 4765-4769
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4765-4769
    • Forster, M.J.1    Dubey, A.2    Dawson, K.3    Stutts, W.A.4    Lai, H.5    Sohal, R.S.6
  • 39
    • 0024500148 scopus 로고
    • Effect of age on brain cortical protein kinase C and its mediation of 5-hydroxytryptamine release
    • Friedman E., and Wang H. Effect of age on brain cortical protein kinase C and its mediation of 5-hydroxytryptamine release. J. Neurochem. 52 (1989) 187-192
    • (1989) J. Neurochem. , vol.52 , pp. 187-192
    • Friedman, E.1    Wang, H.2
  • 40
    • 0030068094 scopus 로고    scopus 로고
    • Activation of K+ channels and suppresison of neuronal activity by secreted β-amyloid precursor protein
    • Furukawa K., Barger S.W., Blalock E.M., and Mattson M.P. Activation of K+ channels and suppresison of neuronal activity by secreted β-amyloid precursor protein. Nature 379 (1996) 74-78
    • (1996) Nature , vol.379 , pp. 74-78
    • Furukawa, K.1    Barger, S.W.2    Blalock, E.M.3    Mattson, M.P.4
  • 41
    • 0030592835 scopus 로고    scopus 로고
    • Effect of phosphatidylserine on the binding properties of glutamate receptors in brain sections from adult and neonatal rats
    • Gagne J., Giguere C., Tocco G., Ohayon M., Thompson R.F., Baudry M., and Massicotte G. Effect of phosphatidylserine on the binding properties of glutamate receptors in brain sections from adult and neonatal rats. Brain Res. 740 (1996) 337-345
    • (1996) Brain Res. , vol.740 , pp. 337-345
    • Gagne, J.1    Giguere, C.2    Tocco, G.3    Ohayon, M.4    Thompson, R.F.5    Baudry, M.6    Massicotte, G.7
  • 42
    • 0029991039 scopus 로고    scopus 로고
    • Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys
    • Gazzaley A.H., Siegel S.J., Kordower J.H., Mufson E.J., and Morrison J.H. Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys. Proc. Natl. Acad. Sci. USA 93 (1996) 3121-3125
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3121-3125
    • Gazzaley, A.H.1    Siegel, S.J.2    Kordower, J.H.3    Mufson, E.J.4    Morrison, J.H.5
  • 43
    • 0026541217 scopus 로고
    • Chronic treatment with phosphotidylserine restores muscarinic cholinergic receptor deficits in the aged mouse brain
    • Gelbmann CM., and Muller W.E. Chronic treatment with phosphotidylserine restores muscarinic cholinergic receptor deficits in the aged mouse brain. Neurobiol. Aging 13 (1991) 45-50
    • (1991) Neurobiol. Aging , vol.13 , pp. 45-50
    • Gelbmann, CM.1    Muller, W.E.2
  • 44
    • 0025098839 scopus 로고
    • Specific decrease of high-affinity agonist states of alphaj-adrenoreceptors in the aging mouse brain
    • Gelbmann CM., and Muller W.E. Specific decrease of high-affinity agonist states of alphaj-adrenoreceptors in the aging mouse brain. J. Neural Transm. 79 (1990) 131-136
    • (1990) J. Neural Transm. , vol.79 , pp. 131-136
    • Gelbmann, CM.1    Muller, W.E.2
  • 45
    • 0027432007 scopus 로고
    • Iron/ascorbate-inducedlipidperoxidation changes membrane fluidity and muscarinic cholinergic receptor binding in rat frontal cortex
    • Ghosh C., Dick M.R., and Ali S.F. Iron/ascorbate-inducedlipidperoxidation changes membrane fluidity and muscarinic cholinergic receptor binding in rat frontal cortex. Neurochem. Int. 23 (1993) 479-484
    • (1993) Neurochem. Int. , vol.23 , pp. 479-484
    • Ghosh, C.1    Dick, M.R.2    Ali, S.F.3
  • 46
    • 0025226169 scopus 로고
    • Aging and stress-induced changes in choline and glutamte uptake in hippocampus and septum of two rat strains differing in longevity and reactivity to stressors
    • Gilad G.M., Gilad V.H., and Tizabi Y. Aging and stress-induced changes in choline and glutamte uptake in hippocampus and septum of two rat strains differing in longevity and reactivity to stressors. Int. J. Dev. Neurosci. 8 (1990) 709-713
    • (1990) Int. J. Dev. Neurosci. , vol.8 , pp. 709-713
    • Gilad, G.M.1    Gilad, V.H.2    Tizabi, Y.3
  • 47
    • 0026567130 scopus 로고
    • Age-related changes in the turnover rates of Dl-dopamine receptors in the retina and in distinct areas of the rat brain
    • Giorgi O., Pibiri M.G., Dal Toso R., and Ragatzu G. Age-related changes in the turnover rates of Dl-dopamine receptors in the retina and in distinct areas of the rat brain. Brain Res. 569 (1992) 323-329
    • (1992) Brain Res. , vol.569 , pp. 323-329
    • Giorgi, O.1    Pibiri, M.G.2    Dal Toso, R.3    Ragatzu, G.4
  • 49
    • 0030294835 scopus 로고    scopus 로고
    • Decline in striatal dopamine Dl and D2 receptor activation in aged F344 rats
    • Gould T.J., Stromberg I., and Bickford P.C. Decline in striatal dopamine Dl and D2 receptor activation in aged F344 rats. Neurobiol. Aging 17 (1996) 877-883
    • (1996) Neurobiol. Aging , vol.17 , pp. 877-883
    • Gould, T.J.1    Stromberg, I.2    Bickford, P.C.3
  • 51
    • 0024398368 scopus 로고
    • Implications of altered drug disposition in the elderly: studies of benzodiazepines
    • Greenblatt D.J., Shader R.I., and Harmatz J.S. Implications of altered drug disposition in the elderly: studies of benzodiazepines. J. Clin. Pharmacol. 29 (1989) 866-872
    • (1989) J. Clin. Pharmacol. , vol.29 , pp. 866-872
    • Greenblatt, D.J.1    Shader, R.I.2    Harmatz, J.S.3
  • 52
    • 0028981972 scopus 로고
    • Phosphoinositidehydrolysis,G_q,phospholipase C., and protein kinase C in postmortem human brain: Effects of postmortem interval, subject age, and Alzheimer's disease
    • Greenwood A.F., Powers RE., and Jope R.S. Phosphoinositidehydrolysis,G_q,phospholipase C., and protein kinase C in postmortem human brain: Effects of postmortem interval, subject age, and Alzheimer's disease. Neuroscience. 69 (1995) 125-138
    • (1995) Neuroscience. , vol.69 , pp. 125-138
    • Greenwood, A.F.1    Powers, RE.2    Jope, R.S.3
  • 53
    • 0028173032 scopus 로고
    • Age-related decrease in GABAA receptor subunits and glutamic acid decarboxylase in the rat inferior colliculus
    • Gutierrez A., Khan Z.U., Morris S.J., and De Bias A.L. Age-related decrease in GABAA receptor subunits and glutamic acid decarboxylase in the rat inferior colliculus. J. Neurosci. 14 (1994) 7469-7477
    • (1994) J. Neurosci. , vol.14 , pp. 7469-7477
    • Gutierrez, A.1    Khan, Z.U.2    Morris, S.J.3    De Bias, A.L.4
  • 54
    • 0024414943 scopus 로고
    • Effect of Aging on concentrations of D2 -receptor-containing neurons in rat striatum
    • Han Z., Kuyatt B.L., Kochman K.A., DeSouza E.B., and Roth G.S. Effect of Aging on concentrations of D2 -receptor-containing neurons in rat striatum. Brain Res. 498 (1989) 299-307
    • (1989) Brain Res. , vol.498 , pp. 299-307
    • Han, Z.1    Kuyatt, B.L.2    Kochman, K.A.3    DeSouza, E.B.4    Roth, G.S.5
  • 55
    • 0027279565 scopus 로고
    • Age-related changes in receptor-mediated and depolarization-induced phosphatidylinositol turnover in mouse brain
    • Hartmann H., and Muller W.E. Age-related changes in receptor-mediated and depolarization-induced phosphatidylinositol turnover in mouse brain. Brain Res. 622 (1993) 86-92
    • (1993) Brain Res. , vol.622 , pp. 86-92
    • Hartmann, H.1    Muller, W.E.2
  • 56
    • 0028169494 scopus 로고
    • Alteration of tubulin-G protein interaction in rat cerebral cortex with aging
    • Hatta S., Ozawa H., Saito T., and Ohshika H. Alteration of tubulin-G protein interaction in rat cerebral cortex with aging. J. Neurochem. 63 (1994) 1104-1110
    • (1994) J. Neurochem. , vol.63 , pp. 1104-1110
    • Hatta, S.1    Ozawa, H.2    Saito, T.3    Ohshika, H.4
  • 57
    • 0029935694 scopus 로고    scopus 로고
    • Increasing age alters transbilayer fluidity and cholesterol asymetry in synaptic plasma membranes of mice
    • Igbavboa U., Avdulov N.A., Schroeder F., and Wood W.G. Increasing age alters transbilayer fluidity and cholesterol asymetry in synaptic plasma membranes of mice. J. Neurochem. 66 (1996) 1717-1725
    • (1996) J. Neurochem. , vol.66 , pp. 1717-1725
    • Igbavboa, U.1    Avdulov, N.A.2    Schroeder, F.3    Wood, W.G.4
  • 58
    • 0026637589 scopus 로고
    • Reduced density of NMDA receptors and increased sensitivity to dizocilpine-induced learning impairment in aged rats
    • Ingram D.K., Garofalo P., Spangler E.L., Mantione C.R., Odano I., and London ED. Reduced density of NMDA receptors and increased sensitivity to dizocilpine-induced learning impairment in aged rats. Brain Res. 580 (1992) 273-280
    • (1992) Brain Res. , vol.580 , pp. 273-280
    • Ingram, D.K.1    Garofalo, P.2    Spangler, E.L.3    Mantione, C.R.4    Odano, I.5    London, ED.6
  • 59
    • 0010457037 scopus 로고    scopus 로고
    • Evaluating the glutamate hypothesis of geriatric memory impairment: focus on hippocampal NMDA receptors
    • Ingram D.K., Shimada A., Mukhin A., and London E.D. Evaluating the glutamate hypothesis of geriatric memory impairment: focus on hippocampal NMDA receptors. Perspectives in Brain Aging 1 (1996) 30-35
    • (1996) Perspectives in Brain Aging , vol.1 , pp. 30-35
    • Ingram, D.K.1    Shimada, A.2    Mukhin, A.3    London, E.D.4
  • 60
    • 0027447488 scopus 로고
    • The detection of age-related decrease of dopamine D1, D2 and serotonin 5-HT2 receptors in living human brain
    • Iyo M., and Yamasaki T. The detection of age-related decrease of dopamine D1, D2 and serotonin 5-HT2 receptors in living human brain. Prog, Neuropsychopharmacol. Biol. Psychiatr. 17 (1993) 415-421
    • (1993) Prog, Neuropsychopharmacol. Biol. Psychiatr. , vol.17 , pp. 415-421
    • Iyo, M.1    Yamasaki, T.2
  • 62
    • 0031051353 scopus 로고    scopus 로고
    • Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain
    • Jope R.S., Song L., and Powers R.E. Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain. Neurobiol. Aging 18 (1997) 111-120
    • (1997) Neurobiol. Aging , vol.18 , pp. 111-120
    • Jope, R.S.1    Song, L.2    Powers, R.E.3
  • 63
    • 0023897554 scopus 로고
    • Age-related decrements in the muscarinic enhancement of K+ - evoked release of endogenous striatal dopamine: an indication of altered cholinergic-dopaminergic reciporcal inhibitory control in senescence
    • Joseph J.A., Dalton T.K., and Hunt W.A. Age-related decrements in the muscarinic enhancement of K+ - evoked release of endogenous striatal dopamine: an indication of altered cholinergic-dopaminergic reciporcal inhibitory control in senescence. Brain Res. 454 (1988) 140-148
    • (1988) Brain Res. , vol.454 , pp. 140-148
    • Joseph, J.A.1    Dalton, T.K.2    Hunt, W.A.3
  • 64
    • 0023895221 scopus 로고
    • Alterations in muscarinic control of striatal dopamine autoreceptors in senescence: a deficit at the ligand -muscarinic receptor interface
    • Joseph J.A., Dalton T.K., Roth G.S., and Hunt W.A. Alterations in muscarinic control of striatal dopamine autoreceptors in senescence: a deficit at the ligand -muscarinic receptor interface. Brain Res. 454 (1988) 149-155
    • (1988) Brain Res. , vol.454 , pp. 149-155
    • Joseph, J.A.1    Dalton, T.K.2    Roth, G.S.3    Hunt, W.A.4
  • 65
    • 0000166021 scopus 로고
    • The striatum, a microcosm for the examination of age-related alterations in the CNS: a selected review
    • Joseph J.A., Roth G.S., and Strong R. The striatum, a microcosm for the examination of age-related alterations in the CNS: a selected review. Rev. Biol. Res. Aging 4 (1990) 181-199
    • (1990) Rev. Biol. Res. Aging , vol.4 , pp. 181-199
    • Joseph, J.A.1    Roth, G.S.2    Strong, R.3
  • 66
    • 0029762697 scopus 로고    scopus 로고
    • Increased sensitivity to oxidative stress and the loss of muscarinic receptor responsiveness in senescence
    • Joseph J.A., Villalobos-Molina R., Denisova N., Erat S., Jimenez N., and Strain J. Increased sensitivity to oxidative stress and the loss of muscarinic receptor responsiveness in senescence. Ann. N. Y. Acad. Sci. 786 (1996) 112-119
    • (1996) Ann. N. Y. Acad. Sci. , vol.786 , pp. 112-119
    • Joseph, J.A.1    Villalobos-Molina, R.2    Denisova, N.3    Erat, S.4    Jimenez, N.5    Strain, J.6
  • 67
    • 0029087761 scopus 로고
    • In vivo assessment of striatal dopamine release in the aged male Fischer 344 rat
    • Kametani H., Iijima S., Spangler E.L., Ingram D.K., and Joseph J.A. In vivo assessment of striatal dopamine release in the aged male Fischer 344 rat. Neurobiol. Aging 16 (1995) 639-646
    • (1995) Neurobiol. Aging , vol.16 , pp. 639-646
    • Kametani, H.1    Iijima, S.2    Spangler, E.L.3    Ingram, D.K.4    Joseph, J.A.5
  • 69
    • 0029002870 scopus 로고
    • Dissociation of striatal GTPase and dopamine release responses to muscarinic cholinergic agonists in F344 rats: influence of age and dietary manipulation
    • Kelly J.F., Joseph J.A., Denisova N.A., Erat S., Mason R.P., and Roth G.S. Dissociation of striatal GTPase and dopamine release responses to muscarinic cholinergic agonists in F344 rats: influence of age and dietary manipulation. J. Neurochem. 64 (1995) 2755-2764
    • (1995) J. Neurochem. , vol.64 , pp. 2755-2764
    • Kelly, J.F.1    Joseph, J.A.2    Denisova, N.A.3    Erat, S.4    Mason, R.P.5    Roth, G.S.6
  • 70
    • 0029093012 scopus 로고
    • Age-related impairment in striatal membrane muscarinic cholinergic signal transduction is associated with reduced membrane bilayer width measured by small angle X-ray diffraction
    • Kelly J.F., Mason R.P., Denisova N.A., Joseph J.A., Erat S., and Roth G.S. Age-related impairment in striatal membrane muscarinic cholinergic signal transduction is associated with reduced membrane bilayer width measured by small angle X-ray diffraction. BBRC. 213 (1995) 869-874
    • (1995) BBRC. , vol.213 , pp. 869-874
    • Kelly, J.F.1    Mason, R.P.2    Denisova, N.A.3    Joseph, J.A.4    Erat, S.5    Roth, G.S.6
  • 71
    • 0026569594 scopus 로고
    • Aging produces a specific pattern of striatal dopamine loss: implications for the etiology of idiopathic Parkinson's disease
    • Kish S.J., Shannak K., Rajput A., Deck J.H.N., and Hornykiewicz O. Aging produces a specific pattern of striatal dopamine loss: implications for the etiology of idiopathic Parkinson's disease. J. Neurochem. 58 (1992) 642-648
    • (1992) J. Neurochem. , vol.58 , pp. 642-648
    • Kish, S.J.1    Shannak, K.2    Rajput, A.3    Deck, J.H.N.4    Hornykiewicz, O.5
  • 72
    • 0026642356 scopus 로고
    • Decreased carbachol-stimulated inositol 1,3,4,5-tetrakisphosphate formation in senescent rat cerebral cortical slices
    • Kurian P., Narang N., and Crews F.T. Decreased carbachol-stimulated inositol 1,3,4,5-tetrakisphosphate formation in senescent rat cerebral cortical slices. Neurobiol. Aging 13 (1992) 521-525
    • (1992) Neurobiol. Aging , vol.13 , pp. 521-525
    • Kurian, P.1    Narang, N.2    Crews, F.T.3
  • 74
    • 0028973318 scopus 로고
    • Regional alterations in ml muscarinic receptor-G protein coupling in Alzheimer's disease
    • Ladner C.J., Celesia G.G., Magnuson D.J., and Lee J.M. Regional alterations in ml muscarinic receptor-G protein coupling in Alzheimer's disease. J. Neuropat. Exp. Neurol. 54 (1995) 783-789
    • (1995) J. Neuropat. Exp. Neurol. , vol.54 , pp. 783-789
    • Ladner, C.J.1    Celesia, G.G.2    Magnuson, D.J.3    Lee, J.M.4
  • 75
    • 0030593431 scopus 로고    scopus 로고
    • Lonotropic glutamate receptor subtypes in the aged memory-impaired and unimpaired Long-Evans rat
    • Le Jeune H., Cecyre D., Rowe W., Meaney M.J., and Quirion R. Lonotropic glutamate receptor subtypes in the aged memory-impaired and unimpaired Long-Evans rat. Neurosci 74 (1996) 349-363
    • (1996) Neurosci , vol.74 , pp. 349-363
    • Le Jeune, H.1    Cecyre, D.2    Rowe, W.3    Meaney, M.J.4    Quirion, R.5
  • 76
    • 0026002726 scopus 로고
    • Age-related differences in the effects of some muscarinic agents on acetylcholine release from rat neostriatal slices
    • Lee H., Cozzi N.V., and Weiler M.H. Age-related differences in the effects of some muscarinic agents on acetylcholine release from rat neostriatal slices. J. Pharmacol. Exp. Ther. 258 (1991) 496-501
    • (1991) J. Pharmacol. Exp. Ther. , vol.258 , pp. 496-501
    • Lee, H.1    Cozzi, N.V.2    Weiler, M.H.3
  • 77
    • 0030071040 scopus 로고    scopus 로고
    • Effects of Postmortem interval, age, and Alzheimer's Disease on G proteins in human brain
    • Li X., Greenwood A.F., Powers R., and Jope R.S. Effects of Postmortem interval, age, and Alzheimer's Disease on G proteins in human brain. Neurobiol. Aging 17 (1996) 115-122
    • (1996) Neurobiol. Aging , vol.17 , pp. 115-122
    • Li, X.1    Greenwood, A.F.2    Powers, R.3    Jope, R.S.4
  • 78
    • 0027478347 scopus 로고
    • Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the (3-amyloid precursor protein
    • Mattson M.P., Cheng B., Culwell A.R., Esch F.S., Liebergurg I., and Rydel R.E. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the (3-amyloid precursor protein. Neuron 10 (1993) 243-254
    • (1993) Neuron , vol.10 , pp. 243-254
    • Mattson, M.P.1    Cheng, B.2    Culwell, A.R.3    Esch, F.S.4    Liebergurg, I.5    Rydel, R.E.6
  • 79
  • 81
    • 0028212950 scopus 로고
    • Effects of peroxidation and aging on rat neocortical ACh-release and protein kinase C
    • Meyer E.M., Judkins J.H., Momol A.E., and Hardwick E.O. Effects of peroxidation and aging on rat neocortical ACh-release and protein kinase C. Neurobiol. Aging 15 (1994) 63-67
    • (1994) Neurobiol. Aging , vol.15 , pp. 63-67
    • Meyer, E.M.1    Judkins, J.H.2    Momol, A.E.3    Hardwick, E.O.4
  • 82
    • 0024333162 scopus 로고
    • Age-related differences in brain choline acetyltransferase, chlinesterases and muscarinic receptor sties in two strains of rats
    • Michalek H., Fortuna S., and Pinter A. Age-related differences in brain choline acetyltransferase, chlinesterases and muscarinic receptor sties in two strains of rats. Neurobiol. Aging 10 (1989) 143-148
    • (1989) Neurobiol. Aging , vol.10 , pp. 143-148
    • Michalek, H.1    Fortuna, S.2    Pinter, A.3
  • 83
    • 0025374970 scopus 로고
    • Membrane viscosity correlates with α-adrenergic signal transduction of the aged rat cerebral cortex
    • Miyamoto A., Aaraiso T., Koyama T., and Ohshika H. Membrane viscosity correlates with α-adrenergic signal transduction of the aged rat cerebral cortex. J. Neurochem. 55 (1990) 70-75
    • (1990) J. Neurochem. , vol.55 , pp. 70-75
    • Miyamoto, A.1    Aaraiso, T.2    Koyama, T.3    Ohshika, H.4
  • 84
    • 0027213514 scopus 로고
    • Age-dependent accumulation of phosphatidylcholine hydroperoxide in the brain and liver of the rat
    • Miyazawa T., Suzuki T., and Fujimoto K. Age-dependent accumulation of phosphatidylcholine hydroperoxide in the brain and liver of the rat. Lipids 28 (1993) 789-793
    • (1993) Lipids , vol.28 , pp. 789-793
    • Miyazawa, T.1    Suzuki, T.2    Fujimoto, K.3
  • 86
    • 0029830125 scopus 로고    scopus 로고
    • Potassium, but not atropine-stimulated cortical acetylcholine efflux, is reduced in aged rats
    • Moore H., Stuckman S., Sarter M., and Bruno J.P. Potassium, but not atropine-stimulated cortical acetylcholine efflux, is reduced in aged rats. Neurobiol. Aging 17 (1996) 565-571
    • (1996) Neurobiol. Aging , vol.17 , pp. 565-571
    • Moore, H.1    Stuckman, S.2    Sarter, M.3    Bruno, J.P.4
  • 87
    • 0002835308 scopus 로고
    • Age-related changes in synaptic neurochemistry
    • Schneider E.L., and Rowe J.W. (Eds), Academic Press, Philadelphia
    • Morgan D.G., and May P.C. Age-related changes in synaptic neurochemistry. In: Schneider E.L., and Rowe J.W. (Eds). Handbook of the Biology of Aging (1990), Academic Press, Philadelphia 219-254
    • (1990) Handbook of the Biology of Aging , pp. 219-254
    • Morgan, D.G.1    May, P.C.2
  • 88
    • 0028109498 scopus 로고
    • Glutamatergic treatment strategies for age-related memory disorders
    • Muller W.E., Scheuer K., and Stoll S. Glutamatergic treatment strategies for age-related memory disorders. Life Sci. 55 (1994) 2147
    • (1994) Life Sci. , vol.55 , pp. 2147
    • Muller, W.E.1    Scheuer, K.2    Stoll, S.3
  • 89
    • 0028000170 scopus 로고
    • Changes in muscarinic cholinergic, PCP, GABAa, Dl and 5-HT2A receptor binding, but not in benzodiazepine receptor binding in the brains of aged rats
    • Nabeshima T., Yamada K., Hayashi T., Hasegawa T., Ishihara S., Kameyama T., Morimasa T., Kaneyuki T., and Shohmori T. Changes in muscarinic cholinergic, PCP, GABAa, Dl and 5-HT2A receptor binding, but not in benzodiazepine receptor binding in the brains of aged rats. Life Sci. 55 (1994) 1585-1593
    • (1994) Life Sci. , vol.55 , pp. 1585-1593
    • Nabeshima, T.1    Yamada, K.2    Hayashi, T.3    Hasegawa, T.4    Ishihara, S.5    Kameyama, T.6    Morimasa, T.7    Kaneyuki, T.8    Shohmori, T.9
  • 90
    • 0025371720 scopus 로고
    • Age-related alteration in excitatory amino acid neurotransmission in rat brain
    • Najlerahim A., Francis P.T., and Bowen D.M. Age-related alteration in excitatory amino acid neurotransmission in rat brain. Neurobiol. Aging 11 (1990) 155-158
    • (1990) Neurobiol. Aging , vol.11 , pp. 155-158
    • Najlerahim, A.1    Francis, P.T.2    Bowen, D.M.3
  • 91
    • 0028988430 scopus 로고
    • In situ determination of m1 and m2 muscarinic receptor binding sites and mRNA's in young and old rat brains
    • Narang N. In situ determination of m1 and m2 muscarinic receptor binding sites and mRNA's in young and old rat brains. Mech. Aging Dev. 78 (1995) 221-239
    • (1995) Mech. Aging Dev. , vol.78 , pp. 221-239
    • Narang, N.1
  • 92
    • 0028860268 scopus 로고
    • Heterotrimeric G proteins, organizers of transmembrane signals
    • Neer E.J. Heterotrimeric G proteins, organizers of transmembrane signals. Cell 80 (1995) 249-257
    • (1995) Cell , vol.80 , pp. 249-257
    • Neer, E.J.1
  • 93
    • 0027936892 scopus 로고
    • Membrane organization in G protein mechanisms
    • Neubig R. Membrane organization in G protein mechanisms. FASEB J. 8 (1994) 939-946
    • (1994) FASEB J. , vol.8 , pp. 939-946
    • Neubig, R.1
  • 94
    • 0027268219 scopus 로고
    • Anticholinergic sensitivity in the aging rat septohippocampal system as assessed in a spacial memory task
    • Nilsson O.G., and Gage F.H. Anticholinergic sensitivity in the aging rat septohippocampal system as assessed in a spacial memory task. Neurobiol. Aging 14 (1993) 487-497
    • (1993) Neurobiol. Aging , vol.14 , pp. 487-497
    • Nilsson, O.G.1    Gage, F.H.2
  • 95
    • 0026476297 scopus 로고
    • Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors
    • Nitsch R.M., Slack B.E., Wurtman R.J., and Growdon J.H. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258 (1992) 304-310
    • (1992) Science , vol.258 , pp. 304-310
    • Nitsch, R.M.1    Slack, B.E.2    Wurtman, R.J.3    Growdon, J.H.4
  • 96
    • 0026501037 scopus 로고
    • Nicotinic and muscarinic subtypes in the human brain: changes with aging and dementia
    • Nordberg A., Alafuzoff I., and Winblad B. Nicotinic and muscarinic subtypes in the human brain: changes with aging and dementia. J. Neurosci. Res. 31 (1992) 103-111
    • (1992) J. Neurosci. Res. , vol.31 , pp. 103-111
    • Nordberg, A.1    Alafuzoff, I.2    Winblad, B.3
  • 97
    • 0027504619 scopus 로고
    • Disturbances in neurotransmission processes in aging and age-related diseases
    • Ossowska K. Disturbances in neurotransmission processes in aging and age-related diseases. Polish J. Pharmacol. 45 (1993) 109-131
    • (1993) Polish J. Pharmacol. , vol.45 , pp. 109-131
    • Ossowska, K.1
  • 98
    • 0028050468 scopus 로고
    • Age-related changes in expression of AMPA-selective glutamate receptor subunits: is calcium permeability altered in hippocampal neurons
    • Pagliusi S.R., Gerrard P., Abdallah M., Talabot D., and Catsicas S. Age-related changes in expression of AMPA-selective glutamate receptor subunits: is calcium permeability altered in hippocampal neurons. Neuroscience 61 (1994) 429-433
    • (1994) Neuroscience , vol.61 , pp. 429-433
    • Pagliusi, S.R.1    Gerrard, P.2    Abdallah, M.3    Talabot, D.4    Catsicas, S.5
  • 99
    • 0028315922 scopus 로고
    • The release and uptake of excitatory amino acids in rat brain: Effect of aging and oxidative stress
    • Palmer A.M., Robichaud P.J., and Reiter C.T. The release and uptake of excitatory amino acids in rat brain: Effect of aging and oxidative stress. Neurobiol. Aging 15 (1994) 103-111
    • (1994) Neurobiol. Aging , vol.15 , pp. 103-111
    • Palmer, A.M.1    Robichaud, P.J.2    Reiter, C.T.3
  • 100
    • 0028956472 scopus 로고
    • Increased production of inositol phosphates and diacylgylcerol in aged cognitively impaired rats after stimulation of muscarinic, metabotropic-glutamate and endothelin receptors
    • Parent A., Rowe W., Meany M.J., and Quiron R. Increased production of inositol phosphates and diacylgylcerol in aged cognitively impaired rats after stimulation of muscarinic, metabotropic-glutamate and endothelin receptors. J. Pharmacol. Exp. Ther. 272 (1995) 1110-1116
    • (1995) J. Pharmacol. Exp. Ther. , vol.272 , pp. 1110-1116
    • Parent, A.1    Rowe, W.2    Meany, M.J.3    Quiron, R.4
  • 101
    • 0029851919 scopus 로고    scopus 로고
    • Functional Impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex
    • Pascale A., Fortino I., Govoni S., Trabucchi M., Wetsel W.C., and Battaini F. Functional Impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex. J. Neurochem. 67 (1996) 2471-2477
    • (1996) J. Neurochem. , vol.67 , pp. 2471-2477
    • Pascale, A.1    Fortino, I.2    Govoni, S.3    Trabucchi, M.4    Wetsel, W.C.5    Battaini, F.6
  • 102
    • 0025989976 scopus 로고
    • Coupling of ml muscarinic receptors to G protein in Alzheimer's Disease
    • Pearce B.D., and Potter L.T. Coupling of ml muscarinic receptors to G protein in Alzheimer's Disease. Alzh. Dis. Assoc. Disord. 5 (1991) 163-172
    • (1991) Alzh. Dis. Assoc. Disord. , vol.5 , pp. 163-172
    • Pearce, B.D.1    Potter, L.T.2
  • 103
    • 0026337669 scopus 로고
    • Efficient experimental design in aging studies
    • Rogers J. Efficient experimental design in aging studies. Neurobiol. Aging 12 (1991) 695-697
    • (1991) Neurobiol. Aging , vol.12 , pp. 695-697
    • Rogers, J.1
  • 104
    • 0003136364 scopus 로고
    • Neurotransmitter metabolism and function in the aging central nervous system
    • Finch C.E., and Schneider E.L. (Eds), Van Nostrand Reinhold, New York
    • Rogers J., and Bloom F.E. Neurotransmitter metabolism and function in the aging central nervous system. In: Finch C.E., and Schneider E.L. (Eds). Handbook of the Biology of Aging (1985), Van Nostrand Reinhold, New York 645-691
    • (1985) Handbook of the Biology of Aging , pp. 645-691
    • Rogers, J.1    Bloom, F.E.2
  • 105
    • 0029045216 scopus 로고
    • Changes in tissue responsiveness to hormones and neurotransmitters during aging
    • Roth G.S. Changes in tissue responsiveness to hormones and neurotransmitters during aging. Exp. Gerontol. 30 (1995) 361-368
    • (1995) Exp. Gerontol. , vol.30 , pp. 361-368
    • Roth, G.S.1
  • 106
    • 0028916836 scopus 로고
    • Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging
    • Roth G.S., Joseph J.A., and Mason R.P. Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging. TINS 18 (1995) 203-206
    • (1995) TINS , vol.18 , pp. 203-206
    • Roth, G.S.1    Joseph, J.A.2    Mason, R.P.3
  • 107
    • 0030605075 scopus 로고    scopus 로고
    • Age-related modifications on the GABAA receptor binding properties from Wistar rat prefrontal cortex
    • Ruano D., Araujo F., Bentareha R., and Vitorica J. Age-related modifications on the GABAA receptor binding properties from Wistar rat prefrontal cortex. Brain Res. 738 (1996) 103-108
    • (1996) Brain Res. , vol.738 , pp. 103-108
    • Ruano, D.1    Araujo, F.2    Bentareha, R.3    Vitorica, J.4
  • 108
    • 0028813937 scopus 로고
    • Aging associated changes in the pharmacological properties of the benzodiazepine (w) receptor isotypes in the rat hippocampus.
    • Ruano D., Benavides J., Machado A., and Vitorica J. Aging associated changes in the pharmacological properties of the benzodiazepine (w) receptor isotypes in the rat hippocampus. J. Neurochem. 64 (1995) 867-873
    • (1995) J. Neurochem. , vol.64 , pp. 867-873
    • Ruano, D.1    Benavides, J.2    Machado, A.3    Vitorica, J.4
  • 110
    • 0028236453 scopus 로고
    • Density of alpha-2A adrenoreceptors and Gi proteins in the human brain: Ratio of high-affinity agonist sites to antagonist sites and effect of age
    • Sastre M., and Garcia-Sevilla J.A. Density of alpha-2A adrenoreceptors and Gi proteins in the human brain: Ratio of high-affinity agonist sites to antagonist sites and effect of age. J. Pharmacol. Exp. Ther. 269 (1994) 1062-1072
    • (1994) J. Pharmacol. Exp. Ther. , vol.269 , pp. 1062-1072
    • Sastre, M.1    Garcia-Sevilla, J.A.2
  • 111
    • 0026588734 scopus 로고
    • Superoxide radical formation and associated biochemical alterations in the plasma membrane of brain, heart, and liver during the lifetime of the rat
    • Sawada M., Sester U., and Carlson J.C. Superoxide radical formation and associated biochemical alterations in the plasma membrane of brain, heart, and liver during the lifetime of the rat. J. Cellular Biochem. 48 (1992) 296-304
    • (1992) J. Cellular Biochem. , vol.48 , pp. 296-304
    • Sawada, M.1    Sester, U.2    Carlson, J.C.3
  • 113
    • 0023837981 scopus 로고
    • Alpha- and beta-adrenergic receptor in the brain during senescence
    • Scarpace P.J., and Abrass I.B. Alpha- and beta-adrenergic receptor in the brain during senescence. Neurobiol. Aging 9 (1988) 53-58
    • (1988) Neurobiol. Aging , vol.9 , pp. 53-58
    • Scarpace, P.J.1    Abrass, I.B.2
  • 115
    • 0025200649 scopus 로고
    • Pre- and post-synaptic cholinergic dysfunction in aged rodent brain regions: new findings and an interpretative review
    • Sherman K.A., and Friedman E. Pre- and post-synaptic cholinergic dysfunction in aged rodent brain regions: new findings and an interpretative review. Int. J. Devel. Neurosci. 8 (1990) 689-708
    • (1990) Int. J. Devel. Neurosci. , vol.8 , pp. 689-708
    • Sherman, K.A.1    Friedman, E.2
  • 116
    • 0025924852 scopus 로고
    • 3H] dopamine uptake in rat striatum during aging
    • 3H] dopamine uptake in rat striatum during aging. J. Neurochem. 56 (1991) 575-579
    • (1991) J. Neurochem. , vol.56 , pp. 575-579
    • Shimizu, I.1    Prasad, C.2
  • 117
    • 0023262790 scopus 로고
    • Patterns of lipid changes in membranes of the aged brain
    • Shinitzky M. Patterns of lipid changes in membranes of the aged brain. Gerontology 33 (1987) 149-154
    • (1987) Gerontology , vol.33 , pp. 149-154
    • Shinitzky, M.1
  • 118
    • 0023575553 scopus 로고
    • Influence of age on neurotransmitter functions
    • Simpkins J.W., and Millard W.J. Influence of age on neurotransmitter functions. Endocr. Metab. Clin. 16 (1987) 893-917
    • (1987) Endocr. Metab. Clin. , vol.16 , pp. 893-917
    • Simpkins, J.W.1    Millard, W.J.2
  • 119
    • 0023620323 scopus 로고
    • Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem brain-a preliminary study in Alzheimer's Disease
    • Smith C.J., Perry E.K., Perry R.H., Fairburn A.F., and Birdsall N.J.M. Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem brain-a preliminary study in Alzheimer's Disease. Neurosci. Lett. 82 (1987) 227-232
    • (1987) Neurosci. Lett. , vol.82 , pp. 227-232
    • Smith, C.J.1    Perry, E.K.2    Perry, R.H.3    Fairburn, A.F.4    Birdsall, N.J.M.5
  • 121
    • 0027972717 scopus 로고
    • Aging diminishes serotonin-stimulated arachadonic acid uptake and cholinergic receptor-activated arachadonic acid release in rat brain cortex membrane
    • Strosznajder J., Samochocki M., and Duran M. Aging diminishes serotonin-stimulated arachadonic acid uptake and cholinergic receptor-activated arachadonic acid release in rat brain cortex membrane. J. Neurochem. 62 (1994) 1048-1054
    • (1994) J. Neurochem. , vol.62 , pp. 1048-1054
    • Strosznajder, J.1    Samochocki, M.2    Duran, M.3
  • 122
  • 123
    • 0030066875 scopus 로고    scopus 로고
    • Impaired synaptic function with aging as characterized by decreased calcium influx and acetylcholine release
    • Tanaka Y., Hasagawa A., and Ando S. Impaired synaptic function with aging as characterized by decreased calcium influx and acetylcholine release. J. Neurosci. Res. 43 (1996) 63-70
    • (1996) J. Neurosci. Res. , vol.43 , pp. 63-70
    • Tanaka, Y.1    Hasagawa, A.2    Ando, S.3
  • 124
    • 0027997011 scopus 로고
    • Effect of sex and age on brain monoamines and spatial learning in rats
    • Tanila H., Taira T., Pieponen T.P., and Honkanen A. Effect of sex and age on brain monoamines and spatial learning in rats. Neurobiol. Aging 15 (1994) 733-741
    • (1994) Neurobiol. Aging , vol.15 , pp. 733-741
    • Tanila, H.1    Taira, T.2    Pieponen, T.P.3    Honkanen, A.4
  • 125
    • 0029993133 scopus 로고    scopus 로고
    • Age-related decline in central cholinergic function demonstrated with scopolamine
    • Tariot P.N., Patel S.V., Cox C., and Henderson R.E. Age-related decline in central cholinergic function demonstrated with scopolamine. Psychopharmacology 125 (1996) 50-56
    • (1996) Psychopharmacology , vol.125 , pp. 50-56
    • Tariot, P.N.1    Patel, S.V.2    Cox, C.3    Henderson, R.E.4
  • 126
    • 0030446363 scopus 로고    scopus 로고
    • The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    • Tien J.Z., Huerta P.T., and Tonegawa S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87 (1996) 1327-1338
    • (1996) Cell , vol.87 , pp. 1327-1338
    • Tien, J.Z.1    Huerta, P.T.2    Tonegawa, S.3
  • 127
    • 0028173236 scopus 로고
    • GAB AB binding sites in early adult and aging rat brain
    • Turgeon S.M., and Albin R.L. GAB AB binding sites in early adult and aging rat brain. Neurobiol. Aging 15 (1994) 705-711
    • (1994) Neurobiol. Aging , vol.15 , pp. 705-711
    • Turgeon, S.M.1    Albin, R.L.2
  • 128
    • 0026750934 scopus 로고
    • Aging-induced decrease in dopaminergic-stimulated phosphoinositide metabolism in rat brain., Neurobiol
    • Undie A.S., and Freidman E. Aging-induced decrease in dopaminergic-stimulated phosphoinositide metabolism in rat brain., Neurobiol. Aging 13 (1992) 505-511
    • (1992) Aging , vol.13 , pp. 505-511
    • Undie, A.S.1    Freidman, E.2
  • 129
    • 0028981562 scopus 로고    scopus 로고
    • Decreased phospholipase C-β immunoreactivity, phosphoinositide metabolism, and protein kinase C activation in senescent F-344 rat brain
    • Undie A.S., Wang H., and Friedman E. Decreased phospholipase C-β immunoreactivity, phosphoinositide metabolism, and protein kinase C activation in senescent F-344 rat brain. Neurobiol. Aging 16 (1996) 19-28
    • (1996) Neurobiol. Aging , vol.16 , pp. 19-28
    • Undie, A.S.1    Wang, H.2    Friedman, E.3
  • 130
    • 0028173235 scopus 로고
    • Dopamine D2, D3 and D4 receptor mRNA levels in rat brain and pituitary during aging
    • Valerio A., Belloni M., Gorno M.L., Tinti C., Memo M., and Spano P. Dopamine D2, D3 and D4 receptor mRNA levels in rat brain and pituitary during aging. Neurobiol. Aging 15 (1994) 713-719
    • (1994) Neurobiol. Aging , vol.15 , pp. 713-719
    • Valerio, A.1    Belloni, M.2    Gorno, M.L.3    Tinti, C.4    Memo, M.5    Spano, P.6
  • 131
    • 0026343957 scopus 로고
    • Age-dependent decrease in the affinity of muscarinic Ml receptors in neocortex of rhesus monkeys
    • Vannucchi M.G., and Goldman-Rakic P.S. Age-dependent decrease in the affinity of muscarinic Ml receptors in neocortex of rhesus monkeys. Proc. Nat. Acad. Sci. USA 88 (1991) 11475-11479
    • (1991) Proc. Nat. Acad. Sci. USA , vol.88 , pp. 11475-11479
    • Vannucchi, M.G.1    Goldman-Rakic, P.S.2
  • 132
    • 0026728101 scopus 로고
    • OC-Adrenergic stimulation of low Km GTPase in rat striata is diminished with age
    • Villalobos-Molina R., Joseph J.A., and Roth G.S. OC-Adrenergic stimulation of low Km GTPase in rat striata is diminished with age. Brain Res. 590 (1992) 303-304
    • (1992) Brain Res. , vol.590 , pp. 303-304
    • Villalobos-Molina, R.1    Joseph, J.A.2    Roth, G.S.3
  • 134
    • 0028304198 scopus 로고
    • Receptor mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients
    • Wang H.Y., and Friedman E. Receptor mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients. Neurosci. Lett. 173 (1994) 37-39
    • (1994) Neurosci. Lett. , vol.173 , pp. 37-39
    • Wang, H.Y.1    Friedman, E.2
  • 135
    • 0029417327 scopus 로고
    • 1-like dopamine sites in rat striatum: Possible role in dopamine-mediated inositol phosphate formation
    • 1-like dopamine sites in rat striatum: Possible role in dopamine-mediated inositol phosphate formation. J. Pharmacol. Exp. Ther. 48 (1995) 988-994
    • (1995) J. Pharmacol. Exp. Ther. , vol.48 , pp. 988-994
    • Wang, H.1    Undie, A.S.2    Friedman, E.3
  • 136
    • 0027258552 scopus 로고
    • Coupling of muscarinic receptors to GTP proteins in postmortem human brain-alterations in Alzheimer's disease
    • Warpman U., Alafuzoff I., and Nordberg A. Coupling of muscarinic receptors to GTP proteins in postmortem human brain-alterations in Alzheimer's disease. Neurosci. Lett. 150 (1993) 39-43
    • (1993) Neurosci. Lett. , vol.150 , pp. 39-43
    • Warpman, U.1    Alafuzoff, I.2    Nordberg, A.3
  • 137
    • 0026030866 scopus 로고
    • Loss of NMDA, but not GABAA, binding in the brains of aged rats and monkeys
    • Wenk G.L., Walker L.C., Price D.L., and Cork L.C. Loss of NMDA, but not GABAA, binding in the brains of aged rats and monkeys. Neurobiol. Aging 12 (1991) 93-98
    • (1991) Neurobiol. Aging , vol.12 , pp. 93-98
    • Wenk, G.L.1    Walker, L.C.2    Price, D.L.3    Cork, L.C.4
  • 138
    • 0028122463 scopus 로고
    • Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
    • West M.J., Coleman P.D., Flood D.G., and Troncoso J.C. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344 (1994) 769-772
    • (1994) Lancet , vol.344 , pp. 769-772
    • West, M.J.1    Coleman, P.D.2    Flood, D.G.3    Troncoso, J.C.4
  • 140
    • 0026567176 scopus 로고
    • Muscarinic receptor concentrations and dopamine release in aged rat striatum
    • Yamagami K., Joseph J.A., and Roth G.S. Muscarinic receptor concentrations and dopamine release in aged rat striatum. Neurobiol. Aging 13 (1991) 51-56
    • (1991) Neurobiol. Aging , vol.13 , pp. 51-56
    • Yamagami, K.1    Joseph, J.A.2    Roth, G.S.3
  • 141
    • 0026524906 scopus 로고
    • Decrement of muscarinic receptor-stimulated low Km GTPase in striatum and hippocampus from aged rat
    • Yamagami K., Joseph J.A., and Roth G.S. Decrement of muscarinic receptor-stimulated low Km GTPase in striatum and hippocampus from aged rat. Brain Res. 576 (1992) 327-331
    • (1992) Brain Res. , vol.576 , pp. 327-331
    • Yamagami, K.1    Joseph, J.A.2    Roth, G.S.3
  • 142
    • 0026326890 scopus 로고
    • Effect of aging and diet restriction on monoamines and amino acids in cerebral cortex of Fischer-344 rats
    • Yeung J.M., and Freidman E. Effect of aging and diet restriction on monoamines and amino acids in cerebral cortex of Fischer-344 rats. Growth, Devel. Aging 55 (1991) 275-283
    • (1991) Growth, Devel. Aging , vol.55 , pp. 275-283
    • Yeung, J.M.1    Freidman, E.2
  • 145
    • 0025254609 scopus 로고
    • Influence of development and aging on nicotinic receptor subtypes in rodent brain
    • Zhang X., Wahlstrom G., and Nordberg A. Influence of development and aging on nicotinic receptor subtypes in rodent brain. Int. J. Devi. Neurosci. 8 (1990) 715-721
    • (1990) Int. J. Devi. Neurosci. , vol.8 , pp. 715-721
    • Zhang, X.1    Wahlstrom, G.2    Nordberg, A.3


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