메뉴 건너뛰기




Volumn 187, Issue 2, 1999, Pages 158-163

Somatic hypermutation and B-cell malignancies

Author keywords

B cells; Follicle centre; Immunoglobulin genes; Lymphoma; Somatic hypermutation

Indexed keywords

ANIMAL CELL; B CELL LYMPHOMA; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOMA; NONHODGKIN LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; REED STERNBERG CELL; REVIEW; SOMATIC MUTATION;

EID: 0032927459     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199901)187:2<158::AID-PATH226>3.0.CO;2-6     Document Type: Review
Times cited : (19)

References (54)
  • 1
    • 0026060620 scopus 로고
    • Intraclonal generation of antibody mutants in germinal centres
    • Jacob J, Kelsoe G, Rajewsky K, Weiss U. Intraclonal generation of antibody mutants in germinal centres. Nature 1991; 354: 389-392.
    • (1991) Nature , vol.354 , pp. 389-392
    • Jacob, J.1    Kelsoe, G.2    Rajewsky, K.3    Weiss, U.4
  • 2
    • 0027491651 scopus 로고
    • Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections
    • Kuppers R, Zhao M, Hansman ML, Rajewsky K. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J 1993; 12: 4955-4967.
    • (1993) EMBO J , vol.12 , pp. 4955-4967
    • Kuppers, R.1    Zhao, M.2    Hansman, M.L.3    Rajewsky, K.4
  • 3
    • 13144250122 scopus 로고    scopus 로고
    • Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2
    • Winter DB, Phung QH, Umar A, et al. Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2. Proc Natl Acad Sci USA 1998; 95: 6953-6958.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6953-6958
    • Winter, D.B.1    Phung, Q.H.2    Umar, A.3
  • 4
    • 0032101017 scopus 로고    scopus 로고
    • Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice
    • Jacobs H, Fukita Y, Van de Horst GTJ, et al. Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. J Exp Med 1998; 187: 1735-1743.
    • (1998) J Exp Med , vol.187 , pp. 1735-1743
    • Jacobs, H.1    Fukita, Y.2    Van De Horst, G.T.J.3
  • 5
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation initiation is linked to transcription initiation
    • Peters A, Storb U. Somatic hypermutation initiation is linked to transcription initiation. Immunity 1996; 4: 57-65.
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 6
    • 0029067875 scopus 로고
    • Targeting of non-Ig sequences in place of the V segment by somatic hypermutation
    • Yelamos J, Klix N, Goyenechea B, et al. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 1995; 376: 225-229.
    • (1995) Nature , vol.376 , pp. 225-229
    • Yelamos, J.1    Klix, N.2    Goyenechea, B.3
  • 7
    • 0029947265 scopus 로고    scopus 로고
    • Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells
    • Smith DS, Creadon G, Jena PK, et al. Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells. J Immunol 1996; 156: 2642-2652.
    • (1996) J Immunol , vol.156 , pp. 2642-2652
    • Smith, D.S.1    Creadon, G.2    Jena, P.K.3
  • 9
    • 0031569118 scopus 로고    scopus 로고
    • Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes
    • Dorner T, Brezinschek H-P. Brezinschek RI, Foster SJ, Domiati-Saad R, Lipsky PE. Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J Immunol 1997; 158: 2779-2789.
    • (1997) J Immunol , vol.158 , pp. 2779-2789
    • Dorner, T.1    Brezinschek, H.-P.2    Brezinschek, R.I.3    Foster, S.J.4    Domiati-Saad, R.5    Lipsky, P.E.6
  • 10
    • 0026443954 scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
    • Rogozin IB, Kolchanov NA. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim Biophys Acta 1992; 1171: 11-18.
    • (1992) Biochim Biophys Acta , vol.1171 , pp. 11-18
    • Rogozin, I.B.1    Kolchanov, N.A.2
  • 11
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity and specific hotspots
    • Betz AG, Rada C, Pannell R, Milstein C, Neuberger MS. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity and specific hotspots. Proc Natl Acad Sci USA 1993; 90: 2385-2388.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2385-2388
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 12
    • 0027227311 scopus 로고
    • Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
    • Betz AG, Neuberger MS, Milstein C. Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today 1993; 14: 405-411.
    • (1993) Immunol Today , vol.14 , pp. 405-411
    • Betz, A.G.1    Neuberger, M.S.2    Milstein, C.3
  • 14
    • 0027932998 scopus 로고
    • H genes are inherently susceptible to amino acid replacement
    • H genes are inherently susceptible to amino acid replacement. Immunol Today 1994; 15: 367-371.
    • (1994) Immunol Today , vol.15 , pp. 367-371
    • Chang, B.1    Casali, P.2
  • 15
    • 0031764112 scopus 로고    scopus 로고
    • Strong intrinsic biases towards mutation and conservation of bases in human IgVH genes during somatic hypermutation prevent statistical analysis of antigen selection
    • in press
    • Dunn-Walters DK, Spencer J. Strong intrinsic biases towards mutation and conservation of bases in human IgVH genes during somatic hypermutation prevent statistical analysis of antigen selection. Immunology 1998; in press.
    • (1998) Immunology
    • Dunn-Walters, D.K.1    Spencer, J.2
  • 16
    • 0031045684 scopus 로고    scopus 로고
    • H genes indicates that ileal lamina propria plasma cells are derived from Peyer's patches
    • H genes indicates that ileal lamina propria plasma cells are derived from Peyer's patches. Eur J Immunol 1997; 27: 463-467.
    • (1997) Eur J Immunol , vol.27 , pp. 463-467
    • Dunn-Walters, D.K.1    Isaacson, P.G.2    Spencer, J.3
  • 17
    • 0030661911 scopus 로고    scopus 로고
    • Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells
    • Dunn-Walters DK, Boursier L, Spencer J. Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells. Eur J Immunol 1997; 27: 2959-2964.
    • (1997) Eur J Immunol , vol.27 , pp. 2959-2964
    • Dunn-Walters, D.K.1    Boursier, L.2    Spencer, J.3
  • 20
    • 0028225791 scopus 로고
    • Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic hypermutation
    • Hummel M, Tamaru J, Kalvelage B, Stein H. Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic hypermutation. Blood 1994; 84: 403-407.
    • (1994) Blood , vol.84 , pp. 403-407
    • Hummel, M.1    Tamaru, J.2    Kalvelage, B.3    Stein, H.4
  • 21
    • 0026636759 scopus 로고
    • Clonal evolution of a follicular lymphoma; evidence for antigen selection
    • Bahler DW, Levy R. Clonal evolution of a follicular lymphoma; evidence for antigen selection. Proc Natl Acad Sci USA 1992; 89: 6770-6774.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6770-6774
    • Bahler, D.W.1    Levy, R.2
  • 23
    • 0006379753 scopus 로고    scopus 로고
    • Affinity maturation without germinal centres
    • Matsumoto M, Lo SF, Carruthers CJL, et al. Affinity maturation without germinal centres. Nature 1996; 382: 462-466.
    • (1996) Nature , vol.382 , pp. 462-466
    • Matsumoto, M.1    Lo, S.F.2    Carruthers, C.J.L.3
  • 24
    • 0029077309 scopus 로고
    • Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity
    • Vescio RA, Cao J, Hong CH, et al. Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity. J Immunol 1995; 155: 2487-2497.
    • (1995) J Immunol , vol.155 , pp. 2487-2497
    • Vescio, R.A.1    Cao, J.2    Hong, C.H.3
  • 25
    • 0032550340 scopus 로고    scopus 로고
    • The normal counterpart of IgD myeloma cells in germinal centre displays extensively mutated IgVH gene, Cmu-Cdelta switch and lambda light chain expression
    • Arpin C, de Bouteiller O, Razanajaona D, et al. The normal counterpart of IgD myeloma cells in germinal centre displays extensively mutated IgVH gene, Cmu-Cdelta switch and lambda light chain expression. J Exp Med 1998; 187: 1169-1178.
    • (1998) J Exp Med , vol.187 , pp. 1169-1178
    • Arpin, C.1    De Bouteiller, O.2    Razanajaona, D.3
  • 26
    • 0030176190 scopus 로고    scopus 로고
    • Normal human IgD+, IgM - Germinal centre B cells can express up to 80 mutations in the variable region of their IgD transcripts
    • Liu YJ, de Bouteiller O, Arpin C, et al. Normal human IgD+, IgM - germinal centre B cells can express up to 80 mutations in the variable region of their IgD transcripts. Immunity 1996; 4: 603-613.
    • (1996) Immunity , vol.4 , pp. 603-613
    • Liu, Y.J.1    De Bouteiller, O.2    Arpin, C.3
  • 27
    • 0023892588 scopus 로고
    • Memory B cells in T cell-dependent antibody responses colonise the splenic marginal zones
    • Liu Y-J, Oldfield S, Maclennan IC. Memory B cells in T cell-dependent antibody responses colonise the splenic marginal zones. Eur J Immunol 1988; 18: 355-362.
    • (1988) Eur J Immunol , vol.18 , pp. 355-362
    • Liu, Y.-J.1    Oldfield, S.2    Maclennan, I.C.3
  • 28
    • 0021845247 scopus 로고
    • Splenic dependence of the antibody response to thymus-independent (TI-2) antigens
    • Amlot PL, Grennan D, Humphrey JH. Splenic dependence of the antibody response to thymus-independent (TI-2) antigens. Eur J Immunol 1985; 15: 508-512.
    • (1985) Eur J Immunol , vol.15 , pp. 508-512
    • Amlot, P.L.1    Grennan, D.2    Humphrey, J.H.3
  • 29
    • 0029127069 scopus 로고
    • Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells
    • Dunn-Walters DK, Isaacson PG, Spencer J. Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells. J Exp Med 1995; 182: 559-566.
    • (1995) J Exp Med , vol.182 , pp. 559-566
    • Dunn-Walters, D.K.1    Isaacson, P.G.2    Spencer, J.3
  • 30
  • 31
    • 0030062645 scopus 로고    scopus 로고
    • Sequence analysis of immunoglobulin variable region genes which encode autoantibodies expressed by lymphomas of mucosa-associated lymphoid tissue
    • Chapman CJ, Dunn-Walters DK, Stevenson FK, Hussell T, Isaacson PG, Spencer J. Sequence analysis of immunoglobulin variable region genes which encode autoantibodies expressed by lymphomas of mucosa-associated lymphoid tissue. J Clin Pathol Clin Mol Pathol 1996; 49: 29-32.
    • (1996) J Clin Pathol Clin Mol Pathol , vol.49 , pp. 29-32
    • Chapman, C.J.1    Dunn-Walters, D.K.2    Stevenson, F.K.3    Hussell, T.4    Isaacson, P.G.5    Spencer, J.6
  • 32
    • 0028968889 scopus 로고
    • Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes
    • Zhu D, Hawkins RE, Hamblin TJ, Stevenson FK. Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes. Blood 1995; 85: 1603-1507.
    • (1995) Blood , vol.85 , pp. 1603-11507
    • Zhu, D.1    Hawkins, R.E.2    Hamblin, T.J.3    Stevenson, F.K.4
  • 33
    • 0030035101 scopus 로고    scopus 로고
    • Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion
    • Du M, Diss TC, Xu C, Peng H, Isaacson PG, Pan L. Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion. Leukaemia 1996; 10: 1190-1197.
    • (1996) Leukaemia , vol.10 , pp. 1190-1197
    • Du, M.1    Diss, T.C.2    Xu, C.3    Peng, H.4    Isaacson, P.G.5    Pan, L.6
  • 34
    • 0031777633 scopus 로고    scopus 로고
    • Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation
    • Dunn-Walters DK, Boursier L, Spencer J, Isaacson PG. Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation. Hum Pathol 1998; 29: 585-593.
    • (1998) Hum Pathol , vol.29 , pp. 585-593
    • Dunn-Walters, D.K.1    Boursier, L.2    Spencer, J.3    Isaacson, P.G.4
  • 35
    • 0032519558 scopus 로고    scopus 로고
    • De novo CD5+ diffuse large B cell lymphomas express VH genes with somatic mutation
    • Taniguchi M, Oka K, Haisa A, et al. De novo CD5+ diffuse large B cell lymphomas express VH genes with somatic mutation. Blood 1998; 91: 1145-1151.
    • (1998) Blood , vol.91 , pp. 1145-1151
    • Taniguchi, M.1    Oka, K.2    Haisa, A.3
  • 36
    • 0032081314 scopus 로고    scopus 로고
    • H genes in follicular and diffuse lymphoma shows ongoing somatic hypermutation and multiple isotype transcripts in early disease with changes during disease progression
    • H genes in follicular and diffuse lymphoma shows ongoing somatic hypermutation and multiple isotype transcripts in early disease with changes during disease progression. Blood 1998; 91: 4292-4299.
    • (1998) Blood , vol.91 , pp. 4292-4299
    • Ottensmeier, C.H.1    Thompsett, A.R.2    Zhu, D.3    Wilkins, B.S.4    Sweetenham, J.W.5    Stevenson, F.K.6
  • 37
    • 0030975517 scopus 로고    scopus 로고
    • Genetic evidence for a clonal link between low and high grade components in gastric MALT B-cell lymphoma
    • Peng H, Du M, Diss TC, Isaacson PG, Pan L. Genetic evidence for a clonal link between low and high grade components in gastric MALT B-cell lymphoma. Histopathology 1997; 30: 425-429.
    • (1997) Histopathology , vol.30 , pp. 425-429
    • Peng, H.1    Du, M.2    Diss, T.C.3    Isaacson, P.G.4    Pan, L.5
  • 38
    • 0031594345 scopus 로고    scopus 로고
    • Immunoglobulin VH genes of high grade mucosa-associated lymphoid tissue lymphomas show a high load of somatic mutations and evidence of antigen dependent affinity maturation
    • Hallas C, Greiner A, Peters K, Muller-Hermelink HK. Immunoglobulin VH genes of high grade mucosa-associated lymphoid tissue lymphomas show a high load of somatic mutations and evidence of antigen dependent affinity maturation. Lab Invest 1998; 78: 277-287.
    • (1998) Lab Invest , vol.78 , pp. 277-287
    • Hallas, C.1    Greiner, A.2    Peters, K.3    Muller-Hermelink, H.K.4
  • 39
    • 0028791756 scopus 로고
    • The accumulation of p53 abnormalities is associated with progression of mucosa-associated lymphoid tissue lymphoma
    • Du M, Peng H, Singh N, Isaacson PG, Pan L. The accumulation of p53 abnormalities is associated with progression of mucosa-associated lymphoid tissue lymphoma. Blood 1995; 86: 4587-4593.
    • (1995) Blood , vol.86 , pp. 4587-4593
    • Du, M.1    Peng, H.2    Singh, N.3    Isaacson, P.G.4    Pan, L.5
  • 40
    • 0028866548 scopus 로고
    • Burkitt's lymphomas express VH genes with a moderate number of antigen selected somatic mutations
    • Tamaru J, Hummel M, Marafioti T, et al. Burkitt's lymphomas express VH genes with a moderate number of antigen selected somatic mutations. Am J Pathol 1995; 147: 1398-1407.
    • (1995) Am J Pathol , vol.147 , pp. 1398-1407
    • Tamaru, J.1    Hummel, M.2    Marafioti, T.3
  • 41
    • 0028985744 scopus 로고
    • Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity
    • Chapman CJ, Mockridge CI, Rowe M, Rickinson AB, Stevenson FK. Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity. Blood 1995; 85: 2176-2181.
    • (1995) Blood , vol.85 , pp. 2176-2181
    • Chapman, C.J.1    Mockridge, C.I.2    Rowe, M.3    Rickinson, A.B.4    Stevenson, F.K.5
  • 42
    • 0029956170 scopus 로고    scopus 로고
    • Nodular lymphocyte-predominant Hodgkin's disease associated with large cell lymphoma: Analysis of Ig gene rearrangements by V J polymerase chain reaction
    • Greiner TC, Gascoyne RD, Anderson ME, et al. Nodular lymphocyte-predominant Hodgkin's disease associated with large cell lymphoma: analysis of Ig gene rearrangements by V J polymerase chain reaction. Blood 1996; 88: 657-666.
    • (1996) Blood , vol.88 , pp. 657-666
    • Greiner, T.C.1    Gascoyne, R.D.2    Anderson, M.E.3
  • 44
    • 0030791751 scopus 로고    scopus 로고
    • Origin of lymphocyte predominant Hodgkin's disease from a clonal expansion of highly mutated germinal centre B cells
    • Marafioti T, Hummel M, Anagnostopoulos I, et al. Origin of lymphocyte predominant Hodgkin's disease from a clonal expansion of highly mutated germinal centre B cells. N Engl J Med 1997; 337: 495-496.
    • (1997) N Engl J Med , vol.337 , pp. 495-496
    • Marafioti, T.1    Hummel, M.2    Anagnostopoulos, I.3
  • 45
    • 0030834265 scopus 로고    scopus 로고
    • Hodgkin and Reed Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal centre derived tumor B cells
    • Braeuninger A, Kuppers R, Stickler JG, Wacker H-H, Rajewsky K, Hansmann M-L. Hodgkin and Reed Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal centre derived tumor B cells. Proc Natl Acad Sci USA 1997; 94: 9337-9342.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9337-9342
    • Braeuninger, A.1    Kuppers, R.2    Stickler, J.G.3    Wacker, H.-H.4    Rajewsky, K.5    Hansmann, M.-L.6
  • 46
    • 0029952779 scopus 로고    scopus 로고
    • Hodgkin and Reed Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumour clone derived from (crippled) germinal centre B cells
    • Kanzler H, Kuppers R, Hansmann ML, Rajewsky K. Hodgkin and Reed Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumour clone derived from (crippled) germinal centre B cells. J Exp Med 1996; 184: 1495-1505.
    • (1996) J Exp Med , vol.184 , pp. 1495-1505
    • Kanzler, H.1    Kuppers, R.2    Hansmann, M.L.3    Rajewsky, K.4
  • 48
    • 0030962279 scopus 로고    scopus 로고
    • Frequent mutation of the 5′ non-coding region of the Bcl-6 gene in acquired immunodeficiency syndrome related non-Hodgkin's lymphomas
    • Gaidano G, Carbone A, Pastore C, et al. Frequent mutation of the 5′ non-coding region of the Bcl-6 gene in acquired immunodeficiency syndrome related non-Hodgkin's lymphomas. Blood 1997; 89: 3755-3762.
    • (1997) Blood , vol.89 , pp. 3755-3762
    • Gaidano, G.1    Carbone, A.2    Pastore, C.3
  • 49
    • 0029614378 scopus 로고
    • Frequent somatic hypermutation of the 5′ non-coding region of the BCL6 gene in B cell lymphoma
    • Migliazza A, Martinotti S, Chen W, et al. Frequent somatic hypermutation of the 5′ non-coding region of the BCL6 gene in B cell lymphoma. Proc Natl Acad Sci USA 1995; 92: 12 520-12 524.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12520-12524
    • Migliazza, A.1    Martinotti, S.2    Chen, W.3
  • 50
    • 2642623612 scopus 로고    scopus 로고
    • Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation
    • Shen HM, Peters A, Baron B, Zhu Z, Storb U. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation. Science 1998; 280: 1750-1752.
    • (1998) Science , vol.280 , pp. 1750-1752
    • Shen, H.M.1    Peters, A.2    Baron, B.3    Zhu, Z.4    Storb, U.5
  • 51
    • 0026551831 scopus 로고
    • Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas
    • Taneka S, Louie DC, Kant JA, Reed JC. Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. Blood 1992; 79: 229-237.
    • (1992) Blood , vol.79 , pp. 229-237
    • Taneka, S.1    Louie, D.C.2    Kant, J.A.3    Reed, J.C.4
  • 52
    • 0029804050 scopus 로고    scopus 로고
    • Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene
    • Matolcsy A, Casali P, Warnke RA. Knowles DM. Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene. Blood 1996; 88: 3937-3944.
    • (1996) Blood , vol.88 , pp. 3937-3944
    • Matolcsy, A.1    Casali, P.2    Warnke, R.A.3    Knowles, D.M.4
  • 53
    • 0027537880 scopus 로고
    • Detection of monoclonality in low-grade B cell lymphomas using the polymerase chain reaction is dependent on primer selection and lymphoma type
    • Diss TC, Peng H, Wotherspoon AC, Isaacson PG, Pan LX. Detection of monoclonality in low-grade B cell lymphomas using the polymerase chain reaction is dependent on primer selection and lymphoma type. J Pathol 1993; 169: 291-295.
    • (1993) J Pathol , vol.169 , pp. 291-295
    • Diss, T.C.1    Peng, H.2    Wotherspoon, A.C.3    Isaacson, P.G.4    Pan, L.X.5
  • 54
    • 0031571278 scopus 로고    scopus 로고
    • DNA vaccines against lymphoma. Promotion of anti-idiotypic antibody responses induced by single chain Fv genes by transfusion into tetanus toxoid fragment C
    • Spellerberg MB, Zhu D, Thompsett A, King CA, Hamblin TJ, Stevenson FK. DNA vaccines against lymphoma. Promotion of anti-idiotypic antibody responses induced by single chain Fv genes by transfusion into tetanus toxoid fragment C. J Immunol 1997; 159: 1885-1892.
    • (1997) J Immunol , vol.159 , pp. 1885-1892
    • Spellerberg, M.B.1    Zhu, D.2    Thompsett, A.3    King, C.A.4    Hamblin, T.J.5    Stevenson, F.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.