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Good review of delivery approaches, focusing on the osmostic method by a pioneer in the field.
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Rapoport SI: Modulation of blood-brain barrier permeability. J Drug Target (1996) 3:417-425. Good review of delivery approaches, focusing on the osmostic method by a pioneer in the field.
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Most comprehensive overview of data supporting the osmotic method by the researchers who have published the majority of work on this approach.
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Kroll RA, Neuwelt EA: Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery (1998) 42:1083-1100. Most comprehensive overview of data supporting the osmotic method by the researchers who have published the majority of work on this approach.
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Measurement of blood-brain barrier permeability with positron emission tomography and [Ga] EDTA
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Kessler R, Goble J, Bird J, Girton M, Doppman J, Rapoport S, Barranger J: Measurement of blood-brain barrier permeability with positron emission tomography and [Ga] EDTA. J Cereb Blood Flow Metab (1984) 4:323-332.
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Krall RA, Pagel MA, Muldoon LL, Roman-Goldstein S, Fiamengo SA, Neuwelt EA: Improving drug delivery to intracerebral tumor and surrounding brain in a rodent model: a comparison of osmotic versus bradykinin modification of the blood-brain and/or blood-tumor barriers. Neurosurgery (1998) 43:879-886.
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Seminal paper demonstrating that systemic bradykinin can increase permeability of the BBTB.
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Inamura T, Black KL: Bradykinin selectively opens bloodtumor barrier in experimental brain tumors. J Cereb Blood FlowMetab (1994) 14:862-870. Seminal paper demonstrating that systemic bradykinin can increase permeability of the BBTB.
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Black Kl, I.T.1
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Doctrow SR, Abelleira SM, Curry LA, Heller-Harrison R, Kozarich JW, Malfroy B, McCarroll LA, Morgan KG, Morrow AR, Musso GF: The bradykinin analog RMP-7 increases intracellular free calcium levels in rat brain microvascular endothelial cells. J Pharmacol Exp T/7er(1994) 271:229-237.
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First evidence that Cereport can increase permeability of brain tissue outside the tumor barrier. Also demonstrated dose response, with increasing doses producing increasingly greater permeabilty effects. Finally, demonstrated that these effects were mediated specifically through B, receptors.
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Bartus RT, Elliott PJ, Hayward NJ, Dean RL, McEwen E, Fisher SK: Permeability of the blood brain barrier by the bradykinin agonist, RMP-7: Evidence for a sensitive, autoregulated, receptor-mediated system. Immunopharmacology (1996) 33:270-278. First evidence that Cereport can increase permeability of brain tissue outside the tumor barrier. Also demonstrated dose response, with increasing doses producing increasingly greater permeabilty effects. Finally, demonstrated that these effects were mediated specifically through B, receptors.
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First paper to demonstrate in vivo efficacy of the novel bradykinin agonist, Cereport, using a rat glioma model. Increased permeability of the BBTB was demonstrated for a wide range of molecular weight compounds.
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Inamura T, Nomura T, Bartus RT, Black KL: Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors. J Neurosurg (1994) 81:752-758. First paper to demonstrate in vivo efficacy of the novel bradykinin agonist, Cereport, using a rat glioma model. Increased permeability of the BBTB was demonstrated for a wide range of molecular weight compounds.
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Matsukado K, Inamura T, Nakano S, Fukui M, Bartus RT, Black KL: Enhanced tumor uptake of carboplatin and survival in glioma-bearing rats by intracarotid infusion of bradykinin analog, RMP-7. Neurosurgery (1996) 39:125-134.
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Dean RL, Elliott PJ, Nagle T, Hayward N, Merchant R, Bartus R: RMP-7 increases uptake of caboplatin into rat gliomas: Comparison of three cell lines. In: American Association for Cancer Research, 20-24 April 1996, Washington, DC, USA. Abstract No 2063.
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Elliott PJ, Hayward NJ, Huff MR, Nagle TL, Black KL, Bartus RT: Unlocking the blood-brain barrier: A role for RMP-7 in brain tumor therapy. Exp Neural (1996) 141:214-224.
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Bartus RT, Elliott PJ, Dean RL, Hayward NJ, Nagle TL, Huff MR, Snodgrass PA, Blunt DG: Controlled modulation of BBS permeability using the bradykinin agonist, RMP-7. Exp Neural (1996) 142:14-28.
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Initial, clear evidence that iv administration of Cereport can reliably increase permeability of the BBTB. This occurred in a dose-related fashion. Similar, though lesser changes were also seen in areas outside the tumor boundary.
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Elliott PJ, Hayward NJ, Dean RL, Blunt DG, Bartus RT: Intravenous RMP-7 selectively increases uptake of carboplatin into rat brain tumors. Cancer Res (1996) 56:3998-4005. Initial, clear evidence that iv administration of Cereport can reliably increase permeability of the BBTB. This occurred in a dose-related fashion. Similar, though lesser changes were also seen in areas outside the tumor boundary.
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Quantitative electron microscopy study demonstrating that iv Cereport can increase permeability of non-tumor BBB. Additionally, it demonstrates that the physical mechanism of action is through opening tight junctions, producing an aqueous corridor for diffusion of water-soluble compounds from the blood to the brain. No evidence of changes in intraendothelial transport was observed.
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Sanovich E, Bartus RT, Friden PM, Dean RL, Le HQ, Brightman MW: Pathway across blood-brain barrier opened by the bradykinin agonist, RMP-7. Brain Res (1995) 705:125-135. Quantitative electron microscopy study demonstrating that iv Cereport can increase permeability of non-tumor BBB. Additionally, it demonstrates that the physical mechanism of action is through opening tight junctions, producing an aqueous corridor for diffusion of water-soluble compounds from the blood to the brain. No evidence of changes in intraendothelial transport was observed.
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Emerich D, Snodgrass P, Pink M, Bloom F, Bartus R: Central analgesic actions of loperamide following transient permeation of the blood brain barrier with Cereport (RMP7). Brain Res (1998) 801:259-266.
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Barth R, Yang W, Moeschberger M, Goodman J, Bartus R: Enhanced delivery of boronophenylalanine for neutron capture therapy of brain tumors using the bradykinin analogue, Cereport (RMP-7). Neurosurgery (1999) 44:351360.
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Black KL, Cloughesy T, Huang SC, Gobin YP, Zhou Y, Grous J, Nelson G, Farahani K, Höh CK, Phelps M: Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas. J Neurosurg (1997) 86:603-609. Initial evidence for increased permeability effects of Cereport in humans.
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