Permeability of the blood brain barrier by the bradykinin agonist, RMP-7: Evidence for a sensitive, auto-regulated, receptor-mediated system

Immunopharmacology

Volumn 33, Issue 1-3, 1996, Pages 270-278

  Bartus, R T ^a,b   Elliott, P ^a   Hayward, N ^a   Dean, R ^a   McEwen, E L ^c   Fisher, S K ^c  

^a ALKERMES INC   (United States)

^b TUFTS UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

B2 receptors; blood brain barrier; blood tumor barrier; bradykinin; desensitization; endothelial cells; permeability; tachyphylaxis; tight junctions

Indexed keywords

BRADYKININ; BRADYKININ B2 RECEPTOR; BRADYKININ B2 RECEPTOR AGONIST; BRADYKININ RECEPTOR AGONIST; BRADYKININ[1-8]; CALCIUM; CARBOPLATIN; DEXTRAN; ICATIBANT; LOBRADIMIL; PHOSPHATIDYLINOSITOL; RADIOISOTOPE;

ANIMAL MODEL; ANIMAL TISSUE; AUTOREGULATION; BLOOD BRAIN BARRIER; BRAIN TUMOR; CALCIUM TRANSPORT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG UPTAKE; GLIOMA; GUINEA PIG; ILEUM; INTRAVENOUS DRUG ADMINISTRATION; MEMBRANE PERMEABILITY; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT; TACHYPHYLAXIS;

EID: 0030175606     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/0162-3109(96)00070-7     Document Type: Conference Paper

References (18)

1. Berridge R, Downes CP and Hanley MR. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J 1982; 206: 587-595.
2. Betz, AL. An overview of the multiple functions of the bloodbrain barrier. In: Frankenheim, J. and Brown, R., eds., Bioavailability of Drugs to the Brain and the BBB, Vol. 120, Rockville. MD, 1992, pp. 54-72.
3. Brightman MW, Hori M, Rapoport SI, Reese TS, Westergaard E. Osmotic opening of tight junctions in cerebral endothelium. J Comp Neurol 1973; 152:317-325.
4. Doctrow SR, Abelleira SM, Curry LA, Heller-Harrison R, Kozarich JW, Malftroy B, McCarroll LA, Morgan KG, Morrow AR, Musso GF, Smart JL, Straub JA, Turnbull B, Gloff CA. The bradykinin analog RMP-7 increases intracellular free calcium levels in rat brain microvascular endothelial cells. J Phar Exp Ther 1994; 271: 229-237.
5. Elliott PJ, Mackie JB, Graney WF, Bartus RT, Zlokovic BV. RMP-7. a bradykinin agonist increases permeability of blood-ocular barrier in the guinea pig. J Invest Opth Vis Sci 1995 (in press).
6. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca+ 2 indicators with greatly improved fluoresence properties. J Biol Chem 1985; 260: 3440-3450
7. Honegger P and Richelson E. Biochemical differentiation of mechanically dissociated mammalian brain in aggregating cell culture. Brain Res 1976; 109: 335-354.
8. Inamura T, Black KL. Bradykinin selectively opens blood-tumor barrier in experimental brain tumors. J Cereb Blood Flow Metab 1994; 14: 862-870.
9. Inamura T, Nomura T, Bartus RT, et al. Intracarotid infusion of RMP-7. a bradykinin analog: A method tor selective drug delivery to brain tumors. J Neurosurg 1994; 81: 752-758.
10. Müller-Esterl W, Alla SA, Quitterer U, Grigoriev S, Maidhof A, Haasemann M, Jarnagin K. Extracellular domains of the bradykinin B2 receptor involved in ligand binding and agonist sensing defined by anti-peptide antibodies. Kinins '95, September 1995. Denver. CO. Poster presentation.
11. Mombouli J-V, Vanhoutte PM. Kinins and endothelial control of vascular smooth muscle. Annu Rev Pharmacol Toxicol 1995; 35: 679-705.
12. Munoz CM, Lee-Lundberg LMF. Receptor-mediated internalization of bradykinin. J B C 1992; 267: 303-309.
13. Nomura T, Inamura T, Black KL. Intracarotid infusion of bradykinin selectively increases blood-tumor permeability in 9L and C6 brain tumors. Brain Res 1994; 658: 62-66.
14. Ohno K, Pettigrew KO, Rapoport ST. Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat. Am J Physiol 1978; 253: H299-H307.
15. Raymond JJ, Robertson DM, Dinsdale HB. Pharmacological modification of bradykinin induced breakdown of the blood brain barrier. Can J Physiol Pharmacol 1986; 13: 214-220
16. Sanovich E, Bartus RT, Friden PM, Dean RL, Le HQ, Brightman MW. Pathway across blood-brain barrier opened by the bradykinin agonist, RMP-7. Brain Res 1995; 705: 125-135.
17. Straub JA, Akiyama A, Parmar P. In vitro plasma metabolism of RMP-7. Pharmaceut Res 1994: 11: 1673-1676.
18. Wahl M, Unterberg A, Whalley ET, Bacthmann A, Young AR, Edvinsson L, Wagner FFW. Effects of bradykinin on cerebral haemodynamics and blood-brain barrier function. In: Edvinsson L. et al., eds., Peptidergic Mechanisms in the Cerebral Circulation. Norwood. Chichester, 1987; pp. 166-190.