Use of Cereport(TM) (RMP-7) to increase delivery of carboplatin to gliomas: Insight and parameters for intracarotid infusion via a single-lumen cannula

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 6, Issue 1, 1999, Pages 15-21

  Bartus, Raymond T ^a,b   Snodgrass, Pamela ^a   Dean, Reginald L ^a   Kim, Byong Su ^a   Black, Keith ^c   Emerich, Dwaine F ^a  

^a ALKERMES INC   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Blood Brain Barrier; Carboplatin; Chemotherapy Delivery; Treatment Protocols

Indexed keywords

BRADYKININ B2 RECEPTOR AGONIST; CARBOPLATIN; LOBRADIMIL; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; CANCER CHEMOTHERAPY; CANNULATION; CAROTID ARTERY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG UPTAKE; FEMALE; GLIOMA; INTRAARTERIAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; TACHYPHYLAXIS; TREATMENT INDICATION;

EID: 0033042741     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.1080/107175499267110     Document Type: Article

References (28)

1. Bartus, R. T., Elliott, P. J., et al. 1996a. Controlled modulation of BBB permeability using the bradykinin agonist, RMP-7. Exp. Neurol. 142:14-28.
2. Bartus, R. T., Elliott, P. J., Hayward, N. J., Dean, R. L., McEwen, E., and Fisher, S. K. 1996b. Permeability of the blood brain barrier by the bradykinin agonist, RMP-7: Evidence for a sensitive, auto-regulated, receptor-mediated system. Immunopharmacology 33:270-278.
3. Black, K., Cloughesy, T., et al. 1997. Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas. J. Neurosurg. 86:603-609.
4. Black, K. L. 1995. Biochemical opening of the blood-brain barrier. Adv. Drug Rev. 15:37-52.
5. Black, P. 1991. Brain tumors. New England J. Med. 324:1471-1476.
6. Brightman, M., and Reese, T. 1969. Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell Biol. 40:648-677.
7. Brismar, J., Bjorklund, A., Elmer, A., and Eneroth, C. 1978. Selective intra-arterial cytostatic injections in malignant head and neck tumors. Neuroradiology 16:434-437.
8. Chow, K. L., Cloughesy T. F., Sayre, J. W., Gobin, Y. P., Villablance, J. P., and Vinuela, F. 1998. Factors predictive of response to selective intra-arterial chemotherapy. American Society for Clinical Oncology/American Society for Neuro-Oncology, May 18, 1998, Los Angeles, CA.
9. Cloughesy, T., Black, K., and Grous, J. 1996. Ascending dose, intra-arterial RMP-7, and carboplatin are safe and tolerable in recurrent malignant glioma patients. Philadelphia: ASCO Annual Meeting Abstract.
10. Elliott, P. J., Hayward N. J., Dean, R. L., Blunt, D. G., and Bartus, R. T. 1996. Intravenous RMP-7 selectively increases uptake of carboplatin into rat brain tumors. Cancer Res. 56:3998-4005.
11. Emerich, D., Snodgrass, P., et al. 1998. Enhanced uptake of carboplatin into brain tumors with intravenous Cereport (RMP-7): Dramatic differences as a function of dosing parameters. Br. J. Cancer Res.
12. Fenstermacher, J., and Cowles, A. 1977. Theoretic limitations of intracarotid infusions in brain tumor chemotherapy. Cancer Treat. Rep. 61:519-526.
13. Ford, J. M., Miles, K. A., Hayball, M. P., Bearcroft, P. W., Bleehen, N. M., and Osborn, C. S. 1996. A simplified technique for measurement of blood-brain barrier permeability using CT: Preliminary results of the effect of RMP-7. In Quantitative Imaging in Oncology, 3-7 April 1994, Newcastle Upon Tyne, UK, ed. K. Faulkner, 126-155.
14. Groothius, D. R., Fischer, J. R., Lapin, G., Bigner, D. D., and Vick, N. A. 1982. Permeability of different experimental brain tumor models to horseradish peroxidase. J. Neuropathol. Exp. Neurol. 41:164-185.
15. Inamura, T., and Black, K. L. 1994. Bradykinin selectively opens blood-tumor barrier in experimental brain tumors. J. Cereb. Blood Flow. Metab. 14:862-870.
16. Inamura, T., Nomura, T., Bartus, R. T., and Black, K. 1994. Intracarotid infusion of RMP-7, a bradykinin analog: A method for selective drug delivery to brain tumors. J. Neurosurg. 81:752-758.
17. Levin, V. 1985. Chemotherapy of primary brain tumors. Neurologic Clinics 3:855-867.
18. Nelson, D., McDonald, J., Lapham, L., Qazi, R., and Rubin, P. 1992. Central nervous system tumors. In Clinical Oncology, ed. J. McDonald, R. Qazi, and P. Rubin, 617-644. Philadelphia: WB Saunders Co.
19. Neuwelt, E. A., Barnett, P. A., McCormick, C. I., Frenkel, E. P., and Minna, J. D. 1985. Osmotic blood-brain barrier modification: Monoclonal antibody, albumin, and methotrexate delivery to cerebrospinal fluid and brain. Neurosurgery 17:419-423.
20. Neuwelt, E. A., Hill, S. A., and Frenkel, E. P. 1984. Osmotic blood-brain barrier modification and combination chemotherapy: Concurrent tumor regression in areas of barrier opening. Neurosurgery 15:362-366.
21. Neuwelt, E. A., and Rapoport, S. I. 1984. Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors. Fed. Proc. 43:214-219.
22. Nomura, T., Inamura, T., and Black, K. L. 1994. Intracarotid infusion of bradykinin selectively increases blood-tumor permeability in 9L and C6 brain tumors. Brain Res. 659:62-66.
23. Ohno, K., Pettlgrew, K., and Rapoport, S. 1978. Lower limits of cerebrovas- cular permeability to nonelectrolytes in the conscious rat. Am. J. Physiol. 253:H299-H307.
24. Pellegrino, L. J., Pellegrino, A. S., and Cushman, A. J. 1986. A Stereotaxic Atlas of the Rat Brain. New York: Plenum Press.
25. Sanovich, E., Bartus, R. T., Friden, P. M., Dean, R. L., Le, H. Q., and Brightman, M. W. 1995. Pathway across blood-brain barrier opened by the bradykinin agonist, RMP-7. Brain Res. 705:125-135.
26. Shibata, S. 1989. Ultrastructure of capillary walls in human brain tumors. Acta Neuropathol. 78:561-571.
27. Wahl, M., Unterberg, A., et al. 1987. Effects of bradykinin on cerebral haemo- dynamics and blood-brain barrier function. In Peptidergic Mechanisms in the Cerebral Circulation, ed. L. Edvinsson, 166-190. Chichester: Norwood.
28. Ziylan, Y. Z., LeFauconnier, J. M., Bernard, G., and Bourre, J. M. 1988. Effect of dexamethasone on transport of alpha-aminoisobutyric acid and sucrose across the blood-brain barrier. J. Neurochem. 51:1338-1342.