The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair

Molecular Brain Research

Volumn 43, Issue 1-2, 1996, Pages 21-29

  Walton, M ^a   Sirimanne, E ^a   Williams, C ^a   Gluckman, P ^a   Dragunow, M ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

cAMP; Hypoxic ischemia; Jun; Neuroprotection; Programmed cell death

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL SURVIVAL; CONTROLLED STUDY; GRANULE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PYRAMIDAL NERVE CELL; RAT;

ANIMALS; ANOXIA; BRAIN ISCHEMIA; CARRIER PROTEINS; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; IMMUNOHISTOCHEMISTRY; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0030608446     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(96)00144-1     Document Type: Article

References (56)

1. Alberts, A.S., Arias, J., Hagiwara, M., Montminy, M.R. and Feramisco, J.R., Recombinant cyclic AMP response element binding protein (CREB) phosphorylated in Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei, J. Biol. Chem., 269 (1994) 7623-7630.
2. Beilharz, E.J., Williams, C.E., Dragunow, M., Sirimanne, E.S. and Gluckman, P.D., Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss, Mol. Brain Res., 29 (1995) 1-14.
3. Bonni, A., Ginty, D.D., Dudek, H. and Greenberg, M.E., Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals, Mol. Cell. Neurosci., 6 (1995) 168-183.
4. Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G. and Silva, A.J., Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein, Cell, 79 (1994) 59-68.
5. Brecht, S., Gass, P., Anton, F., Bravo, R., Zimmermann, M. and Herdegen, T., Induction of c-Jun and suppression of CREB transcription factor proteins in axotomized neurons of the substantia nigra and covariation with tyrosine hydroxylase, Mol. Cell. Neurosci., 5 (1994) 431-441.
6. Castrillo, J.L., Theill, L.E. and Karin, M., Function of the homeodomain protein GHF1 in pituitary cell proliferation, Science, 253 (1991) 197-199.
7. Chrivia, J.C., Kwok, R.P.S., Lamb, N., Hagiwara, M., Montminy, M.R. and Goodman, R.H., Phosphorylated CREB binds specifically to the nuclear protein CBP, Nature, 365 (1993) 855-859.
8. Cotman, C.W. and Anderson, A.J., A potential role for apoptosis in neurodegeneration and Alzheimer's disease, Mol. Neurobiol., 10 (1995) 19-45.
9. Dash, P.K., Karl, K.A., Colicos, M.A., Prywes, R. and Kandel, E.R., cAMP response element-binding protein is activated by calcium/calmodulin as well as cAMP-dependent protein kinase, Proc. Natl. Acad. Sci. USA, 88 (1991) 5061-5065.
10. Dragunow, M., Young, D., Hughes, P., MacGibbon, G., Lawlor, P., Singleton, K., Sirimanne, E., Beilharz, E. and Gluckman, P., Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischemic brain injury? Mol. Brain Res., 18 (1993) 347-352.
11. Dragunow, M., Beilharz, E., Sirimanne, E., Lawlor, P., Williams, C., Bravo, R. and Gluckman, P., Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischemic injury to the young rat brain, Mol. Brain Res., 25 (1994) 19-33.
12. Dragunow, M., Faull, R.L.M., Lawlor, P., Beilharz, E., Singleton, K., Walker, L. and Mee, E., In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal cortex, NeuroReport, 6 (1995) 1053-1057.
13. Dragunow, M. and Preston, K., The role of inducible transcription factors in apoptotic nerve cell death, Brain Res. Rev., 21 (1995) 1-28.
14. Enslen, H., Sun, P., Brickey, D., Soderling, S.H., Klamo, E. and Soderling, T.R., Characterization of calcium/calmodulin-dependent protein kinase IV, J. Biol. Chem., 269 (1994) 15520-15527.
15. Estus, S., Zaks, W.J., Freeman, R.S., Gruda, M., Bravo, R. and Johnson, E.M., Altered gene expression in neurons during programmed cell death: identification of c-Jun as necessary for neuronal apoptosis, J. Cell Biol., 127 (1994) 1717-1727.
16. Frank, D.A. and Greenberg, M.E., CREB: a mediator of long-term memory from mollusks to mammals, Cell, 79 (1994) 5-8.
17. Ginty, D.D., Kornhauser, J.M., Thompson, M.A., Bading, H., Mayo, K.E., Takahashi J.S. and Greenberg, M.E., Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and circadian clock, Science, 260 (1993) 238-241.
18. Ginty, D.D., Bonni, A. and Greenberg, M.E., Nerve growth factor activates a ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB, Cell, 77 (1994) 713-725.
19. Gonzalez, G.A. and Montminy, M.R., Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133, Cell, 59 (1989) 675-680.
20. Gonzalez, G.A., Yamamoto, K.K., Fischer, W.H., Karr, D., Menzel, P., Biggs, W., Vale, W.W. and Montminy, M.R., A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence, Nature, 337 (1989) 749-752.
21. Greenberg, M.E., Thompson, M.A. and Sheng, M., Calcium regulation of immediate early gene transcription, J. Physiol. (Paris), 86 (1992) 99-108.
22. Guitart, X., Thompson, M.A., Mirante, C.K., Greenberg, M.E. and Nestler, E.J., Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus, J. Neurochem., 58 (1992) 1168-1171.
23. Ham, J., Babij, C., Whitfield, J., Pfarr, C.M., Lallemand, D., Yaniv, M. and Rubin, L.L., A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death, Neuron, 14 (1995) 927-939.
24. Herdegen, T., Fiallos-Estrada, C.E., Schmind, W., Bravo, R. and Zimmermann, M., The transcription factors c-Jun, Jun D, and CREB, but not Fos and Krox-24, are differentially regulated in axotomized neurons following transection of rat sciatic nerve, Mol. Brain Res., 14 (1992) 155-165.
25. Herdegen, T., Bastmeyer, M., Bahr, M., Stuermer, C., Bravo, R. and Zimmermann, M., Expression of Jun, Krox, and CREB transcription factors in goldfish and rat retinal ganglion cells following optic nerve lesion is related to axonal sprouting, J. Neurobiol., 24 (1993) 528-543.
26. Herdegen, T., Sandkuhler, J., Gass, P., Kiessling, M., Bravo, R. and Zimmermann, M., Jun, Fos, Krox, and CREB transcription factor proteins in the rat cortex: basal expression and induction by spreading depression and epileptic seizures, J. Comp. Neurol., 333 (1993) 271-288.
27. Hoeffler, J.P., Meyer, T.E., Yun, Y., Jameson, J.L. and Habener, J.F., Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA, Science, 242 (1988) 1430-1433.
28. Hughes, P., Beilharz, E., Gluckman, P. and Dragunow, M., Brain-derived neurotrophic factor is induced as an immediate early gene following N-methyl-D-aspartate receptor activation, Neuroscience, 57 (1993) 319-328.
29. Hughes, P. and Dragunow, M., Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system, Pharmacol. Rev., 47 (1995) 133-178.
30. Imaki, J., Yoshida, K. and Yamashita, K., A developmental study of cyclic AMP-response element binding protein (CREB) by in situ hydridization, histochemistry and immunocytochemistry in the rat neocortex, Brain Res., 651 (1994) 269-274.
31. Klempt, N.D., Sirimanne, E., Gunn, A.J., Klempt, M., Singh, K., Williams, C. and Gluckman, P.D., Hypoxia-ischemia induces transforming growth factor β1 mRNA in the infant brain, Mol. Brain Res., 13 (1992) 93-101.
32. Kokaia, Z., Metsis, M., Kokaia, M., Bengzon, J., Elmer, E., Smith, M-L., Timmusk, T., Siesjo, B.K., Persson, H. and Lindvall, O., Brain insults in rats induce increased expression of the BDNF gene through differential use of multiple promoters, Eur. J. Neurosci., 6 (1994) 587-596.
33. Kwok, P.P.S., Lundblad, J.R., Chrivia, J.C., Richards, J.P., Bachinger, H.P., Brennan, R.G., Roberts, S.G.E., Green, M.R. and Goodman, R.H., Nuclear protein CBP is a coactivator for the transcription factor CREB, Nature, 370 (1994) 223-229.
34. Lamph, W.W., Dwarki, V.J., Ofir, R., Montminy, M. and Verma, I.M., Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation, Proc. Natl. Acad. Sci. USA., 87 (1990) 4320-4324.
35. Lee, K.A.W. and Masson, N., Transcriptional regulation by CREB and its relatives, Biochim. Biophys. Acta, 1174 (1993) 221-233.
36. Lindvall, O., Ernfors, P., Bengzon, J., Kokaia, Z., Smith, M.-L., Siesjo, B.K. and Persson, H., Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma, Proc. Natl. Acad. Sci. USA, 89 (1992) 648-652.
37. Masquilier, D. an Sassone-Corsi, P., Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun, J. Biol. Chem., 267 (1992) 22460-22466.
38. Matthews, R.P., Guthrie, C.R., Wailes, L.M., Zhao, X., Means, A.R. and McKnight, G.S., Calcium/Calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression, Mol. Cell. Biol., 14 (1994) 6107-6116.
39. Montminy, M.R., Sevarino, K.A., Wagner, J.A. and Mandel, G., Identification of a cyclic-AMP-responsive element within the rat somatostatin gene, Proc. Natl. Acad. Sci. USA, 83 (1986) 6682-6686.
40. Montminy, M.R. and Bilezikjian, L.M., Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene, Nature, 328 (1987) 175-178.
41. Montminy, M.R., Gonzalez, G.A. and Yamamoto, K.K., Regulation of cAMP-inducible genes by CREB, Trends Neurosci., 13 (1990) 184-188.
42. Nordheim, A., CREB takes CBP to tango, Nature, 370 (1994) 177-178.
43. Pennypacker, K.R., Hudson, P.M., Hong, J.S. and McMillian, M.K., DNA binding activity of CREB trancription factors during ontogeny of the central nervous system, Dev. Brain Res., 86 (1995) 242-249.
44. Schmidt-Kastner, R. and Freund, T.F., Selective vulnerability of the hippocampus in brain ischemia, Neuroscience, 40 (1991) 599-636.
45. Sheng, M., Thompson, M.A. and Greenberg, M.E., CREB: a calcium-regulated transcription factor phosphorylated by calmodulin-dependent kinases, Science, 252 (1991) 1427-1430.
46. Shozuhara, H., Onodera, H., Katoh-Semba, R., Kato, K., Yamasaki, Y. and Kogure, K., Temporal profiles of nerve growth factor β-subunit level in rat brain regions after transient ischemia, J. Neurochem., 59 (1992) 175-180.
47. Sirimanne, E.S., Guan, J., Williams, C.E. and Gluckman, P.D., Two models for determining the mechanisms of damage and repair after hypoxic-ischemic injury in the developing rat brain, J. Neurosci. Methods, 55 (1994) 7-14.
48. Struthers, R.S., Vale, W.W., Arias, C., Sawchenko, P.E. and Montminy, M.R., Somtotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant, Nature, 350 (1991) 622-624.
49. Takeda, A., Onodera, H., Sugimoto, A., Kogure, K., Obinata, M. and Shibahara, S., Coordinated expression of messenger RNAs for nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in the rat hippocampus following transient forebrain ischemia, Neuroscience, 55 (1993) 23-31.
50. Tsukahara, T., Yonekawa, Y., Tanaka, K., Ohara, O., Watanabe, S., Kimura, T., Nishijima, T. and Tangiguchi, T., The role of brain-derived neurotrophic factor in transient forebrain ischemia in the rat brain, Neurosurgery, 34 (1994) 323-331.
51. Vallejo, M., Transcriptional control of gene expression by cAMP-response element binding proteins, J. Neuroendocrinol., 6 (1994) 587-596.
52. Walker, W.H., Fucci, L. and Habener, J.F., Expression of the gene encoding transcription factor cyclic adenosine 3′,5′-monophosphate (cAMP) response element-binding protein (CREB): regulation by follicle-stimulating hormone-induced cAMP signaling in primary rat Sertoli cells, Endocrinology, 136 (1995) 3534-3545.
53. Widnell, K.L., Russell, D.S. and Nestler, E.J., Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro, Proc. Natl. Acad. Sci. USA., 91 (1994) 10947-10951.
54. Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J. and Greenberg, M.E., Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis, Science, 270 (1995) 1326-1331.
55. Yamamoto, K.K., Gonzalez, G.A., Biggs, W.H. and Montminy, M.R., Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB, Nature, 334 (1988) 494-498.
56. Yin, J.C.P., Wallach, J.S., Del Vecchio, Wilder, E.L., Zhou, H., Quinn, W.G. and Tully, T., Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila, Cell, 79 (1994) 49-58.