Uncoupling of stem cell inhibition from monocyte chemoattraction in MIP-1α by mutagenesis of the proteoglycan binding site

EMBO Journal

Volumn 15, Issue 23, 1996, Pages 6506-6515

  Graham, Gerard J ^a   Wilkinson, Peter C ^b   Nibbs, Robert J B ^a   Lowe, Sharon ^a   Kolset, Svein O ^c   Parker, Anne ^a   Freshney, Mary G ^a   Tsang, Monica L S ^d   Pragnell, Ian B ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF OSLO   (Norway)

^d R and D Systems Inc   (United States)

Author keywords

Chemoattractant; Inhibition; MIP 1 ; Proteoglycan; Stem cell

Indexed keywords

CHEMOATTRACTANT; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MUTANT PROTEIN; PROTEOGLYCAN;

ANIMAL CELL; ARTICLE; BINDING SITE; CHEMOTAXIS; CONTROLLED STUDY; DNA TRANSFECTION; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; STEM CELL; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 0029823071     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb01041.x     Document Type: Article

References (48)

1. Ackerman, S.K. and Douglas, S.D. (1978) Purification of human monocytes on microexudate-coated surfaces. J. Immunol., 120, 1372-1374.
2. Ahuja, S.K., Gao, J.-L. and Murphy, P.M. (1994) Chemokine receptors and molecular mimicry. Immunol. Today, 15, 281-287.
3. Broxmeyer, H.E., Sherry, B., Lu, L., Cooper, S., Oh, K., Tekamp-Olson, P., Kwon, B.S. and Cerami, A. (1990) Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells. Blood, 76, 1110-1116.
4. Chen, C. and Okayama, H. (1987) High efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol., 7, 2745-2752.
5. Combadiere, C., Ahuja, S.K., VanDamme, J., Tiffany, H.L., Gao, J.-L. and Murphy, P.M. (1995) Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B. J. Biol. Chem., 270, 29671-29675.
6. Esko, J.D., Stewart, T.E. and Taylor, W.H. (1985) Animal cell mutants defective in glycosaminoglycan biosynthesis. Proc. Natl Acad. Sci. USA, 82, 3197-3201.
7. Gewirtz, A.M., Zhang, J., Ratajczak, J., Ratajczak, M., Park, K.S., Li, C., Yan, Z. and Poncz, M. (1995) Chemokine regulation of human megakaryocytopoiesis. Blood, 86, 2559-2567.
8. Gilat, D., Hershkoviz, R., Makori, Y.A., Vlodavsky, I. and Lider, O. (1994) Regulation of adhesion of CD4+ T lymphocytes to intact or heparinase-treated subendothelial extracellular matrix by diffusible or anchored RANTES and MIP-1β. J. Immunol., 153, 4899-4906.
9. Gordon, M.Y., Riley, G.P., Watt, S.M. and Greaves, M.F. (1987) Compartmentalization of a haematopoietic growth factor (GM-CSF) by glycosaminoglycans in the bone marrow microenvironment. Nature, 326, 463-466.
10. Graham, G.J. and Pragnell, I.B. (1991) Treating cancer: the potential role of stem cell inhibitors. Eur. J. Cancer, 27, 952-953.
11. Graham, G.J., Wright, E.G., Hewick, R., Wolpe, S.D., Wilkie, N.M., Donaldson, D., Lorimore, S. and Pragnell, I.B. (1990) Identification and characterisation of an inhibitor of haemopoietic stem cell proliferation. Nature, 344, 442-444.
12. Graham, G.J., Freshney, M.F., Donaldson, D. and Pragnell, I.B. (1992) Purification and biochemical characterisation of human and murine stem cell inhibitors (SCI). Growth Factors, 7, 151-160.
13. Graham, G.J., Zhou, L., Weatherbee, J.A., Tsang, M.L.-S., Napolitano, M., Leonard, W.J. and Pragnell, J.B. (1993) Characterisation of a receptor for MIP-1α and related proteins on human and murine cells. Cell Growth Differ., 4, 137-146.
14. Graham, G.J. et al. (1994) Aggregation of the chemokine MIP-1α is a dynamic and reversible phenomenon: Biochemical and biological analyses. J. Biol Chem., 269, 4974-4978.
15. Gupta, S.K. and Singh, J.P. (1994) Inhibition of endothelial cell proliferation by platelet factor-4 involves a unique action on S-phase progression. J. Cell Biol., 127, 1121-1127.
16. Holyoake, T.L., Freshney, M.G., Konwalinka, G., Haun, M., Petzer, A., Fitzsimons, E., Lucie, N.P., Wright, E.G. and Pragnell, I.B. (1993) Mixed colony formation in vitro by the heterogeneous compartment of multipotential progenitors in human bone marrow. Leukaemia, 7, 207-213.
17. Islam, L.N. and Wilkinson, P.C. (1988) Chemotactic factor-induced polarisation, receptor redistribution and locomotion of human blood monocytes. Immunology, 64, 501-507.
18. Jackson, R.L., Busch, S.J. and Cardin, A.D. (1991) Glycosaminoglycans: Molecular properties, protein interactions and role in physiological processes. Physiol. Rev., 71, 481-539.
19. Kolset, S.O., Mann, D.M., Uhlin-Hansen, L., Winberg, J.-O. and Ruoslahti, E. (1996) Serglycin-binding proteins in activated macrophages and platelets. J. Leukocyte Biol., 59, 545-554.
20. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
21. Lidholt, K., Weinke, J.L., Kiser, C.S., Lugemwa, F.N., Bame, K.J., Cheifetz, S., Massague, J., Lindahl, U. and Esko, J.D. (1992) A single mutation affects both N-acetylglucosaminyltranferase and glucuronosyltranferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis. Proc. Natl Acad. Sci. USA, 89, 2267-2271.
22. Lodi, P.J., Garrett, D.S., Kuszewski, J., Tsang, M.L.-S., Weatherbee, J.A., Leonard, W.J., Gronenborn, A.M. and Clore, G.M. (1994) High resolution solution structure of the β-chemokine hMIP-1β by multidimensional NMR. Science, 263, 1762-1767.
23. Lord, B.I., Dexter, T.M., Clements, J.M., Hunter, M.A. and Gearing, A.J.H. (1992) Macrophage inflammatory protein protects multipotent haemopoietic cells from the cytotoxic effects of hydroxyurea in vivo. Blood, 79, 2605-2609.
24. Lorimore, S.A., Pragnell, I.B., Eckman, L. and Wright, E.G. (1990) Synergistic interactions allow colony formation in vitro by murine haemopoietic stem cells. Leuk. Res., 14, 481-489.
25. Luster, A.D., Greenberg, S.M. and Leder, P. (1995) The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. J. Exp. Med., 182, 219-231.
26. Maione, T.E., Gray, G.S., Hunt, A.J. and Sharpe, R.J. (1991) Inhibition of tumour growth in mice by an analogue of platelet factor 4 that lacks affinity for heparin and retains potent angiostatic activity. Cancer Res., 51, 2077-2083.
27. Munson, P.J. and Robard, D. (1980) A versatile computerised approach for the characterisation of ligand binding systems. Anal. Biochem., 107, 220-239.
28. Neote, K., DiGregorio, D., Mak, J.Y., Horuk, R. and Schall, T.J. (1993) Molecular cloning, functional expression and signalling characteristics of a C-C chemokine receptor. Cell, 72, 415-425.
29. Newman, I. and Wilkinson, P.C. (1992) Methods for phenotyping polarised and locomotive human lymphocytes. J. Immunol. Methods, 147, 43-50.
30. Parkinson, E.K., Graham, G.J., Daubersies, P., Burns, J.E., Heufler, C., Plumb, M., Schuler, G. and Pragnell, J.B. (1993) A haemopoietic stem cell inhibitor (SCI/MIP-1α) also inhibits clonogenic epidermal keratinocyte proliferation. J. Invest. Dermatol., 101, 113-117.
31. Power, C.A., Meyer, A., Nemeth, K., Bacon, K.B., Hoogewerf, A.J., Proudfoot, A.E.I. and Wells, T.N.C. (1995) Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. J. Biol. Chem., 270, 19495-19500.
32. Pragnell, I.B. et al. (1988) The effect of stem cell proliferation regulators demonstrated with an in vitro assay. Blood, 72, 196-202.
33. Roberts, R., Gallagher, J., Spooncer, E., Allen, T.D., Bloomfield, F. and Dexter, T.M. (1988) Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis. Nature, 332, 376-379.
34. Roghani, M., Mansukhani, A., Dell'Era, P., Bellosta, P., Basilico, C., Rifkin, D.B. and Mosactelli, D. (1994) Heparin increases the affinity of bFGF for its receptor, but is not required for binding. J. Biol. Chem., 269, 3976-3984.
35. Ruoslahti, E. (1988) Structure and biology of proteoglycans. Annu. Rev. Cell Biol., 4, 229-255.
36. Samson, M., Labbe, O., Mollereau, C., Vassart, G. and Parmentier, M. (1996) Molecular cloning and functional expression of a new human CC chemokine receptor gene. Biochemistry, 35, 3362-3367.
37. Schall, T.J. (1991) Biology of the RANTES/SIS cytokine family. Cytokine, 3, 165-183.
38. Skelton, N.J., Aspiras, F., Ogez, J. and Schall, T.J. (1995) Proton NMR assignments and solution conformation of RANTES, a chemokine of the C-C type. Biochemistry, 34, 5329-5342.
39. Spivak-Kroizman, T. et al. (1994) Heparin-induced oligomerisation of FGF molecules is responsible for FGF receptor dimerisation, activation and cell proliferation. Cell, 79, 1015-1024.
40. Stoeckle, M.Y. and Barker, K.A. (1990) Two burgeoning families of platelet factor-4 related proteins: mediators of the inflammatory response. New Biol., 2, 313-323.
41. Stuckey, J.A., St Charles, R. and Edwards, B.F.P. (1992) A model of the platelet factor 4 complex with heparin. Proteins: Structure Funct. Genet., 14, 277-287.
42. Tanaka, Y., Adams, D.H., Hubscher, S., Hirnao, H., Siebenlist, U. and Shaw, S. (1993) T-cell adhesion induced by proteoglycan-immobilised cytokine MIP-1 beta. Nature, 361, 79-82.
43. Tuschil, A., Lam, C., Haslberger, A. and Lindley, I. (1992) Interleukin-8 stimulates calcium transients and promotes epidermal cell proliferation. J. Invest. Dermatol., 99, 294-298.
44. Webb, L.M.C., Ehrengruber, M.U., Clark-Lewis, I., Baggiolini, M. and Rot, A. (1993) Binding to heparin sulphate or heparin enhances neutrophil responses to interleukin 8 Proc. Natl Acad. Sci. USA, 90, 7158-7162.
45. Weir, M.P. and Sparks, J. (1987), Purification and renaturation of recombinant interleukin-2. Biochem. J., 245, 85-91.
46. Witt, D.P. and Lander, A.D. (1994) Differential binding of chemokines to glycosaminoglycan subpopulations. Curr. Biol., 4, 394-400
47. Zhang, X., Chen, L., Bancroft, D.P., Lai, C.K. and Maione, T.E. (1994) Crystal structure of recombinant platelet factor 4. Biochemistry, 33, 8361-8366.
48. Zigmond, S.H. and Hirsch, J.G. (1973) Leukocyte locomotion and chemotaxis, New methods of evaluation and demonstration of a cell-derived chemotactic factor. J. Exp. Med., 137, 387-410.