Cytokines in non-genotoxic hepatocarcinogenesis

Carcinogenesis

Volumn 20, Issue 8, 1999, Pages 1397-1401

  Roberts, Ruth A ^a   Kimber, Ian ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; NOTE; PRIORITY JOURNAL; VIRUS HEPATITIS;

ANIMALS; CYTOKINES; FORECASTING; HEPATITIS B, CHRONIC; HUMANS; INTERLEUKINS; LIVER; LIVER NEOPLASMS; MICE; RATS; RECEPTORS, TUMOR NECROSIS FACTOR; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032842585     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.8.1397     Document Type: Note

References (84)

1. Kato, M., Popp, J.A., Conolly, R.B. and Cattley, R.C. (1993) Relationship between hepatocyte necrosis, proliferation and initation induced by diethylnitrosamine in the male F344 rat. Fundam. Appl. Toxicol., 20, 155-162.
2. Ashby, J., Brady, A., Elcombe, C.R., Elliot, B.M., Ishmael, J., Odum, J., Tugwood, J.D., Kettle, S. and Purchase, I.F.H. (1994) Mechanistically-based human hazard assessment of peroxisome-proliferator-induced hepatocarcinogenesis. Hum. Exp. Toxicol., 13, S1-S117.
3. Columbano, A., Ledda-Columbano, G.M., Ennas, M.G., Curto, M., Chelo, A. and Pani, P. (1990) Cell proliferation and promotion of rat liver carcinogenesis: different effects of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme altered foci. Carcinogenesis, 11, 771-776.
4. Berman, J.S., Hiley, C.R. and Wilson, A.C. (1983) Comparison of the effects of the hypolipidaemic agents ICI53072 and clofibrate with those of phenobarbitone on liver size, blood flow and DNA content in the rat. Br. J. Pharmacol., 78, 533-541.
5. Poland, A. and Knudson, J.C. (1982) 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanisms of toxicity. Annu. Rev. Pharmacol. Toxicol., 22, 517-554.
6. Neveu, M.J., Hully, J.R., Paul, D.L. and Pitot, H.C. (1990) Reversible alterations in the expression of the gap junctional protein connexin 32 during tumour promotion in rat liver and its role during cell proliferation. Cancer Commun., 2, 21-31.
7. Moody, D.E., Reddy, J.K., Lake, B.G., Popp, J.A. and Reese, D.H. (1991) Peroxisome proliferation and non-genotoxic carcinogenesis: commentary on a symposium. Fundam. Appl. Toxicol., 6, 233-248.
8. Ames, B.N. and Gold, L.S. (1990) Too many rodent carcinogens: mitogenesis increases mutagenesis. Science, 249, 970-971.
9. Schulte-Hermann, R., Grasl-Kraupp, B. and Bursch, W. (1995) Apoptosis and hepatocarcinogenesis. In Liver Regeneration and Carcinogenesis. Academic Press, New York, NY, pp. 141-178.
10. Roberts, R.A., Hickman, J.A., Nebert, D.W., Richburg, J.H. and Goldsworthy, T.L. (1997) Perturbation of the mitosis/apoptosis balance: a fundamental mechanism in toxicology. Symposium overview. Fundam. Appl. Toxicol., 38, 107-115.
11. Pitot, H. (1998) Hepatocyte death in hepatocarcinogenesis. Hepatology, 28, 1-5.
12. Schulte-Hermann, R. (1979) Adaptive liver growth induced by xenobiotic compounds: its nature and mechanism. Arch. Toxicol. Suppl., 2, 113-124.
13. Roberts, R.A., Soames, A.R., Gill, J.H. James, N.J. and Wheeldon, E. (1996) Nongenotoxic hepatocarcinogens stimulate DNA synthesis and suppress apoptosis but in different hepatocyte populations. Biochem. Soc. Trans., 24, 599S.
14. Periano, C., Fry, R.J.M., Staffeldt, E. and Christopher, J.P. (1975) Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin amd dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumourigenesis in the rat. Cancer Res., 35, 2884-2890.
15. Christensen, J., Gonzalez, A., Cattley, R. and Goldsworthy, T. (1998) Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens. Cell Growth Differ., 9, 815-825.
16. Bayly, A.C, Roberts, R.A. and Dive, C. (1994) Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator, nafenopin. J. Cell Biol., 125, 197-203.
17. Oberhammer, F., Pavelka, M., Sharma, S., Tiefenbacher, R., Purchio, A.F., Bursch, W. and Schulte-Hermann, R. (1992) Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor α1. Proc. Natl Acad. Sci. USA, 89, 5408-5412.
18. Andus, T., Bauer, J. and Gerok, W. (1991) Effects of cytokines on the liver. Hepatology, 13, 364-375.
19. Brass, E. and Vetter, W.H. (1994) IL6 but not TNF alpha, increases lipogenesis in rat primary hepatocyte cultures. Biochem. J., 301, 193-197.
20. Gill, J.H., Roberts, R.A. and Dive, C. (1998) The nongenotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFß1, DNA damage and Fas. Carcinogenesis, 19, 299-304.
21. Heller, R.A. and Kronke, M. (1994) Tumor necrosis factor receptor-mediated signalling pathways. J. Cell Biol., 126, 5-9.
22. Edwards, M., Keller, B., Kauffman, F. and Thurman, R. (1993) The involvement of Kupffer cells in carbon tetrachloride toxicity. Toxicol. Appl. Pharmacol., 119, 275-279.
23. Akerman, P., Cote, P., Yang, S., McClain, C., Nelson, S., Bagby, G. and Diehl, A.M. (1992) Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am. J. Physiol., 263, 579-585.
24. Kubo, Y., Yasunaga, M., Masuhara, M., Terai, S., Nakamura, T. and Okita, K. (1996) Hepatocyte proliferation induced in rats by lead nitrate is suppressed by several TNF alpha inhibitors. Hepatology, 23, 104-114.
25. Bruccoleri, A., Gallucci, R., Germolec, D.R., Blackspear, P., Simeonova, P., Thurman, R.G. and Luster, M.I. (1997) Induction of early-immediate genes by tumor necrosis factor-alpha contribute to liver repair following chemical-induced hepatotoxicity. Hepatology, 25, 133-141.
26. Yamada, Y. and Fausto, N. (1998) Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor. Am. J. Pathol., 152, 1577-1589.
27. Rink, L. and Kirchner, H. (1996) Recent progress in the tumor necrosis factor-alpha field. Int. Arch. Allergy Immunol., 111, 199-209.
28. Tartaglia, L.A., Weber, R.F., Figari, I.S., Reynolds, C., Palladino, M.A.Jr and Goeddell, D.V. (1991) The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc. Natl Acad. Sci. USA, 88, 9292-9296.
29. Liu, Z., Hsu, H., Goeddel, D. and Karin, M. (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappa B activation prevents cell death. Cell, 87, 565-576.
30. Wallace, D. (1997) Cell death induction by TNF: a matter of self control. Trends Biochem. Sci., 22, 107-109.
31. Karin, M. and Delhase, M. (1998) JNK or IKK, AP-1 or NFκB, which are the targets for MEK kinase 1 action? Proc. Natl Acad. Sci. USA, 95, 9067-9069.
32. Chinnaiyan, A.M., Tepper, C.G., Seldin, M.F., O'Rourke, K., Kischkel, F.C., Hellbardt, S., Krammer, P.H., Peter, M.E. and Dixit, V.M. (1996) FADD/ MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J. Biol. Chem., 271, 4961-4965.
33. Yamada, Y., Kirillova, I., Peschon, J.J. and Fausto, N. (1997) Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc. Natl Acad Sci. USA, 94, 141-1446.
34. Bojes, H.K. and Thurman, R.G. (1996) Peroxisome proliferators activate kupffer cells in vivo. Cancer Res., 56, 1-4.
35. Bojes, H.K., Germolec, D.R., Simeonova, P., Bruccolrei , A., Schoonhoven, R., Luster, M.I. and Thurman, R.G. (1997) Antibodies to tumor necrosis factor-alpha prevent increases in cell replication in liver due to the potent peroxisome proliferator WY-14,643. Carcinogenesis, 18, 669-674.
36. Rose, M.L., Germolec, D., Schoonhoven, R. and Thurman, R.G. (1997) Kupffer cells are causally responsible for the mitogenic effect of peroxisome proliferators. Carcinogenesis, 18, 1453-1456.
37. Rusyn, I., Tsukamoto, H. and Thurman, R.G. (1998) Wy-14,643 rapidly activates nuclear factor KB in Kupffer cells before hepatocytes. Carcinogenesis, 19, 1217-1222.
38. Shinozuka, H., Kubo, Y., Katyal, S., Coni, P., Ledda-Columbano, M.G., Columbano, A. and Nakamura, T. (1994) Roles of growth factors and of tumor necrosis factor-alpha on liver cell proliferation induced in rats by lead nitrate. Lab. Invest., 71, 35-41.
39. Rolfe, M., James, N.H. and Roberts, R.A. (1997) Tumour necrosis factor alpha (TNF-alpha) suppresses apoptosis and induces S-phase in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis, 18, 2277-2280.
40. Beyer, H.S. and Theologides, A. (1993) Tumor necrosis factor-alpha is a direct hepatocyte mitogen in the rat. Biochem. Mol. Biol. Int., 29, 1-4.
41. Decker, K. (1990) Biologically active products of stimulated liver macrophages (Kupffer cells). Eur. J. Biochem., 192, 245-261.
42. Rose, M., Rivers, C., Blair, B., Graves, L., Cattley, R., Schoonhoven, R., Svenberg, J. and Thurman, R. (1999) Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators. Carcinogenesis, 20, 27-33.
43. Li, Y., Leung, L.K., Spear, B.T. and Glauert, H.P. (1996) Activation of hepatic NFκB by phenobarbital in rats. Biochem. Biophys. Res. Commun., 229, 982-989.
44. Li, Y., Leung, L., Glauert, H. and Spear, B. (1996) Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-κB activity. Carcinogenesis, 17, 2305-2309.
45. Shinagawa, T., Yoshioka, K., Kakamu, T., Ishikawa, T., Itoh, Y. and Takayanagi, M. (1991) Apoptosis in cultured rat hepatocytes: the effects TNFα and interleukin gamma. J. Pathol., 165, 247-253.
46. Shinozuka, H., Ohmura, T., Katyal, S.L., Zedda, A.I., Ledda-Columbano, G. and Columbano, A. (1996) Possible roles of nonparenchymal cells in hepatocyte proliferation induced by lead nitrate and by tumor necrosis factor alpha. Hepatology, 23, 1572-1577.
47. Menegazzi, M., Carcereri-De Prati, A., Shinozuka, H., Pibiri, M., Piga, R., Columbano, A. and Ledda-Columbano, G.M. (1997) Liver cell proliferation induced by nafenopin and cyproterone acetate is not associated with increases in activation of transcription factors NF-κB and AP-1 or with expression of tumor necrosis factor-alpha. Hepatology, 25, 585-592.
48. Holden, P.R., Hasmall, S.C, James, N.H., West, D.R., Brindle, R., Gonzalez, F.J., Peters, J.M. and Roberts, R.A. (1999) TNFα: role in suppression of apoptosis by peroxisome proliferators. Cell. Mol. Biol., submitted.
49. Dinarello, C. (1988) Biology of interleukin 1. FASEB J., 2, 108-115.
50. Eder, J. (1997) Tumour necrosis factor alpha and interleukin-1 signaling: do MAPKK kinases connect it all? Trends Pharmacol. Sci., 18, 319-322.
51. May, M.J. and Ghosh, S. (1998) Signal transduction through NF-kappaB. Immunol. Today, 19, 80-88.
52. Akira, S., Hirano, T., Taga, T. and Kishimoto, T. (1990) Biology of multifunctional cytokines: IL6 and related molecules (IL1 and TNF alpha). FASEB J., 4, 2860-2867.
53. Michalopoulus, G.K. and DeFrances, M.C. (1997) Liver regeneration. Science, 276, 60-66.
54. Koga, M. and Ogasawara, H. (1991) Induction of hepatocyte mitosis in intact adult rat by IL1α and IL6. Life Sci., 49, 1263-1270.
55. Nakamura, T., Rieko, A. and Ichihara, A. (1988) Interleukin-1beta is a potent growth inhibitor of adult rat hepatocytes in primary culture. Exp. Cell Res., 179, 488-497.
56. Boulton, R., Woodman, A., Calnan, D., Seldon, C., Tam, F. and Hodgson, H. (1997) Nonparenchymal cells from regenerating rat liver generate IL1-alpha and IL1-beta: a mechanism of negative regulation of hepatocyte proliferation. Hepatology, 26, 49-58.
57. Gregory, S., Wing, E., Danowski, K., van Rooijen, N., Dyer, K. and Tweardy, D. (1998) IL6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections. J. Immunol., 160, 6056-6061.
58. Kordula, T., Rokita, H., Koj, A., Fiers, A., Gauldie, J. and Baumann, H. (1991) Effects of IL6 and LIF on the acute phase response and DNA synthesis in cultured rat hepatocytes. Lymphokine Cytokine Res., 10, 23-26.
59. Cressman, D., Greenbaum, L., DeAngelis, R., Ciliberto.G., Furth, E., Poli, V. and Taub, R. (1996) Liver failure and defective hepatocyte regeneration in IL6 deficient mice. Science, 274, 1379-1383.
60. Tsukui, T., Kikuchi, K., Mabuchi, A., Sudo, T., Sakamoto, N., Sato, K., Tsuneoka, K. and Yokomoro, K. (1992) Production of macrophage colony stimulating factor by adult murine parenchymal liver cells (hepatocytes). J. Leukocyte Biol., 52, 383-341.
61. Baffet, G., Braciak, T., Fletcher, R., Gauldie, J., Fey, G. and Northemann, W. (1991) Autocrine activity of IL6 secreted by hepatoma cells. Mol. Biol. Med., 8, 141-156.
62. Cressman, D., Diamond, R. and Taub, R. (1995) Rapid activation of the Stat3 trancription complex in liver regeneration. Hepatology, 21, 1443-1449.
63. Satoh, M. and Yamazaki, M. (1992) Tumor necrosis factor stimulates DNA synthesis of mouse hepatocytes in primary culture and is suppressed by transforming growth factor-beta and interleukin 6. J. Cell. Physiol., 150, 134-139.
64. Rai, R., Loffreda, S., Karp, C., Yang, S.-Q., Lin, H.-Z. and Diehl, A. (1997) Kupffer cell depletion abolishes induction of IL10 and permits sustained overexpression of TNF-alpha messenger RNA in thr regenerating rat liver. Hepatology, 25, 889-895.
65. Thornton, A., Ham, J. and Kunkel, S. (1992) Kupffer cell-derived cytokines induce the synthesis of a leukocyte chemotactic peptide, IL8 in human hepatoma and primary hepatocyte cultures. Hepatology, 15, 1112-1122.
66. Webber, E., Bruix, J., Pierce, R. and Fausto, N. (1998) Tumor necrosis factor primes hepatocytes for DNA replication in the rat. Hepatology, 28, 1226-1234.
67. Issemann, I. and Green, S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 347, 645-650.
68. Lee, S.S.-T., Pineau, T., Drago, J., Lee, E.J., Owens, J.O., Kroetz, D.L., Fernandez-Salguero, P.M., Westphal, H. and Gonzalez, F.J. (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleitrophic effects of peroxisome proliferators. Mol. Cell. Biol., 15, 3012-3022.
69. Gonzalez, F.J. (1997) Recent update on the PPAR alpha-null mouse. Biochimie, 79, 139-144.
70. Gonzalez, F. (1997) The role of peroxisome proliferator activated receptor alpha in peroxisome proliferation, physiological homeostasis and chemical carcinogenesis. In Dietary Fat and Cancer (edited by AICR). Plenum Press, New York, NY, pp. 109-125.
71. Peters, J.M., Cattley, R.C. and Gonzalez, F.J. (1997) Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator, Wy-14,643. Carcinogenesis, 18, 2029-2033.
72. Myers, K.A., Lambe, K., Aldridge, T.C., Macdonald, N. and Tugwood, J.D. (1997) Amino acids in both the DNA binding and ligand binding domains influence the transcriptional activity of the human peroxisome proliferator acivated receptor alpha. Biomed. Biophys. Res. Commun., 239, 522-526.
73. Roberts, R.A., James, N.H., Woodyatt, N., Macdonald, N. and Tugwood, J. (1998) Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPARα). Carcinogenesis, 19, 43-48.
74. Hasmall, S., James, N., Macdonald, N., Gonzalez, F., Peters, J. and Roberts, R. (1999) Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARα and TNFα. Mutat. Res., in press.
75. Braissant, O., Foufelle, F., Scotto, C., Dauca, M. and Wahli, W. (1996) Differential expression of peroxisome-proliferator activated receptors (PPARs): tissue distribution of PPAR-alpha, beta and gamma in the adult rat. Endocrinology, 137, 354-366.
76. Tugwood, J.D., Issemann, I., Anderson, R.G., Bundell, K.R., McPheat, W.L. and Green, S. (1992) The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J., 11, 433-439.
77. Aldridge, T.C., Tugwood, J.D. and Green, S. (1995) Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. Biochem. J., 306, 473-479.
78. Black, R., Rauch, C. and Cerretti, D. (1997) A metalloproteinase disintegrin that releases TNF alpha from cells. Nature, 385, 729-733.
79. Moss, M., Jin, S.-L.C., Milla, M., Burkhart, W. and Becherer, J. (1997) Cloning of a disintegrin metalloproteinase that processes TNF-alpha. Nature, 385, 733-736.
80. Thornberry, N.A., Rano, T.A., Peterson, E.P. et al. (1997) A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem., 272, 17907-17911.
81. Thornberry, N.A., Bull, H.G., Calacay, J.R. et al. (1992) A novel heterodimeric cysteine protease is required for interleukin-1 processing in monocytes. Nature, 356, 768-774.
82. Beier, K., Volkl, A. and Fahimi, D. (1997) TNF-alpha downregulates the PPAR-alpha and the mRNA encoding peroxisomal proteins in rat liver. FEBS Lett., 412, 385-387.
83. Nakamoto, Y., Guidotti, L., Kuhlen, C., Fowler, P. and Chisari, F. (1998) Immune pathogenesis of hepatocellular carcinoma. J. Exp. Med., 188, 341-350.
84. Matsubara, K. and Tokina, T. (1990) Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis. Mol. Biol. Med., 7, 243-260.