Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens

Cell Growth and Differentiation

Volumn 9, Issue 9, 1998, Pages 815-825

  Christensen, James G ^a,b   Gonzales, Andrea J ^a,c,d   Cattley, Russell C ^a   Goldsworthy, Thomas L ^a,e  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d PFIZER INC   (United States)

^e INTEGRATED LABORATORY SYSTEMS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BLEOMYCIN; CARCINOGEN; NAFENOPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHENOBARBITAL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA;

ADOLESCENT; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; LIVER CANCER; LIVER CARCINOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; BLEOMYCIN; CARCINOGENS; CELLS, CULTURED; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; NAFENOPIN; PHENOBARBITAL; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0031695507     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Gold, L. S., Stone, T. H., Manley, N. B., and Bernstein, L. Target organs in chronic bioassays of 533 chemical carcinogens. Environ. Health Perspect., 93: 233-246, 1991.
2. Gold, L. S., Manley, N. B., Slone, T. H., Garfinkel, G. B., Rohrbach, L., and Ames, B. N. The fifth plot of the carcinogenic potency database: results of animal bioassay published in the general literature through 1989. Environ. Health Perspect., 100: 65-135, 1993.
3. Tennant, R., and Zeiger, E. Genetic toxicology: current status of methods of carcinogen identification. Environ. Health Perspect., 100: 307-315, 1993.
4. Tennant, R. W., Margolin, B. H., Shelby, M. D., Zeiger, E., Haseman, J. K., Spaulding, J., Caspary, W., Resnick, M., Stasiewicz, S., Anderson, B., and Minor, R. Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science (Washington DC), 236: 933-941, 1987.
5. Bursch, W., and Lauer, B. Influence of liver tumor promoters on cell death by apoptosis in mouse liver. Arch. Pharmacol. Suppl., 322: R119, 1983.
6. Bursch, W., Lauer, B., Timmerman-Trosiener, I., Barthel, G., Schuppler, J., and Schulte-Hermann, R. Controlled cell death (apoptosis) of normal and putative neoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis (Lond.), 5: 53-58, 1984.
7. Schulte-Hermann, R., Timmerman-Trosiener, I., and Schuppler, J. Response of liver foci in rats to hepatic tumor promoters. Toxicol. Pathol., 10: 63-70, 1982.
8. Schulte-Hermann, R., Timmerman-Trosnier, I., Barthel, G., and Bursch, W. DNA synthesis, apoptosis and phenotypic expression as determinants of growth altered foci in rat liver during phenobarbital promotion. Cancer Res., 50: 5127-5135, 1990.
9. Schulte-Hermann, R., Grasl-Kraupp, B., and Bursch, W. Apoptosis and hepatocarcinogenesis. In: R. J. Jirtle (ed.), Liver Regeneration and Carcinogenesis, pp. 141-178. San Diego: Academic Press, 1995.
10. Schulte-Hermann, R., Bursch, W., and Grasl-Kraupp, B. Active cell death (apoptosis) in liver biology and disease. In: Boyer, J. L. and Ockner, R. K. (eds.), Progress in Liver Disease, Vol. XIII, pp. 1-35. Philadelphia: W. B. Saunders Company, 1995.
11. Columbano, A., Ledda-Columbano, G. M., Rao, P. M., Rajalakshmit, S., and Sarma, D. S. R. Occurrence of cell death (apoptosis) in preneoplastic and neoplastic liver cells: a sequential study. Am. J. Pathol., 116: 441-446, 1984.
12. Malarkey, D., Devereaux, T., Dinse, G., Mann, P., and Maronpot, R. Hepatocarcinogenicity of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice independent of ras proto-oncogene activation. Carcinogenesis (Lond.), 16: 2617-2625, 1995.
13. Grasl-Kraupp, B., Ruttkay-Nedecky, B., Mullauer, L., Taper, H., Huber, W., Bursch, W., and Schulte-Hermann, R. Inherent increase of apoptosis in liver tumors: implications for carcinogenesis and tumor regression. Hepatology, 25: 906-912, 1997.
14. Oberhammer, F. A., and Qin, H-M. Effect of three tumour promoters on the stability of hepatocyte cultures and apoptosis after transforming growth factor-β1. Carcinogenesis (Lond.), 16: 1363-1371, 1995.
15. Woerner, W., and Schrenk, D. Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorine, ultraviolet light, or transforming growth factor-β1. Cancer Res., 56: 1272-1278, 1996.
16. Bayly, A. C., Roberts, R. A., and Dive, C. Suppression of liver cell apoptosis in vitro by the nongenotoxic carcinogen and peroxisome proliferator nafenopin. J. Cell Biol., 125: 197-203, 1994.
17. Miyazaki, A., Bai, L., and Sato, J. Influence of liver tumor promoters and structurally related chemicals on survival of normal adult rat hepatocytes in primary culture. J. Cancer Res. Clin. Oncol., 116: 259-263, 1990.
18. Muakkassah-Kelly, S. F., Bieri, F., Waechter, F., Bentley, P., and Staubli, W. Long-term maintenance of hepatocytes in primary culture in the presence of DMSO: further characterization and effect of nafenopin, a peroxisome proliferator. Exp. Cell Res., 171: 37-51, 1987.
19. Cleary, M. L., and Sklar, J. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint cluster region near a transcriptionally active locus on chromosome 18. Proc. Natl. Acad. Sci. USA, 82: 7439-7443, 1985.
20. Tsujimoto, Y., Cossman, J., Jaffe, E., and Croce, C. M. Involvement of the bcl-2 gene in human follicular lymphoma. Science (Washington DC), 228: 1440-1443, 1985.
21. Bakhshi, A., Jensen, J. P., Goldman, P., Wright, J. J., McBride, O. W., Epstein, A. L., and Korsmeyer, S. J. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on chromosome 18. Cell, 41: 899-906, 1985.
22. Reed, J. C. Bcl-2 and the regulation of programmed cell death. J. Cell Biol., 124: 1-6, 1994.
23. Hockenberry, D., Nunez, G., Milliman, C., Schreiber, R. D., and Korsmeyer, S. J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (Lond.), 348: 334-336, 1990.
24. Vaux, D. L., Cory, S., and Adams, J. M. Bcl-2 gene promotes haemotopoetic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature (Lond.), 335: 440-442, 1988.
25. Yin, X-M., Oltvai, Z. N., and Korsmeyer, S. J. BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with bax. Nature (Lond.), 369: 321-323, 1994.
26. Williams, G. T., and Smith, C. A. Molecular regulation of apoptosis: genetic controls on cell death. Cell, 74: 777-779, 1993.
27. Oltvai, Z. N., Milliman, C. L., and Korsmeyer, S. J. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates cell death. Cell, 74: 609-619, 1993.
28. Boise, L. H., Gonzalez-Garcia, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., and Mao, X. Bcl-x, a bcl-2 related gene that functions as a dominant regulator of apoptosis. Cell, 74: 597-608, 1993.
29. Sato, T., Hanada, M., Bodrus, S., Irie, S., Iwama, N., Boise, L. H., Thompson, C. B., Golemis, E., Forig, L., Wang, H. G., and Reed, J. C. Interactions among members of the bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad Sci. USA, 91: 9238-9242, 1994.
30. Miyashita, T., and Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80: 293-299, 1995.
31. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847-849, 1993.
32. Oberhammer, F. A., Bursch, W., Parzefall, W., Breit, P., Erber, E., Stadler, M., and Schulte-Hermann, R. Effects of transforming growth factor-β on cell death in cultured rat hepatocytes. Cancer Res., 51: 2478-2485, 1991.
33. Oberhammer, F. A., Pavleka, M., Sharma, S., Tiefenbacher, R., Purchio, A. F., Bursch, W., and Schulte-Hermann, R. Induction of apoptosis in cultured rat hepatocytes and regressing liver by transforming growth factor-β1. Proc. Natl. Acad. Sci. USA, 89: 5408-5412, 1992.
34. Russell, W. E., Coffey, R. J., Ouellette, R. J., and Moses, H. L. Transforming growth factor β reversibly inhibits the early proliferative response to partial hepatectomy in rat. Proc. Natl. Acad. Sci. USA, 89: 5126-5130, 1988.
35. Jirtle, R. L., Hankins, G. R., Reisenbichler, H., and Boyer, I. J. Regulation of mannose-6-phosphate/insulin-like growth factor-II receptors and transforming growth factor β during liver tumor promotion with phenobarbital. Carcinogenesis (Lond.), 15: 1473-1478, 1994.
36. Sue, S. R., Chari, R. S., Kong, F. M., Mills, J. J., Fine, R. L., Jirtle, R. L., and Meyers, W. C. Transforming growth factor-β receptors and mannose-6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma. Ann. Surg., 222: 171-178, 1995.
37. Riesenbichler, H., Chari, R., Boyer, I., and Jirtle, R. Transforming growth factor-β receptors type I, II, and III in phenobarbital-promoted rat liver tumors. Carcinogenesis (Lond.), 15: 2763-2767, 1994.
38. Moser, G. J., Wolf, D. C., Harden, R., Standeven, A. M., Mills, J. J., Jirtle, R. L., and Goldsworthy, T. L. Cell proliferation and regulation of negative growth factors in mouse liver foci. Carcinogenesis (Lond.), 17: 1835-1840, 1996.
39. Jirtle, R. L., and Meyer, S. Liver tumor promotion: effect of phenobarbital and EGF and protein kinase C signal transduction and TGF-β1 expression. Dig. Dis. Sci., 36: 659-668, 1991.
40. DeSouza, A. T., Hankins, G. R., Washington, M. K., Orton, T. C., and Jirtle, R. L. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat. Gen., 11: 447-449, 1995.
41. DeSouza, A. T., Hankins, G. R., Washington, M. K., Fine, R. L., Orton, T. C., and Jirtle, R. L. Frequent loss of heterozygosity on 6q at the mannose-6-phosphate/insulin-like growth factor receptor locus in human hepatocellular tumors. Oncogene, 10: 1725-1729, 1995.
42. Kastan, M. B., Zhan, Q., El-Diery, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, A. J. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD 45 is defective in ataxia telangiectasia. Cell, 71: 587-597, 1992.
43. Hollstein, M., Rice, K., Greenblatt, M. S., Soussi, T., Fuchs, R., Sorlie, T., Hovig, E., Smith-Sorenson, B., Montesano, R., and Harris, C. C. Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res., 22: 3551-3555, 1994.
44. Gorczyca, W., Gong, J., and Darzynkiewicz, Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res., 53: 1945-1951, 1993.
45. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119: 493-501, 1992.
46. Sgonc, R., Boeck, G., Dietrich, H., Gruber, J., Recheis, H., and Wick, G. Simultaneous determination of cell surface antigens and apoptosis. Trends Genet., 10: 41-42, 1994.
47. McGahon, A., Martin, S. J., Bissonnette, R. P., Mahboubi, A., Shi, Y., Mogil, R. J., Nishioka, W. K., and Green, D. R. The end of the cell line: methods for the study of apoptosis in vitro. In: L. M. Schwartz and B. A. Osborne (eds.), Methods in Cell Biology: Cell Death, Vol. 46, pp. 172-173. San Diego: Academic Press, 1995.
48. Moser, G., and Goldsworthy, T. L. Growth factor regulation in mouse liver carcinogenesis. CIIT Activities, 16: 1-8, 1996.
49. Pitot, H. C. Protooncogene activation in multistage murine hepatocarcinogenesis. In: D. E. Stevenson, R. M. McClain, J. A. Popp, J. M. Ward, T. J. Slaga, and H. C. Pitot (eds.), Mouse liver carcinogenesis: mechanisms and species comparisons, Vol. 331, pp. 311-324. New York: Wiley-Liss, 1990.
50. Ward, J. M., Diwan, B. A., Lubet, R. A., Henneman, J. R., and Devor, D. E. Liver tumor promoters and other mouse carcinogens. In: D. E. Stevenson, R. M. McClain, J. A. Popp, J. M. Ward, T. J. Slaga, and H. C. Pitot (eds.), Mouse Liver Carcinogenesis: Mechanisms and Species Comparisons, Vol. 331, pp. 85-108. New York: Wiley-Liss, 1990.
51. Ward, J. M., Rice, J. M., Creasia, D., Lynch, P., and Riggs, C. Dissimilar patterns of promotion by di-(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice. Carcinogenesis (Lond.), 4: 1021-1029, 1983.
52. Ward, J. M., Ohshima, M., Lynch, P., and Riggs, C. Di(2-ethylhexyl)-phthalate but not phenobarbital promotes N-nitrosodiethyl amine initiated hepatocellular proliferative lesions after short term exposure in male B6C3F1 mice. Cancer Lett., 24: 49-55, 1984.
53. Kedderis, G. L., Argenbright, L. S., and Miwa, G. T. Studies with nitrogen-containing steroids and freshly isolated rat hepatocytes: role of cytochrome P-450 in detoxication. Toxicol. Appl. Pharmacol., 93: 403-412, 1988.
54. Dunnett, C. W. A multiple comparisons procedure for comparing several treatments with a control. J. Am. Stat. Assoc., 50: 1096-1121, 1955.
55. Steel, R. G. D., and Torrie, J. H. Principles and Procedures of Statistics, pp. 126-311. New York: McGraw-Hill, 1980.