Liver cell proliferation induced by nafenopin and cyproterone acetate is not associated with increases in activation of transcription factors NF-κB and AP-1 or with expression of tumor necrosis factor α

Hepatology

Volumn 25, Issue 3, 1997, Pages 585-592

  Menegazzi, Marta ^a   Carcereri De Prati, Alessandra ^a   Suzuki, Hisanori ^a   Shinozuka, Hisashi ^b   Pibiri, Monica ^c   Piga, Rosaria ^c   Columbano, Amedeo ^c   Ledda Columbano, Giovanna M ^c  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYPROTERONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NAFENOPIN; NITRIC OXIDE SYNTHASE; TRANSCRIPTION FACTOR AP 1;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INDUCTION; GENE EXPRESSION REGULATION; LIVER CELL; LIVER REGENERATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; BINDING, COMPETITIVE; CARBON TETRACHLORIDE; CELL DIVISION; CYPROTERONE ACETATE; HEPATECTOMY; HYPERPLASIA; LEAD; LIVER; LIVER REGENERATION; MALE; MITOGENS; NAFENOPIN; NF-KAPPA B; NITRATES; RATS; RATS, WISTAR; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031056849     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510250316     Document Type: Article

References (21)

1. Fausto N, Webber EM. Liver regeneration. In: Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Shafritz DA, eds. The liver: biology and pathobiology. Ed 3. New York: Raven, 1994:1059-1084.
2. Scearce LM, Lee J, Naji L, Greenbaum L, Cressman DE, Taub R. Rapid activation of latent transcription factor complexes reflects initiating signals in liver regeneration. Cell Death Diff 1996;3:51-59.
3. Tewari M, Dobrzanski P, Mohn KL, Cressman DE, Hsu J, Bravo R, Taub B. Rapid induction in regenerating liver of RL/IF-1 (an IκB that inhibits NF-κB, Rel-B-p50 and c-Rel-p50) and PHF, a novel κB site-binding complex. Mol Cell Biol 1992;12:2898-2908.
4. FitzGerald MJ, Webber EM, Donovan JR, Fausto N. Rapid DNA binding by nuclear factor κB in hepatocytes at the start of liver regeneration. Cell Growth Diff 1995;6:417-427.
5. Grilli M, Chiou J-S, Lenardo MJ. NF-κB and Rel: participants in a multiform transcriptional regulatory system. Int Rev Cytol 1993;143:1-62.
6. Akerman P, Cote P, Yang S-Q, McClain C, Nelson S, Bagby GJ, Diehl AM. Antibodies to tumor necrosis factor-α inhibit liver regeneration after partial hepatectomy. Am J Physiol 1992;263:G579-G585.
7. Shinozuka H, Kubo Y, Katyal SL, Coni P, Ledda-Columbano GM, Columbano A, Nakamura T. Roles of hepatocyte growth factor and tumor necrosis factor-α on liver cell proliferation induced in rats by lead nitrate. Lab Invest 1994;71:35-41.
8. Ledda-Columbano GM, Columbano A, Cannas A, Simbula G, Okita K, Kayano K, Kubo Y, et al. Dexamethasone inhibits induction of liver tumor necrosis factor-α mRNA and liver growth induced by lead nitrate and ethylene dibromide. Am J Pathol 1994;145:951-958.
9. Mealy K, Wilmore DW. Tumor necrosis factor and hepatic cell mass. Br J Surg 1991;78:331-333.
10. Feingold KK, Barker MR, Jones AL, Grunfeld C. Localization of tumor necrosis factor stimulated DNA synthesis in the liver. HEPATOLOGY 1991;13:773-779.
11. Shinozuka H, Ohmura T, Katyal SL, Zedda AI, Ledda-Columbano GM, Columbano A. Possible roles of nonparenchymal cells in hepatocyte proliferation induced by lead nitrate and by tumor necrosis factor-α. HEPATOLOGY 1996;23:1572-1577.
12. Geller DA, Nussler AK, Di Silvio M, Lowenstein CJ, Shapiro RA, Wang SC, Simmons RL. Cytokines, endotoxins and glucocorticoid regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci USA 1993;90:522-526.
13. Moncada S, Palmer RJ, Higgs EA. Biosynthesis of nitric oxide from L-arginine. A pathway for the regulation of cell function and communication. Biochem Pharmacol 1989;38:1709-1716.
14. Decker CF, Obolenskaya MY. Cytokines, nitric oxide synthesis and liver regeneration. J Gastroenterol Hepatol 1995;10:S12-S17.
15. Hortelano S, Dewez B, Genaro AM, Diaz-Guerra M, Bosca L. Nitric oxide is released in regenerating liver after partial hepatectomy. HEPATOLOGY 1995;21:776-786.
16. Fausto N, Laird AD, Webber EM. Role of growth factors and cytokines in hepatic regeneration. FASEB J 1995;9:1527-1536.
17. Haber BA, Mohn KL, Diamond RH, Taub R. Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration. J Clin Invest 1993;91:1319-1326.
18. Mead JE, Fausto N. Transforming growth factor-α (TGF-α may be a physiological regulator of liver regeneration via an autocrine mechanism). Proc Natl Acad Sci USA 1989;86:1558-1562.
19. Michalopoulos GK. Liver regeneration: molecular mechanism of growth control. FASEB J 1990;4:240-249.
20. Kinoshita T, Hirao S, Matsumoto K, Nakamura T. Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy. Biochem Biophys Res Commun 1991;177:330-335.
21. Coni P, Pichiri-Coni G, Ledda-Columbano GM, Rao PM, Rajalakshmi S, Sarma DSR, Columbano A. Liver hyperplasia is not necessarily associated with increased expression of c-fos and c-myc mRNA. Carcinogenesis 1990;11:835-839.