Tumour necrosis factor α (TNFα) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: A mediator of the hepatocarcinogenicity of peroxisome proliferators?

Carcinogenesis

Volumn 18, Issue 11, 1997, Pages 2277-2280

  Rolfe, Mark ^a   James, Neil H ^a   Roberts, Ruth A ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NAFENOPIN; PEROXISOME PROLIFERATOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CELL DIVISION; DNA; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICROBODIES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031428482     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.11.2277     Document Type: Article

References (42)

1. Reddy, J.K., Azarnoff, D.L. and Hignite, C.E. (1980) Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature, 283, 397-398.
2. Moody, D.E., Rao, M.S. and Reddy, J.K. (1977) Mitogenic effect in mouse liver induced by a hypolipidaemic drug, nafenopin. Virch. Arch. Pathol., 323, 291-296.
3. Barber, E.D., Astill, B.D., Moran, E.J., Schneider, B.F., Gray, T.J.B., Lake, B.G. and Evans, J.G. (1987) Peroxisome induction studies on seven phthalate esters. Toxicol. Indust. Health, 3, 130.
4. Ashby, J., Brady, A., Elcombe, C.R., Elliot, B.M., Ishmael, J., Odum, J., Tugwood, J.D., Kettle, S. and Purchase, I.F.H. (1994) Mechanistically-based human hazard assessment of peroxisome-proliferator-induced hepatocarcinogenesis. Hum. Exp. Toxicol., 13, S1-S117.
5. Lake, B.G. (1995) Peroxisome proliferation: current mechanisms relating to non genotoxic carcinogenesis. Toxicol. Lett., 82/83, 673-681.
6. Elcombe, C.R. and Mitchell, A. (1986) Peroxisome proliferation due to di(2-ethyl)phthalate: species differences and possible mechanisms. Environ. Health Perspect., 70, 211-219.
7. Bentley, P., Calder, I., Elcombe, E., Grasso, P. Stringer, D. and Wiegand, H.J. (1993) Hepatic peroxisome proliferation in rodents and its significance to humans. Food. Chem. Toxic., 31, 857-907.
8. Williams, G.M. and Perrone, C. (1995) Mechanism-based risk assessment of peroxisome proliferating rodent hepatocarcinogens. In Reddy, J.K., Suga, T., Mannaerts, G.P., Lazarow, P.B. and Subramani, S. (eds) Peroxisomes: Biology and Role in Toxicology and Disease. The New York Academy of Sciences, New York, pp. 554-572.
9. Ames, B.N. and Gold, L.S. (1990) Too many rodent carcinogens: mitogenesis increases mutagenesis. Science, 249, 970-971.
10. Bursch, B., Lauer, B., Timmerman-Trosiener, I., Barthel, G., Schuppler, J. and Schulte-Hermann, R. (1984) Controlled death (apoptosis) of normal and preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis, 5, 453-458.
11. Gerbracht, U., Bursch, W., Kraus, P., Putz, B., Reinacher, M., Timmerman-Trosiener, I. and Schulte-Hermann, R. (1990) Effects of the hypolipidaemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver. Carcinogenesis, 11, 617-624.
12. James, N.H. and Roberts, R.A. (1996) Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than with suppression of apoptosis. Carcinogenesis, 17, 1623-1632.
13. Roberts, R.A., Soames, A.R., Gill, J.H., James, N.H. and Wheeldon, E.B. (1995) Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different discrete hepatocyte populations. Carcinogenesis. 16, 1693-1698.
14. Bayly, A.C., Roberts, R.A. and Dive, C. (1994) Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator, nafenopin. J. Cell Biol., 125, 197-203.
15. Bruccoleri, A., Gallucci, R., Germolec, D.R., Blackspear, P. Simeonova, P., Thurman, R.G. and Luster, M.I. (1997) Induction of early-immediate genes by tumor necrosis factor-alpha contribute to liver repair following chemical-induced hepatotoxicity. Hepatology, 25, 133-141.
16. Yamada, Y., Kirillova, I., Peschon, J.J. and Fausto, N. (1997) Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc. Natl Acad. Sci., 94, 1441-1446.
17. Akerman, P. Cote, P., Yang, S., McClain, C., Nelson, S., Bagby, G. and Diehl, A.M. (1992) Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am. J. Physiol., 263, 579-585.
18. Ledda-Columbano, G.M., Columbano, A., Cannas, A., Simbula, G., Okita, K., Kayano, K., Kubo, Y., Katyal, S.L. and Shinozuka, H. (1994) Dexamethasone inhibits induction of liver tumor necrosis factor-alpha mRNA and liver growth by lead nitrate and ethylene dibromide. Am. J. Path., 145, 951-958.
19. Beutler, B. and Cerami, A. (1988) Cachectin, tumor necrosis factor alpha: a macrophage hormone governing cellular metabolism and inflammatory response. Endocr. Rev., 9, 57-66.
20. Shinagawa, T., Yoshioka, K., Kakamu, T., Ishikawa, T., Itoh, Y. and Takayanagi, M. (1991) Apoptosis in cultured rat hepatocytes: the effects TNFα and interleukin gamma. J. Pathol., 165, 247-253.
21. Nussler, A.K., Di Silvio, M., Lui, Z.Z., Geller, D.A., Freeswick, P., Dorko, K., Bartoli, F. and Billiar, T.R. (1995) Further characterisation and comparison of inducible nitric oxide synthase in mouse, rat and human hepatocytes. Hepatology, 21, 1552-1560.
22. Freeman, M.F and Tukey, J.W. (1950) Transformations related to the angular and the square root. Annals. Maths. Stats., 21, 607-610.
23. Cary, N.C. (1989) SAS/STAT User's Guide. SAS Institute Incorporated, New York.
24. Bojes, H.K., Germolec, D.R., Simeonova.P., Bruccolrei, A., Schoonhoven, R., Luster, M.I. and Thurman, R.G. (1997) Antibodies to tumor necrosis factor-alpha prevent increases in cell replication in liver due to the potent peroxisome proliferator WY-14 643. Carcinogenesis, 18, 669-674.
25. Columbano, A. and Shinozuka, H. (1996) Liver regeneration 8: liver regeneration versus direct hyperplasia. FASEB J., 10, 1118-1128.
26. Menegazzi, M., Carcereri-De-Prati, A., Shinozuka, H., Pibiri, M., Piga, R., Columbano, A. and Ledda-Columbano, G.M. (1997) Liver cell proliferation induced by nafenopin and cyproterone acetate is not associated with increases in activation of transcription factors NF-kB and AP-1 or with expression of tumor necrosis factor-alpha. Hepatology, 25, 585-592.
27. Kim, Y.-M., de Vera, M., Watkins, S.C. and Billiar, T.R. (1997) Nitric oxide protects cultures rat hepatocytes from tumor necrosis factor-alpha induced apoptosis by inducing heat shock protein 70 expression. J. Biol. Chem., 272, 1402-1411.
28. Deviere, J., Content, J., Denys, C., Vandenbussche, P., Schandene, L., Wybran, J. and Dupont, E. (1990) Excessive in vitro bacterial LPS-induced production of monokines in cirrhosis. Hepatology, 8, 237-242.
29. Chinnaiyan, A.M., Tepper, C.G., Seldin, M.F., O-Rourke, K., Kischkel, F.C., Hellbardt, S., Krammer, P.H., Peter, M.E. and Dixit, V.M. (1996) FADD/ MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J. Biol. Chem., 271, 4961-4965.
30. Kuenstle, G., Leist, M., Uhlig, S., Revesz, L., Feifel, R., MacKenzie, A. and Wendel, A. (1997) ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNFα. Immunol. Lett., 55, 5-10.
31. Taub, R. (1996) Liver regeneration 4: transcriptional control of liver regeneration. FASEB J., 10, 413-427.
32. Heller, R.A. and Kronke, M. (1994) Tumor necrosis factor receptor-mediated signalling pathways. J. Cell Biol., 126, 5-9.
33. Liu, Z., Hsu, H., Goeddel, D. and Karin, M. (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappa B activation prevents cell death. Cell, 87, 565-576.
34. Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R. and Verma, I.M. (1996) Suppression of TNF-alpha-induced apoptosis by NF-kappa B. Science, 274, 787-789.
35. Beg, A.A. and Baltimore, D. (1996) An essential role for NF-kappa B in preventing TNF-alpha-induced cell death. Science, 274, 782-784.
36. Li, Y., Leung, L.K., Glauert, H.P. and Spear, B.T. (1996) Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kappa B activity. Carcinogenesis, 17, 2305-2309.
37. Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J. and Evan, G. (1997) Suppression of c-Myc-induced apoptosis by ras signalling through PI(3) K and PKB. Nature, 385, 544-548.
38. Issemann, I. and Green, S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 347, 645-650.
39. Issemann, I., Prince, R.A., Tugwood, J.D. and Green, S. (1993) The peroxisome proliferator-activated receptor: retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs. J. Mol. Endocrin., 11, 37-47.
40. Lee, S.S.-T., Pineau, T., Drago, J., Lee, E.J., Owens, J.O., Kroetz, D.L., Fernandez-Salguero, P.M., Westphal, H. and Gonzalez, F.J. (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleitrophic effects of peroxisome proliferators. Mol. Cell. Biol., 15, 3012-3022.
41. Decker, K. (1990) Biologically active products of stimulated liver macrophages (Kupffer cells). Eur. J. Biochem., 192, 245-261.
42. Bojes, H.K. and Thurman, R.G. (1996) Peroxisome proliferators activate Kupffer cells in vivo. Cancer Res., 56, 1-4.