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Volumn 73, Issue 10, 1999, Pages 8308-8319

Regulation of adenovirus-mediated transgene expression by the viral E4 gene products: Requirement for E4 ORF3

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GENE PRODUCT; TRANSMEMBRANE CONDUCTANCE REGULATOR;

EID: 0032823287     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.10.8308-8319.1999     Document Type: Article
Times cited : (49)

References (65)
  • 2
    • 0028914687 scopus 로고
    • Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains
    • Barr, D., J. Tubb, D. Fergusson, A. Scaria, A. Lieber, C. Wilson, J. Perkins, and M. A. Kay. 1995. Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains. Gene Ther. 2:151-155.
    • (1995) Gene Ther. , vol.2 , pp. 151-155
    • Barr, D.1    Tubb, J.2    Fergusson, D.3    Scaria, A.4    Lieber, A.5    Wilson, C.6    Perkins, J.7    Kay, M.A.8
  • 4
    • 0023764622 scopus 로고
    • Development of adenovirus vectors for the expression of heterologous genes
    • Berkner, K. L. 1988. Development of adenovirus vectors for the expression of heterologous genes. BioTechniques 6:616-629.
    • (1988) BioTechniques , vol.6 , pp. 616-629
    • Berkner, K.L.1
  • 5
    • 0032926836 scopus 로고    scopus 로고
    • Analysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5
    • Boivin, D., M. R. Morrison, R. C. Marcellus, E. Querido, and P. E. Branton. 1999. Analysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5. J. Virol. 73:1245-1253.
    • (1999) J. Virol. , vol.73 , pp. 1245-1253
    • Boivin, D.1    Morrison, M.R.2    Marcellus, R.C.3    Querido, E.4    Branton, P.E.5
  • 6
    • 0022371467 scopus 로고
    • A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
    • Boshart, M., F. Weber, G. Jahn, K. Dorsch-Hasler, B. Fleckenstein, and W. Schaffner. 1985. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell 41:521-530.
    • (1985) Cell , vol.41 , pp. 521-530
    • Boshart, M.1    Weber, F.2    Jahn, G.3    Dorsch-Hasler, K.4    Fleckenstein, B.5    Schaffner, W.6
  • 7
    • 0030730116 scopus 로고    scopus 로고
    • Prospect for adenovirus-mediated gene therapy of inherited diseases of the myocardium
    • Bowles, N. E., and Q. Wang. 1997. Prospect for adenovirus-mediated gene therapy of inherited diseases of the myocardium. Cardiovasc. Res. 35:422-430.
    • (1997) Cardiovasc. Res. , vol.35 , pp. 422-430
    • Bowles, N.E.1    Wang, Q.2
  • 8
    • 0024571586 scopus 로고
    • Redundant control of adenovirus late gene expression by early region 4
    • Bridge, E., and G. Ketner. 1989. Redundant control of adenovirus late gene expression by early region 4. J. Virol. 63:631-638.
    • (1989) J. Virol. , vol.63 , pp. 631-638
    • Bridge, E.1    Ketner, G.2
  • 10
    • 0030728433 scopus 로고    scopus 로고
    • Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo
    • Brough, D. E., C. Hsu, V. A. Kulesa, G. M. Lee, L. J. Cantolupo, A. Lizonova, and I. Kovesdi. 1997. Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo. J. Virol. 71:9206-9213.
    • (1997) J. Virol. , vol.71 , pp. 9206-9213
    • Brough, D.E.1    Hsu, C.2    Kulesa, V.A.3    Lee, G.M.4    Cantolupo, L.J.5    Lizonova, A.6    Kovesdi, I.7
  • 12
    • 0019446161 scopus 로고
    • Deletion mutants of adenovirus 2: Isolation and initial characterization of virus carrying mutations near the right end of the viral genome
    • Challberg, S. S., and G. Ketner. 1981. Deletion mutants of adenovirus 2: isolation and initial characterization of virus carrying mutations near the right end of the viral genome. Virology 114:196-209.
    • (1981) Virology , vol.114 , pp. 196-209
    • Challberg, S.S.1    Ketner, G.2
  • 13
    • 0029977774 scopus 로고    scopus 로고
    • Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli
    • Chartier, C., E. Degryse, M. Gantzer, A. Dieterlé, A. Pavirani, and M. Mehtali. 1996. Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J. Virol. 79:4805-4810.
    • (1996) J. Virol. , vol.79 , pp. 4805-4810
    • Chartier, C.1    Degryse, E.2    Gantzer, M.3    Dieterlé, A.4    Pavirani, A.5    Mehtali, M.6
  • 15
    • 0344466764 scopus 로고    scopus 로고
    • Submitted for publication
    • Christ, M., et al. Submitted for publication.
    • Christ, M.1
  • 16
    • 0026551721 scopus 로고
    • The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2
    • Chroboczek, J., F. Bieber, and B. Jacrot. 1992. The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2. Virology 186:280-285.
    • (1992) Virology , vol.186 , pp. 280-285
    • Chroboczek, J.1    Bieber, F.2    Jacrot, B.3
  • 20
    • 0021020342 scopus 로고
    • A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells
    • Czerkinsky, C. C., L.-A. Nilsson, H. Nygren, O. Ouchterlony, and A. Tarkowski. 1983. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J. Immunol. Methods 65:109-121.
    • (1983) J. Immunol. Methods , vol.65 , pp. 109-121
    • Czerkinsky, C.C.1    Nilsson, L.-A.2    Nygren, H.3    Ouchterlony, O.4    Tarkowski, A.5
  • 21
    • 0028934815 scopus 로고
    • Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression
    • Dai, Y., E. M. Schwarz, D. Gu, W. W. Zhang, N. Sarvetnick, and I. M. Verma. 1995. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. USA 92:1401-1405.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1401-1405
    • Dai, Y.1    Schwarz, E.M.2    Gu, D.3    Zhang, W.W.4    Sarvetnick, N.5    Verma, I.M.6
  • 23
    • 0030052130 scopus 로고    scopus 로고
    • Adenovirus replication is coupled with dynamic properties of the PML nuclear structure
    • Doucas, V., A. M. Ishov, A. Roma, H. Juguilon, M. D. Weitzman, R. M. Evans, and G. G. Maul. 1996. Adenovirus replication is coupled with dynamic properties of the PML nuclear structure. Genes Dev. 10:196-207.
    • (1996) Genes Dev. , vol.10 , pp. 196-207
    • Doucas, V.1    Ishov, A.M.2    Roma, A.3    Juguilon, H.4    Weitzman, M.D.5    Evans, R.M.6    Maul, G.G.7
  • 24
    • 0028179010 scopus 로고
    • A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
    • Dyck, I. A, G. G. Maul, W. Miller, J. D. Chen, Jr., A. Kakizuka, and R. M. Evans. 1994. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 76:333-343.
    • (1994) Cell , vol.76 , pp. 333-343
    • Dyck, I.A.1    Maul, G.G.2    Miller, W.3    Chen J.D., Jr.4    Kakizuka, A.5    Evans, R.M.6
  • 25
    • 0028618419 scopus 로고
    • Prolonged transgene expression in cotton rat lung with recombinant adenoviruses in E2a
    • Engelhardt, J. F., L. Litzky, and J. M. Wilson. 1994. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses in E2a. Hum. Gene Ther. 5:1217-1229.
    • (1994) Hum. Gene Ther. , vol.5 , pp. 1217-1229
    • Engelhardt, J.F.1    Litzky, L.2    Wilson, J.M.3
  • 26
    • 0029670374 scopus 로고    scopus 로고
    • Lack of persistence of E1-recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs
    • Fang, B., H. Wang, G. Gordon, D. A. Bellinger, M. S. Read, K. M. Brinkhous, S. L. C. Woo, and R. C. Eisensmith. 1996. Lack of persistence of E1-recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs. Gene Ther. 3:217-222.
    • (1996) Gene Ther. , vol.3 , pp. 217-222
    • Fang, B.1    Wang, H.2    Gordon, G.3    Bellinger, D.A.4    Read, M.S.5    Brinkhous, K.M.6    Woo, S.L.C.7    Eisensmith, R.C.8
  • 28
    • 0029959867 scopus 로고    scopus 로고
    • Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy
    • Gao, G. P., Y. Yang, and J. M. Wilson. 1996. Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy. J. Virol. 70:8934-8943.
    • (1996) J. Virol. , vol.70 , pp. 8934-8943
    • Gao, G.P.1    Yang, Y.2    Wilson, J.M.3
  • 29
    • 0029664338 scopus 로고    scopus 로고
    • Elimination of both E1 and E2a from adenovirus vectors further improves prospects for in vivo human gene therapy
    • Gorziglia, M. I., M. J. Kadan, S. Yei, J. Lim, G. M. Lee, R. Luthra, and B. C. Trapnell. 1996. Elimination of both E1 and E2a from adenovirus vectors further improves prospects for in vivo human gene therapy. J. Virol. 70: 4173-4178.
    • (1996) J. Virol. , vol.70 , pp. 4173-4178
    • Gorziglia, M.I.1    Kadan, M.J.2    Yei, S.3    Lim, J.4    Lee, G.M.5    Luthra, R.6    Trapnell, B.C.7
  • 30
    • 0026484050 scopus 로고
    • Adenovirus based expression vectors and recombinant vaccines
    • R. W. Ellis (ed.), Butterworth-Heinemann, Newton, Mass.
    • Graham, F. L., and L. Prevec. 1992. Adenovirus based expression vectors and recombinant vaccines, p. 363-390. In R. W. Ellis (ed.), Vaccines: new approaches to immunological problems. Butterworth-Heinemann, Newton, Mass.
    • (1992) Vaccines: New Approaches to Immunological Problems , pp. 363-390
    • Graham, F.L.1    Prevec, L.2
  • 31
    • 0344035630 scopus 로고    scopus 로고
    • Submitted for publication
    • Grave, L., et al. Submitted for publication.
    • Grave, L.1
  • 32
    • 0040947384 scopus 로고    scopus 로고
    • Stromelysin-3 induction and interstitial collagenase repression by retinoic acid
    • Guérin, E., M.-G. Ludwig, P. Basset, and P. Angiard. 1997. Stromelysin-3 induction and interstitial collagenase repression by retinoic acid. J. Biol. Chem. 272:11088-11095.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11088-11095
    • Guérin, E.1    Ludwig, M.-G.2    Basset, P.3    Angiard, P.4
  • 33
    • 0024344731 scopus 로고
    • Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection
    • Hoang, M.-M., and P. Hearing. 1989. Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection. J. Virol. 63:2605-2615.
    • (1989) J. Virol. , vol.63 , pp. 2605-2615
    • Hoang, M.-M.1    Hearing, P.2
  • 34
    • 0024756945 scopus 로고
    • The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor E2F, through a direct complex
    • Huang, M.-M., and P. Hearing. 1989. The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor E2F, through a direct complex. Genes Dev. 3:1699-1710.
    • (1989) Genes Dev. , vol.3 , pp. 1699-1710
    • Huang, M.-M.1    Hearing, P.2
  • 35
    • 0028533695 scopus 로고
    • The impact of development stage, route of administration, and the immune system on adenovirus-mediated gene transfer
    • Kass-Eissler, A., E. Falck-Pedersen, D. H. Elfenbein, M. Alvira, P. M. Buttrick, and L. A. Leinwand. 1994. The impact of development stage, route of administration, and the immune system on adenovirus-mediated gene transfer. Gene Ther. 1:395-402.
    • (1994) Gene Ther. , vol.1 , pp. 395-402
    • Kass-Eissler, A.1    Falck-Pedersen, E.2    Elfenbein, D.H.3    Alvira, M.4    Buttrick, P.M.5    Leinwand, L.A.6
  • 36
    • 0027360098 scopus 로고
    • Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription
    • Kleinberger, T., and T. Shenk. 1993. Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription. J. Virol. 67:7556-7560.
    • (1993) J. Virol. , vol.67 , pp. 7556-7560
    • Kleinberger, T.1    Shenk, T.2
  • 37
    • 0032498630 scopus 로고    scopus 로고
    • E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway which is not inhibited by zVAD-fmk
    • Lavoie, J. N., M. Nguyen, R. C. Marcellus, P. E. Branton, and G. C. Shore. 1998. E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway which is not inhibited by zVAD-fmk. J. Cell Biol. 140:637-645.
    • (1998) J. Cell Biol. , vol.140 , pp. 637-645
    • Lavoie, J.N.1    Nguyen, M.2    Marcellus, R.C.3    Branton, P.E.4    Shore, G.C.5
  • 38
    • 0030955245 scopus 로고    scopus 로고
    • E4 gene function in adenovirus, adenovirus-vector and adeno-associated virus infections
    • Leppard, K. N. 1997. E4 gene function in adenovirus, adenovirus-vector and adeno-associated virus infections. J. Gen. Virol. 78:2131-2138.
    • (1997) J. Gen. Virol. , vol.78 , pp. 2131-2138
    • Leppard, K.N.1
  • 41
    • 0344466761 scopus 로고    scopus 로고
    • Unpublished data
    • Lusty, M. Unpublished data.
    • Lusty, M.1
  • 42
    • 0031816872 scopus 로고    scopus 로고
    • The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis
    • Marcellus, R. C., J. N. Lavole, D. Boivin, G. C. Shore, G. Ketner, and P. E. Branton. 1998. The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis. J. Virol. 72:7144-7153.
    • (1998) J. Virol. , vol.72 , pp. 7144-7153
    • Marcellus, R.C.1    Lavole, J.N.2    Boivin, D.3    Shore, G.C.4    Ketner, G.5    Branton, P.E.6
  • 43
    • 0030999469 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer: Influence of transgene, mouse strain and type of immune response on persistence of transgene expression
    • Michou, A. I., L. Santoro, M. Christ, V. Julliard, A. Pavirani, and M. Mehtali. 1997. Adenovirus-mediated gene transfer: influence of transgene, mouse strain and type of immune response on persistence of transgene expression. Gene Ther 4:473-482.
    • (1997) Gene Ther , vol.4 , pp. 473-482
    • Michou, A.I.1    Santoro, L.2    Christ, M.3    Julliard, V.4    Pavirani, A.5    Mehtali, M.6
  • 44
    • 0029836780 scopus 로고    scopus 로고
    • Evaluation of the concentration and bioactivity of adenovectors for gene therapy
    • Mittereder, N., K. L. March, and B. C. Trapnell. 1996. Evaluation of the concentration and bioactivity of adenovectors for gene therapy. J. Virol. 70:7498-7509.
    • (1996) J. Virol. , vol.70 , pp. 7498-7509
    • Mittereder, N.1    March, K.L.2    Trapnell, B.C.3
  • 45
    • 0030824640 scopus 로고    scopus 로고
    • Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: Comparison of E2a wild type and E2a deleted vectors
    • Morral, N., W. O'Neal, H. Zhou, C. Längston, and A. Beaudet. 1997. Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors. Hum. Gene Ther. 8:1275-1286.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 1275-1286
    • Morral, N.1    O'Neal, W.2    Zhou, H.3    Längston, C.4    Beaudet, A.5
  • 46
    • 0026669557 scopus 로고
    • Adenovirus E4orf4 reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1
    • Müller, U., T. Klelnberger, and T. Shenk. 1992. Adenovirus E4orf4 reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1. J. Virol. 66:5867-5878.
    • (1992) J. Virol. , vol.66 , pp. 5867-5878
    • Müller, U.1    Klelnberger, T.2    Shenk, T.3
  • 48
    • 0028137826 scopus 로고
    • Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs
    • Nordqvist, K., K. Öhman, and G. Akusjärvi. 1994. Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs. Mol. Cell. Biol. 14:437-445.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 437-445
    • Nordqvist, K.1    Öhman, K.2    Akusjärvi, G.3
  • 49
    • 0027202350 scopus 로고
    • Two adenovirus proteins with redundant activities in virus growth facilitate tripartite leader mRNA accumulation
    • Ohman, K., K, Nordqvist, and G. Akusjärvi. 1993. Two adenovirus proteins with redundant activities in virus growth facilitate tripartite leader mRNA accumulation. Virology 194:50-58.
    • (1993) Virology , vol.194 , pp. 50-58
    • Ohman, K.1    K, N.2    Akusjärvi, G.3
  • 51
    • 0032505771 scopus 로고    scopus 로고
    • Non-specific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses
    • Otake, K., D. L. Ennist, K. Harrod, and B. C. Trapnell. 1998. Non-specific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses. Hum. Gene Ther. 10:2207-2222.
    • (1998) Hum. Gene Ther. , vol.10 , pp. 2207-2222
    • Otake, K.1    Ennist, D.L.2    Harrod, K.3    Trapnell, B.C.4
  • 53
    • 3543030401 scopus 로고    scopus 로고
    • Adenovirus-mediated persistent cystic fibrosis transmembrane conductance regulator expression in mouse airway epithelium
    • Scaria, A., J. A. St. George, C. Jiang, J. M. Kaplan, S. C. Wadsworth, and R. J. Gregory. 1998. Adenovirus-mediated persistent cystic fibrosis transmembrane conductance regulator expression in mouse airway epithelium. J. Virol. 72:7302-7309.
    • (1998) J. Virol. , vol.72 , pp. 7302-7309
    • Scaria, A.1    St George, J.A.2    Jiang, C.3    Kaplan, J.M.4    Wadsworth, S.C.5    Gregory, R.J.6
  • 55
    • 0000557447 scopus 로고    scopus 로고
    • Adenoviridae: The viruses and their replication
    • B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Raven Press, Philadelphia, Pa.
    • Shenk, T. 1996. Adenoviridae: the viruses and their replication, p. 2111-2148. In B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Virology. Raven Press, Philadelphia, Pa.
    • (1996) Virology , pp. 2111-2148
    • Shenk, T.1
  • 56
    • 0031949940 scopus 로고    scopus 로고
    • Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells
    • Shtrichman, R., and T. Kleinberger. 1998. Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells. J. Virol. 72:2975-2982.
    • (1998) J. Virol. , vol.72 , pp. 2975-2982
    • Shtrichman, R.1    Kleinberger, T.2
  • 58
    • 0027768571 scopus 로고
    • Adenoviral vectors for gene transfer
    • Trapnell, B. C. 1993. Adenoviral vectors for gene transfer. Adv. Drug Delivery Rev. 12:185-199.
    • (1993) Adv. Drug Delivery Rev. , vol.12 , pp. 185-199
    • Trapnell, B.C.1
  • 59
    • 0029936764 scopus 로고    scopus 로고
    • Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors
    • Tripathy, S. K., H. B. Black, E. Goldwasser, and J. M. Leiden. 1996. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nat. Med. 2:545-550.
    • (1996) Nat. Med. , vol.2 , pp. 545-550
    • Tripathy, S.K.1    Black, H.B.2    Goldwasser, E.3    Leiden, J.M.4
  • 61
    • 0031008929 scopus 로고    scopus 로고
    • Persistent transgene expression in mouse liver following in vivo gene transfer with a △E1/△E4 adenovirus vector
    • Wang, Q., G. Greenburg, D. Bunch, D. Farson, and M. H. Finer. 1997. Persistent transgene expression in mouse liver following in vivo gene transfer with a △E1/△E4 adenovirus vector. Gene Ther. 4:393-400.
    • (1997) Gene Ther. , vol.4 , pp. 393-400
    • Wang, Q.1    Greenburg, G.2    Bunch, D.3    Farson, D.4    Finer, M.H.5
  • 62
    • 9244220682 scopus 로고    scopus 로고
    • Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-inffected hepatocytes in vivo
    • Yang, Y., K. U. Jooss, Q. Su, H. C. J. Ertl, and J. M. Wilson. 1996. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-inffected hepatocytes in vivo. Gene Ther. 3:137-144.
    • (1996) Gene Ther. , vol.3 , pp. 137-144
    • Yang, Y.1    Jooss, K.U.2    Su, Q.3    Ertl, H.C.J.4    Wilson, J.M.5
  • 63
    • 0029803090 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of human factor IX gene in immunodeficient and normal mice: Evidence for prolonged stability and activity of the trans-gene in liver
    • Yao, S. N., A. Farjo, B. J. Roessler, B. L. Davidson, and K. Kurachi. 1996. Adenovirus-mediated transfer of human factor IX gene in immunodeficient and normal mice: evidence for prolonged stability and activity of the trans-gene in liver. Vir. Immunol. 9:141-153.
    • (1996) Vir. Immunol. , vol.9 , pp. 141-153
    • Yao, S.N.1    Farjo, A.2    Roessler, B.J.3    Davidson, B.L.4    Kurachi, K.5
  • 64
    • 0029655456 scopus 로고    scopus 로고
    • Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit
    • Yen, P., J. F. Dedieu, C. Orsini, E. Vigne, P. Denefie, and M. Perricaudet. 1996. Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit. J. Virol. 70:559-565.
    • (1996) J. Virol. , vol.70 , pp. 559-565
    • Yen, P.1    Dedieu, J.F.2    Orsini, C.3    Vigne, E.4    Denefie, P.5    Perricaudet, M.6


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