Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit

Journal of Virology

Volumn 70, Issue 1, 1996, Pages 559-565

  Yeh, Patrice ^a   Dedieu, Jean François ^a   Orsini, Cécile ^a   Vigne, Emmanuelle ^a   Denefle, Patrice ^b   Perricaudet, Michel ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS ANTIGEN; VIRUS PROTEIN;

ADENOVIRUS; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; TRANSGENE; VERO CELL; VIRUS GENE;

ADENOVIRUS E1 PROTEINS; ADENOVIRUS E4 PROTEINS; ADENOVIRUSES, HUMAN; ANIMAL; BASE SEQUENCE; BETA-GALACTOSIDASE; CAPSID; CELL LINE; CLONING, MOLECULAR; GENE DELETION; GENES, VIRAL; GENETIC COMPLEMENTATION TEST; HUMAN; KINETICS; MAMMARY TUMOR VIRUS, MOUSE; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; RECOMBINATION, GENETIC; REPETITIVE SEQUENCES, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T;

EID: 0029655456     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.1.559-565.1996     Document Type: Article

References (48)

1. Blanton, R. A., and T. H. Carter. 1979. Autoregulation of adenovirus type 5 early gene expression. III Transcription studies in isolated nuclei. J. Virol. 29:458-465.
2. Bridge, E., and G. Ketner. 1989. Redundant control of adenovirus late gene expression by early region 4. J. Virol. 63:631-638.
3. Bridge, E., S. Medghalchi, S. Ubol, M. Leesong, and G. Ketner. 1993. Adenovirus early region 4 and viral DNA synthesis. Virology 193:794-801.
4. Brough, D. E., V. Cleghon, and D. F. Klessig. 1992. Construction, characterization, and utilization of cell lines which inducibly express the adenovirus DNA-binding protein. Virology 190:624-634.
5. Challberg, S. S., and G. Ketner. 1981. Deletion mutants of adenovirus 2: isolation and initial characterization of virus carrying mutation near the right end of the viral genome. Virology 114:196-209.
6. Chang, L.-S., and T. Shenk. 1990. The adenovirus DNA-binding protein stimulates the rate of transcription directed by adenovirus and adeno-associated virus promoters. J. Virol. 64:2103-2109.
7. 6a.Dedieu, J.-F. Unpublished data
8. Dix, I., and K. N. Leppard. 1993. Regulated splicing of adenovirus type 5 E4 transcripts and regulated cytoplasmic accumulation of E4 mRNA. J. Virol. 67:3226-3231.
9. Engelhardt, J. F., L. Litzky, and J. M. Wilson. 1994. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum. Gene Ther 5:1217-1229.
10. Engelhardt, J. F., Y. Yang, L. D. Stratford-Perricaudet, E. D. Allen, K. Kozarsky, M. Perricaudet, J. R. Yankaskas, and J. M. Wilson. 1993. Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Nat. Genet. 4:27-34.
11. Engelhardt, J. F., X. Ye, B. Doranz, and J. M. Wilson. 1994. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA 91:6196-6200
12. Falgout, B., and G. Ketner. 1987. Adenovirus early region 4 is required for efficient virus particle assembly. J. Virol. 61:3759-3768.
13. Freyer, G. A., Y. Katoh, and R. J. Roberts. 1984. Characterization of the major mRNAs from adenovirus 2 early region 4 by cDNA cloning and sequencing Nucleic Acids Res. 12:3503-3519
14. Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
15. Halbert, D. N., J. R. Cutt, and T. Shenk. 1985. Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff. J. Virol. 56:250-257.
16. Hemström, C., K. Nordqvist, U. Pettersson, and A. Virtanen. 1988. Gene product of region E4 of adenovirus type 5 modulates accumulation of certain viral polypeptides. J. Virol. 62:3258-3264.
17. Hollenberg, S. M., C. Weinberger, E. S. Ong, G. Cerelli, A. Oro, R. Lebo, E. B. Thompson, M. G. Rosenfeld, and R. M. Evans. 1985. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature (London) 318:635-641.
18. Huang, M. M., and P. Hearing. 1989. Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection. J. Virol. 63:2605-2615.
19. Imperiale, M. J., H.-T. Kao, L. T. Feldman, J. R. Nevins, and S. Strickland. 1984. Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity. Mol. Cell. Biol. 4:867-874.
20. Klessig, D. F., D. E. Brough, and U. Cleghon. 1984. Introduction, stable integration, and controlled expression of a chimeric adenovirus gene whose product is toxic to the recipient human cell. Mol. Cell. Biol 4:1354-1362.
21. La Thangue, N. B. 1994. DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19:108-114
22. Marsh, J. L., M. Erfle, and E. J. Wykes. 1984. The pIC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation. Gene 32:481-485.
23. Müller, U., T. Kleinberger, and T. Shenk. 1992. Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1 J. Virol. 66:5867-5878.
24. Nevins, J. R., and J. J. Winkler. 1980. Regulation of early adenovirus transcription: a protein product of early region 2 specifically represses region 4 transcription. Proc. Natl. Acad. Sci. USA 77:1893-1897.
25. Nordqvist, K., K. Öhman, and G. Akusjarvi. 1994. Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs. Mol. Cell. Biol. 14:437-445.
26. Ohman, K., K. Nordqvist, and G. Akusjarvi. 1993. Two adenovirus proteins with redundant activities in virus growth facilitate tripartite leader mRNA accumulation. Virology 194:50-58.
27. Onclercq, R., P. Gilardi, A. Lavenu, and C. Cremisi. 1988. c-myc products trans-activate the adenovirus E4 promoter in EC stem cells by using the same target sequence as E1A products. J. Virol. 62:4533-4537.
28. Peonypacker, K. R., J.-S. Hong, and M. K. McMillian. 1994. Pharmacological regulation of AP-1 transcription factor DNA binding activity. FASEB J. 8:475-478.
29. Pilder, S., M. Moore, J. Logan, and T. Shenk. 1986. The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol. Cell. Biol 6:470-476.
30. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
31. Sandler, A. B., and G. Ketner. 1989. Adenoviral early region 4 is essential for normal stability of late nuclear RNAs. J. Virol. 63:624-630.
32. Schaack, J., X. Guo, W. Y.-W. Ho, M. Karlok, C. Chen, and D. Ornelles. 1995. Adenovirus type 5 precursor terminal protein-expressing 293 and HcLa cell lines. J. Virol. 69:4079-4085.
33. Spergel, J. M., and S. Chen-Kiang. 1991. Il-6 enhances a cellular activity which functionally substitutes for E1A in trans-activation Proc. Natl Acad. Sci. USA 88:6472-6476.
34. Spergel, J. M., W. Hsu, S. Akira, B. Thimmappaya, T. Kishimoto, and S. Chen-Kiang. 1992 NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A. J. Virol. 66:1021-1030.
35. Stallcup, M. R., and L. D. Washington. 1983. Region-specific initiation of mouse mammary tumor virus RNA synthesis by endogenous RNA polymerase II in preparation of cell nuclei. J. Biol. Chem. 258:2802-2809.
36. Stratford-Perricaudet, L. D., I. Makeh, M. Perricaudet, and P. Briand. 1992. Widespread long-term gene transfer to mouse skeletal muscles and heart via an adenovirus vector. J. Clin Invest. 90:626-630.
37. Tigges, M. A., and H. J. Raskas. 1984. Splice junctions in adenovirus 2 early region 4 mRNAs: multiple splice sites produce 18 to 24 RNAs. J. Virol. 50:106-117.
38. van der Vliet, P. C., and J. S. Sussenbach. 1975 An adenovirus type 5 gene function required for initiation of viral DNA replication. Virology 67:415-426.
39. 37a.Vigne, E. Unpublished data.
40. 37b.Vigne, E., and J.-F. Dedieu. Unpublished data.
41. Virtanen, A., P. Gilardi, A. Naslund, J. M. LeMoullec, U. Pettersson, and M. Perricaudet. 1984. mRNAs from human adenovirus 2 early region 4. J. Virol. 51:822-831.
42. Weiden, M. D., and H. S. Ginsberg. 1994. Deletion of the E4 region of the genome produces adenovirus DNA concatemers. Proc. Natl. Acad Sci. USA 91:153-157.
43. Weinberg, D. H., and G. Ketner. 1983. A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2. Proc. Natl. Acad. Sci. USA 80:5383-5386.
44. Weinberg, D. H., and G. Ketner. 1986. Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression. J. Virol. 57:833-838
45. Yang, Y., Q. Li, H. C. J. Ertl, and J. M. Wilson. 1995. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004-2015.
46. Yang, Y., F. A. Nunes, K. Berencsi, E. E. Furth, E. Gonczol, and J. M. Wilson. 1994 Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci USA 91:4407-4411.
47. Yew, P. R., X. Liu, and A. J. Berk. 1994. Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev. 8:190-202.
48. Zhang, Y., D. Feigenblum, and R. J. Schneider. 1994. A late adenovirus factor induces eIF-4E dephosphorylation and inhibition of cell protein synthesis. J. Virol 68:7040-7050.