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Volumn 61, Issue 1, 1999, Pages 131-140

Identification and analysis of dihydrofolate reductase alleles from Plasmodium falciparum present at low frequency in polyclonal patient samples

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; ANTIMALARIAL AGENT; CHLORCYCLOGUANIL; CHLOROQUINE; CLOCIGUANIL; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; DIHYDROPTEROATE SYNTHASE; FANSIDAR; PYRIMETHAMINE; UNCLASSIFIED DRUG;

EID: 0032799545     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1999.61.131     Document Type: Article
Times cited : (18)

References (62)
  • 1
    • 0013820394 scopus 로고
    • Inhibition of folate biosynthesis and function as a basis for chemotherapy
    • Hitchings GS, Burchall JJ, 1965. Inhibition of folate biosynthesis and function as a basis for chemotherapy. Adv Enzymol 27: 417-468.
    • (1965) Adv Enzymol , vol.27 , pp. 417-468
    • Hitchings, G.S.1    Burchall, J.J.2
  • 3
    • 0024989797 scopus 로고
    • The dihydrofolate reductase-thymidylate synthase gene in the drug resistance of malaria parasites
    • Hyde JE, 1990. The dihydrofolate reductase-thymidylate synthase gene in the drug resistance of malaria parasites. Pharmacol Ther 48: 45-59.
    • (1990) Pharmacol Ther , vol.48 , pp. 45-59
    • Hyde, J.E.1
  • 7
    • 0027074439 scopus 로고
    • Antimalarial drug resistance: The pace quickens
    • White NJ, 1992. Antimalarial drug resistance: the pace quickens. J Antimicrob Chemother 30: 571-585.
    • (1992) J Antimicrob Chemother , vol.30 , pp. 571-585
    • White, N.J.1
  • 8
    • 0030271322 scopus 로고    scopus 로고
    • Strategies for the prevention of antimalarial drug resistance: Rationale for combination chemotherapy for malaria
    • White NJ, Olliaro PL, 1996. Strategies for the prevention of antimalarial drug resistance: rationale for combination chemotherapy for malaria. Parasitol Today 12: 399-401.
    • (1996) Parasitol Today , vol.12 , pp. 399-401
    • White, N.J.1    Olliaro, P.L.2
  • 9
    • 0004900623 scopus 로고    scopus 로고
    • Winning the war against malaria
    • Wirth DF Cattani L, 1997. Winning the war against malaria. Technol Rev 100: 52-61.
    • (1997) Technol Rev , vol.100 , pp. 52-61
    • Wirth, D.F.1    Cattani, L.2
  • 10
    • 0031963057 scopus 로고    scopus 로고
    • Kenyan Plasmodium falciparum field isolates: Correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in dihydrofolate reductase domain
    • Nzila-Mouanda A, Eberu EK, Sibley CH, Winstanley PA, Watkins WM, 1998. Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in dihydrofolate reductase domain. Antimicrob Agents Chemother 42: 164-169.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 164-169
    • Nzila-Mouanda, A.1    Eberu, E.K.2    Sibley, C.H.3    Winstanley, P.A.4    Watkins, W.M.5
  • 11
    • 0000841123 scopus 로고
    • Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria
    • Peterson DS, Walliker D, Wellems TE, 1988. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc Natl Acad Sci USA 85: 9114-9118.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9114-9118
    • Peterson, D.S.1    Walliker, D.2    Wellems, T.E.3
  • 12
    • 0025252334 scopus 로고
    • Molecular basis of differential resistance to cycloguanil and pyrimethamine in plasmodium falciparum malaria
    • Peterson DS, Milhous WK, Wellems TE, 1990. Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc Natl Acad Sci USA 87: 3018-3022.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3018-3022
    • Peterson, D.S.1    Milhous, W.K.2    Wellems, T.E.3
  • 13
    • 0029050608 scopus 로고
    • Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: Polymerase chain reaction methods for surveillance in Africa
    • Plowe CV, Djimde A, Bouare M, Doumbo O, Wellems TE, 1995. Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am J Trop Med Hyg 52: 565-568.
    • (1995) Am J Trop Med Hyg , vol.52 , pp. 565-568
    • Plowe, C.V.1    Djimde, A.2    Bouare, M.3    Doumbo, O.4    Wellems, T.E.5
  • 16
    • 0030801206 scopus 로고    scopus 로고
    • Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins
    • Wang P, Lee CS, Bayoumi R, Djimde A, Doumbo O, Swedberg G, Dao LD, Mshinda H, Tanner M, Watkins WM, Sims PFG, Hyde JE, 1997. Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Mol Biochem Parasitol 89: 161-177.
    • (1997) Mol Biochem Parasitol , vol.89 , pp. 161-177
    • Wang, P.1    Lee, C.S.2    Bayoumi, R.3    Djimde, A.4    Doumbo, O.5    Swedberg, G.6    Dao, L.D.7    Mshinda, H.8    Tanner, M.9    Watkins, W.M.10    Sims, P.F.G.11    Hyde, J.E.12
  • 17
    • 0030909993 scopus 로고    scopus 로고
    • Drug-resistant malaria: Laboratory and field investigations
    • Warhurst DC, 1997. Drug-resistant malaria: laboratory and field investigations. J Pharm Pharmacol 2: 3-7.
    • (1997) J Pharm Pharmacol , vol.2 , pp. 3-7
    • Warhurst, D.C.1
  • 18
    • 0000828663 scopus 로고    scopus 로고
    • The mechanisms of drug action and resistance in malaria
    • Cowman AF, 1997. The mechanisms of drug action and resistance in malaria. Mol Genet Drug Resist 3: 221-246.
    • (1997) Mol Genet Drug Resist , vol.3 , pp. 221-246
    • Cowman, A.F.1
  • 19
    • 0000854414 scopus 로고
    • Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum
    • Cowman AF, Morry MJ, Biggs BA, Cross GA, Foote SJ, 1988. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc Natl Acad Sci USA 85: 9109-9113.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9109-9113
    • Cowman, A.F.1    Morry, M.J.2    Biggs, B.A.3    Cross, G.A.4    Foote, S.J.5
  • 20
    • 0030464590 scopus 로고    scopus 로고
    • Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania
    • Curtis J, Duraisingh MT, Trigg JK, Mbwana H, Warhurst DC, Curtis CF, 1996. Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania. Trans R Soc Trop Med Hyg 90: 678-680.
    • (1996) Trans R Soc Trop Med Hyg , vol.90 , pp. 678-680
    • Curtis, J.1    Duraisingh, M.T.2    Trigg, J.K.3    Mbwana, H.4    Warhurst, D.C.5    Curtis, C.F.6
  • 21
    • 0030483531 scopus 로고    scopus 로고
    • Geographic differences in the sensitivity of a polymerase chain reaction for the detection of Plasmodium falciparum infection
    • Jelinek T, Proll S, Hess F, Kabagambe G, von Sonnenburg F, Loscher T, Kilian AH, 1996. Geographic differences in the sensitivity of a polymerase chain reaction for the detection of Plasmodium falciparum infection. Am J Trop Med Hyg 55: 647-651.
    • (1996) Am J Trop Med Hyg , vol.55 , pp. 647-651
    • Jelinek, T.1    Proll, S.2    Hess, F.3    Kabagambe, G.4    Von Sonnenburg, F.5    Loscher, T.6    Kilian, A.H.7
  • 22
    • 0030678031 scopus 로고    scopus 로고
    • High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimetharriine resistance
    • Jelinek T, Renn AM, Curtis J, Duraisingh MT, Lemnge MM, Mhina J, Bygbjerg IC, Warhurst DC, 1997. High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimetharriine resistance. Trop Med Int Health 2: 1075-1079.
    • (1997) Trop Med Int Health , vol.2 , pp. 1075-1079
    • Jelinek, T.1    Renn, A.M.2    Curtis, J.3    Duraisingh, M.T.4    Lemnge, M.M.5    Mhina, J.6    Bygbjerg, I.C.7    Warhurst, D.C.8
  • 23
    • 0031900990 scopus 로고    scopus 로고
    • In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment
    • Curtis J, Duraisingh MT, Warhurst DC, 1998. In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. J Infect Dis 177: 1429-1433.
    • (1998) J Infect Dis , vol.177 , pp. 1429-1433
    • Curtis, J.1    Duraisingh, M.T.2    Warhurst, D.C.3
  • 24
    • 0010600225 scopus 로고    scopus 로고
    • Association between antifol resistance in vitro and DBFR gene point mutation in Plasmodium falciparum isolates
    • de Pecoulas PE, Basco LK, LeBras J, Mazabraud A, 1996. Association between antifol resistance in vitro and DBFR gene point mutation in Plasmodium falciparum isolates. Trans R Soc Trop Med Hyg 90: 181-182.
    • (1996) Trans R Soc Trop Med Hyg , vol.90 , pp. 181-182
    • De Pecoulas, P.E.1    Basco, L.K.2    LeBras, J.3    Mazabraud, A.4
  • 26
    • 0031282471 scopus 로고    scopus 로고
    • Plasmodium falciparum: Asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant
    • Sirawarapom W, Yongkiettrakul S, Sirawarapom R, Yuthavong Y, Santi DV, 1997. Plasmodium falciparum: asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant. Exp Parasitol 87: 245-252.
    • (1997) Exp Parasitol , vol.87 , pp. 245-252
    • Sirawarapom, W.1    Yongkiettrakul, S.2    Sirawarapom, R.3    Yuthavong, Y.4    Santi, D.V.5
  • 27
    • 0025338631 scopus 로고
    • Mutant dihydrofolate reductase-thymidylate synthase genes in pyrimethamine-resistant Plasmodium falciparum with polymorphic chromosome duplications
    • Tanaka M, Gu HM, Bzik DJ, Li WB, Inselburg J, 1990. Mutant dihydrofolate reductase-thymidylate synthase genes in pyrimethamine-resistant Plasmodium falciparum with polymorphic chromosome duplications. Mol Biochem Parasitol 42: 83-91.
    • (1990) Mol Biochem Parasitol , vol.42 , pp. 83-91
    • Tanaka, M.1    Gu, H.M.2    Bzik, D.J.3    Li, W.B.4    Inselburg, J.5
  • 28
    • 0031106426 scopus 로고    scopus 로고
    • Plasmodium falciparum: Direct cloning and expression of pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase domains
    • Hekmat-Nejad M, Lee PC, Rathod PK, 1997. Plasmodium falciparum: direct cloning and expression of pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase domains. Exp Parasitol 85: 303-305.
    • (1997) Exp Parasitol , vol.85 , pp. 303-305
    • Hekmat-Nejad, M.1    Lee, P.C.2    Rathod, P.K.3
  • 29
    • 0031282343 scopus 로고    scopus 로고
    • Plasmodium falciparum: Kinetic interactions of YvIR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase
    • Hekmat-Nejad M, Rathod PK, 1997. Plasmodium falciparum: kinetic interactions of YvIR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase. Exp Parasitol 87: 222-228.
    • (1997) Exp Parasitol , vol.87 , pp. 222-228
    • Hekmat-Nejad, M.1    Rathod, P.K.2
  • 30
    • 0030813699 scopus 로고    scopus 로고
    • The efficacy of antifolate antimalarial combinations in Africa: A predictive model based on pharmacodynamic and pharmacokinetic analyses
    • Watkins WM, Mberu EK, Winstanley PA, Plowe CV, 1997. The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses. Parasitol Today 13: 459-464.
    • (1997) Parasitol Today , vol.13 , pp. 459-464
    • Watkins, W.M.1    Mberu, E.K.2    Winstanley, P.A.3    Plowe, C.V.4
  • 31
    • 0029775095 scopus 로고    scopus 로고
    • Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea
    • Reeder JC, Rieckmann KH, Genton B, Lorry K, Wines B, Cowman AF, 1996. Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea. Am J Trop Med Hyg 55: 209-213.
    • (1996) Am J Trop Med Hyg , vol.55 , pp. 209-213
    • Reeder, J.C.1    Rieckmann, K.H.2    Genton, B.3    Lorry, K.4    Wines, B.5    Cowman, A.F.6
  • 32
    • 0031924182 scopus 로고    scopus 로고
    • Molecular epidemiology of malaria in Yaounde, Cameroon I. Analysis of point mutations in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum
    • Basco LK, Ringwald P, 1998. Molecular epidemiology of malaria in Yaounde, Cameroon I. Analysis of point mutations in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Am J Trop Med Hyg 58: 369-373.
    • (1998) Am J Trop Med Hyg , vol.58 , pp. 369-373
    • Basco, L.K.1    Ringwald, P.2
  • 33
    • 0032145128 scopus 로고    scopus 로고
    • Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast
    • Cortese JF, Plowe CV, 1998. Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast. Mol Biochem Parasitol 94: 205-214.
    • (1998) Mol Biochem Parasitol , vol.94 , pp. 205-214
    • Cortese, J.F.1    Plowe, C.V.2
  • 34
    • 0030765551 scopus 로고    scopus 로고
    • DHFR gene point mutation as a predictor of Plasmodium falciparum resistance to cycloguanil in malaria cases from Africa imported to France
    • Durand R, Ramiliarisoa O, Secardin Y, Eldin de Pecoulas P, Basco LK, Le Bras J, 1997. DHFR gene point mutation as a predictor of Plasmodium falciparum resistance to cycloguanil in malaria cases from Africa imported to France. Trans R Soc Trop Med Hyg 91: 460-461.
    • (1997) Trans R Soc Trop Med Hyg , vol.91 , pp. 460-461
    • Durand, R.1    Ramiliarisoa, O.2    Secardin, Y.3    Eldin De Pecoulas, P.4    Basco, L.K.5    Le Bras, J.6
  • 36
    • 0028872311 scopus 로고
    • Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum
    • Basco LK, de Eldin PEP, Wilson CM, Le Bras J, Mazabraud A, 1995. Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum. Mol Biochem Parasitol 69:135-138.
    • (1995) Mol Biochem Parasitol , vol.69 , pp. 135-138
    • Basco, L.K.1    De Eldin, P.E.P.2    Wilson, C.M.3    Le Bras, J.4    Mazabraud, A.5
  • 37
    • 0029586497 scopus 로고
    • Analysis of pfmdrI and drug susceptibility in fresh isolates of Plasmodium falciparum from sub-Saharan Africa
    • Basco LK Le Bras J, Rhoades Z, Wilson CM, 1995. Analysis of pfmdrI and drug susceptibility in fresh isolates of Plasmodium falciparum from sub-Saharan Africa. Mol Biochem Parasitol 74:157-166.
    • (1995) Mol Biochem Parasitol , vol.74 , pp. 157-166
    • Basco, L.K.1    Le Bras, J.2    Rhoades, Z.3    Wilson, C.M.4
  • 38
    • 0029587427 scopus 로고
    • Use of a semi-nested PCR diagnosis test to evaluate antifolate resistance of Plasmodium falciparum isolates
    • de Pecoulas PE, Abdallah B, Dje MK, Basco LK, Le Bras J, Mazzabraud A, 1995. Use of a semi-nested PCR diagnosis test to evaluate antifolate resistance of Plasmodium falciparum isolates. Mol Cell Probes 9: 391-397.
    • (1995) Mol Cell Probes , vol.9 , pp. 391-397
    • De Pecoulas, P.E.1    Abdallah, B.2    Dje, M.K.3    Basco, L.K.4    Le Bras, J.5    Mazzabraud, A.6
  • 40
    • 0031461034 scopus 로고    scopus 로고
    • Proguanil resistance in Plasmodium falciparum African isolates: Assessment by mutation-specific polymerase chain reaction and in vitro susceptibility testing
    • Parzy D, Doerig C, Pradines B, Rico A, Fusai T, Doury JC, 1997. Proguanil resistance in Plasmodium falciparum African isolates: assessment by mutation-specific polymerase chain reaction and in vitro susceptibility testing. Am J Trop Med Hyg 57: 646-650.
    • (1997) Am J Trop Med Hyg , vol.57 , pp. 646-650
    • Parzy, D.1    Doerig, C.2    Pradines, B.3    Rico, A.4    Fusai, T.5    Doury, J.C.6
  • 41
    • 0024460302 scopus 로고
    • Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum
    • Zolg JW, Plitt JR, Chen G-X, Palmer S, 1989. Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum. Mol Biochem Parasitol 36: 253-262.
    • (1989) Mol Biochem Parasitol , vol.36 , pp. 253-262
    • Zolg, J.W.1    Plitt, J.R.2    Chen, G.-X.3    Palmer, S.4
  • 42
    • 0025177028 scopus 로고
    • Detection of pyrimethamine resistance in Plasmodium falciparum by mutation-specific polymerase chain reaction
    • Zolg JW, Chen GX, Plitt JR, 1990. Detection of pyrimethamine resistance in Plasmodium falciparum by mutation-specific polymerase chain reaction. Mol Biochem Parasitol 39: 257-265.
    • (1990) Mol Biochem Parasitol , vol.39 , pp. 257-265
    • Zolg, J.W.1    Chen, G.X.2    Plitt, J.R.3
  • 43
    • 0032079104 scopus 로고    scopus 로고
    • Plasmodium falciparum: Detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by pcr and restriction digestion
    • Duraisingh MT, Curtis J, Warhurst DC, 1998. Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp Parasitol 89: 1-8.
    • (1998) Exp Parasitol , vol.89 , pp. 1-8
    • Duraisingh, M.T.1    Curtis, J.2    Warhurst, D.C.3
  • 44
    • 0026442804 scopus 로고
    • The phenotype of a dihydrofolate reductase mutant in saccharomyces cerevisiae
    • Huang T, Barclay BJ, Kalman TI, von Borstel RC, Hastings PJ, 1992. The phenotype of a dihydrofolate reductase mutant in Saccharomyces cerevisiae. Gene 121: 167-171.
    • (1992) Gene , vol.121 , pp. 167-171
    • Huang, T.1    Barclay, B.J.2    Kalman, T.I.3    Von Borstel, R.C.4    Hastings, P.J.5
  • 45
    • 0031002773 scopus 로고    scopus 로고
    • Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum
    • Wooden JM, Hartwell LH, Vasquez B, Sibley CH, 1997. Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum. Mol Biochem Parasitol 85: 25-40.
    • (1997) Mol Biochem Parasitol , vol.85 , pp. 25-40
    • Wooden, J.M.1    Hartwell, L.H.2    Vasquez, B.3    Sibley, C.H.4
  • 48
    • 0026917894 scopus 로고
    • Plasmodium falciparum: A simple polymerase chain reaction method for differentiating strains
    • Wooden JM, Gould EE, Paull AT, Sibley CH, 1992. Plasmodium falciparum: a simple polymerase chain reaction method for differentiating strains. Exp Parasitol 74: 207-212.
    • (1992) Exp Parasitol , vol.74 , pp. 207-212
    • Wooden, J.M.1    Gould, E.E.2    Paull, A.T.3    Sibley, C.H.4
  • 49
    • 0026006245 scopus 로고
    • Prevalence of the dihydrofolate reductase Asn-108 mutation as the basis for pyrimethamine-resistant falciparum malaria in the Brazilian Amazon
    • Peterson DS, di Santi SM, Povoa M, Calvosa VS, do Rosario VE, Wellms TE, 1991. Prevalence of the dihydrofolate reductase Asn-108 mutation as the basis for pyrimethamine-resistant falciparum malaria in the Brazilian Amazon. Am J Trop Med Hyg 45: 492-497.
    • (1991) Am J Trop Med Hyg , vol.45 , pp. 492-497
    • Peterson, D.S.1    Di Santi, S.M.2    Povoa, M.3    Calvosa, V.S.4    Do Rosario, V.E.5    Wellms, T.E.6
  • 50
    • 0024669291 scopus 로고
    • A system or shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
    • Sikorski RS, Hieter P, 1989. A system or shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
    • (1989) Genetics , vol.122 , pp. 19-27
    • Sikorski, R.S.1    Hieter, P.2
  • 52
    • 0023663213 scopus 로고
    • Molecular characterization of the Saccharomyces cerivisiae dihydrofolate reductase gene (DFR 1)
    • Lagosky PA, Taylor GR, Haynes RH, 1987. Molecular characterization of the Saccharomyces cerivisiae dihydrofolate reductase gene (DFR 1). Nucleic Acids Res 15: 10355-10371.
    • (1987) Nucleic Acids Res , vol.15 , pp. 10355-10371
    • Lagosky, P.A.1    Taylor, G.R.2    Haynes, R.H.3
  • 53
    • 0001651897 scopus 로고
    • Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene
    • Bzik DJ, Li WB, Horii T, Inselburg J, 1987. Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene. Proc Natl Acad Sci USA 84: 8360-8364.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8360-8364
    • Bzik, D.J.1    Li, W.B.2    Horii, T.3    Inselburg, J.4
  • 54
    • 0020529962 scopus 로고
    • Transformation of intact yeast cells treated with alkali cations
    • Ito H, Fukuda Y, Murata K, Kimura A, 1983. Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153: 163-168.
    • (1983) J Bacteriol , vol.153 , pp. 163-168
    • Ito, H.1    Fukuda, Y.2    Murata, K.3    Kimura, A.4
  • 56
    • 0030925154 scopus 로고    scopus 로고
    • Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: Pharmacokinetics and therapeutic range
    • Winstanley P, Watkins W, Muhia D, Szwandt S, Amukoye E, Marsh K, 1997. Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic range. Trans R Soc Trop Med Hyg 91: 322-327.
    • (1997) Trans R Soc Trop Med Hyg , vol.91 , pp. 322-327
    • Winstanley, P.1    Watkins, W.2    Muhia, D.3    Szwandt, S.4    Amukoye, E.5    Marsh, K.6
  • 57
    • 0032078232 scopus 로고    scopus 로고
    • Sequence variations in the Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene and their relationship with pyrimethamine resistance
    • de Pecoulas PE, Tahar R, Ouatas T, Mazabraud A, Basco LK, 1998. Sequence variations in the Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene and their relationship with pyrimethamine resistance. Mol Biochem Parasitol 92: 265-273.
    • (1998) Mol Biochem Parasitol , vol.92 , pp. 265-273
    • De Pecoulas, P.E.1    Tahar, R.2    Ouatas, T.3    Mazabraud, A.4    Basco, L.K.5
  • 58
    • 0032145128 scopus 로고    scopus 로고
    • Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast
    • Cortese JF, Plowe CV, 1998. Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast. Mol Biochem Parasitol 94: 205-214.
    • (1998) Mol Biochem Parasitol , vol.94 , pp. 205-214
    • Cortese, J.F.1    Plowe, C.V.2
  • 60
    • 0030272853 scopus 로고    scopus 로고
    • Plasmodium falciparum: Mutation pattern in the dihydrofolate reductase thymidylate synthase genes of Vietnamese isolates, a novel mutation, and coexistence of two clones in a Thai patient
    • Zindrou S, Dung NP, Sy ND, Skold O, Swedberg G, 1996. Plasmodium falciparum: mutation pattern in the dihydrofolate reductase thymidylate synthase genes of Vietnamese isolates, a novel mutation, and coexistence of two clones in a Thai patient. Exp Parasitology 84: 56-64.
    • (1996) Exp Parasitology , vol.84 , pp. 56-64
    • Zindrou, S.1    Dung, N.P.2    Sy, N.D.3    Skold, O.4    Swedberg, G.5
  • 61
    • 0028952026 scopus 로고
    • Amplification by polymerase chain reaction of Plasmodium falciparum DNA from Giemsa-stained thin blood smears
    • Kimura M, Kaneko O, Inoue A, Ishii A, Tanabe K, 1995. Amplification by polymerase chain reaction of Plasmodium falciparum DNA from Giemsa-stained thin blood smears. Mol Biochem Parasitol 70: 193-197.
    • (1995) Mol Biochem Parasitol , vol.70 , pp. 193-197
    • Kimura, M.1    Kaneko, O.2    Inoue, A.3    Ishii, A.4    Tanabe, K.5
  • 62
    • 0025969310 scopus 로고
    • Simplified preparation of malarial blood samples for polymerase chain reaction
    • Warhust DC, Awad El Kariem FM, Miles MA, 1991. Simplified preparation of malarial blood samples for polymerase chain reaction. Lancet 337: 303-304.
    • (1991) Lancet , vol.337 , pp. 303-304
    • Warhust, D.C.1    Awad, E.2    Kariem, F.M.3    Miles, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.