Apolipoprotein E ∈4 association with dementia in a population-based study: The Framingham Study

Neurology

Volumn 46, Issue 3, 1996, Pages 673-677

  Myers, R H ^a   Schaefer, E J ^b   Wilson, P W F ^c   D'Agostino, R ^d   Ordovas, J M ^b   Espino, A ^b   Au, R ^a   White, R F ^a   Knoefel, J E ^a   Cobb, J L ^d   McNulty, K A ^a   Beiser, A ^d,e   Wolf, P A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS UNIVERSITY   (United States)

^c FRAMINGHAM HEART STUDY   (United States)

^d Boston University   (United States)

^e BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; FEMALE; GENETIC LINKAGE; GENOTYPE; HUMAN; LIPOPROTEIN METABOLISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; ADULT; COHORT ANALYSIS; DEMENTIA; GENETICS; INCIDENCE; LONGITUDINAL STUDY; MIDDLE AGED; MOLECULAR GENETICS; MOLECULAR PROBE; NUCLEOTIDE SEQUENCE; RISK; SENSITIVITY AND SPECIFICITY;

APOLIPOPROTEIN E; APOLIPOPROTEIN E4;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BASE SEQUENCE; COHORT STUDIES; DEMENTIA; FEMALE; HUMANS; INCIDENCE; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MOLECULAR PROBES; MOLECULAR SEQUENCE DATA; ODDS RATIO; SENSITIVITY AND SPECIFICITY;

EID: 0029664414     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.46.3.673     Document Type: Article

References (37)

1. Bachman DL, Wolf PA, Linn RT, et al. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology 1992;42:115-119.
2. Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. PNAS 1993;90:1977-1981.
3. Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-1472.
4. Mayeux R, Stern Y, Ottman R, et al. The apolipoprotein ∈4 allele in patients with Alzheimer's disease. Ann Neurol 1993; 34:752-754.
5. van Duijn CM, de Knijff P, Cruts M, et al. Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nat Genet 1994;7:74-78.
6. Kuusisto J, Koivisto K, Kervinen K, et al. Association of apolipoprotein E phenotype with late-onset Alzheimer's disease: population-based study. BMJ 1994;309:636-638.
7. Noguchi S, Murakumi K, Yamada N. Apolipoprotein E genotype and Alzheimer's disease [letter]. Lancet 1993;342:737.
8. Shimano H, Ishibashi S, Murase T, et al. Plasma apolipoproteins in patients with multi-infarct dementia. Atherosclerosis 1989;79:257-260.
9. Dawber TR. The Framingham Study. Cambridge, MA: Harvard University Press, 1980.
10. Dawber TR, Meadors GF, and Moore FE. Epidemiological approaches to heart disease: the Framingham Study. Am J Public Health 1951;41:279-286.
11. Kannel WB, Feinleib F, McNamara PM, et al. An investigation of coronary heart disease in families. Am J Epidemiol 1979;110:281-290.
12. Bachman DL, Wolf PA, Linn RT, et al. Incidence of dementia and probable Alzheimer's disease in a general population: The Framingham Study. Neurology 1993;43:515-519.
13. Folstein M, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
14. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hha I. J Lipid Res 1990;31:545-548.
15. Schaefer EJ, Gregg RE, Ghiselli G, et al. Familial apolipoprotein E deficiency. J Clin Invest 1986;78:1206-1219.
16. Ordovas JM, Litwack-Klein L, Wilson PWF, et al. Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apoE1 and apoE5 isoforms. J Lipid Res 1987;28:371-380.
17. Utterman G. Apolipoprotein E polymorphism in health and disease. Am Heart J 1987;113:433-440.
18. Boerwinkle E, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man. Ann Hum Genet 1987;51:211-226.
19. Pericak-Vance MA, Bebout JL, Gaskell PC, et al. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet 1991;48:1034-1050.
20. Namba Y, Tomonaga M, Kawasaki H, et al. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res 1991;541:163-166.
21. Das HK, McPherson J, Bruns GAP, et al. Isolation, characterization and mapping to chromosome 19 of the human apolipoprotein E gene. J Biol Chem 1985;260:6240-6247.
22. Poirier J, Davignon J, Bouthillier D, et al. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993;342:697-699.
23. Payami H, Kaye J, Heston LL, et al. Apolipoprotein E genotype and Alzheimer's disease [letter]. Lancet 1993;342:738.
24. Borgaonkar DS, Schmidt LC, Martin SE, et al. Linkage of late-onset Alzheimer's disease with apolipoprotein E type 4 on chromosome 19. Lancet 1993;342:625.
25. Myers RH, Schaefer EJ, Wilson PWF, et al. Apolipoprotein E allele 4 is associated with dementia in the Framingham Study. In: Iqbal K, Mortimer J, Winblad B, Wisniewski H, eds. Research advances in Alzheimer's disease and related disorders. John Wiley & Sons, Ltd. Chichester, England: 1995: 63-70.
26. Corder EH, Saunders AM, Risch NJ, et al. Protective effect of apolipoprotein E type 2 allele for late-onset Alzheimer disease. Nat Genet 1994;7:180-184.
27. Wilson PWF, Myers RH, Larson MG, et al. Apolipoprotein E alleles, dyslipidemia, and coronary heart disease: The Framingham Offspring Study. JAMA 1994;272:1666-1671.
28. van Duijn CM, de Knijff P, Wehnert A, et al. The apolipoprotein E2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. Ann Neurol 1995;37:605-610.
29. Corder EH, Saunders AM, Strittmatter WJ, et al. Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease. Neurology 1995;45:1323-1328.
30. Kawamata J, Tanaka S, Shimohama S, Ueda K, Kimura J. Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia. J Neurol Neurosurg Psychiatry 1994;57:1414-1416.
31. St. Clair D, Norrman J, Perry R, Yates C, Wilcock G, Brookes A. Apolipoprotein E ∈4 allele frequency in patients with Lewy body dementia, Alzheimer's disease and age-matched controls. Neurosci Lett 1994;176:45-46.
32. Galasko D, Saitoh T, Xia Y, et al. The apolipoprotein E allele ∈4 is over-represented in patients with the Lewy body variant of Alzheimer's disease. Neurology 1994;44:1950-1951.
33. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939-944.
34. Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and risk of Alzheimer's disease in late-onset families. Science 1993;261:921-923.
35. Strittmatter WJ, Weisgraber KH, Goedert M, et al. Hypothesis: microtubule instability and paired helical filament formation in Alzheimer's disease brain are related to apolipoprotein E genotype. Exp Neurol 1994;125:163-171.
36. Strittmatter WJ, Weisgraber KH, Huang DY, et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. PNAS 1993;90:8098-8102.
37. Jarvik GP, Wijsman EM, Kukull WA, et al. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology 1995;45:1092-1096.