Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes

Neuroscience Letters

Volumn 232, Issue 1, 1997, Pages 37-40

  Svensson, Anne Lie ^a   Warpman, Ulrika ^a   Hellström Lindahl, Ewa ^a   Bogdanovic, Nenad ^a   Lannfelt, Lars ^a   Nordberg, Agneta ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alzheimer's disease; Apolipoprotein E; Choline acetyltransferase activity; Muscarinic receptors; Nicotinic receptors; Temporal cortex

Indexed keywords

APOLIPOPROTEIN E; CHOLINE ACETYLTRANSFERASE; MUSCARINIC RECEPTOR; NICOTINIC RECEPTOR;

ALZHEIMER DISEASE; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; SCORING SYSTEM; TEMPORAL CORTEX;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; CHOLINE O-ACETYLTRANSFERASE; GENOTYPE; HUMANS; MIDDLE AGED; RECEPTORS, MUSCARINIC; RECEPTORS, NICOTINIC; TEMPORAL LOBE;

EID: 0030855949     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00573-9     Document Type: Article

References (29)

1. Arendt, T., Schindler, C., Bruckner, M.K., Eschrich, K., Bigl, V., Zedlick, D. and Marcova, L., Neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein ∈4 allele, J. Neurosci., 17 (1997) 516-529.
2. Alafuzoff, I., Iqbal, K., Friden, H., Adolfsson, R. and Winblad, B., Histopathological criteria for progressive dementia disorders: clinical-pathological correlations and classification by multivariate data analysis, Acta Neuropathol., 74 (1987) 209-225.
3. Basun, H., Grut, M., Winblad, B. and Lannfelt, L., Apolipoprotein ∈4 allele and disease progression in patients with late-onset Alzheimer's disease, Neurosci. Lett., 183 (1995) 32-34.
4. Blennow, K., Bogdanovic, N., Alafuzoff, I., Ekman, R. and Davidsson, P., Synaptic pathology in Alzheimer's disease: relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele, J. Neural Transm., 103 (1996) 603-618.
5. Corder, E.H., Jelic, V., Basun, H., Lannfelt, L., Valind, S., Winblad, B. and Nordberg, A., No difference in cerebral glucose metabolism in Alzheimer patients with differing apolipoprotein E genotypes, Arch. Neurol., 54 (1997) 273-277.
6. Corder, E.H., Saunders, A.M., Strittmatter, W.J., Schmechel, D.E., Gaskell, P.C., Small, G.W., Roses, A.D., Haines, J.L. and Periack-Vance, M.A., Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, Science, 261 (1993) 921-923.
7. Gomez-Isla, T., Hollister, R., West, H., Mui, S., Growdon, J.H., Petersen, R.C., Parisi, J.E. and Hyman, B.T., Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease, Ann. Neural., 41 (1997) 17-24.
8. Gordon, I., Grauer, E., Genis, I., Sehayek, E. and Michaelson, D.M., Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice, Neurosci. Lett., 199 (1995) 1-4.
9. Landén, M., Hesse, C., Fredman, P., Regland, B., Wallin, A. and Blennow, K., Apolipoprotein E in cerebrospinal fluid from patients with Alzheimer's disease and other forms of dementia is reduced but without any correlation to the apoE4 isoform, Dementia, 7 (1996) 273-278.
10. Lucotte, G., Oddoze, C. and Michel, B.-F., Apolipoprotein E genotype allele ∈4 and response to tacrine in Alzheimer's disease, Alzheim. Res., 2 (1996) 101-102.
11. Morris, C.M., Massey, H.M., Benjamin, R., Leake, A., Broadbent, C., Griffiths, M., Lamb, H., Brown, A., Ince, P.G., Tyrer, S., Thompson, P., McKeith, I.G., Edwardson, J.A., Perry, R.H. and Perry, E.K., Molecular biology of APO E alleles in Alzheimer's and non-Alzheimer's dementias, J. Neural Transm., 47(Suppl.) (1996) 205-218.
12. Nordberg, A., Alafuzoff, I. and Winblad, B., Nicotinic and muscarinic subtypes in the human brain: changes with aging and dementia, J. Neurosci. Res., 31 (1992) 103-111.
13. Nordberg, A., Larsson, C., Perdahl, E. and Winblad, B., Cholinergic activity in hippocampus in chronic alcoholism, Drug Alcohol. Depend., 10 (1982) 333-334.
14. 11C-nicotine binding in normal and Alzheimer brains - in vivo assessment using positron emission tomography, Alzheim. Dis. Assoc. Disord., 9 (1995) 21-27.
15. 3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains, Neurosci. Lett., 72 (1986) 115-119.
16. Norrmann, J., Brookes, A.J., Yates, C. and St Clair, D., Apolipoprotein E genotype and its effect on duration and severity of early and late onset Alzheimer's disease, Br. J. Psychiatry, 167 (1995) 533-536.
17. Ohm, T.G., Kirca, M., Bohl, J., Scharnagl, H., Gross, W. and März, W., Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation, Neuroscience, 66 (1995) 583-587.
18. Perry, E.K., Tomlinson, B.E., Blessed, G., Bergmann, K., Gibson, P.H. and Perry, R.H., Correlation of cholinergic abnormalities with senile plaques and mental test score in senile dementia, Br. Med. J., 2 (1978) 1457-1459.
19. Poirier, J., Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease, Trends Neurosci., 17 (1994) 525-530.
20. Poirier, J., Delisle, M.-C., Quirion, R., Aubert, I., Farlow, M., Lahiri, D., Hui, S., Bertrand, P., Nalbantoglu, J., Gilfix, B.M. and Gauthier, S., Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 92 (1995) 12260-12264.
21. Polvikoski, T., Sulkava, R., Haltia, M., Kainulainen, K., Vuorio, A., Verkkoniemi, A., Niinisto, L., Halonen, P. and Kontula, K., Apolipoprotein E, dementia and cortical deposition of β-amyloid protein, N. Engl. J. Med., 333 (1995) 1242-1247.
22. Reiman, E.M., Caselli, R.J. and Yun, L.S., et al., Preclinical evidence of Alzheimer's disease in persons homozygous for the ∈4 allele for apolipoprotein E, N. Engl. J. Med., 334 (1996) 752-758.
23. Roses, A.D., The predictive value of APOE genotyping in the early diagnosis of dementia of the Alzheimer type: data from three independent series. In K. Iqbal, B. Winblad, T. Nishimura, M. Takeda and H.M. Wisniewski (Eds.), Alzheimer's Disease, Biology, Diagnosis and Therapeutics, Wiley and Sons, Chichester, UK, 1997, pp. 85-91.
24. Schmechel, D.E., Saunders, A.M., Strittmatter, W.J., Crain, B.J., Hulette, C.M., Joo, S.H., Pericak-Vance, M.A., Goldgaber, D. and Roses, A.D., Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease, Proc. Natl. Acad. Sci. USA, 90 (1993) 9649-9653.
25. Soininen, H., Kosunen, O., Helisalmi, S., Mannermaa, A., Paljärvi, L., Talasniemi, S., Ryynänen, M. and Riekkinen, P. Sr., A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein ∈4 allele, Neurosci. Lett., 187 (1995) 79-82.
26. Strittmatter, W.J., Saunders, A.M., Schmechel, D.E., Pericak-Vance, M.A., Enghild, J., Salvesen, G.S. and Roses, A.D., Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease, Proc. Natl. Acad. Sci. USA, 90 (1993) 1977-1981.
27. Strittmatter, W.J., Weisgraber, K.H., Goedert, M., Saunders, A.M., Huang, D., Corder, E.H., Dong, L.-M., Jakes, R., Alberts, M.J., Gilbert, J.R., Han, S.-H.H., Einstein, G., Schmechel, D.E., Pericak-Vance, M.A. and Roses, A.D., Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype, Exp. Neurol., 125 (1994) 163-171.
28. Svensson, A.-L., Alafuzoff, I. and Nordberg, A., Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists, Brain Res., 596 (1992) 142-148.
29. Warpman, U. and Nordberg, A., Epibatidine and ABT 418 reveal selective losses of α4β2 nicotinic receptors in Alzheimer brains, NeuroReport, 6 (1995) 2419-2423.