Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E ε4

American Journal of Human Genetics

Volumn 59, Issue 3, 1996, Pages 664-675

  Rao, Valluri S ^a   Cupples, L Adrienne ^a   Van Duijn, Cornelia M ^d   Kurz, Alexander ^e   Green, Robert C ^f   Chui, Helena ^g   Duara, Ranjan ^h   Auerbach, Sanford A ^a   Volicer, Ladislav ⁱ   Wells, John ⁱ   Van Broeckhoven, Christine ^j   Growdon, John H ^b   Haines, Jonathan L ^b,c   Farrer, Lindsay A ^a,b,c  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^h UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

ⁱ VETERANS AFFAIRS MEDICAL CENTER   (United States)

^j UNIVERSITY OF ANTWERP   (Belgium)

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Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; FAMILY HISTORY; FEMALE; GENDER; GENE SEGREGATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INHERITANCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; COMPUTER SIMULATION; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MODELS, GENETIC;

EID: 19244362467     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Atwood LD, Wilson AF, Elston RC, Bailey-Wilson JE (1992) Computational aspects of fitting a mixture of two normal distributions using maximum likelihood methods. Commun Stat Simul Comput 21:769-781
2. Bailey-Wilson JE, Elston RC (1987) Statistical analysis for genetic epidemiology (SAGE). LSU Medical Center, New Orleans
3. Bonney GE (1984) On the statistical determination of major gene mechanisms in continuous human traits: regressive models. Am J Med Genet 18:731-749
4. _ (1986) Regressive logistic models for familial disease and other binary traits. Biometrics 42:611-625
5. Borgaonkar DS, Schmidt LC, Martin SE, Kanzer MD, Edelsohn L, Growdon J, Farrer LA (1993) Linkage of late-onset Alzheimer disease with apolipoprotein E type 4 on chromosome 19. Lancet 342:625