T cell receptor (TCR) engagement in apoptosis-defective, but interleukin 2 (IL-2)-producing, T cells results in impaired ZAP70/CD3-ζ association

Journal of Experimental Medicine

Volumn 187, Issue 8, 1998, Pages 1179-1192

  Sahuquillo, Almudena G ^a   Roumier, Anne ^c   Teixeiro, Emma ^b   Bragado, Rafael ^a   Alarcón, Balbino ^c  

^a Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD69 ANTIGEN; CYTOKINE; FAS ANTIGEN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MONOCLONAL ANTIBODY; OKT 3; PROTEIN P21; RECOMBINANT GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; TYROSINE;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LEUKEMIA CELL LINE; LYMPHOCYTE DIFFERENTIATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANTIGENS, CD3; APOPTOSIS; CELL COMPARTMENTATION; CELL MEMBRANE; CLONE CELLS; FAS LIGAND PROTEIN; HUMANS; INTERLEUKIN-2; JURKAT CELLS; MEMBRANE GLYCOPROTEINS; MUTATION; PHOSPHOPROTEINS; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0032550311     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.8.1179     Document Type: Article

References (60)

1. Reth, M. 1989. Antigen receptor tail clue. Nature. 338:383-384.
2. Qian, D., and A. Weiss. 1997. T cell antigen receptor transduction. Curr. Opin. Cell Biol. 9:205-212.
3. Wange, R.L., and L.E. Samelson. 1996. Complex complexes: signaling at the TCR. Immunity. 5:197-205.
4. Chan, A.C., and A.S. Shaw. 1995. Regulation of antigen receptor signal transduction by protein tyrosine kinases. Curr. Opin. Immunol. 8:394-401.
5. Iwashima, M., B.A. Irving, N.S.C. Van Oers, A.C. Chan, and A. Weiss. 1994. Sequential interactions of the TCR with distinct cytoplasmic tyrosine kinases. Science. 263:1136-1139.
6. Isakov, N., R.L. Wange, W.H. Burgess, J.D. Watts, R. Aebersold, and L.E. Samelson. 1995. ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity. J. Exp. Med. 181: 375-380.
7. Bu, J.Y., A.S. Shaw, and A.C. Chan. 1995. Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance. Proc. Natl. Acad. Sci. USA. 92:5106-5110.
8. Osman, N., S.C. Lucas, H. Turner and D. Cantrell. 1995. A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif. J. Biol. Chem. 270:13981-13986.
9. Van Oers, N.S.C., N. Killeen, and A. Weiss. 1996. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. J. Exp. Med. 183: 1053-1062.
10. Wu, J., Q. Zhao, T. Kurosaki, and A. Weiss. 1997. The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction. J. Exp. Med. 10:1877-1882.
11. Duplay, P., M. Thome, F. Hervé, and O. Acuto. 1994. p56lck interacts via its src homology 2 domain with the ZAP-70 kinase. J. Exp. Med. 179:1163-1172.
12. Steller, H. 1995. Mechanisms and genes of cellular suicide. Science. 267:1445-1462.
13. Nagata, S. 1997. Apoptosis by death factor. Cell. 88:355-365.
14. Strasser, A. 1995. Death of a T cell. Nature. 373:385-386.
15. Van Parijs, L., and A.K. Abbas. 1996. Role of Fas-mediated cell death in the regulation of immune responses. Curr. Opin. Immunol. 8:355-361.
16. Wong, B., and Y. Choi. 1997. Pathways leading to cell death in T cells. Curr. Opin. Immunol. 9:358-364.
17. Winoto, A. 1997. Cell death in the regulation of immune responses. Curr. Opin. Immunol. 9: 365-370.
18. Zheng, L., G. Fisher, R.E. Miller, J. Peschon, D.H. Lynch, and M.J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumor necrosis factor. Nature. 377:348-351.
19. Sytwu, H.K., R.S. Libau, and H.O. McDevitt. 1996. The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity. 5:17-30.
20. Park, C.G., S.Y. Lee, G. Kandala, S.Y. Lee, and Y. Choi. 1996. A novel gene product that couples TCR signaling to Fas (CD95) expression in activation-induced cell death. Immunity. 4:583-591.
21. Anel, A., M. Buferne, C. Boyer, A.M. Schmitt-Verhulst, and P. Golstein. 1994. T cell receptor-induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A. Eur. J. Immunol. 24:2469-2476.
22. Dhein, J., H. Walczak, C. Baumler, K.M. Debatin, and P.H. Krammer. 1995. Autocrine T-cell suicide mediated by APO-1/(Fas/GD95). Nature. 373:438-441.
23. Brunner, T., J.Y. Nam, D. LaFace, and C.F. Ware. 1996. Activation-induced cell death in murine T cell hybridomas: differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506. Int. Immunol. 8:1017-1026.
24. Hodge, M.R, A.M. Ranger, F.C. de la Brousse, T. Hoey, M.J. Grusby, and L.H. Glimcher. 1996. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity. 4:397-405.
25. Latinis, K.M., L.L. Carr, E.J. Peterson, L.A. Norian, S.L. Eliason, and G.A. Koretzky. 1997. Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events. J. Immunol. 158:4602-4611.
26. Vignaux, F., E. Vivier, B. Malissen, V. Depraetere, S. Nagata, and P. Golstein. 1995. TCR/CD3 coupling to Fas-based cytotoxicity. J. Exp. Med. 181:781-786.
27. Combadière, B., M. Freedman, L. Chen, E.W. Shores, P. Love, and M.J. Lenardo. 1996. Qualitative and quantitative contributions of the T cell receptor ζ chain to mature T cell apoptosis. J. Exp. Med. 183:2109-2117.
28. Rodríguez-Tarduchy, G., A.G. Sahuquillo, B. Alarcón, and R. Bragado. 1996. Apoptosis but not other activation events is inhibited by a mutation in the transmembrane domain of T cell receptor β that impairs CD3ζ association. J. Biol. Chem. 271:30417-30425.
29. Letourneur, F., and R.D. Klausner. 1991. T-cell and basophil activation through the cytoplasmic tail of T-cell receptor ζ family proteins. Proc. Natl. Acad. Sci. USA. 88:8905-8909.
30. lck-mediated up-regulation of T cell antigen receptor-CD3 signaling in T cells. J. Biol. Chem. 267:7871-7879.
31. Huby, R.D.J., G.W. Carlile, and S.C. Ley. 1995. Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells. J. Biol. Chem. 270: 30241-30244.
32. Alarcón, B., S.C. Ley, F. Sánchez-Madrid, R.S. Blumberg, S.T. Ju, M. Fresno, and C. Terhorst. 1991. The CD3-γ and CD3-δ subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes. EMBO (Eur. Mol. Biol. Organ.) J. 10:903-912.
33. Alkan, S., C. Akdis, and H. Towbin. 1994. Chemiluminescent and enzyme-linked immunoassays for sensitive detection of human IFN-γ. J. Immunoassay. 15:217-238.
34. Shaw, A.C., R.N. Mitchell, Y.K. Wever, J. Campos-Torres, A.K. Abbas, and P. Leder. 1990. Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation. Cell. 63:381-392.
35. Bonay, P., S. Munro, M. Fresno, and B. Alarcón. 1996. Intra-Golgi transport inhibition by megalomicin. J. Biol. Chem. 271:3719-3726.
36. Valitutti, S., Müller, S., M. Salio, and A. Lanzavecchia. 1997. Degradation of T cell receptor (TCR)-CD3-ζ complexes after antigenic stimulation. J. Exp. Med. 185:1859-1864.
37. Kishimoto, H., R.T. Kubo, H. Yorifuji, T. Nakayama, Y. Asano, and T. Tada. 1995. Physical dissociation of the TCR/ CD3 complex accompanies receptor ligation. J. Exp. Med. 182:1997-2006.
38. Wegener, A.M.K., F. Letourneur, A. Hoeveler, T. Brocker, F. Luton and B. Malissen. 1992. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell. 68:83-95.
39. Granja, C., L.L. Lin, E.J. Yunis, V. Relias, and J.D. Dasgupta. 1991. PLCγ1: a possible mediator of T cell receptor function. J. Biol. Chem. 266:16277-16280.
40. Secrist, J.P., L. Karnitz, and R.T. Abraham. 1991. T cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-γ1. J. Biol. Chem. 266:12135-12139.
41. Weiss, A., G. Koretzky, R.C. Schatzman, and T. Kadlecek. 1991. Functional activation of the T cell antigen receptor induces tyrosine phosphorylation of phospholipase C-γ1. Proc. Natl. Acad. Sci. USA. 88:5484-5488.
42. Park, D.J., H.W. Rho, and S.G. Rhee. 1991. CD3 stimulation causes phosphorylation of phospholipase C-γ1 on serine and tyrosine residues in a human T cell line. Proc. Natl. Acad. Sci. USA. 88:5453-5456.
43. Katzav, S., M. Sutherland, G. Packham, T. Yi, and A. Weiss. 1994. The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-vav. J. Biol. Chem. 269:32579-32585.
44. Sloan-Lancaster, J., A.S. Shaw, J.B. Rothbard, and P.M. Allen. 1994. Partial T cell signaling: Altered phospho-ζ and lack of ZAP70 recruitment in APL-induced T cell anergy. Cell. 79:913-922.
45. Madrenas, J., R.L. Wange, J.L. Wang, N. Isakov, L.E. Samelson, and R.N. Germain. 1995. ζ phosphorylation without ZAP70 activation induced by TCR antagonists or partial agonists. Science. 267:515-518.
46. Smith, J.A., J.Y. Tso, M.R. Clark, M.S. Cole, and J.A. Bluestone. 1997. Nonmitogenic anti-CD3 monoclonal antibodies deliver partial T cell receptor signal and induce clonal anergy. J. Exp. Med. 185:1413-1422.
47. Sieh, M., A. Batzer, J. Schlessinger, and A. Weiss. 1994. Grb2 and phospholipase Cγ1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T cell receptor stimulation. Mol. Cell. Biol. 14:4435-4442.
48. Buday, L., S.E. Egan, P. Rodríguez-Viciana, D.A. Cantrell and J. Downward. 1994. A complex of Grb2-adapter protein, SOS exchange factor and a 36 kD membrane bound tyrosine phosphoprotein is implicated in Ras activation in T cells. J. Biol. Chem. 269:9019-9023.
49. Motto, D., S. Ross, J. Jackman, Q. Sun, A.L. Olson, P. Findell, and G. Koretzky. 1994. In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor activated protein tyrosine kinase. J. Biol. Chem. 269:21608-21613.
50. Isakov, N., R.L. Wange, J.D. Watts, R. Aebersold, and L.E. Samelson. 1996. Purification and characterization of human ZAP70 protein-tyrosine kinase from a baculovirus expression system. J. Biol. Chem. 271:15753-15761.
51. lck/CD4 to the activated T cell receptor/CD3/ζ complex. J. Exp. Med. 181: 1997-2006.
52. Huby, R.D.J., M. Iwashima, A. Weiss, and S.C. Ley. 1997. ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domains. J. Cell Biol. 137:1639-1649.
53. Exley, M., L. Varticovski, M. Peter, J. Sancho, and C. Terhorst. 1994. Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor ζ chain is dependent on T cell activation. J. Biol. Chem. 269:15140-15146.
54. Sunder-Plassmann, R., F. Lialios, M. Madsen, S. Koyasu, and E.L. Reinherz. 1997. Functional analysis of immunoreceptor tyrosine-based activation motif (ITAM)-mediated signal transduction: the two YxxL segments within a single CD3ζ-ITAM are functionally distinct. Eur. J. Immunol. 27:2001-2009.
55. Plas, D.R., R. Johnson, J.T. Pingel, R.J. Matthews, M. Dalton, G. Roy, A.C. Chan, and M.L. Thomas. 1996. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science. 272:1173-1176.
56. Graef, I.A., L.J. Holsinger, S. Diver, S.L. Schreiber, and G.R. Crabtree. 1997. Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. EMBO (Eur. Mol. Biol. Organ.) J. 16:5618-5628.
57. Eischen, C.M., B.L. Williams, W. Zhang, L.E. Samelson, D.H. Lynch, R.T. Abraham, and P.J. Leibson. 1997. ZAP-70 tyrosine kinase is required for the up-regulation of fas ligand in activation-induced T cell apoptosis. J. Immunol. 159:1135-1139.
58. Yamasaki, S., M. Takamatsu, and M. Iwashima. 1996. The kinase, SH3 and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localization. Mol. Cell. Biol. 13:7408-7417.
59. lck in T-cell receptor/CD3 mediated apoptosis and Fas-ligand induction in Jurkat cells. Biochem. Biophys. Res. Commun. 213:994-1001.
60. González-García, A., L.R. Borlado, E. Leonardo, I. Mérida, C. Martínez-A., and A.C. Carrera. 1997. Lck is necessary and sufficient for Fas-ligand expression and apoptotic cell death in mature cycling T cells. J. Immunol. 158:4104-4112.