Activation-induced cell death in murine T cell hybridomas, differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506

International Immunology

Volumn 8, Issue 7, 1996, Pages 1017-1026

  Brunner, Thomas ^a   Yoo, Nam Jin ^a   LaFace, Drake ^a   Ware, Carl F ^b   Green, Douglas R ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Calcineurin; T cell activation

Indexed keywords

CYCLOSPORIN A; FAS ANTIGEN; LIGAND; TACROLIMUS;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HYBRIDOMA; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TARGET CELL;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CYCLOSPORINE; FAS LIGAND PROTEIN; HYBRIDOMAS; IMMUNOSUPPRESSIVE AGENTS; LIGANDS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; T-LYMPHOCYTES; TACROLIMUS;

EID: 0030018311     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.7.1017     Document Type: Article

References (56)

1. Duval, E. and Wyllie, A. H. 1986. Death and the cell. Immunol. Today 7:115.
2. Smith, C. A., Williams, G. T., Kingston, R., Jenkinson, E. J. and Owen, J. T. 1989. Antibodies to the CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 337:181.
3. Jenkinson, E. J., Kingston, R., Smith, C. A., Williams, G. T. and Owen, J. T. 1989. Antigen-induced apoptosis in developing T cells: a mechanism for negative selection of the T cell receptor repertoire Eur. J. Immunol. 19:2175.
4. lo thymocytes in vivo. Science 250:1720.
5. Shi, Y. Bissonnette, R. P., Parfrey, N., Szalay, M., Kubo, R. T. and Green, D. R. 1991. In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes J. Immunol. 146:3340.
6. Kabelitz, D., Pohl, T. and Pechhold, K. 1993. Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes. Immunol. Today 14:338.
7. Russel, J. H., White, C. L., Loh, D. Y. and Meleedey-Rey, P. 1991. Receptor-stimulated death pathway is opened by antigen in mature T cells. Proc. Natl Acad. Sci. USA 88:2151
8. Lenardo, M. J. 1991. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature 353:858.
9. Radvanyi, L. G., Mills, G. B. and Miller, R. G. 1993. Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death. J. Immunol. 150:5704.
10. Meyaard, L., Otto, S. A., Jonker, R. R., Mijnster, M. J., Keet, R. P. and Miedema, F. 1992. Programmed death of T cells in HIV-1 infection. Science 257:217
11. Banda, N. K., Bernier, J., Kurahara, D. K., Kurrle, R., Haigwood, N., Sekaly, R. P. and Finkel, T. H. 1992. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J. Exp. Med. 176:1099.
12. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J. Exp Med. 175:331.
13. Gougeon, M. L., Garcia, S., Heeney, J., Tschopp, R., Lecoeur, H., Guetard, D., Rame, V., Dauguet, C. and Montagnier, L. 1993. Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res. Hum. Retrovirus 9:553.
14. Green, D. R., Mahboubi, A., Nishioka, W., Oja, S., Echeverri, F., Shi, Y., Glynn, J., Yang, Y., Ashwell, J. and Bissonnette, R. 1994. Promotion and inhibition of activation-induced apoptosis in T-cell hybridomas by oncogenes and related signals. Immunol. Rev. 142:321.
15. Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Machboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F. and Green, D. R. 1995. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373:441
16. Ju, S.-T., Panka, D. J., Cui, H., Ettinger, R., El-Khatib, M., Sherr, D. H., Stanger, B. Z. and Marshak-Rothstein, A. 1995. Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444.
17. Dhein, J., Walczak, H., Baeumler, C., Debatin, K.-M. and Krammer, P. H. 1995 Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373:438.
18. Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y. and Nagata, S. 1991. The polypeptide encoded by the cDNA for the human cell surface antigen Fas can mediate apoptosis. Cell 66:233.
19. Oehm, A., Behrmann, I., Falk, W., Pawlita, M., Maier, G., Klas, C., Li-Weber, M., Richards, S., Dhein, J., Trauth, B. C., Ponstingl, H. and Krammer, P. H. 1992. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the TNF/NGF receptor superfamily. J. Biol. Chem. 267:10709.
20. Yonehara, S., Ishii, A. and Yonehara, M. 1989. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-down-regulated with the receptor of tumor necrosis factor J. Exp. Med. 169:1747.
21. Trauth, B., Klas, C., Peters, A. M. J., Matzku, S., Moller, P., Falk, W., Debatin, K.-M. and Krammer, P. H. 1989. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301.
22. Suda, T., Takahashi, T., Golstein, P. and Nagata, S. 1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169.
23. Kaegi, D., Vignaux, F., Ledermann, B., Buerki, K., Depraetere, V., Nagata, S., Hengartner, H. and Golstein, P. 1994. Fas and perforin pathways as major mechanisms of T cell mediated cytotoxicity. Science 265:528.
24. Kojima, H., Shinohara, N., Hanaoka, S., Someya-Shirota, Y., Takagaki, Y., Ohno, H., Saito, T., Katayama, T., Yagita, H., Okumura, K., Shinkai, Y., Alt, F. W., Matsuzawa, A., Yonehara, S. and Takayama, H. 1994. Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity 1:357.
25. 2+-independent T cell-mediated cytotoxocity. J. Exp. Med. 177:195.
26. + T cell-mediated cytotoxicity. J. Immunol. 152:1127.
27. Walsh, C. M., Glass, A. A., Chiu, V. and Clark, W. R. 1994. The role of the Fas lytic pathway in a perfonn-less CTL hybridoma. J. Immunol. 153:2506.
28. Hanabuchi, S., Kobayashi, M., Kawasaki, A., Shinohara, N., Matsuzawa, A., Nishimura, Y., Kobayashi, Y., Yonehara, S., Yagita, H. and Okumura, K. 1994. Fas and its ligand in a general mechanism of T cell-mediated cytotoxicity. Proc. Natl Acad. Sci. USA 91:4930.
29. Shi, Y., Sahai, B. M. and Green, D. R. 1989. Cyclosporin A inhibits activation-induced cell death in T cell hybridomas and thymocytes. Nature 339:625.
30. 2+ requirements and sensitivity to cyclosporin A. J. Immunol. 142:4085.
31. Bierer, B. E., Mattola, P. S., Standaert, R. F., Herzenberg, L. A., Burakoff, S. J., Crabtree, G. and Schreiber, S. L. 1990. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc. Natl Acad. Sci. USA 87:9231.
32. Fruman, D. A., Mather, P. E., Burakoff, S. J. and Bierer, B. E. 1992. Correlation of calcineurin phosphatase activity and programmed cell death in T cell hybridomas. Eur. J. Immunol. 22:2513.
33. Shi, Y., Szalay, M. G., Paskar, L., Boyer, M., Singh, B. and Green, D. R. 1990. Activation-induced death in T cell hybridomas is due to apoptosis. J. Immunol. 144:3326.
34. Leo, O., Foo, M., Sachs, D. H., Samelson, L. E. and Bluestone, J. A. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl Acad. Sci. USA 84:1374.
35. McGahon, A. J., Martin, S. J., Bissonnette, R. P., Mahboubi, A., Shi, Y., Mogil, R. J., Nishioka, W. K. and Green, D. R 1995. The end of the (cell) line: methods for the study of apoptosis in vitro. Methods Cell Biol. 46:153.
36. Shevach, E. M. 1985. The effects of cyclosporin A on the immune system. Annu. Rev. Immunol. 3:397.
37. Sato, T., Irie, S., Kitada, S. and Reed, J. C. 1995. FAP-1, a protein tyrosine phosphatase that associates with Fas. Science 268:411.
38. Klas, C., Debatin, K.-M., Jonker, R. R. and Krammer, P. H. 1993. Activation interferes with the APO-1 pathway in mature human T cells. Int. Immunol. 5:625.
39. Fruman, D. A., Burakoff, S. J. and Bierer, B. E. 1994. Immunophilins in protein folding and immunosuppression. FASEB J. 8:391.
40. Crowe, P. D., Walter, B. N., Mohler, K. M., Otten-Evans, C., Black R. A. and Ware, C. F. 1995. A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes. J. Exp. Med. 181:000.
41. Liu, J., Farmer, J. D. J., Lane, W. S., Friedman, J., Weissman, I. and Schreiber, S. L. 1991. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807.
42. Dutz, J. P., Fruman, D. A., Burakoff, S. J. and Bierer, B. A. 1993. A role for calcineurin in degranulation of murine cytotoxic T lymphocytes. J. Immunol. 150:2591.
43. Woronicz, J. D., Calnan, B., Ngo, V. and Winoto, A. 1994 Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature 367:277.
44. Liu, D.-G., Smith, S. W., McLaughlin, K. A., Schwartz, L. M. and Osborne, B A. 1994. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature 367:281.
45. Yazdanbakhsh, K., Choi, J.-W., Li, Y., Lau, L. F. and Choi, Y. 1995. Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77. Proc. Natl Acad. Sci. USA 92:437.
46. O'Keefe, S. J., Tamura, J., Kincaid, R. L., Tocci, M. J. and O'Neill, E. A. 1992. FK506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357:692.
47. Clipstone, N. A. and Crabtree, G. R. 1992. Identification of calcineurin as a key signalling enzyme in T lymphocyte activation. Nature 357:695.
48. Takahashi, T., Tanaka, M., Inazawa, J., Abe, T., Suda, T. and Nagata, S. 1994. Human Fas ligand: gene structure, chromosomal location and species specificity. Int. Immunol. 6:1567.
49. Frantz, B., Nordby, E. C., Bren, G., Steffan, N., Paya, C. V., Kincaid, R. L., Tocci, M. J., O'Keefe, S. J. and O'Neill, E. A. 1994. Calcineurin acts in synergy with PMA to inactivate IκB/MAD3, an inhibitor of NF-κB. EMBO J. 13:861.
50. Anel, A., Buferne, M., Boyer, C., Schnitt-Verhulst, A.-M. and Golstein, P. 1994. T cell receptor-induced Fas-ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A. Eur. J. Immunol. 24:2469.
51. Owen-Schaub, L. B., Yonehara, S., Crump, W. L. and Grim, E. A. 1992. DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cell. Immunol. 140:197.
52. Iway, K., Miyawaki, T., Takizawa, T., Konno, A., Ohta, K., Yachie, A., Seki, H. and Taniguchi, N. 1994. Differential expression of bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes monocytes and neutrophils. Blood 84:1201.
53. Adachi, M., Watanabe-Fukunaga, R. and Nagata, S. 1993. Aberrant transcription caused by insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc. Natl Acad. Sci. USA 90:1756.
54. Singer, G. G. and Abbas, A. K. 1994 The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice Immunity 1:365.
55. Mogil, R. J., Radvanyi, L., Gonzales-Quintial, R., Miller, R., Mills, G., Theofilopoulos, A. N. and Green, D. R. 1995. Fas (CD95) participates in peripheral T-cell deletion and associated apoptosis in vivo. Int. Immunol. 7:1451.
56. Gonzalo, J. A., de Alboran, I. M., Ales-Martinez, J. E., Martinez-A., C. and Kroemer, G. 1992. Expansion and clonal deletion of peripheral T cells induced by bacterial superantigen is independent of the interleukin-2 pathway Eur. J. Immunol. 22:1007.