Enzyme-mediated spatial segregation on individual polymeric support beads: Application to generation and screening of encoded combinatorial libraries

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 16, 1996, Pages 8194-8199

  Vágner, Josef ^a,d   Barany, George ^a   Lam, Kit S ^b   Krchňák, Viktor ^c,e   Sepetov, Nikolai F ^c   Ostrem, James A ^c   Štrop, Peter ^c   Lebl, Michal ^c,e  

^a University of Minnesota   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c Selectide Corporation   (United States)

^d NOVO NORDISK A S   (Denmark)

^e Houghten Pharmaceuticals Inc   (United States)

Author keywords

combinatorial chemistry; encoded libraries; peptides; proteolytic enzymes; solid phase synthesis

Indexed keywords

ANTIBODY; BETA ENDORPHIN; CHYMOTRYPSIN; POLYMER; POLYOXYETHYLENE; POLYSTYRENE; PROTEINASE; STREPTAVIDIN; SYNTHETIC PEPTIDE; THROMBIN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME MECHANISM; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; RECEPTOR BINDING; SPECTROSCOPY;

AMINO ACID SEQUENCE; ENDOPEPTIDASES; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYETHYLENE GLYCOLS; POLYSTYRENES; PROTEIN BINDING;

EID: 0029776685     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.16.8194     Document Type: Article

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