Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis

Blood

Volumn 87, Issue 5, 1996, Pages 1780-1792

  Lowell, Clifford A ^a   Niwa, Maho ^b   Soriano, Philippe ^b   Varmus, Harold E ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

ALBERS SCHOENBERG DISEASE; ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DISEASE; BONE REMODELING; COLONY FORMING UNIT C; CONTROLLED STUDY; ENZYME DEFICIENCY; EXTRAMEDULLARY HEMATOPOIESIS; GENOTYPE; LEUKOPENIA; MALE; MOUSE; MUTANT; NONHUMAN; OSTEOCLAST; PHENOTYPE; PRIORITY JOURNAL; SURVIVAL;

EID: 0030067201     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.5.1780.bloodjournal8751780     Document Type: Article

References (46)

1. Bolen JB, Rowley RB, Spana C, Tsygankov AY: The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J 6:3403, 1992
2. Tsygankov A, Bolen J: The Src family of tyrosine protein kinases in hemopoietic signal transduction. Stem Cells 11:371, 1993
3. Eiseman E, Bolen JB: Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 355:78, 1992
4. Wang AV, Scholl PR, Geha RS: Physical and functional association of the high affinity immunoglobulin G receptor (Fc γ RI) with the kinases Hck and Lyn. J Exp Med 180:1165, 1994
5. Morio T, Geha RS, Chatila TA: Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases. Eur J Immunol 24:651, 1994
6. fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70:741, 1992
7. Stein PL, Vogel H, Soriano P: Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev 8:1999, 1994
8. Soriano P, Montgomery C, Geske R, Bradley A: Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64:693, 1991
9. Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER: Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258:1903, 1992
10. Lowell CA, Soriano P, Varinus HE: Functional overlap in the src gene family: Inactivation of hck and fgr impairs natural immunity. Genes Dev 8:387, 1994
11. Copeland NG, Jenkins NA, Gilbert DJ, Eppig JT, Maltais LJ, Miller JC, Dietrich WF, Weaver A, Lincoln SE, Steen RG: A genetic linkage map of the mouse: current applications and future prospects. Science 262:57, 1993
12. Metcalf D: Hematopoietic Colony Stimulatory Factors New York, NY, Elsevier Science, 1984
13. Heyworth CM, Spooncer E: In vitro clonal assays for murine multipotential and lineage restricted myeloid progenitor cells, in Testa NG, Molineux G (eds): Haemopoiesis: A Practical Approach. New York, NY, IRL, 1993, p 37
14. Lord BI: In vivo assays for multipotential and marrow repopulating cells, in Testa NG, Molineux G (eds): Haemopoiesis: A Practical Approach. New York, NY, URL, 1993, p 1
15. Akatsu T, Tamura T, Takahashi N, Udagawa N, Tanaka S, Sasaki T, Yamaguchi A, Nagata N, Suda T: Preparation and characterization of a mouse osteoclast-like multinucleated cell population. J Bone Miner Res 7:1297, 1992
16. Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin TJ, Suda T: Origin of osteoclasts: Mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci USA 87:7260, 1990
17. Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin TJ, Suda T: The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 125:1805, 1989
18. Harlow E, Lane D: Antibodies: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1988
19. Sukegawa J, Akatsuka T, Sugawara I, Mori S, Yamamoto T, Toyoshima K: Monoclonal antibodies to the amino-terminal sequence of the c-yes gene product as specific probes of its expression. Oncogene 5:611, 1990
20. Lowe C, Yoneda T, Boyce BF, Chen H, Mundy GR, Soriano P: Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. Proc Natl Acad Sci USA 90:4485, 1993
21. Yoshida H, Hayashi S, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa S: The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345:442, 1990
22. Hestdal K, Ruscetti FW, Ihle JN, Jacobsen SE, Dubois CM, Kopp WC, Longo DL, Keller JR: Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. J Immunol 147:22, 1991
23. Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF: c-Fos: A key regulator of osteoclastmacrophage lineage determination and bone remodeling. Science 266:443, 1994
24. Wang ZQ, Ovitt C, Grigoriadis AE, Mohle-Steinlein U, Ruther U, Wagner EF: Bone and haematopoietic defects in mice lacking c-fos. Nature 360:741, 1992
25. Johnson RS, Spiegelman BM, Papaioannou V: Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71:577, 1992
26. Begg SK, Radley JM, Pollard JW, Chisholm OT, Stanley ER, Bertoncello I: Delayed hematopoietic development in osteopetrotic (op/op) mice. J Exp Med 177:237, 1993
27. Okada S, Wang ZQ, Grigoriadis AE, Wagner EF, Ruden T: Mice lacking c-fos have normal hematopoietic stem cells but exhibit altered B-cell differentiation due to an impaired bone marrow environment. Mol Cell Biol 14:382, 1994
28. c-src in association with intracellular membranes. J Cell Biol 119:1003, 1992
29. c-src. Cell 49:75, 1987
30. lyn with the interleukin 2 receptor: Implications for redundancy and pleiotropism in cytokine signal transduction. Proc Natl Acad Sci USA 90:4201, 1993
31. Twamley-Stein GM, Pepperkok R, Ansorge W, Courtneidge SA: The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH3T3 cells. Proc Natl Acad Sci USA 90:7696, 1993
32. Rugh R. The mouse: Reproduction and development. New York, NY, Oxford University Press, 1990
33. Yanai N, Matsuya Y, Obinata M: Spleen stromal cell lines selectively support erythroid colony formation. Blood 74:2391, 1989
34. Van Den Heuvel R, Schoeters G, Leppens H, Vanderborght O: Stromal cells in long-term cultures of liver, spleen, and bone marrow at different developmental ages have different capacities to maintain GM-CFC proliferation. Exp Hematol 19:115, 1991
35. Willman CL, Stewart CC, Longacre TL, Head DR, Habersett R, Ziegler SF, Perlmutter RM: Expression of the c-fgr and hck protein-tyrosine kinases in acute myeloid leukemic blasts is associated with early commitment and differentiation events in the mono-cytic and granulocytic lineages. Blood 77:726, 1991
36. lck. Nature 357:161, 1992
37. Nilsson SK, Bertoncello I: Age-related changes in extramedullary hematopoiesis in the spleen of normal and perturbed osteopetrotic (op/op) mice. Exp Hematol 22:377, 1994
38. Shalhoub V, Jackson ME, Lian JB, Stein GS, Marks S Jr: Gene expression during skeletal development in three osteopetrotic rat mutations. Evidence for osteoblast abnormalities. J Biol Chem 266:9847, 1991
39. Shalhoub V, Bettencourt B, Jackson ME, MacKay CA, Glimcher MJ, Marks S Jr, Stein GS, Lian JB: Abnormalities of phosphoprotein gene expression in three osteopetrotic rat mutations: Elevated mRNA transcripts, protein synthesis, and accumulation in bone of mutant animals. J Cell Physiol 158:110, 1994
40. c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. J Clin Invest 90:1622, 1992
41. c-src, preferentially on ruffled border membranes. FEBS Lett 313:85, 1992
42. 3 potentiate bone resorption. J Biol Chem 268:9901, 1993
43. Kaplan KB, Bibbins KB, Swedlow JR, Arnaud M, Morgan DO, Varmus HE: Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J 13:4745, 1994
44. -/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes Dev 9:1505, 1995
45. Robbins SM, Quintrell NA, Bishop JM: Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae. Mol Cell Biol 15:3507, 1995
46. Resh MD: Myristoylation and palmitoylation of src-family members: The fats of the matter. Cell 76:41, 1994