메뉴 건너뛰기




Volumn 5, Issue 4, 1998, Pages 244-253

Chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; CHLORAMBUCIL; CYCLIN DEPENDENT KINASE; CYCLOPHOSPHAMIDE; CYTOKINE; DOXORUBICIN; FLUDARABINE; IMMUNOGLOBULIN G ANTIBODY; LYMPHOCYTE ANTIGEN; MELARSOPROL; PREDNISONE; PURINE DERIVATIVE; VINCRISTINE;

EID: 0032431803     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199807000-00003     Document Type: Review
Times cited : (28)

References (124)
  • 1
    • 0030909335 scopus 로고    scopus 로고
    • Bladder carcinoma and other second malignancies after radiotherapy for prostate carcinoma
    • Neugut Al, Ahsan H, Robinson E, Ennis RD: Bladder carcinoma and other second malignancies after radiotherapy for prostate carcinoma. Cancer 1997, 79:1600-1604.
    • (1997) Cancer , vol.79 , pp. 1600-1604
    • Neugut, A.I.1    Ahsan, H.2    Robinson, E.3    Ennis, R.D.4
  • 2
    • 0031053476 scopus 로고    scopus 로고
    • A case-control study to investigate the risk of leukaemia associated with exposure to benzene in petroleum marketing and distribution workers in the United Kingdom
    • Rushton L, Romaniuk H: A case-control study to investigate the risk of leukaemia associated with exposure to benzene in petroleum marketing and distribution workers in the United Kingdom. Occup Environ Med 1997, 54:152-166.
    • (1997) Occup Environ Med , vol.54 , pp. 152-166
    • Rushton, L.1    Romaniuk, H.2
  • 3
    • 0030739815 scopus 로고    scopus 로고
    • The role of hepatitis C virus in the aetiology of non-Hodgkins lymphoma - A regional association?
    • McColl MD, Singer IO, Tait RC, McNeil IR, Cumming RL, Hogg RB: The role of hepatitis C virus in the aetiology of non-Hodgkins lymphoma - a regional association? Leuk Lymphoma 1997, 26:127-130.
    • (1997) Leuk Lymphoma , vol.26 , pp. 127-130
    • McColl, M.D.1    Singer, I.O.2    Tait, R.C.3    McNeil, I.R.4    Cumming, R.L.5    Hogg, R.B.6
  • 5
    • 0030971345 scopus 로고    scopus 로고
    • Occupational and residential magnetic field exposure and leukemia and central nervous system tumors
    • Feychting M, Forssen U, Floderus B: Occupational and residential magnetic field exposure and leukemia and central nervous system tumors. Epidemiology 1997, 8:384-389.
    • (1997) Epidemiology , vol.8 , pp. 384-389
    • Feychting, M.1    Forssen, U.2    Floderus, B.3
  • 7
    • 0029794418 scopus 로고    scopus 로고
    • Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia
    • Garcia-Marco JA, Caldas C, Price CM, Wiedemann LM, Ashworth A, Catovsky D: Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia. Blood 1996, 88:1568-1575.
    • (1996) Blood , vol.88 , pp. 1568-1575
    • Garcia-Marco, J.A.1    Caldas, C.2    Price, C.M.3    Wiedemann, L.M.4    Ashworth, A.5    Catovsky, D.6
  • 8
    • 0030769460 scopus 로고    scopus 로고
    • Lack of clonal BCRA2 gene deletion on chromosome 13 in chronic lymphocytic leukaemia
    • Panayiotidis P, Ganeshaguru K, Rowntree C, Jabbar SA, Hoffbrand VA, • Foroni L: Lack of clonal BCRA2 gene deletion on chromosome 13 in chronic lymphocytic leukaemia. Br J Haematol 1997, 97:844-847. Despite the report that the BRCA2 gene may be involved in greater than 80% of patients with CLL, this study failed to detect a single case of homozygous or heterozygous deletion of BCRA2 using probes for exons 11 and 26-27 of the BRCA2 gene (at 13q12) in the leukemia cells of 44 patients examined.
    • (1997) Br J Haematol , vol.97 , pp. 844-847
    • Panayiotidis, P.1    Ganeshaguru, K.2    Rowntree, C.3    Jabbar, S.A.4    Hoffbrand, V.A.5    Foroni, L.6
  • 9
    • 0030939098 scopus 로고    scopus 로고
    • Interphase cytogenetics in chronic lymphocytic leukemia
    • Garcia-Marco JA, Price CM, Catovsky D: Interphase cytogenetics in • chronic lymphocytic leukemia. Cancer Genet Cytogenet 1997, 94:52-58. Patients were investigated for 13q deletions using flourescent in situ hybridization analysis of the RB1 locus (13q14) and DNA probes for 13q12.3 (BRCA2) and 13q14 (RB1 and DBM locus). Twenty-eight of 35 (80%) cases showed deletion of a 1Mb 13q12.3 encompassing the BCRA2 locus, where as 22/35 (63%) were deleted at 13q14. These data suggest that abnormalities of 13q are more frequent than trisomy 12 in CLL and provide evidence for the presence of a new candidate gene at 13q12.3 that may be involved in the pathogenesis of CLL. However, deletions at 13q12.3 have yet to be observed by other investigators in CLL.
    • (1997) Cancer Genet Cytogenet , vol.94 , pp. 52-58
    • Garcia-Marco, J.A.1    Price, C.M.2    Catovsky, D.3
  • 10
    • 0030896465 scopus 로고    scopus 로고
    • Genes and chromosomes in chronic B-cell leukemia
    • Crossen PE: Genes and chromosomes in chronic B-cell leukemia. Cancer • Genet Cytogenet 1997, 94:44-51. Trisomy 12 in association with complex karyotypic abnormalities is associated with a poor prognosis, and flourescent in situ hybridization studies show a strong correlation between trisomy 12, atypical morphology, and advanced disease. Ten percent to 15% of patients were found to have mutations of p53. The presence of such mutations was associated with advanced disease, resistance to treatment, and poor survival.
    • (1997) Cancer Genet Cytogenet , vol.94 , pp. 44-51
    • Crossen, P.E.1
  • 11
    • 0030930177 scopus 로고    scopus 로고
    • Cytogenetic, fluorescence in situ hybridisation, and clinical evaluation of translocations with concomitant deletion at 13q14 in chronic lymphocytic leukaemia
    • Gardiner AC, Corcoran MM, Oscier DG: Cytogenetic, fluorescence in situ hybridisation, and clinical evaluation of translocations with concomitant deletion at 13q14 in chronic lymphocytic leukaemia. Genes Chromosomes Cancer 1997, 20:73-81.
    • (1997) Genes Chromosomes Cancer , vol.20 , pp. 73-81
    • Gardiner, A.C.1    Corcoran, M.M.2    Oscier, D.G.3
  • 13
    • 0024352654 scopus 로고
    • Molecular analyses of chromosome 12 in chronic lymphocytic leukemia
    • Einhorn S, Burvall K, Juliusson G, Gahrton G, Meeker T: Molecular analyses of chromosome 12 in chronic lymphocytic leukemia. Leukemia 1989, 3:871-874.
    • (1989) Leukemia , vol.3 , pp. 871-874
    • Einhorn, S.1    Burvall, K.2    Juliusson, G.3    Gahrton, G.4    Meeker, T.5
  • 14
    • 0023411553 scopus 로고
    • Origin of trisomy 12 in B-cell chronic lymphocytic leukemia
    • Crossen PE, Horn HL: Origin of trisomy 12 in B-cell chronic lymphocytic leukemia [letter]. Cancer Genet Cytogenet 1987, 28:185-186.
    • (1987) Cancer Genet Cytogenet , vol.28 , pp. 185-186
    • Crossen, P.E.1    Horn, H.L.2
  • 15
    • 0030148594 scopus 로고    scopus 로고
    • Trisomy 12 in chronic lymphocytic leukaemia
    • Matutes E: Trisomy 12 in chronic lymphocytic leukaemia [comment]. Leuk Res 1996, 20:375-377.
    • (1996) Leuk Res , vol.20 , pp. 375-377
    • Matutes, E.1
  • 16
    • 0030992413 scopus 로고    scopus 로고
    • Cytogenetic studies in seventy-six cases of B-chronic lymphoproliferative disorders
    • Sole F, Woessner S, Perez-Losada A, Florensa L, Montero S, Asensio A, • et al.: Cytogenetic studies in seventy-six cases of B-chronic lymphoproliferative disorders. Cancer Genet Cytogenet 1997, 93:160-166. In a study of 76 patients with various chronic B-cell lymphoproliferative disease, abnormalities of chromosomes 6, 11, or 13 were observed most frequently in the leukemia cells of patients with common CLL, whereas trisomy 12 was frequently found in CLL mixed-cell type, in follicular lymphoma in leukemic phase, and chronic prolymphocytic leukemia.
    • (1997) Cancer Genet Cytogenet , vol.93 , pp. 160-166
    • Sole, F.1    Woessner, S.2    Perez-Losada, A.3    Florensa, L.4    Montero, S.5    Asensio, A.6
  • 17
    • 0029885596 scopus 로고    scopus 로고
    • Trisomy 12 is a rare cytogenetic finding in typical chronic lymphocytic leukemia
    • Woessner S, Sole F, Perez-Losada A, Florensa L, Vila RM: Trisomy 12 is a rare cytogenetic finding in typical chronic lymphocytic leukemia [see comments]. Leuk Res 1996, 20:369-374.
    • (1996) Leuk Res , vol.20 , pp. 369-374
    • Woessner, S.1    Sole, F.2    Perez-Losada, A.3    Florensa, L.4    Vila, R.M.5
  • 18
    • 9044226530 scopus 로고    scopus 로고
    • Trisomy 12 defines a group of CLL with atypical morphology: Correlation between cytogenetic, clinical and laboratory features in 544 patients
    • Matutes E, Oscier D, Garcia-Marco J, Ellis J, Copplestone A, Gillingham R, et al.: Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients. Br J Haematol 1996, 92:382-388.
    • (1996) Br J Haematol , vol.92 , pp. 382-388
    • Matutes, E.1    Oscier, D.2    Garcia-Marco, J.3    Ellis, J.4    Copplestone, A.5    Gillingham, R.6
  • 19
    • 0030756151 scopus 로고    scopus 로고
    • Monoallelic p53 deletion in chronic lymphocytic leukemia detected by interphase cytogenetics
    • Amiel A, Arbov L, Manor Y, Fejgin M, Elis A, Gaber E, Lishner M: • Monoallelic p53 deletion in chronic lymphocytic leukemia detected by interphase cytogenetics. Cancer Genet Cytogenet 1997, 97:97-100. This study found p53 gene mutations in leukemia cells of 10%-15% of patients with CLL. In addition, this study found a statistically significant correlation between p53 deletion and disease progression.
    • (1997) Cancer Genet Cytogenet , vol.97 , pp. 97-100
    • Amiel, A.1    Arbov, L.2    Manor, Y.3    Fejgin, M.4    Elis, A.5    Gaber, E.6    Lishner, M.7
  • 20
    • 0029052763 scopus 로고
    • Trisomy 12 in Richter's transformation of chronic lymphocytic leukemia
    • Brynes RK, McCourty A, Sun NC, Koo CH: Trisomy 12 in Richter's transformation of chronic lymphocytic leukemia. Am J Clin Pathol 1995, 104:199-203.
    • (1995) Am J Clin Pathol , vol.104 , pp. 199-203
    • Brynes, R.K.1    McCourty, A.2    Sun, N.C.3    Koo, C.H.4
  • 21
    • 0030992562 scopus 로고    scopus 로고
    • Transformation of chronic lymphocytic leukemia to immunoblastic lymphoma (Richter's syndrome)
    • Shahidi H, Leslie WT, Wool NL, Gregory SA: Transformation of chronic lymphocytic leukemia to immunoblastic lymphoma (Richter's syndrome) [clinical conference], Med Pediatr Oncol 1997, 29:146-151.
    • (1997) Med Pediatr Oncol , vol.29 , pp. 146-151
    • Shahidi, H.1    Leslie, W.T.2    Wool, N.L.3    Gregory, S.A.4
  • 22
    • 0028365328 scopus 로고
    • Trisomy 12 in B-cell chronic lymphocytic leukaemia: Assessment of lineage restriction by simultaneous analysis of immunophenotype and genotype in interphase cells by fluorescence in situ hybridization
    • Garcia-Marco J, Matutes E, Morilla R, Ellis J, Oscier D, Fantes J, et al.: Trisomy 12 in B-cell chronic lymphocytic leukaemia: assessment of lineage restriction by simultaneous analysis of immunophenotype and genotype in interphase cells by fluorescence in situ hybridization. Br J Haematol 1994, 87:44-50.
    • (1994) Br J Haematol , vol.87 , pp. 44-50
    • Garcia-Marco, J.1    Matutes, E.2    Morilla, R.3    Ellis, J.4    Oscier, D.5    Fantes, J.6
  • 23
    • 0030039406 scopus 로고    scopus 로고
    • Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia
    • Mould S, Gardiner A, Corcoran M, Oscier DG: Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia. Br J Haematol 1996, 92:389-392.
    • (1996) Br J Haematol , vol.92 , pp. 389-392
    • Mould, S.1    Gardiner, A.2    Corcoran, M.3    Oscier, D.G.4
  • 24
    • 0028210712 scopus 로고
    • Clinical and morphologic features of B-cell small lymphocytic lymphoma with del(6)(q21q23)
    • Offit K, Louie DC, Parsa NZ, Filippa D, Gangi M, Siebert R, Chaganti RS: Clinical and morphologic features of B-cell small lymphocytic lymphoma with del(6)(q21q23). Blood 1994, 83:2611-2618.
    • (1994) Blood , vol.83 , pp. 2611-2618
    • Offit, K.1    Louie, D.C.2    Parsa, N.Z.3    Filippa, D.4    Gangi, M.5    Siebert, R.6    Chaganti, R.S.7
  • 25
    • 0030934737 scopus 로고    scopus 로고
    • Polymorphism of the tumour necrosis factor-alpha and lymphotoxin-alpha genes in chronic lymphocytic leukaemia
    • Demeter J, Porzsolt F. Ramisch S, Schmidt D, Schmid M, Messer G: • Polymorphism of the tumour necrosis factor-alpha and lymphotoxin-alpha genes in chronic lymphocytic leukaemia. Br J Haematol 1997, 97:107-112. A provocative study that provides data indicating that patients with CLL possess an allele of the TNF-α gene that governs lower levels of inducible TNF-α more frequently than normal control subjects. The authors speculate that the risk for developing CLL is associated with a genetic polymorphism that influences the expression of this cytokine gene.
    • (1997) Br J Haematol , vol.97 , pp. 107-112
    • Demeter, J.1    Porzsolt, F.2    Ramisch, S.3    Schmidt, D.4    Schmid, M.5    Messer, G.6
  • 26
    • 0030971829 scopus 로고    scopus 로고
    • Cytogenetic and interphase cytogenetic characterization of atypical chronic lymphocytic leukemia carrying BCL1 translocation
    • Cuneo A, Bigoni R, Negrini M, Bullrich F, Veronese ML, Roberti MG, et al.: • Cytogenetic and interphase cytogenetic characterization of atypical chronic lymphocytic leukemia carrying BCL1 translocation. Cancer Res 1997, 57:1144-1150. Flourescent in situ hybridization using yeast artifical chromosomes were used to probe for t(11;14), deletions on chromosome 11 at BCL-1, or deletions at 13q14 in CLL. Although some leukemia samples had deletions at BCL-1, these samples were atypical in morphology, shared immunologic features with mantle zone cell lymphoma, and were obtained from patients that had isolated peripheral blood and marrow lymphocytosis, with or without mild to moderate spleen involvement, and a more aggressive clinical course. Nevertheless, most the 13q14 deletions that typically are found in leukemia cells of patients with common CLL The authors suggest that these samples represent a variant of CLL that shares features of mantle zone cell lymphoma.
    • (1997) Cancer Res , vol.57 , pp. 1144-1150
    • Cuneo, A.1    Bigoni, R.2    Negrini, M.3    Bullrich, F.4    Veronese, M.L.5    Roberti, M.G.6
  • 27
    • 0029417029 scopus 로고
    • Cytogenetic analysis of B cell chronic lymphoid leukemias classified according to morphologic and immunophenotypic (FAB) criteria
    • Hernandez JM, Mecucci C, Criel A, Meeus P, Michaux I, Van Hoof A, et al.: Cytogenetic analysis of B cell chronic lymphoid leukemias classified according to morphologic and immunophenotypic (FAB) criteria. Leukemia 1995, 9:2140-2146.
    • (1995) Leukemia , vol.9 , pp. 2140-2146
    • Hernandez, J.M.1    Mecucci, C.2    Criel, A.3    Meeus, P.4    Michaux, I.5    Van Hoof, A.6
  • 28
    • 0030797556 scopus 로고    scopus 로고
    • Detection of 14q32.33 translocation and t(11;14) in interphase nuclei of chronic B-cell leukemia/lymphomas by in situ hybridization
    • Takashima T, Itoh M, Ueda Y, Nishida K, Tamaki T, Misawa S, et al.: Detection of 14q32.33 translocation and t(11;14) in interphase nuclei of chronic B-cell leukemia/lymphomas by in situ hybridization, Int J Cancer 1997, 72:31-38.
    • (1997) Int J Cancer , vol.72 , pp. 31-38
    • Takashima, T.1    Itoh, M.2    Ueda, Y.3    Nishida, K.4    Tamaki, T.5    Misawa, S.6
  • 29
    • 0029859127 scopus 로고    scopus 로고
    • t(11;14)(q13;q32): Chronic lymphocytic leukaemia or mantle cell leukaemia?
    • Dascalescu C, Gressin R, Callanan M, Sotto JJ, Leroux D: t(11;14)(q13;q32): chronic lymphocytic leukaemia or mantle cell leukaemia? [letter]. Br J Haematol 1996, 95:572-573.
    • (1996) Br J Haematol , vol.95 , pp. 572-573
    • Dascalescu, C.1    Gressin, R.2    Callanan, M.3    Sotto, J.J.4    Leroux, D.5
  • 31
    • 1842328565 scopus 로고    scopus 로고
    • 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis
    • Dohner H, Stilgenbauer S, James MR, Benner A, Weilguni T, Bentz M, et •• al.: 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood 1997, 89:2516-2522. These investigators examine the leukemia cells of 214 patients with B-CLL were studied by flourescent in situ hybridization using the yeast artifical chromosome clone 755b11 from chromosome region 11q22.3-q23.1. Forty-three (20%) had deletions in this region. Patients with 11q deletions were younger (P = 0.01). 11q deletions were associated with extensive peripheral, abdominal, and mediastinal lymphadenopathy (P < 0.001). Patients with 11q deletions had a more rapid disease progression as shown by a shorter treatment-free interval (9 months vs 43 months; P < 0.001). The prognostic effect of 11q deletion on survival strongly depended on the age: in patients less than 55 years old, the median survival time was significantly shorter in the deletion group (64 months vs 209 months; P < 0.001), whereas in patients greater than or equal to 55 years of age there was no significant difference (94 months vs 111 months; P = 0.82). The authors conclude that 11q deletions identifies a new clinical subset of CLL characterized by extensive lymph node involvement and, at least in younger patients, a shorter duration of survival.
    • (1997) Blood , vol.89 , pp. 2516-2522
    • Dohner, H.1    Stilgenbauer, S.2    James, M.R.3    Benner, A.4    Weilguni, T.5    Bentz, M.6
  • 32
    • 0030813843 scopus 로고    scopus 로고
    • Frequent loss of the 11q14-24 region in chronic lymphocytic leukemia: A study by comparative genomic hybridization. Tampere CLL Group
    • Karhu R, Knuutila S, Kallioniemi OP, Siltonen S, Aine R, Vilpo L, Vilpo J: Frequent loss of the 11q14-24 region in chronic lymphocytic leukemia: a study by comparative genomic hybridization. Tampere CLL Group. Genes Chromosomes Cancer 1997, 19:286-290.
    • (1997) Genes Chromosomes Cancer , vol.19 , pp. 286-290
    • Karhu, R.1    Knuutila, S.2    Kallioniemi, O.P.3    Siltonen, S.4    Aine, R.5    Vilpo, L.6    Vilpo, J.7
  • 33
    • 0022186009 scopus 로고
    • A 14;19 translocation in B-cell chronic lymphocytic leukemia: A new recurring chromosome aberration
    • Ueshima Y, Bird ML, Vardiman JW, Rowley JD: A 14;19 translocation in B-cell chronic lymphocytic leukemia: a new recurring chromosome aberration, Int J Cancer 1985, 36:287-290.
    • (1985) Int J Cancer , vol.36 , pp. 287-290
    • Ueshima, Y.1    Bird, M.L.2    Vardiman, J.W.3    Rowley, J.D.4
  • 35
    • 0030883073 scopus 로고    scopus 로고
    • BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: A molecular and cytogenetic study
    • McKeithan TW, Takimoto GS, Ohno H, Bjorling VS, Morgan R, Hecht BK, et al.: BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: a molecular and cytogenetic study. Genes Chromosomes Cancer 1997, 20:64-72.
    • (1997) Genes Chromosomes Cancer , vol.20 , pp. 64-72
    • McKeithan, T.W.1    Takimoto, G.S.2    Ohno, H.3    Bjorling, V.S.4    Morgan, R.5    Hecht, B.K.6
  • 37
    • 0030963115 scopus 로고    scopus 로고
    • Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia
    • Yamada Y, Hatta Y, Murata K, Sugawara K, Ikeda S, Mine M, et al.: Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia. J Clin Oncol 1997, 15:1778-1785.
    • (1997) J Clin Oncol , vol.15 , pp. 1778-1785
    • Yamada, Y.1    Hatta, Y.2    Murata, K.3    Sugawara, K.4    Ikeda, S.5    Mine, M.6
  • 38
    • 0027158429 scopus 로고
    • Changes in mechanisms of monocyte/macrophage-mediated cytotoxicity during culture. Reactiveoxygen intermediates are involved in monocyte-mediated cytotoxicity, whereas reactive nitrogen intermediates are employed by macrophages in tumor cell killing
    • Martin JH, Edwards SW: Changes in mechanisms of monocyte/macrophage-mediated cytotoxicity during culture. Reactiveoxygen intermediates are involved in monocyte-mediated cytotoxicity, whereas reactive nitrogen intermediates are employed by macrophages in tumor cell killing. J Immunol 1993, 150:3478-3486.
    • (1993) J Immunol , vol.150 , pp. 3478-3486
    • Martin, J.H.1    Edwards, S.W.2
  • 39
    • 0030751625 scopus 로고    scopus 로고
    • Analysis of the cyclin-dependent kinase inhibitors p18 and p19 in mantle-cell lymphoma and chronic lymphocytic leukemia
    • Williams ME, Whitefield M, Swerdlow SH: Analysis of the cyclin-dependent kinase inhibitors p18 and p19 in mantle-cell lymphoma and chronic lymphocytic leukemia. Ann Oncol 1997, 8 Suppl 2:71-73.
    • (1997) Ann Oncol , vol.8 , Issue.SUPPL. 2 , pp. 71-73
    • Williams, M.E.1    Whitefield, M.2    Swerdlow, S.H.3
  • 40
    • 0029990349 scopus 로고    scopus 로고
    • B-chronic lymphocytic leukemia: A malignancy of anti-self B cells
    • Caligaris-Cappio F: B-chronic lymphocytic leukemia: a malignancy of anti-self B cells. Blood 1996, 87:2615-2620.
    • (1996) Blood , vol.87 , pp. 2615-2620
    • Caligaris-Cappio, F.1
  • 41
    • 0030639650 scopus 로고    scopus 로고
    • Ig VH1 genes expressed in B-cell chronic lymphocytic leukemia exhibit distinctive molecular features
    • Johnson TA, Rassenti LZ, Kipps TJ: Ig VH1 genes expressed in B-cell •• chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol 1997, 158:235-246. This study demonstrates that the immunoglobulins expressed in CLL are not representative of those expressed by normal B cells. As such, this study provides the first compelling evidence that the immunoglobulins expressed in this disease are selected, suggesting that they play a role in the etiopathogenesis of this disease.
    • (1997) J Immunol , vol.158 , pp. 235-246
    • Johnson, T.A.1    Rassenti, L.Z.2    Kipps, T.J.3
  • 42
    • 0031016703 scopus 로고    scopus 로고
    • Molecular characterization of IgA- and/or IgG-switched chronic lymphocytic leukemia B cells
    • Matolcsy A, Casali P, Nador RG, Liu YF, Knowles DM: Molecular characterization of IgA- and/or IgG-switched chronic lymphocytic leukemia B cells. Blood 1997, 89:1732-1739.
    • (1997) Blood , vol.89 , pp. 1732-1739
    • Matolcsy, A.1    Casali, P.2    Nador, R.G.3    Liu, Y.F.4    Knowles, D.M.5
  • 43
  • 44
    • 0027337036 scopus 로고
    • Molecular analysis of VH and VL regions expressed in IgG-bearing chronic lymphocytic leukemia (CLL): Further evidence that CLL is a heterogeneous group of tumors
    • Ebeling SB, Schutte ME, Logtenberg T: Molecular analysis of VH and VL regions expressed in IgG-bearing chronic lymphocytic leukemia (CLL): further evidence that CLL is a heterogeneous group of tumors. Blood 1993, 82:1626-1631.
    • (1993) Blood , vol.82 , pp. 1626-1631
    • Ebeling, S.B.1    Schutte, M.E.2    Logtenberg, T.3
  • 45
    • 0028945621 scopus 로고
    • Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells
    • Hashimoto S, Dono M, Wakai M, Allen SL, Lichtman SM, Schulman P, et al.: Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells. J Exp Med 1995, 181:1507-1517.
    • (1995) J Exp Med , vol.181 , pp. 1507-1517
    • Hashimoto, S.1    Dono, M.2    Wakai, M.3    Allen, S.L.4    Lichtman, S.M.5    Schulman, P.6
  • 46
    • 0030905707 scopus 로고    scopus 로고
    • Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities
    • H genes with significantly more somatic mutations (6.5% ± 1.67%). These results suggest that the clonal history of the two subsets of CLL differ, thus challenging the notion that trisomy 12 is acquired during the course of disease progression.
    • (1997) Blood , vol.89 , pp. 4153-4160
    • Oscier, D.G.1    Thompsett, A.2    Zhu, D.3    Stevenson, F.K.4
  • 47
    • 0030957372 scopus 로고    scopus 로고
    • Lack of allelic exclusion in B cell chronic lymphocytic leukemia
    • Rassenti LZ, Kipps TJ: Lack of Allelic Exclusion in B cell chronic lympho•• cytic leukemia. J Exp Med 1997, 185:1435-1445. This study demonstrates that approximately 6% of patients with CLL have leukemic B cells that express more than one functional Ig heavy chain and therefore lack allelic exclusion.
    • (1997) J Exp Med , vol.185 , pp. 1435-1445
    • Rassenti, L.Z.1    Kipps, T.J.2
  • 48
    • 0030761477 scopus 로고    scopus 로고
    • Aberrations of the B-cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia
    • Thompson AA, Talley JA, Do HN, Kagan HL, Kunkel L, Berenson J, et al.: •• Aberrations of the B-cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia. Blood 1997, 90:1387-1394. This study found that most CLL samples examined had somatic mutations predicted to affect expression and function of the immunoglobulin accessory protein, Ig-β (CD79b), that is required for the expression and signal transduction of surface immunoglobulin. The authors suggest that such aberations underlie the diminished expression and signaling capacity of surface immunoglobulin that appear characteristic of this leukemia.
    • (1997) Blood , vol.90 , pp. 1387-1394
    • Thompson, A.A.1    Talley, J.A.2    Do, H.N.3    Kagan, H.L.4    Kunkel, L.5    Berenson, J.6
  • 50
    • 0029744948 scopus 로고    scopus 로고
    • Engraftment of human chronic lymphocytic leukemia cells in SCID mice: In vivo and in vitro studies
    • Hummel JL, Lichty BD, Reis M, Dube I, Kamel-Reid S: Engraftment of human chronic lymphocytic leukemia cells in SCID mice: in vivo and in vitro studies. Leukemia 1996, 10:1370-1376.
    • (1996) Leukemia , vol.10 , pp. 1370-1376
    • Hummel, J.L.1    Lichty, B.D.2    Reis, M.3    Dube, I.4    Kamel-Reid, S.5
  • 52
    • 0030031864 scopus 로고    scopus 로고
    • Establishment of a human B-CLL xenograft model: Utility as a preclinical therapeutic model
    • Mohammad RM, Mohamed AN, Hamdan MY, Vo T, Chen B, Katato K, et al.: Establishment of a human B-CLL xenograft model: utility as a preclinical therapeutic model. Leukemia 1996, 10:130-137.
    • (1996) Leukemia , vol.10 , pp. 130-137
    • Mohammad, R.M.1    Mohamed, A.N.2    Hamdan, M.Y.3    Vo, T.4    Chen, B.5    Katato, K.6
  • 53
    • 0030974961 scopus 로고    scopus 로고
    • A model for human B-chronic lymphocytic leukemia in human/mouse radiation chimera: Evidence for tumor-mediated suppression of antibody production in low-stage disease
    • Shimoni A, Marcus H, Canaan A, Ergas D, David M, Berrebi A, Reisner Y: A model for human B-chronic lymphocytic leukemia in human/mouse radiation chimera: evidence for tumor-mediated suppression of antibody production in low-stage disease. Blood 1997, 89:2210-2218.
    • (1997) Blood , vol.89 , pp. 2210-2218
    • Shimoni, A.1    Marcus, H.2    Canaan, A.3    Ergas, D.4    David, M.5    Berrebi, A.6    Reisner, Y.7
  • 56
    • 0027239823 scopus 로고
    • bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
    • Hanada M, Delia D, Aiello A, Stadtmauer E, Reed JC: bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 1993, 82:1820-1828.
    • (1993) Blood , vol.82 , pp. 1820-1828
    • Hanada, M.1    Delia, D.2    Aiello, A.3    Stadtmauer, E.4    Reed, J.C.5
  • 57
    • 0029871942 scopus 로고    scopus 로고
    • Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome
    • Robertson LE, Plunkett W, McConnell K, Keating MJ, McDonnell TJ: Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. Leukemia 1996, 10:456-459.
    • (1996) Leukemia , vol.10 , pp. 456-459
    • Robertson, L.E.1    Plunkett, W.2    McConnell, K.3    Keating, M.J.4    McDonnell, T.J.5
  • 58
    • 0029897734 scopus 로고    scopus 로고
    • Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX
    • McConkey DJ, Chandra J, Wright S, Plunkett W, McDonnell TJ, Reed JC, Keating M: Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX. J Immunol 1996, 156:2624-2630.
    • (1996) J Immunol , vol.156 , pp. 2624-2630
    • McConkey, D.J.1    Chandra, J.2    Wright, S.3    Plunkett, W.4    McDonnell, T.J.5    Reed, J.C.6    Keating, M.7
  • 59
    • 9544248773 scopus 로고    scopus 로고
    • In leukaemic CD5+ B cells the expression of BCL-2 gene family is shifted toward protection from apoptosis
    • Gottardi D, Alfarano A, De Leo AM, Stacchini A, Aragno M, Rigo A, et al.: In leukaemic CD5+ B cells the expression of BCL-2 gene family is shifted toward protection from apoptosis. Br J Haematol 1996, 94:612-618.
    • (1996) Br J Haematol , vol.94 , pp. 612-618
    • Gottardi, D.1    Alfarano, A.2    De Leo, A.M.3    Stacchini, A.4    Aragno, M.5    Rigo, A.6
  • 60
    • 0029858942 scopus 로고    scopus 로고
    • Regulation of clinical chemoresistance by bcl-2 and bax oncoproteins in B-cell chronic lymphocytic leukaemia
    • Pepper C, Bentley P, Hoy T: Regulation of clinical chemoresistance by bcl-2 and bax oncoproteins in B-cell chronic lymphocytic leukaemia. Br J Haematol 1996, 95:513-517.
    • (1996) Br J Haematol , vol.95 , pp. 513-517
    • Pepper, C.1    Bentley, P.2    Hoy, T.3
  • 62
    • 0029940595 scopus 로고    scopus 로고
    • Leukaemic CD5+ B-cell apoptosis: Co-incidence of cell death and DNA fragmentation with reduced bcl-2 expression
    • Tangye SG, Raison RL: Leukaemic CD5+ B-cell apoptosis: co-incidence of cell death and DNA fragmentation with reduced bcl-2 expression. Br J Haematol 1996, 92:950-953.
    • (1996) Br J Haematol , vol.92 , pp. 950-953
    • Tangye, S.G.1    Raison, R.L.2
  • 63
    • 0029970093 scopus 로고    scopus 로고
    • Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression
    • Agular-Santelises M, Rottenberg ME, Lewin N, Mellstedt H, Jondal M: Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression, Int J Cancer 1996, 69:114-119.
    • (1996) Int J Cancer , vol.69 , pp. 114-119
    • Agular-Santelises, M.1    Rottenberg, M.E.2    Lewin, N.3    Mellstedt, H.4    Jondal, M.5
  • 64
    • 0029623024 scopus 로고    scopus 로고
    • Bcl-2 expression and glucocorticoid-induced apoptosis of leukemic and lymphoma cells
    • Smets LA, van den Berg JD: Bcl-2 expression and glucocorticoid-induced apoptosis of leukemic and lymphoma cells. Leuk Lymphoma 1996, 20:199-205.
    • (1996) Leuk Lymphoma , vol.20 , pp. 199-205
    • Smets, L.A.1    Van Den Berg, J.D.2
  • 65
    • 0026655474 scopus 로고
    • Bcl-2 initiates a new category of oncogenes: Regulators of cell death
    • Korsmeyer SJ: Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 1992, 80:879-886.
    • (1992) Blood , vol.80 , pp. 879-886
    • Korsmeyer, S.J.1
  • 66
    • 0031414141 scopus 로고    scopus 로고
    • Human tumour antigens recognized by T cells: New perspectives for anti-cancer vaccines?
    • Coulie PG: Human tumour antigens recognized by T cells: new perspectives for anti-cancer vaccines? Mol Med Today 1997, 3:261-268.
    • (1997) Mol Med Today , vol.3 , pp. 261-268
    • Coulie, P.G.1
  • 68
    • 0029978058 scopus 로고    scopus 로고
    • Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: Relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance
    • Thomas A, el Rouby S, Reed JC, Krajewski S, Silber R, Potmesil M, Newcomb EW: Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. Oncogene 1996, 12:1055-1062.
    • (1996) Oncogene , vol.12 , pp. 1055-1062
    • Thomas, A.1    El Rouby, S.2    Reed, J.C.3    Krajewski, S.4    Silber, R.5    Potmesil, M.6    Newcomb, E.W.7
  • 69
    • 0029899181 scopus 로고    scopus 로고
    • Molecular thanatopsis: A discourse on the BCL2 family and cell death
    • Yang E, Korsmeyer SJ: Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood 1996, 88:386-401.
    • (1996) Blood , vol.88 , pp. 386-401
    • Yang, E.1    Korsmeyer, S.J.2
  • 71
    • 0030832602 scopus 로고    scopus 로고
    • Fludarabine ability to down-regulate Bcl-2 gene product in CD5+ leukaemic B cells: In vitro/in vivo correlations
    • Gottardi D, De Leo AM, Alfarano A, Stacchini A, Circosta P, Gregoretti • MG, et al.: Fludarabine ability to down-regulate Bcl-2 gene product in CD5+ leukaemic B cells: in vitro/in vivo correlations. Br J Haematol 1997, 99:147-157. This study found that fludarabine (9-beta-D-arabinofuranosyl-2-fluoradenine, Fara-A) down-regulated the expression of BCL-2 in 5 of 12 CLL samples tested in vitro. The down-regulation of BCL-2 mRNA was maximal at 48 hours, and bcl-2 protein down-regulation was prominent after 48 h. The authors provide data suggesting the susceptibility of leukemia cells to fludarabine-induced down modulation of bcl-2 correlated with the sensitivity to this drug in vivo.
    • (1997) Br J Haematol , vol.99 , pp. 147-157
    • Gottardi, D.1    De Leo, A.M.2    Alfarano, A.3    Stacchini, A.4    Circosta, P.5    Gregoretti, M.G.6
  • 72
    • 0030893716 scopus 로고    scopus 로고
    • CD6 ligation modulates the Bcl-2/Bax ratio and protects chronic lymphocytic leukemia B cells from apoptosis induced by anti-IgM
    • Osorio LM, De Santiago A, Aguilar-Santelises M, Mellstedt H, Jondal M: CD6 ligation modulates the Bcl-2/Bax ratio and protects chronic lymphocytic leukemia B cells from apoptosis induced by anti-IgM. Blood 1997, 89:2833-2841.
    • (1997) Blood , vol.89 , pp. 2833-2841
    • Osorio, L.M.1    De Santiago, A.2    Aguilar-Santelises, M.3    Mellstedt, H.4    Jondal, M.5
  • 74
    • 18544400988 scopus 로고    scopus 로고
    • Immunolocalization of the ICE/Ced-3-family protease, CPP32 (Caspase-3), in non-Hodgkin's lymphomas, chronic lymphocytic leukemias, and reactive lymph nodes
    • Krajewski S, Gascoyne RD, Zapata JM, Krajewska M, Kitada S, Chhanabhai M, et al.: Immunolocalization of the ICE/Ced-3-family protease, CPP32 (Caspase-3), in non-Hodgkin's lymphomas, chronic lymphocytic leukemias, and reactive lymph nodes. Blood 1997, 89:3817-3825.
    • (1997) Blood , vol.89 , pp. 3817-3825
    • Krajewski, S.1    Gascoyne, R.D.2    Zapata, J.M.3    Krajewska, M.4    Kitada, S.5    Chhanabhai, M.6
  • 75
    • 0030931876 scopus 로고    scopus 로고
    • Caspases: The executioners of apoptosis
    • Cohen GM: Caspases: the executioners of apoptosis. Biochem J 1997, 326:1-16.
    • (1997) Biochem J , vol.326 , pp. 1-16
    • Cohen, G.M.1
  • 76
    • 0030838164 scopus 로고    scopus 로고
    • The caspase family of cysteine proteases
    • Thornberry NA: The caspase family of cysteine proteases. Br Med Bull 1997, 53:478-490.
    • (1997) Br Med Bull , vol.53 , pp. 478-490
    • Thornberry, N.A.1
  • 77
    • 0030905543 scopus 로고    scopus 로고
    • Involvement of CED-3/ICE proteases in the apoptosis of B-chronic lymphocytic leukemia cells
    • Bellosillo B, Dalmau M, Colomer D, Gil J: Involvement of CED-3/ICE • proteases in the apoptosis of B-chronic lymphocytic leukemia cells. Blood 1997, 89:3378-3384. This study indicates that CED-3 interleukin 1β-like converting enzyme-like proteases play an important role in the apoptosis of B-CLL cells induced by either dexamethasone or fludarabine.
    • (1997) Blood , vol.89 , pp. 3378-3384
    • Bellosillo, B.1    Dalmau, M.2    Colomer, D.3    Gil, J.4
  • 78
    • 0030971074 scopus 로고    scopus 로고
    • Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies
    • Wang D, Freeman GJ, Levine H, Ritz J, Robertson MJ: Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies. Br J Haematol 1997, 97:409-417.
    • (1997) Br J Haematol , vol.97 , pp. 409-417
    • Wang, D.1    Freeman, G.J.2    Levine, H.3    Ritz, J.4    Robertson, M.J.5
  • 79
    • 0026754538 scopus 로고
    • Interleukin 4 protects chronic lymphocylic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression
    • Dancescu M, Rubio-Trujillo M, Biron G, Bron D, Delespesse G, Sarfati M: Interleukin 4 protects chronic lymphocylic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression. J Exp Med 1992, 176:1319-1326.
    • (1992) J Exp Med , vol.176 , pp. 1319-1326
    • Dancescu, M.1    Rubio-Trujillo, M.2    Biron, G.3    Bron, D.4    Delespesse, G.5    Sarfati, M.6
  • 80
    • 0030819843 scopus 로고    scopus 로고
    • Interleukin-4 prevents spontaneous in-vitro apoptosis in chronic lymphatic leukaemia but sensitizes B-CLL cells to melphalan cytotoxicity
    • Pu QQ, Bezwoda WR: Interleukin-4 prevents spontaneous in-vitro apoptosis in chronic lymphatic leukaemia but sensitizes B-CLL cells to melphalan cytotoxicity. Br J Haematol 1997, 98:413-417.
    • (1997) Br J Haematol , vol.98 , pp. 413-417
    • Pu, Q.Q.1    Bezwoda, W.R.2
  • 81
    • 0031018830 scopus 로고    scopus 로고
    • Interleukin-4 is a pleotropic cytokine with effects on B-cell malignancies
    • Dutcher JP, Venkatraj U, Makower D, Wiernik PH: Interleukin-4 is a pleotropic cytokine with effects on B-cell malignancies [comment]. Leuk Res 1997,21:17-19.
    • (1997) Leuk Res , vol.21 , pp. 17-19
    • Dutcher, J.P.1    Venkatraj, U.2    Makower, D.3    Wiernik, P.H.4
  • 82
    • 0030894009 scopus 로고    scopus 로고
    • Human cytokines suppress apoptosis of leukaemic CD5+ B cells and preserve expression of bd-2
    • Tangye SG. Raison RL: Human cytokines suppress apoptosis of leukaemic CD5+ B cells and preserve expression of bd-2. Immunol Cell Biol 1997, 75:127-135.
    • (1997) Immunol Cell Biol , vol.75 , pp. 127-135
    • Tangye, S.G.1    Raison, R.L.2
  • 83
    • 0031044585 scopus 로고    scopus 로고
    • Analysis of blood T-cell cytokine expression in B-chronic lymphocytic leukaemia: Evidence for increased levels of cytoplasmic IL-4 in resting and activated CDS T cells
    • Mu X, Kay NE, Gosland MP, Jennings CD: Analysis of blood T-cell cytokine expression in B-chronic lymphocytic leukaemia: evidence for increased levels of cytoplasmic IL-4 in resting and activated CDS T cells. Br J Haematol 1997, 96:733-735.
    • (1997) Br J Haematol , vol.96 , pp. 733-735
    • Mu, X.1    Kay, N.E.2    Gosland, M.P.3    Jennings, C.D.4
  • 84
    • 0031033449 scopus 로고    scopus 로고
    • Protection from apoptotic cell death by interleukin-4 is increased in previously treated chronic lymphocytic leukemia patients
    • Frankfurt OS, Byrnes JJ, Villa L: Protection from apoptotic cell death by interleukin-4 is increased in previously treated chronic lymphocytic leukemia patients [see comments]. Leuk Res 1997, 21:9-16.
    • (1997) Leuk Res , vol.21 , pp. 9-16
    • Frankfurt, O.S.1    Byrnes, J.J.2    Villa, L.3
  • 86
    • 0028031971 scopus 로고
    • Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells
    • Lotz M, Ranheim E, Kipps TJ: Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells. J Exp Med 1994, 179:999-1004.
    • (1994) J Exp Med , vol.179 , pp. 999-1004
    • Lotz, M.1    Ranheim, E.2    Kipps, T.J.3
  • 87
    • 0030898146 scopus 로고    scopus 로고
    • Heterogenous response of B lymphocytes to transforming growth factor-beta in B-cell chronic lymphocytic leukaemia: Correlation with the expression of TGF-beta receptors
    • Lagneaux L, Delforge A, Bron D, Massy M, Bernier M, Stryckmans P: Heterogenous response of B lymphocytes to transforming growth factor-beta in B-cell chronic lymphocytic leukaemia: correlation with the expression of TGF-beta receptors. Br J Haematol 1997, 97:612-620.
    • (1997) Br J Haematol , vol.97 , pp. 612-620
    • Lagneaux, L.1    Delforge, A.2    Bron, D.3    Massy, M.4    Bernier, M.5    Stryckmans, P.6
  • 89
    • 0029051433 scopus 로고
    • Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells
    • Ranheim EA, Cantweli MJ, Kipps TJ: Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells. Blood 1995, 85:3556-3565.
    • (1995) Blood , vol.85 , pp. 3556-3565
    • Ranheim, E.A.1    Cantweli, M.J.2    Kipps, T.J.3
  • 90
    • 0032032524 scopus 로고    scopus 로고
    • Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells
    • Kato K, Cantwell MJ, Sharma S, Kipps TJ: Gene transfer of CD40-ligand •• induces autologous immune recognition of chronic lymphocytic leukemia B cells. J Clin Invest 1998, 101:1133-1141. Using replication defective adenovirus encoding CD154 (Ad-CD154), CLL B cells were modified to express a functional ligand for CD40. This not only induced expression of immune accessory molecules on the infected leukemia cell, but also allowed it to transactivate noninfected bystander leukemia B cells into highly effective antigen-presenting cells that were capable of inducing generation of cytotoxic T lymphocytes specific for autologous non-modified leukemia cells. This strategy may allow for immuno-gene therapy of this disease.
    • (1998) J Clin Invest , vol.101 , pp. 1133-1141
    • Kato, K.1    Cantwell, M.J.2    Sharma, S.3    Kipps, T.J.4
  • 91
    • 0030846220 scopus 로고    scopus 로고
    • Acquired CD40-ligand deficiency in patients with chronic lymphocytic leukemia
    • Cantwell MJ, Hua T, Pappas J, Kipps TJ: Acquired CD40-ligand deficiency •• in patients with chronic lymphocytic leukemia. Nature Med 1997, 3:984-989. This study demonstrates that CLL B cells effectively down-modulate expression of the CD40-ligand (CD154) on activated T cells, thus precluding expression of this important immune accessory molecule. This activity likely contributes to the immune deficiency that is acquired by patients with this disease, an immune deficiency that shares many features with that of patients who have a genetic defect in the expression of CD40-ligand.
    • (1997) Nature Med , vol.3 , pp. 984-989
    • Cantwell, M.J.1    Hua, T.2    Pappas, J.3    Kipps, T.J.4
  • 92
    • 0030996214 scopus 로고    scopus 로고
    • The CD40 ligand. At the center of the immune universe?
    • Grewal IS, Flavell RA: The CD40 ligand. At the center of the immune universe? Immunol Res 1997, 16:59-70.
    • (1997) Immunol Res , vol.16 , pp. 59-70
    • Grewal, I.S.1    Flavell, R.A.2
  • 93
    • 0030879857 scopus 로고    scopus 로고
    • Atypical lymphocyte morphology: An adverse prognostic factor for disease progression in stage A CLL independent of trisomy 12
    • Oscier DG, Matutes E, Copplestone A, Pickering RM, Chapman R, • Gillingham R, Catovsky D, Hamblin TJ: Atypical lymphocyte morphology: an adverse prognostic factor for disease progression in stage A CLL independent of trisomy 12. Br J Haematol 1997, 98:934-939. In a univariate analysis the presence of trisomy 12 was found to correlate with progressive disease, but this was largely a consequence of the association between trisomy 12 and atypical lymphocyte morphology. The authors conclude that atypical lymphocyte morphology is an important prognostic factor in stage A CLL.
    • Br J Haematol 1997 , vol.98 , pp. 934-939
    • Oscier, D.G.1    Matutes, E.2    Copplestone, A.3    Pickering, R.M.4    Chapman, R.5    Gillingham, R.6    Catovsky, D.7    Hamblin, T.J.8
  • 94
    • 0030927114 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia: Recent progress in biology, diagnosis, and therapy
    • Montserrat E, Bosch F, Rozman C: B-cell chronic lymphocytic leukemia: recent progress in biology, diagnosis, and therapy. Ann Oncol 1997, 8 Suppl 1:93-101.
    • (1997) Ann Oncol , vol.8 , Issue.SUPPL. 1 , pp. 93-101
    • Montserrat, E.1    Bosch, F.2    Rozman, C.3
  • 95
    • 0030928277 scopus 로고    scopus 로고
    • Clinical correlations of immunophenotypic variations and the presence of trisomy 12 in B-cell chronic lymphocytic leukemia
    • Tefferi A, Bartholmai BJ, Witzig TE, Jenkins RB. Li CY, Hanson CA, et al.: Clinical correlations of immunophenotypic variations and the presence of trisomy 12 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet 1997, 95:173-177.
    • (1997) Cancer Genet Cytogenet , vol.95 , pp. 173-177
    • Tefferi, A.1    Bartholmai, B.J.2    Witzig, T.E.3    Jenkins, R.B.4    Li, C.Y.5    Hanson, C.A.6
  • 96
    • 0029912022 scopus 로고    scopus 로고
    • Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia
    • Sarfati M, Chevret S, Chastang C, Biron G, Stryckmans P, Delespesse G, et al.: Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia. Blood 1996, 88:4259-4264.
    • (1996) Blood , vol.88 , pp. 4259-4264
    • Sarfati, M.1    Chevret, S.2    Chastang, C.3    Biron, G.4    Stryckmans, P.5    Delespesse, G.6
  • 97
    • 0030979310 scopus 로고    scopus 로고
    • Prognostic impact of the serum levels of soluble CD23 in B-cell chronic lymphocytic leukemia
    • Knauf WU, Ehlers B, Mohr B, Thiel E, Langenmayer I, Hallek M, et al.: Prognostic impact of the serum levels of soluble CD23 in B-cell chronic lymphocytic leukemia [letter]. Blood 1997, 89:4241-4242.
    • (1997) Blood , vol.89 , pp. 4241-4242
    • Knauf, W.U.1    Ehlers, B.2    Mohr, B.3    Thiel, E.4    Langenmayer, I.5    Hallek, M.6
  • 98
    • 0018955264 scopus 로고
    • Behaviour of serum beta 2-microglobulin and acute phase reactant proteins in chronic lymphocytic leukaemia. A multicentre study
    • Spati B, Child JA, Kerruish SM, Cooper EH: Behaviour of serum beta 2-microglobulin and acute phase reactant proteins in chronic lymphocytic leukaemia. A multicentre study. Acta Haematol 1980, 64:79-86.
    • (1980) Acta Haematol , vol.64 , pp. 79-86
    • Spati, B.1    Child, J.A.2    Kerruish, S.M.3    Cooper, E.H.4
  • 99
    • 0029829395 scopus 로고    scopus 로고
    • Serum beta(2)-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma
    • Hallek M, Wanders L, Ostwald M, Busch R, Senekowitsch R, Stern S, et al.: Serum beta(2)-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma. Leuk Lymphoma 1996, 22:439-447.
    • (1996) Leuk Lymphoma , vol.22 , pp. 439-447
    • Hallek, M.1    Wanders, L.2    Ostwald, M.3    Busch, R.4    Senekowitsch, R.5    Stern, S.6
  • 100
    • 0030663994 scopus 로고    scopus 로고
    • Active and indolent chronic lymphocytic leukaemia-immune and hormonal peculiarities
    • Everaus H, Luik E, Lehtmaa J: Active and indolent chronic lymphocytic leukaemia-immune and hormonal peculiarities. Cancer Immunol Immunother 1997, 45:109-114.
    • (1997) Cancer Immunol Immunother , vol.45 , pp. 109-114
    • Everaus, H.1    Luik, E.2    Lehtmaa, J.3
  • 102
    • 0028938262 scopus 로고
    • Telomerase activity in normal leukocytes and in hematologic malignancies
    • Counter CM, Gupta J, Harley CB, Leber B, Bacchetti S: Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 1995, 85:2315-2320.
    • (1995) Blood , vol.85 , pp. 2315-2320
    • Counter, C.M.1    Gupta, J.2    Harley, C.B.3    Leber, B.4    Bacchetti, S.5
  • 103
    • 0030952339 scopus 로고    scopus 로고
    • Telomere dynamics and cytogenetic changes in human hematologic neoplasias: A working hypothesis
    • Ohyashiki K, Ohyashiki JH: Telomere dynamics and cytogenetic changes in human hematologic neoplasias: a working hypothesis. Cancer Genet Cytogenet 1997, 94:67-72.
    • (1997) Cancer Genet Cytogenet , vol.94 , pp. 67-72
    • Ohyashiki, K.1    Ohyashiki, J.H.2
  • 104
    • 0031025929 scopus 로고    scopus 로고
    • Expression of adhesion molecules in 113 patients with B-cell chronic lymphocytic leukemia: Relationship with clinico-prognostic features
    • Domingo A, Gonzalez-Barca E, Castellsague X, Fernandez-Sevilla A, Granena A, Crespo N, Ferran C: Expression of adhesion molecules in 113 patients with B-cell chronic lymphocytic leukemia: relationship with clinico-prognostic features. Leuk Res 1997, 21:67-73.
    • (1997) Leuk Res , vol.21 , pp. 67-73
    • Domingo, A.1    Gonzalez-Barca, E.2    Castellsague, X.3    Fernandez-Sevilla, A.4    Granena, A.5    Crespo, N.6    Ferran, C.7
  • 106
    • 0003108715 scopus 로고    scopus 로고
    • High dose chlorambucil versus Binet's modified cyclophosphamide, doxorubicin, vincristine, and prednisone regimen in the treatment of patients with advanced B-cell chronic lymphocytic leukemia. Results of an international multicenter randomized trial
    • International Society for Chemo-Immunotherapy, Vienna.
    • Jaksic B, Brugiatelli M, Krc I, Losonczi H, Holowiecki J, Planinc-Peraica A, • et al.: High dose chlorambucil versus Binet's modified cyclophosphamide, doxorubicin, vincristine, and prednisone regimen in the treatment of patients with advanced B-cell chronic lymphocytic leukemia. Results of an international multicenter randomized trial. International Society for Chemo-Immunotherapy, Vienna. Cancer 1997, 79:2107-2114. This study found that high-dose chlorambucil was an effective and well-tolerated treatment for patients with advanced or progressive CLL. The authors recommend its wider use, possibly in comparison with or in combination with new therapeutic agents, such as purine analogues.
    • (1997) Cancer , vol.79 , pp. 2107-2114
    • Jaksic, B.1    Brugiatelli, M.2    Krc, I.3    Losonczi, H.4    Holowiecki, J.5    Planinc-Peraica, A.6
  • 107
    • 0024319910 scopus 로고
    • Fludarabine: A new agent with major activity against chronic lymphocytic leukemia
    • Keating MJ, Kantarjian H, Talpaz M, Redman J, Koller C, Barlogie B, et al.: Fludarabine: a new agent with major activity against chronic lymphocytic leukemia. Blood 1989, 74:19-25.
    • (1989) Blood , vol.74 , pp. 19-25
    • Keating, M.J.1    Kantarjian, H.2    Talpaz, M.3    Redman, J.4    Koller, C.5    Barlogie, B.6
  • 108
    • 0031036424 scopus 로고    scopus 로고
    • Treatment of refractory chronic lymphocytic leukemia with fludarabine phosphate via the group C protocol mechanism of the National Cancer Institute: Five-year follow-up report
    • Sorensen JM, Vena DA, Fallavollita A, Chun HG, Cheson BD: Treatment of • refractory chronic lymphocytic leukemia with fludarabine phosphate via the group C protocol mechanism of the National Cancer Institute: five-year follow-up report. J Clin Oncol 1997, 15:458-465. This study describes the toxicity and activity of fludarabine in refractory CLL in a setting that more closely resembles clinical practice than most published trials.
    • (1997) J Clin Oncol , vol.15 , pp. 458-465
    • Sorensen, J.M.1    Vena, D.A.2    Fallavollita, A.3    Chun, H.G.4    Cheson, B.D.5
  • 109
    • 0030005637 scopus 로고    scopus 로고
    • Salvage therapy with fludarabine in patients with progressive B-chronic lymphocytic leukemia
    • Gjedde SB, Hansen MM: Salvage therapy with fludarabine in patients with progressive B-chronic lymphocytic leukemia. Leuk Lymphoma 1996, 21:317-320.
    • (1996) Leuk Lymphoma , vol.21 , pp. 317-320
    • Gjedde, S.B.1    Hansen, M.M.2
  • 110
    • 0030000389 scopus 로고    scopus 로고
    • Fludarabine monophosphate in refractory B-chronic lymphocytic leukemia: Maintenance may be significant to sustain response
    • Angelopoulou MA, Poziopoulos C, Boussiotis VA, Kontopidou F, Pangalis GA: Fludarabine monophosphate in refractory B-chronic lymphocytic leukemia: maintenance may be significant to sustain response. Leuk Lymphoma 1996, 21:321-324.
    • (1996) Leuk Lymphoma , vol.21 , pp. 321-324
    • Angelopoulou, M.A.1    Poziopoulos, C.2    Boussiotis, V.A.3    Kontopidou, F.4    Pangalis, G.A.5
  • 111
    • 0030696074 scopus 로고    scopus 로고
    • Fludarabine and granulocyte colony-stimulating factor (G-CSF) in patients with chronic lymphocytic leukemia
    • O'Brien S, Kantarjian H, Beran M, Koller C, Talpaz M, Lerner S, Keating • MJ: Fludarabine and granulocyte colony-stimulating factor (G-CSF) in patients with chronic lymphocytic leukemia. Leukemia 1997, 11:1631-1635. The study found that administration of granulocyte colony-stimulating factor following fludarabine could reduce the incidences of myelosuppression and infections compared with historical controls.
    • (1997) Leukemia , vol.11 , pp. 1631-1635
    • O'Brien, S.1    Kantarjian, H.2    Beran, M.3    Koller, C.4    Talpaz, M.5    Lerner, S.6    Keating, M.J.7
  • 113
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H treatment in chronic lymphocytic leukemia
    • Osterborg A, Dyer MJ, Bunjes D, Pangalis GA, Bastion Y, Catovsky D, •• Mellstedt H: Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol 1997, 15:1567-1574. This study found that CAMPATH-1H had significant activity in patients with advanced and chemotherapy-resistant CLL.
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3    Pangalis, G.A.4    Bastion, Y.5    Catovsky, D.6    Mellstedt, H.7
  • 114
    • 0031027623 scopus 로고    scopus 로고
    • Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia
    • Bowen AL, Zomas A, Emmett E, Matutes E, Dyer MJ, Catovsky D: Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia. Br J Haematol 1997, 96:617-619.
    • (1997) Br J Haematol , vol.96 , pp. 617-619
    • Bowen, A.L.1    Zomas, A.2    Emmett, E.3    Matutes, E.4    Dyer, M.J.5    Catovsky, D.6
  • 115
    • 0030964964 scopus 로고    scopus 로고
    • In vivo 'purging' of residual disease in CLL with Campath-1H
    • Dyer MJ, Kelsey SM, Mackay HJ, Emmett E, Thornton P, Hale G, et al.: In • vivo 'purging' of residual disease in CLL with Campath-1H. Br J Haematol 1997, 97:669-672. This study suggests that treatment with CAMPATH-1H may be of value in eradicating residual disease in CLL and facilitate high-dose therapy in young patients.
    • (1997) Br J Haematol , vol.97 , pp. 669-672
    • Dyer, M.J.1    Kelsey, S.M.2    Mackay, H.J.3    Emmett, E.4    Thornton, P.5    Hale, G.6
  • 116
    • 0031439511 scopus 로고    scopus 로고
    • Impact of splenomegaly on therapeutic response and I-131-LYM-1 dosimetry in patients with B-lymphocytic malignancies
    • Shen S, DeNardo GL, O'Donnell RT, Yuan A, DeNardo DA, DeNardo SJ: Impact of splenomegaly on therapeutic response and I-131-LYM-1 dosimetry in patients with B-lymphocytic malignancies. Cancer 1997, 80:2553-2557.
    • (1997) Cancer , vol.80 , pp. 2553-2557
    • Shen, S.1    DeNardo, G.L.2    O'Donnell, R.T.3    Yuan, A.4    DeNardo, D.A.5    DeNardo, S.J.6
  • 117
    • 0031471674 scopus 로고    scopus 로고
    • Increased survival associated with radiolabeled Lym-1 therapy for non-Hodgkin's lymphoma and chronic lymphocytic leukemia
    • DeNardo GL, Lamborn KR, Goldstein DS, Kroger LA, DeNardo SJ: Increased survival associated with radiolabeled Lym-1 therapy for non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Cancer 1997, 80:2706-2711.
    • (1997) Cancer , vol.80 , pp. 2706-2711
    • DeNardo, G.L.1    Lamborn, K.R.2    Goldstein, D.S.3    Kroger, L.A.4    DeNardo, S.J.5
  • 119
    • 13344287042 scopus 로고    scopus 로고
    • HLA-identical sibling bone marrow transplantation in younger patients with chronic lymphocytic leukemia
    • European Group for Blood and Marrow Transplantation and the International Bone Marrow Transplant Registry
    • Michallet M, Archimbaud E, Bandini G, Rowlings PA, Deeg HJ, Gahrton G, et al.: HLA-identical sibling bone marrow transplantation in younger patients with chronic lymphocytic leukemia. European Group for Blood and Marrow Transplantation and the International Bone Marrow Transplant Registry. Ann Intern Med 1996, 124:311-315.
    • (1996) Ann Intern Med , vol.124 , pp. 311-315
    • Michallet, M.1    Archimbaud, E.2    Bandini, G.3    Rowlings, P.A.4    Deeg, H.J.5    Gahrton, G.6
  • 120
    • 9544236183 scopus 로고    scopus 로고
    • Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation
    • Provan D, Bartlett-Pandite L, Zwicky C, Neuberg D, Maddocks A, Corradini P, et al.: Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation. Blood 1996, 88:2228-2235.
    • (1996) Blood , vol.88 , pp. 2228-2235
    • Provan, D.1    Bartlett-Pandite, L.2    Zwicky, C.3    Neuberg, D.4    Maddocks, A.5    Corradini, P.6
  • 121
    • 1842291548 scopus 로고    scopus 로고
    • Detection of trisomy 12 and Rb-deletion in CD34+ cells of patients with B-cell chronic lymphocytic leukemia
    • Gahn B, Schafer C, Neef J, Troff C, Feuring-Buske M, Hiddemann W, •• Wormann B: Detection of trisomy 12 and Rb-deletion in CD34+ cells of patients with B-cell chronic lymphocytic leukemia. Blood 1997. 89:4275-4281. This study found that trisomy 12 and Rb-deletion may be present in the CD34+ stem cells of patients with CLL, suggesting that the malignant transformation in B-CLL may involve early hematopoietic stem cells that have yet to undergo B cell differentiation.
    • (1997) Blood , vol.89 , pp. 4275-4281
    • Gahn, B.1    Schafer, C.2    Neef, J.3    Troff, C.4    Feuring-Buske, M.5    Hiddemann, W.6    Wormann, B.7
  • 122
    • 0030816681 scopus 로고    scopus 로고
    • Detection of trisomy 12 in CD34+ progenitor cells in a patient with B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization
    • Gahn B, Schafer C, Neef J, Troff C, Feuring-Buske M, Hiddemann W, Wormann B: Detection of trisomy 12 in CD34+ progenitor cells in a patient with B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization. Ann Oncol 1997, 8 Suppl 2:55-57.
    • (1997) Ann Oncol , vol.8 , Issue.SUPPL. 2 , pp. 55-57
    • Gahn, B.1    Schafer, C.2    Neef, J.3    Troff, C.4    Feuring-Buske, M.5    Hiddemann, W.6    Wormann, B.7
  • 123
    • 0030927544 scopus 로고    scopus 로고
    • Bone marrow transplantation for low-grade B-cell malignancies
    • Gribben JG: Bone marrow transplantation for low-grade B-cell malignan• cies. Curr Opin Oncol 1997, 9:117-121. This article reviews current concepts and trends in cell transplantation for clinical diseases that are relevant to chronic lymphocytic leukemia.
    • (1997) Curr Opin Oncol , vol.9 , pp. 117-121
    • Gribben, J.G.1
  • 124
    • 8244222296 scopus 로고    scopus 로고
    • Allogeneic blood or marrow transplantation for chronic lymphocytic leukaemia: Timing of transplantation and potential effect of fludarabine on acute graft-versus-host disease
    • Khouri IF, Przepiorka D, van Besien K, O'Brien S, Palmer JL, Lerner S, et • al.: Allogeneic blood or marrow transplantation for chronic lymphocytic leukaemia: timing of transplantation and potential effect of fludarabine on acute graft-versus-host disease. Br J Haematol 1997, 97:466-473. This study suggests that allogeneic-stem-cell transplantation can induce durable remission in patients with CLL refractory to fludarabine. It also suggests that prior exposure to fludarabine may decrease the incidence to severe acute graft versus host disease, possibly through its immunosuppressive effects.
    • (1997) Br J Haematol , vol.97 , pp. 466-473
    • Khouri, I.F.1    Przepiorka, D.2    Van Besien, K.3    O'Brien, S.4    Palmer, J.L.5    Lerner, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.