Frequent loss of the 11q14-24 region in chronic lymphocytic leukemia: A study by comparative genomic hybridization

Genes Chromosomes and Cancer

Volumn 19, Issue 4, 1997, Pages 286-290

  Karhu, Ritva ^a   Knuutila, Sakari ^b   Kallioniemi, Olli P ^c   Siitonen, Sanna ^a   Aine, Risto ^a   Vilpo, Leena ^a   Vilpo, Juhani ^a   Ala Kaila, K ^d   Honkanen, T ^d   Hurme, M ^d   Jouppila, J ^d   Kallioniemi, O P ^d   Koivunen, E ^d   Lehtinen, M ^d   Lehtinen, T ^d   Lumio, J ^d   Oivanen, P ^d   Oksanen, K ^d   Pertovaara, H ^d   Rantala, I ^d   Seppala E ^d   Siitonen, S ^d   Simola, K ^d   Sinisalo, M ^d   more..

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d Tampere University Hospital ^*

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CHROMOSOME 11Q; CHROMOSOME LOSS; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; DNA HYBRIDIZATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; KARYOTYPING; MALE; MOLECULAR GENETICS; PATHOGENESIS; PRIORITY JOURNAL;

AGED; CHROMOSOME ABERRATIONS; CHROMOSOME BANDING; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 13; DNA, NEOPLASM; FEMALE; GENE AMPLIFICATION; HUMANS; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LEUKEMIA, B-CELL, CHRONIC; MALE; MIDDLE AGED; PHENOTYPE;

EID: 0030813843     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199708)19:4<286::AID-GCC12>3.0.CO;2-E     Document Type: Article

References (18)

1. Autio K, Elonen E, Teerenhovi L, Knuutila S (1987) Cytogenic and immunologic characterization of mitotic cells in chronic lymphocytic leukaemia. Eur J Haematol 39:289-298.
2. Bennett JM, Catovsky D, Daniel M-T, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1989) Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. J Clin Pathol 42:567-584.
3. Bentz M, Huck K, du Manoir S, Joos S, Werner CA, Fischer K, Dohner H. Lichter P (1995) Comparative genomic hybridization in chronic B-cell leukemias shows a high incidence of chromosomal gains and losses. Blood 85:3610-3618.
4. Binet JL, Auquier A, Digihiero G, Chastang C, Piguet H, Goasguen J, Vaugier G, Potron G, Colona P, Oberling F, Thomas M, Tchernia G, Jacquillat C, Boivin P, Lesty C, Duault MT, Monconduit M, Belabbes S, Gremy F (1981) A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 48:198-206.
5. Döhner H, Stilgenbauer S, Liebisch P, Benner A, Schröder M, Weilguni T, Schlenck R, Fiscer K, Bentz M, James MR, Lichter P (1995) 11q deletions are the second most common chromosome aberration in B-cell chronic lymphocytic leukemia and are associated with advanced stages and marked lymphadenopathy. Blood 86:345a.
6. Fegan CD, Davies FE (1996) Karyotyping and molecular abnormalities in chronic lymphocytic leukemia. J Clin Pathol Mol Pathol 49:M185-M191.
7. General Haematologic Task Force of BCSH (1994) Immunophenotyping in the diagnosis of chronic lymphoproliferative disorders. J Clin Pathol 47:871-875.
8. Hernandez JM, Mecucci C, Criel A, Meeus P, Michaux I, van Hoof A, Verhoef G, Louwagie A, Scheiff JM, Michaux JL (1995) Cytogenetic analysis of B cell chronic lymphoid leukemias classified according to the morphologic and immunophenotypic (FAB) criteria. Leukemia 9:2140-2146.
9. ISCM (1995) An International System for Human Cytogenetic Nomenclature. Mitelman F (ed). Basel: S. Karger.
10. Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D (1992) Comparative genomic hybridization for molecular cytogenctic analysis of solid tumors. Science 258-818-821.
11. Kallioniemi OP, Kallioniemi A, Piper J, Isola J, Waldman FM, Gray JW, Pinkel D (1994) Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chromosom Cancer 10:231-243.
12. Knuutila S, Elonen E, Teerenhovi L, Rossi L, Leskinen R, Bloomfield CD, de la Chapelle A (1986) Trisomy 12 in B cells of patients with B-cell chronic lymphocytic leukemia. N Engl J Med 314:865-869.
13. Matutes E, Owusu Ankomah K, Morilla R, Garcia Marco J, Houlihan A, Que TH, Catovsky D (1994) The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia 8:1640-1645.
14. Matutes E, Oscier D, Garcia-Marco J, Ellis J, Copplestone A, Gillingham R, Hamblin T, Lens D, Swansbury GJ, Catovsky D (1996) Trisomy 12 defines a group of CLL with atypical morphology: Correlation between cytogenetic, clinical and laboratory features in 544 patients. Br J Haematol 92:382-388.
15. Piper J, Rutovitz D, Sudar D, Kallioniemi A, Kallioniemi OP, Waldman FM, Gray JW, Pinkel D (1995) Computer image analysis of comparative genomic hybridization. Cytometry 19:10-26.
16. Rai KR, Sawitsky A, Chronkite EP, Chanana AD, Levy RN, Pasternack BS (1975) Clinical staging of chronic lymphocytic leukemia. Blood 46:219-234.
17. Rozman C, Montserrat E, Rodríguez-Fernández JM, Ayats R, Vallespí T, Parody R, Ríos A, Prados D, Morey M, Gomis F, Alcalá A, Gutiérrez M, Maldonado J, González C, Giralt M, Hernández-Nieto L, Cabrera A, Fernández-Rañada JM (1984) Bone marrow histologic pattern-the best single prognostic parameter in chronic lymphocytic leukemia: A multivariate survival analysis of 329 cases. Blood 64:642-648.
18. Tanner MM, Tirkkonen M, Kallioniemi A, Collins C, Stokke T, Karhu R, Kowbel D, Shadravan F, Hintz M, Kuo WL, Waldman FM, Isola JJ, Gray JW, Kallioniemi O-P (1994) Increased copy number at 20q13 in breast cancer: Defining the critical region and exclusion of candidate genes. Cancer Res 54:4257-1260.