Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia

British Journal of Haematology

Volumn 92, Issue 2, 1996, Pages 389-392

  Mould, S ^a   Gardiner, A ^a   Corcoran, M ^a   Oscier, D G ^a  

^a ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

Author keywords

Chromosome 13q14 abnormalities; Chronic lymphocytic leykaemia; Cytogenetics; Fluorescence in situ hybridization; Trisomy 12

Indexed keywords

ADULT; AGED; ARTICLE; CELL STRUCTURE; CHROMOSOME 12; CHROMOSOME 13; CHROMOSOME DAMAGE; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CYTOGENETICS; FEMALE; HUMAN; IN SITU HYBRIDIZATION; KARYOTYPE; MALE; PRIORITY JOURNAL; TRISOMY;

EID: 0030039406     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1492.x     Document Type: Article

References (13)

1. Binet, J.L., Auquier, A., Digiero, G., Chastang, C., Piquet, H., Goasguen, J., Vaugier, G., Potron, G., Calona, P., Oberling, F., Thomas, M., Tchernia, G., Jacquillat, C., Boivin, P., Lesty, C., Duault, M.T., Monconduit, M., Berabbes, S. & Gremy, F. (1981) A new prognostic classilication of chronic lymphocytic leukaemia derived from a multivariate survival analysis. Cancer, 48, 198-206.
2. Bohlander, S.K., Espinosa, R., III, Fernald, A.A., Rowley, J.D., Le Beau, M.M. & Diaz, M.O. (1994) Sequence independent amplification and labelling of yeast artificial chromosomes for fluorescent in situ hybridisation. Cytogenetics and Cell Genetics, 65, 108.
3. Criel, A., Wlodarska, I., Meeus, P., Stul, M., Louwagie, A., Van Hoof, A., Hidajat, M., Mecucci, C. & Van den Berghe, H. (1994) Trisomy 12 is uncommon in typical chronic lymphocytic leukaemias. British Journal of Haematology, 87, 523-528.
4. Dohner, H., Pilz, T., Fischer, K., Cabot, G., Diehl, D., Fink, T., Stilgenbauer, S., Bentz, M. & Lichter, P. (1994) Molecular cytogenetic analysis of RB-1 deletions in chronic B-cell leukaemias. Leukaemia and Lymphoma, 16, 97-103.
5. Garcia-Marco, J., Matutes, K., Morilla, R., Ellis, J., Oscier, D., Fantes, J., Catovsky, D. & Price, C. (1994) Trisomy 12 in B-cell chronic lymphocytic leukaemia: assessment of lineage restriction by simultaneous analysis of immunophenotype and genotype in interphase cells by fluorescence in situ hybridization. British Journal of Haematology, 87, 44-50.
6. Hawthorn, L.A., Chapman, R., Oscier, D. & Cowell, J. (1993) The consistent 13q14 translocation breakpoint seen in chronic B-cell leukaemia (BCLL) involves deletion of the D13S25 locus which lies distal to the retinoblastoma predisposition gene. Oncogene, 8, 1415-1419.
7. Jabbar, S.A., Ganeshaguru, K., Wickeremasinghe, R.G., Hoffbrand, A.V. & Foroni, L. (1995) Deletion of chromosome 13 (band q14) but not trisomy 12 is a clonal event in B-chronic lymphocytic leukaemia (CLL). British Journal of Haematology, 90, 476-478.
8. Juliusson, G., Oscier, D.G., Fitchett, M., Ross, F., Stockdill, G., Mackie, M.J., Parker, A.C., Castodi, G.L., Cuneo, A., Knuutila, S., Elonen, E. & Gahrton, G. (1990) Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. New England Journal of Medicine, 323, 720-724.
9. Matutes, E., Oscier, D., Garcia-Marco, J., Ellis, J., Chapman, R., Gillingham, R., Hamblin, T., Lens, D. & Catovsky, D. (1995) Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetics, clinical and laboratory features in 544 CLL patients. (Abstract). British Journal of Haematology, 89, (Suppl. 1), 51.
10. Oscier, D.G. (1994) Cytogenetic and molecular abnormalities in chronic lymphocytic leukemia. Blood Reviews, 8, 88-97.
11. Que, T.H., Garcia Marco, J., Ellis, J., Matutes, R., Brito Babapulle, V., Boyle, S. & Catovsky, D. (1993) Trisomy 12 in chronic lymphocytic leukemia detected by fluorescent in situ hybridisation: analysis by stage, immunophenotype and morphology. Blood, 82, 571-575.
12. Raskind, W.H., Tirumali, N., Jacobsen, R., Singer, J. & Fialkow, P.J. (1984) Evidence for a multistep pathogenesis of a myelodysplastic syndrome. Blood, 63, 1318-1323.
13. Ross, F.M. & Stockdill, G. (1987) Clonal chromosome abnormalities in chronic lymphocytic leukaemia patients revealed by TPA stimulation of whole blood cultures. Cancer Genetics and Cytogenetics, 25, 109-121.