Trisomy 12 defines a group of CLL with atypical morphology: Correlation between cytogenetic, clinical and laboratory features in 544 patients

British Journal of Haematology

Volumn 92, Issue 2, 1996, Pages 382-388

  Matutes, E ^a   Oscier, D ^b   Garcia Marco, J ^a   Ellis, J ^a   Copplestone, A ^c   Gillingham, R ^b   Hamblin, T ^b   Lens, D ^a   Swansbury, G J ^a   Catovsky, D ^a  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

^b ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

^c DERRIFORD HOSPITAL   (United Kingdom)

Author keywords

Atypical lymphocytes; CLL; CLL PL; Del13q; Trisomy 12

Indexed keywords

ARTICLE; CHROMOSOME DAMAGE; CHRONIC LYMPHATIC LEUKEMIA; CYTOGENETICS; GENE EXPRESSION; HUMAN; IN SITU HYBRIDIZATION; KARYOTYPE; MAJOR CLINICAL STUDY; MORPHOLOGY; PHENOTYPE; PRIORITY JOURNAL; TRISOMY;

EID: 9044226530     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1478.x     Document Type: Article

References (19)

1. Binet, J.L., Catovsky, D., Dighiero, G., Gale, R.P., Montserrat, E., Rai, K.R., Rozman, C. & Sawitski, A. (1989) Chronic lymphocytic leukemia: recommendations for diagnosis, staging and response criteria. Annals of Internal Medicine, 110, 236.
2. Bird, M.L., Ueshima, Y., Rowley, J.D., Haren, J.M. & Vardiman, J.W. (1989) Chromosome abnormalities in B-cell chronic lymphocytic leukemia and their clinical correlations. Leukemia, 3, 182-191.
3. Criel, A., Wlodarska, I., Meeus, P., Stul, M., Louwagie, A., Van Hoof, A., Hidajat, M., Mecucci, C. & Van den Berghe, H. (1994) Trisomy 12 is uncommon in typical chronic lymphocytic leukaemias. British Journal of Haematology, 87, 523-528.
4. Fichett, M., Griffiths, M.J., Oscier, D.G., Johnson, S. & Seabright, M. (1987) Chromosome abnormalities involving band 13q14 in hematological malignancies. Cancer Genetics and Cytogenetics, 24, 143-150.
5. Garcia-Marco, J., Matutes, E., Morilla, R., Ellis, J., Oscier, D., Fantes, J., Catovsky, D. & Price, D. (1994) Trisomy 12 in B-cell chronic lymphocytic leukaemia: assessment of lineage restriction by simultaneous analysis of immunophenotype and genotype in interphase cells by fluorescence in situ hybridization. British Journal of Haematology, 87, 44-50.
6. Juliusson, G., Oscier, D.G., Fitchett, M., Ross, F.M., Stockdill, G., Mackie, J.J., Parker, A.C., Castoldi, G.L., Cuneo, A., Knuutila, S., Elonen, E. & Gahrton, G. (1990) Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. New England Journal of Medicine, 323, 720-724.
7. Juliusson, G., Oscier, D.G. & Gahrton, G. (1991) Cytogenetic findings and survival in B-cell chronic lymphocytic leukemia: second IWCLL compilation of data on 662 patients. Leukemia and Lymphoma, 5, (Suppl.), 21-25.
8. Matutes, E., Owusu-Ankomah, K., Morilla, R., Garcia Marco, J., Houlihan, A., Que, T.H. & Catovsky, D. (1994) The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia, 8, 1640-1645.
9. Melo, J.V., Brito-Babapulle, V., Pombo de Oliveira, M.S., Galton, D.A.G. & Catovsky, D. (1987) The relationship between chronic lymphocytic leukemia and prolymphocytic leukemia. Chronic Lymphocytic Leukemia: Recent Progress and Future Direction (ed. by R. P. P. Gale and K. R. Rai), pp. 205-214. Alan R. Liss, New York.
10. Offit, K., Louie, D.C., Parsa, N.Z., Filippa, D., Gangi, M., Siebert, R. & Chaganti, R.S.K. (1994) Clinical and morphologic features of B-cell small lymphocytic lymphoma with del(6)(q21q23). Blood, 83, 2611-2618.
11. Oscier. D.G. (1994) Cytogenetic and molecular abnormalities in chronic lymphocytic leukemia. Blood Reviews, 8, 88-97.
12. Oscier, D.G., Fitchett, M. & Hamblin, T.J. (1988) Chromosomal abnormalities in B-CLL. Nouvelle Revue Française d'Hématologie, 30, 397-398.
13. Perez Losada, A., Wessaman, M., Tiainen, M., Hopman A.H.N., Willard, H.K., Sole, F., Caballin, M.R., Woessner, S. & Knuutila, S. (1991) Trisomy 12 in chronic lymphocytic leukemia: an interphase cytogenetic study. Blood, 78, 775-779.
14. Peterson, L.C., Lindquist, L.L., Chruch, S. & Kay, N.E. (1992) Frequent clonal abnormalities of chromosome hand 13q14 in B-cell chronic lymphocytic leukemia: multiple clones, subclones and nonclonal alterations in 82 Midwestern patients. Genes, Chromosomes and Cancer, 4, 273-280.
15. Que, T.H., Garcia Marco, J., Ellis, J., Matutes, E., Brito Bahapulle, V., Boyle, S. & Catovsky, D. (1993) Trisomy 12 in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: analysis by stage, immunophenotype and morphology. Blood, 82, 571-575.
16. Raghoebier, S., Kibbelaar, R.E., Kleiverda, J.K., van Krieken, J.H.J.M., Kok, F. & Klui, Ph.M. (1992) Mosaicism of trisomy 12 in chronic lymphocytic leukemia detected by non-radioactive in situ hybridization. Leukemia, 6, 1220-1226.
17. Reining, G., Clodi, K., Konnig, M., Haas, O.A. & Mannhalter, C. (1994) Detection of trisomy 12 in chronic lymphocytic leukaemia: comparison of a polymerase chain reaction based technique with fluorescence in situ hybridization. British Journal of Haematology, 87, 843-845.
18. Stilgenbauer, S., Dohner, H., Bulgay-Morschel, M., Weitz, S., Bentz, M. & Lichter, P. (1993) High frequency of monoallelic retinoblastoma gene deletion in B-cell chronic lymphoid leukemia shown by interphase cytogenetics. Blood, 81, 2118-2124.
19. Witzig, T.E., Borell, T.J., Herath, J.F., Tefferi, A., Li, C-Y. & Jenkins, R.B. (1994) Detection of trisomy 12 by FISH in untreated B-chronic lymphocytic leukemia: correlation with stage and CD20 antigen expression intensity. Leukemia and Lymphoma, 14, 447-451.