Genetic abnormalities in chronic lymphocytic leukemia and their clinical and prognostic implications

Cancer Genetics and Cytogenetics

Volumn 94, Issue 1, 1997, Pages 27-35

  Dierlamm, Judith ^b   Michaux, Lucienne ^a   Criel, Arnold ^b   Wlodarska, Iwona ^b   Van Den Berghe, Herman ^b   Hossfeld, Dieter Kurt ^c  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b Department of Hematology ^*

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME 12; CHROMOSOME 13Q; CHRONIC LYMPHATIC LEUKEMIA; FOLLOW UP; GENE DELETION; GENE LOCUS; GENETIC LINKAGE; HUMAN; LEUKEMOGENESIS; PRIORITY JOURNAL; PROGNOSIS; REVIEW; TREATMENT PLANNING; TUMOR SUPPRESSOR GENE;

EID: 0030978165     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(96)00246-4     Document Type: Article

References (84)

1. Turk W (1903): Ein System der Lymphomatosen. Wien Klin Wochenschr 16:1073.
2. Minot GP, Isaacs R (1924): Lymphatic leukemia. Age, incidence, duration and benefit derived from irradiation. Boston Med Surg J 191:1-4.
3. Bennett JM, Catovsky D, Daniel M-T, Flandrin G, Galton DAG, Gralnick HR, Sultan C, The French-American (FAB) Cooperative Group (1989): Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. J Clin Pathol 42:567-584.
4. Salomon-Nguyen F, Valensi F, Merle-Beral H, Flandrin G (1995): A scoring system for the classification of CD5-B CLL versus CD5+ B CLL and B PLL. Leuk & Lymph 16:445-450.
5. Rai K, Sawitsky A, Cronkite E, Chanana AB, Leey RN, Pasternack BS (1975): Clinical staging of chronic lymphocytic leukemia. Blood 46:219-234.
6. Binet JL, Leporrier M, Dighiero G, Charron D, D'Athis P, Vangier G, Merle-Beral H, Natali JC, Raphael UK, Nizet B, Fallezoni JY (1977): A clinical staging system for chronic lymphocytic leukemia. Prognostic significance. Cancer 40:855-865.
7. Lee J, Dixon D, Kantarjian H, Keating U, Talpaz M (1987): Prognosis of chronic lymphocytic leukemia: A multivariate regression analysis of 325 untreated patients. Blood 69:929-936.
8. Montserrat E, Virolas N, Reverter JC, Rozman C (1988): Natural history of chronic lymphocytic leukemia: On the progression and prognosis of early clinical stages. Nouv Rev Fr Hematol 30:359-361.
9. Rozman C, Montserrat E, Rodriguez-Fernandez JM, Ayats R, Vallespi T, Parody R, Rios A, Prados D, Morey M, Gomis F, Alcata A, Gutierrez M, Maldonado J, Gonzalez C, Giralt M, Hernandez-Nieto L, Cabrena A, Fernandez-Ranada JM (1984): Bone marrow histologic pattern. The best single prognostic parameter in chronic lymphocytic leukemia. A multivariate analysis of 329 cases. Blood 64:662-668.
10. Juliusson G, Oscier DG, Fitchett M, Ross FM, Stockdill G, Mackie MJ, Parker AC, Castoldi GL, Cuneo A, Knuutila S, Elonen E, Gahrton G (1990): Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities, N Engl J Med 323:720-724.
11. Gahrton G, Zech L, Robèrt K-H, Bird AG (1979): Mitogenic stimulation of leukemic cells by Epstein-Barr virus. N Engl J Med 301:438-439.
12. Knuutila S, Elonen E, Teerenhovi L, Rossi L, Leskinen R, Bloomfield CD, de la Chapelle A (1986): Trisomy 12 in B cells of patients with B-cell chronic lymphocytic leukemia. N Engl J Med 314:865-869.
13. Teerenhovi L, Knuutila S, Ekblom M, Rossi L, Borgström GH, Tallman JK, Andersson L, de la Chapelle A (1984): A method for simultaneous study of the karyotype, morphology, and immunologic phenotype of mitotic cells in hematologic malignancies. Blood 64:1116-1122.
14. Autio K, Elonen E, Teerenhovi L, Knuutila S (1987): Cytogenetic and immunologic characterization of mitotic cells in chronic lymphocytic leukemia. Eur J Haematol 39:289-298.
15. Perez Losada A, Wessman M, Tiainen M, Hopman AHN, Willard HF, Solé F, Caballín MR, Woessner S, Knuutila S (1991): Trisomy 12 in chronic lymphocytic leukemia: An interphase cytogenetic study. Blood 78:775-779.
16. Raghoebier S, Kibbelaar RE, Kleiverda JK, Kluin-Nelemans JC, van Krieken JHJM, Kok F, Kluin Ph. M. (1992): Mosaicism of trisomy 12 in chronic lymphocytic leukemia detected by non-radioactive In Situ hybridization. Leukemia 6:1220-1226.
17. Tiainen M, Popp S, Parlier V, Emmerich P, Bellomo MJ, Ruutu T, Cremer T, Knuutila S (1992): Chromosomal in situ suppression hybridization of immunologically classified mitotic cells in hematologic malignancies. Genes Chromosom Cancer 4:135-140.
18. Escudier SM, Pereira-Leahy JM, Drach JW, Weier HU, Goodacre AM, Cork MA, Trujillo JM, Keating MJ, Andreeff M (1993): Fluorescent in situ hybridization and cytogenetic studies of trisomy 12 in chronic lymphocytic leukemia. Blood 81:2702-2707.
19. Garcia-Marco J, Matutes E, Morilla R, Ellis J, Oscier D, Fantes J, Catovsky D, Price CM (1994): Trisomy 12 in B-cell chronic lymphocytic leukaemia: assessment of lineage restriction by simultaneous analysis of immunophenotype and genotype in interphase cells by fluorescence in situ hybridization. Br J Haematol 87:44-50.
20. Juliusson G, Oscier D, Gahrton G (1991): Cytogenetic findings and survival in B-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients. Leukemia Lymphonia Suppl:21-25.
21. Juliusson G, Gahrton G (1993): Chromosome abnormalities in B-cell chronic lymphocytic leukemia. In: Chronic Lymphocytic Leukemia. Scientific advances and clinical development. BD Cheson, ed., Marcel Dekker, New York, pp 83-103.
22. Juliusson G, Robert K-H, Öst Å, Friberg K, Biberfeld P, Nilsson B, Zech L, Gahrton G (1985): Prognostic information from cytogenetic analysis in chronic B-lymphocytic leukemia and leukemic immunocytoma. Blood 65:134-141.
23. Juliusson G (1986): Immunologic and cytogenetic studies improve prognosis prediction in chronic B-lymphocytic leukemia. A multivariate analysis of 24 variables. Cancer 58:688-693.
24. Juliusson G, Gahrton G (1985): Abnormal/normal metaphase ratio and prognosis in chronic B-lymphocytic leukemia. Cancer Genet Cytogenet 18:307-313.
25. Juliusson GK, Friberg K, Gahrton G (1988): Consistency of chromosomal aberrations in chronic B-lymphocytic leukemia. A longitudinal cytogenetic study of 41 patients. Cancer 62:500-506.
26. Nowell PC, Moreau L, Growney P, Besa EC (1988): Karyotypic stability in chronic B-cell leukemia. Cancer Genet Cytogenet 33:155-160.
27. Oscier D, Fitchett M, Herbert T, Lambert T (1991): Karyotypic evolution in B-cell chronic lymphocytic leukemia. Genes Chromosom Cancer 3:16-20.
28. Fegan C, Robinson H, Thompson P, Whittaker JA, White D (1995): Karyotypic evolution in CLL: identification of a new sub-group of patients with deletions of 11q and advanced or progressive disease. Leukemia 9:2003-2008.
29. Crossen PE, Horn HL (1987): Origin of trisomy 12 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet 28:185-186.
30. Einhorn S, Burvall K, Juliusson G, Gahrton G, Meeker T (1989): Molecular analyses of chromosome 12 in chronic lymphocytic leukemia. Leukemia 3:871-874.
31. Mecucci C, Delannoy A, Van den Berghe H (1988): The origin of trisomy 12 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet 36:203-204.
32. Han T, Ozer H, Sadamori N, Emrich L, Gomez GA, Henderson ES, Bloom ML, Sandberg AA (1984): Prognostic importance of cytogenetic abnormalities in patients with chronic lymphocytic leukemia. N Engl J Med 310:288-292.
33. Hernandez JM, Mecucci C, Criel A, Meeus P, Michaux L, Van Hoof A, Verhoef G, Louwagie A, Scheiff J-M, Michaux J-L, Boogaerts M, Van den Berghe H (1995): Cytogenetic analysis of B cell chronic lymphoid leukemias classified according to morphologic and immunophenotypic (FAB) criteria. Leukemia 9:2140-2146.
34. Johansson B, Mertens F, Mitelman F (1995): Cytogenetic evolution patterns in non-Hodgkin's lymphoma. Blood 86:3905-3914.
35. Anastasi J, Le Beau MM, Vardiman JW, Fernald M, Larson RA, Rowley JD (1992): Detection of trisomy 12 in chronic lymphocytic leukemia by fluorescence in situ hybridization to interphase cells: a simple and sensitive method. Blood 79:1796-1801.
36. Cuneo A, Wlodarska L Sayed Aly M, Piva N, Carli MG, Fagioli F, Tallarico A, Pazzi I, Ferrari L, Cassiman JJ, Van den Berghe H, Castoldi GL (1992): Non-radioactive in situ hybridization for the detection and monitoring of trisomy 12 in B-cell chronic lymphocytic leukemia. Brit J Haematol 81:192-196.
37. Qumsiyeh MB, Tharapel SA (1992): Interphase detection of trisomy 12 in B-cell chronic lymphocytic leukemia by fluorescence hybridization in situ. Leukemia 6:602-605.
38. Döhner H, Pohl S, Bulgay-Mörschel M, Stilgenbauer S, Bentz M, Lichter P (1993): Trisomy 12 in chronic lymphoid leukemias - a metaphase and interphase cytogenetic analysis. Leukemia 7:516-520.
39. Criel A, Wlodarska I, Meeus P, Stul M, Louwagie A, Van Hoof A, Hidajat M, Mecucci C, Van den Berghe H (1994): Trisomy 12 is uncommon in typical chronic lymphocytic leukaemias. Brit J Haematol 87:523-528.
40. Arif M, Tanaka K, Asou H, Ohno R, Kamada N (1995): Independent clones of trisomy 12 and retinoblastoma gene deletion in Japanese B cell chronic lymphocytic leukemia, detected by fluorescence in situ hybridization. Leukemia 9:1822-1827.
41. Que TH, Garcia-Marco J, Ellis J, Matutes E, Brito-Babapulle V, Boyle S, Catovsky D (1993): Trisomy 12 in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: Analysis by stage, immunophenotype, and morphology. Blood 82:571-575.
42. Matutes E, Oscier D, Garcia-Marco J, Ellis J, Copplestone A, Gillingham R, Hamblin T, Lens D, Swansbury GJ, Catovsky D (1996): Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients. Br J Haematol 92:382-388.
43. Garcia-Marco J, Matutes E, Price CM, Ellis J, Que TH, Lens D, Catovsky D (1994): Correlation of trisomy 12 with expression of the proliferating nuclear antigen K-67 in chronic lymphocytic leukemia: Br J Haematol 86 (Suppl 1):24.
44. Garcia-Marco J, Price CM, Ellis J, Morilla R, Lens D, Matutes E, Oscier D, Catovsky D (1994): "In vitro" proliferation in chronic lymphocytic leukemia. An interphase cytogenetic analysis of clonal growth after mitogen stimulation. Blood 84 (Suppl 1):453.
45. Gahrton G, Robèrt K-H, Friberg K, Juliusson G, Biberfeld P, Zech L (1982): Cytogenetic mapping of the duplicated segment of chromosome 12 in lymphoproliferative disorders. Nature 297:513-514.
46. Gahrton G, Juliusson G, Robert K-H, Fribert K (1987): Role of chromosomal abnormalities in chronic lymphocytic leukemia. Blood Reviews 1:183-392.
47. Xiao H, Block AW, Romano J, Dadley B, Han T, Sandberg AA (1990): i(12q) in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet 50:171-172.
48. McManus AP, Bailie KEM, Jess H (1994): A derivative chromosome 14 resulting in partial trisomy of chromosome 12 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet 76:159-160.
49. Watanabe T, Hotta T, Ichikawa A, Kinoshita T, Nagai H, Uchida T, Murate T, Saito H (1994): The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. Blood 84:3158-3165.
50. Robèrt K-H, Gahrton G, Friberg K, Zech L, Nilsson B (1982): Extra chromosome 12 and prognosis in chronic lymphocytic leukaemia. Scand J Haematol 28:163-168.
51. Sadamori N, Han T, Minowada J, Sandberg AA (1984): Clinical significance of cytogenetic findings in untreated patients with B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet 11:45-51.
52. Pittman S, Catovsky D (1984): Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia. Br J Haematol 58:64-660.
53. Fitchett M, Griffiths MJ, Oscier DG, Johnson S, Seabright M (1987): Chromosome abnormalities involving band 13q14 in hematologic malignancies. Cancer Genet Cytogenet 24:143-150.
54. Brown AG, Ross FM, Dunne EM, Steel CM, Weir-Thompson EM (1993): Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene. Nature Genet 3:67-72.
55. Marshall CJ (1991): Tumor Suppressor Genes. Cell 64:313-326.
56. Stilgenbauer S, Döhner H, Bulgay-Mörschel M, Weitz S, Bentz M, Lichter P (1993): High frequency of monoallelic retinoblastoma gene deletion in B-cell chronic lymphoid leukemia shown by interphase cytogenetics. Blood 81:2118-2124.
57. Döhner H, Pilz T, Fischer K, Cabot G, Diehl D, Fink T, Stilgenbauer S, Bentz M, Lichter P (1994): Molecular cytogenetic analysis of RB-1 deletions in chronic B-cell leukemias. Leuk & Lymph 16:97-103.
58. Liu Y, Grander D, Söderhäll S, Juliusson G, Gahrton G, Einhorn S (1992): Retinoblastoma gene deletions in B-cell chronic lymphocytic leukemia. Genes Chromosom Cancer 4:250-256.
59. Kay NE, Suen R, Ranheim E, Peterson LC (1993): Confirmation of Rb gene defects in B-CLL clones and evidence for variable predominance of the Rb defective cells within the CLL clone. Br J Haematol 84:257-264.
60. Chapman RM, Corcoran MM, Gardiner A, Hawthorn LA, Cowell JK, Oscier DG (1994): Frequent homozygous deletions of the D13S25 locus in chromosome region 13q14 defines the location of a gene critical in leukaemogenesis in chronic B-cell lymphocytic leukaemia. Oncogene 9:1289-1293.
61. Liu Y, Szekely L, Grandér D, Söderhäll S, Juliusson G, Gahrton G, Linder S, Einhorn S (1993): Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: Evidence for a role of an adjacent locus. Proc Natl Acad Sci USA 90:8697-8701.
62. Hawthorn LA, Chapman R, Oscier D, Cowell JK (1993): The consistent 13q14 translocation breakpoint seen in chronic B-cell leukemia (BCLL) involves deletion of the D12S25 locus which lies distal to the retinoblastoma predisposition gene. Oncogene 8:1415-1419.
63. Liu Y, Hermanson M, Grandér D, Merup M, Wu X, Heyman M, Rasool O, Juliusson G, Gahrton G, Detlofsson R, Nikiforova N, Buys C, Söderhäll S, Yankovsky N, Zabarovsky E, Einhorn S (1995): 13q deletions in lymphoid malignancies. Blood 86:1911-1915.
64. Stilgenbauer S, Leupolt E, Ohl S, Weiss G, Schröder M, Fischer K, Bentz M, Lichter P, Döhner H (1995): Heterogeneity of deletions involving RB-1 and the D13S25 locus in B-cell chronic lymphocytic leukemia revealed by fluorescence in situ hybridization. Cancer Res 55:3475-3477.
65. Mould S, Gardiner A, Corcoran M, Oscler DG (1996): Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia, Br J Haematol 92:389-392.
66. Van den Berghe H, Parloir C, David G, Michaux JL, Ferrant A, Sokal G (1979): A new characteristic karyotypic anomaly in lymphoproliferative disorders. Cancer 44:188-195.
67. Weisenburger DD, Sanger WG, Armitage JO, Purtilo DT (1987): Intermediate lymphocytic lymphoma: Immunophenotypic and cytogenetic findings. Blood 69:1617-1621.
68. van den Berg E, De Wolf-Peeters C, Van den Oord J, Wlodarska I, Delabie J, Stul M, Thomas J, Michaux J-L, Mecucci C, Cassiman J-J, Van den Berghe H (1991): Translocation (11;14): A cytogenetic anomaly associated with B-cell lymphomas of non-follicle centre cell lineage. J Pathol 163:13-18.
69. Newman RA, Peterson B, Davey FR, Brabyn C, Collins H, Brunetto VL, Duggan DB, Weiss RB, Royston I, Millard FE, Miller AA, Bloomfleld CD (1993): Phenotypic markers and BCL-1 gene rearrangements in B-cell chronic lymphocytic leukemia: A cancer and leukemia group B study. Blood 82:1239-1246.
70. Kobayashi H, Espinosa III R, Fernald M, Begy C, Diaz MO, Le Beau MM, Rowley JD (1993): Analysis of deletions of the long arm of chromosome 11 in hematologic malignancies with fluorescence in situ hybridization. Genes Chromosom Cancer 8:246-252.
71. Offit K, Louie DC, Parsa NZ, Filippa D, Gangi M, Siebert R, Chaganti RS (1994): Clinical and morphologic features of B-cell small lymphocytic lymphoma with del(6)(q21q23). Blood 83: 2611-2618.
72. Rechavi G, Katzir N, Simoni FB, Holtzman F, Mandel F, Gurfinkel N, Givol D, Ben-Bassat I, Ramot B (1989): A search for bel1, bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia. Leukemia 3:57-60.
73. McKeithan TW, Rowley JD, Shows TB, Diaz MO (1987): Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 84:9257-9260.
74. Gaidano G, Ballerini P, Gong JZ, Inghirami G, Neri A, Newcomb EW, Magrath IA, Knowles DM, Dalla-Favera R (1991): p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci USA 88:5413-5417.
75. Fenaux P, Preudhomme C, Laï JL, Quiquandon I, Jonveaux P, Vanrumbeke M, Sartiaux C, Morel P, Loucheux-Lefebvre MH, Bauters F, Berger R, Kerckaert JP (1992): Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis. Leukemia 6:246-250.
76. El Rouby S, Thomas A, Costin D, Rosenberg CR, Potmesil M, Silber R, Newcomb EW (1993): p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. Blood 82:3452-3459.
77. Newcomb EW (1995): P53 gene mutations in lymphoid diseases and their possible relevance to drug resistance. Leukemia & Lymphoma 17:211-221.
78. Döhner H, Fischer K, Bentz M, Hansen K, Benner A, Cabot G, Diehl D, Schlenk R, Coy J, Stilgenbauer S, Volkmann M, Galle PR, Poustka A, Hunstein W, Lichter P (1995): p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood 85:1580-1589.
79. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Mueller-Hermeling H-K, Pileri SA, Piris MA, Ralflkiaer E, Warnke RA (1994): A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84:1361-1392.
80. Bienz N, Cardy DLN, Leyland MJ, Hultén MA (1993): Trisomy 12 in B-cell chronic lymphocytic leukaemia: an evaluation of 33 patients by direct fluorescence in situ hybridization (FISH). Br J Haematol 85:819-822.
81. Cuneo A, Bigoni R, Balboni M, Carli MG, Piva N, Fagioli F, Latorraca A, Wlodarska I, Van den Berghe H, Castoldi G (1994): Trisomy 12 in chronic lymphocytic leukemia and hairy cell leukemia: a cytogenetic and interphase cytogenetic study. Leuk & Lymph 15:167-172.
82. Witzig TE, Borell TJ, Herath JF, Tefferi A, Li C-Y, Jenkins RB (1994): Detection of trisomy 12 by FISH In untreated B-chronic lymphocytic leukemia: correlation with stage and CD20 antigen expression Intensity. Leukemia Lymphoma 14:447-451.
83. Knauf WU, Knuutila S, Zelgmeister B, Thiel E (1995): Trisomy 12 in B-cell chronic lymphocytic leukemia: correlation with advanced disease, atypical morphology, high levels of sCD25, and with refractoriness to treatment. Leuk & Lymph 19:289-294.
84. Woessner S, Solé F, Pérez-Losada A, Florensa L, Vilá RM (1996): Trisomy 12 is a rare cytogenetic finding in typical chronic lymphocytic leukemia. Leuk Res 20:369-374.