Heart transplants in interferon-γ, interleukin 4, and interleukin 10 knockout mice: Recipient environment alters graft rejection

Journal of Clinical Investigation

Volumn 100, Issue 10, 1997, Pages 2449-2456

  Räisänen Sokolowski, Anne ^a   Mottram, Patricia L ^b   Glysing Jensen, Troels ^a   Satoskar, Abhay ^a   Russell, Mary E ^a,c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cytokine regulation; Graft survival; Inflammatory activation; Targeted gene deficiency

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; GENE DELETION; GRAFT SURVIVAL; HEART TRANSPLANTATION; INFLAMMATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE NECROSIS;

EID: 0344316937     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119787     Document Type: Article

References (43)

1. Abbas, A., K. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature. 383:787-793.
2. Räisänen-Sokolowski, A., T. Glysing-Jensen, P. Mottram, and M. Russell. 1997. Sustained anti-CD4/CD8 blocks inflammatory activation and intimal thickening in mouse heart allografts. Arterioscl. Thromb. Vasc. Biol. 17:2115-2122.
3. Dallman, M., C. Larsen, and P. Morris. 1991. Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. J. Exp. Med. 174:493-496.
4. Takeuchi, T., R. Lowry, and B. Konieczny. 1992. Heart allografts in murine systems: the differential activation of TH2-like effector cells in peripheral tolerance. Transplantation (Baltimore). 53:1281-1294.
5. Sayegh, M.H., E. Akalin, W.W. Hancock, M.E. Russell, C.B. Carpenter, P.S. Linsley, and L.A. Turka. 1995. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J. Exp. Med. 181(5):1869-1874.
6. Binder, J., M. Lehmann, E. Graser, W. Hancock, B. Watschinger, K. Onodera, M. Sayegh, H.-D. Volk, and J. Kupiec-Weglinski. 1996. The effects of nondepleting CD4 targeted therapy in presensitized rat recipient of cardiac allografts. Transplantation (Baltimore). 61:804-811.
7. Hancock, W.W., M.H. Sayegh, X.-G. Zheng, R. Peach, P.S. Linsley, and L.A. Turka. 1996. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc. Natl. Acad. Sci. USA. 93:13967-13972.
8. Onodera, K., W. Hancock, E. Graser, M. Lehmann, M. Sayegh, T. Strom, H.-D. Volk, and J. Kupiec-Weglinski. 1997. Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients. J. Immunol. 158:1572-1581.
9. VanBuskirk, A.M., M.E. Wakely, and C.G. Orosz. 1996. Transfusion of polarized TH2-like cell populations into SCID mouse cardiac allograft recipients results in acute allograft rejection. Transplantation (Baltimore). 62(2):229-238.
10. Saleem, S., B. Konieczny, R. Lowry, F. Baddoura, and F. Lakkis. 1996. Acute rejection of vascularized heart allografts in the absence of IFN-γ. Transplantation (Baltimore). 62:1908-1911.
11. Picotti, J., S. Chan, R. Goodman, J. Magram, E. Eichwald, and D. Bishop. 1996. IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. J. Immunol. 157:1951-1957.
12. Lakkis, F., B. Konieczny, S. Saleem, F. Baddoura, P. Linsley, D. Alexander, R. Lowry, T. Pearson, and C. Larsen. 1997. Blocking the CD28-B7 T cell costimulation pathway induced long term cardiac allograft acceptance in the absence of IL-4. J. Immunol. 158:2443-2448.
13. Corry, R.J., H.J. Winn, and P.S. Russell. 1973. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation (Baltimore). 16(4):343-350.
14. Mottram, P.L., J.A. Smith, A. Mason, A. Mirisklavos, L.J. Dumble, and G.J. Clunie. 1988. Electrocardiographic monitoring of cardiac transplants in mice. Cardiovasc. Res. 22(5):315-321.
15. Dalton, D.K., S. Pitts-Meek, S. Keshav, I.S. Figari, A. Bradley, and T.A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science. 259 (5102):1739-1742.
16. Kühn, R., K. Rajewsky, and W. Müller. 1991. Generation and analysis of interleukin-4 deficient mice. Science. 254:707-710.
17. Kühn, R., J. Löhler, D. Rennick, K. Rajewsky, and W. Müller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75:263-274.
18. Mottram, P.L., W.R. Han, L.J. Purcell, I.F. McKenzie, and W.W. Hancock. 1995. Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy. Transplantation (Baltimore). 59(4):559-565.
19. Pearson, T., J. Madsen, C. Larsen, P. Morris, and K. Wood. 1992. Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody. Transplantation (Baltimore). 54:475-483.
20. Billingham, M.E., R.B. Nathaniel, N.R.B. Cary, M.E. Hammond, J. Kemnitz, C. Marboe, H.A. McCallister, D.C. Snovar, G.L. Winters, and A. Zerbe. 1990. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: heart rejection study group. J. Heart Transplant. 9:587-593.
21. Russell, M.E., A.F. Wallace, W.W. Hancock, M.H. Sayegh, D.H. Adams, N.E.S. Sibinga, L.R. Wyner, and M.J. Karnovsky. 1995. Upregulation of cytokines associated with macrophage activation in the Lewis to F344 rat chronic cardiac rejection model. Transplantation (Baltimore). 59(4):572-578.
22. Russell, M.E., W.W. Hancock, E. Akalin, A.F. Wallace, T. Glysing-Jensen, T. Willett, and M.H. Sayegh. 1996. Chronic cardiac rejection in the Lewis to F344 rat model: blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis. J. Clin. Invest. 97:833-838.
23. Birch, D., L. Kolmodin, W. Laird, N. McKinney, J. Wong, K. Young, G. Zangenberg, and M. Zoccoli. 1996. Simplified hot start PCR. Nature. 381:445-446.
24. Roux, K. 1995. Optimization and troubleshooting in PCR. PCR Methods Appl. 4(5):S185-S194.
25. Andersson, U., and J. Andersson. 1994. Immunolabeling of cytokine-producing cells in tissues and in cell suspension. In Cytokine-producing Cells. D. Fradelizie, and D. Emelie, editors. INSERM, Paris. 32-49.
26. Brown, M., L. Engelman, J. Frane, M. Hill, R. Jennrich, and J. Toporek. 1983. BMDP Statistical Software: 1983 Printing with Additions. University of California Press, Berkeley, CA. 733 pp.
27. Russell, M.E., D.H. Adams, L.R. Wyner, Y. Yamashita, N.J. Halnon, and M.J. Karnovsky. 1993. Early and persistent induction of monocyte chemoattractant protein 1 in rat cardiac allografts. Proc. Natl. Acad. Sci. USA. 90(13):6086-6090.
28. Russell, M.E., A.F. Wallace, L.R. Wyner, J.B. Newell, and M.J. Karnovsky. 1995. Upregulation and modulation of inducible nitric oxide synthesis in rat cardiac allografts with chronic rejection and transplant arteriosclerosis. Circulation. 92:457-464.
29. Utans, U., R.J. Arceci, Y. Yamashita, and M.E. Russell. 1995. Cloning and characterization of allograft inflammatory factor-1: a novel macrophage factor identified in rat cardiac allografts with chronic rejection. J. Clin. Invest. 95:2954-2962.
30. Rollins, B.J. 1996. Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease. Mol. Med. Today. 2(5):198-204.
31. Lowry, R.P., B. Konieczny, D. Alexander, C. Larsen, T. Pearson, S. Smith, and S. Narula. 1995. Interleukin-10 eliminates anti-CD3 monoclonal antibody-induced mortality and prolongs heart allograft survival in inbred mice. Transplant. Proc. 27(1):392-394.
32. Oian, S., W. Li, F. Fu, L. Lu, J. Fung, and A. Thomson. 1996. Systemic administration of cellular interleukin-10 can exacerbate cardiac allograft rejection in mice. Transplantation (Baltimore). 62:1709-1714.
33. Konieczny, B., E. Elwood, C. Larsen, T. Pearson, P. Linsley, and F. Lakkis. May 1997. Absence of IFN-gamma reduces murine cardiac and skin allograft survival following costimulation blockade. American Society of Transplant Physicians Annual Meeting, Chicago. 7(Abstr.):86.
34. Qin, L., K.D. Chavin, Y. Ding, H. Tahara, J.P. Favaro, J.E. Woodward, T. Suzuki, P.D. Robbins, M.T. Lotze, and J.S. Bromberg. 1996. Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival. J. Immunol. 156(6):2316-2323.
35. Dusting, G. 1995. Nitric oxide in cardiovascular disorders. J. Vasc. Res. 32:143-161.
36. Lowry, R., and T. Takeuchi. 1994. The Th1, Th2 paradigm and transplantation tolerance. R,G. Landes Company, Austin, TX. 134 pp.
37. Mosmann, T., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today. 17:138-147.
38. Szalay, G., C. Ladel, C. Blum, and S. Kaufmann. 1996. IL-4 neutralization or TNF-α treatment ameliorate disease by an intracellular pathogen in IFN-γ receptor deficient mice. J. Immunol. 157:4746-4750.
39. Hickey, M., P. Reinhardt, L. Ostrovsky, W. Jones, M. Jutila, D. Payne, J. Elliot, and P. Kubes. 1997. Tumor necrosis factor-α induces leukocyte recruitment by different mechanisms in vivo and in vitro. J. Immunol. 158:3391-3400.
40. Manourny-Schwartz, B., G. Chiocchia, N. Bessis, O. Abehsira-Amar, F. Bateux, S. Muller, S. Huang, M. Boisser, and C. Fournier. 1997. High susceptability to collagen-induced arthritis in mice lacking IFN-γ receptors. J. Immunol. 158:5501-5506.
41. Vermeire, K., H. Heremans, M. Vandeputte, S. Huang, A. Billiau, and P. Matthys. 1997. Accelerated collagen-induced arthritis in IFN-γ receptor-deficient mice. J. Immunol. 158:5507-5513.
42. Nickerson, P., J. Steiger, X. Zheng, A. Steele, W. Steurer, P. Roy-Chaudhury, and T. Strom. 1997. Manipulation of cytokine networks in transplantation: false hope or realistic opportunity for tolerance? Transplantation (Baltimore). 63:489-494.
43. Orosz, C.G. 1996. Networked alloimmunity: a brief reexamination of some basic concepts in transplantation immunobiology. J. Heart Lung Transplant. 15:1063-1068.